NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration by XiaoLu Zhang, XiaoLu Zhang, HuanNa Tian, HuanNa Tian, HaiMei Bo, Li Zhong

“…In vitro, oxygen-glucose deprivation (OGD)-challenged HT22 hippocampal neurons were co-cultured with M-EV to assess viability, migration, and apoptosis.ResultsM-EV outperformed conventional EVs in functional recovery, with miR-139-5p and miR-133b identified as key miRNAs enriched in M-EV, mediating neuroprotective effects. …”
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Green Processing of <i>Ilex guayusa</i>: Antioxidant Concentration and Caffeine Reduction Using Encapsulation by Supercritical Antisolvent Process by Miguel Ángel Meneses, Jhulissa Guzmán, Jhulissa Cabrera, Jorge Magallanes, Eduardo Valarezo, María del Cisne Guamán-Balcázar

“…These results highlight the effectiveness of the SAE co-precipitation process in developing low-caffeine functional ingredients with potential food and pharmaceutical applications.…”
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EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS by V. S. Shirinsky, V. M. Nepomnyashikh, M. I. Leonova, O. L. Krugleeva, V. S. Kozhevnikov, N. Yu. Solovyova, A. V. Shurlygina, G. I. Litvinenko, I. V. Shirinsky, O. A. Malysheva

“…Assessment of pharmacological effects included counting functional evaluation of T-cells, B-cells and phagocytes, as well as morning and evening serum levels of IgE, IL-4 and IFN-γ. …”
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Face Mesh for Dementia Detection: Evaluating Data Augmentation in Deep Learning and Traditional Machine Learning by Chuheng Zheng, Mondher Bouazizi, Taichi Okunishi, Tomoaki Ohtsuki, Momoko Kitazawa, Toshiro Horigome, Taishiro Kishimoto

“…Language-based approaches for dementia detection have received considerable attention in research due to dementia&#x2019;s nature of hurting cognitive and language functions. Facial features, on the other hand, have been comparatively neglected despite their potential in identifying AD. …”
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APPLICATION OF PHOSPHODIESTERASE TYPE 5 INHIBITORS SILDENAFIL IN PATIENTS WITH PULMONARY HYPERTENSION by T. V. Martynyuk, Z. H. Dadacheva, V. M. Paramonov, O. A. Arkhipova, S. N. Nakonechnikov, I. Ye. Chazova

“…After three months of treatment significant hemodynamic and functional class improvements were noted in every sildenafil group as compared to placebo. …”
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Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions by Dongyun Ye, Zhihui Hao, Shusheng Tang, Tony Velkov, Chongshan Dai

“…Exposure to AFB₁ can disrupt the structure and functionality of reproductive organs, leading to gametogenesis impairment in males, subsequently reducing fertility. …”
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Research progress on the microbial metabolism and transport of polyamines and their roles in animal gut homeostasis by Chong Zhang, Yongkang Zhen, Yunan Weng, Jiaqi Lin, Xinru Xu, Jianjun Ma, Yuhong Zhong, Mengzhi Wang

“…Collectively, these regulatory effects help maintain intestinal epithelial homeostasis and ensure the integrity of the gut barrier. …”
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A Deep-Layered Water Flow Optimizer for Global Continuous Optimization Problems and Parameter Estimation of Solar Photovoltaic Models by Zhentao Tang, Kaiyu Wang, Mingxin Zhu, Yongxuan Yao, Lan Zhuang, Huiqin Chen, Jing Li, Li Yan, Shangce Gao

“…In the experimental section, we compare DWFO with nine state-of-the-art algorithms on the IEEE Congress on Evolutionary Computation 2017 (CEC2017) benchmark functions and the CEC2011 real-world optimization problems. …”
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A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels by Julia María Coronas-Serna, Teresa Fernández-Acero, María Molina, Víctor J. Cid

“…By heterologous expression in Saccharomyces cerevisiae, we have developed a humanized yeast system as a tool for functional studies on higher eukaryotic PI3K. Here we restrict PI3K activity in yeast to specific plasma membrane (PM) microdomains by fusing the p110α PI3K catalytic subunit to either a septin or an eisosome component. …”
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Multimodal Metaverse Healthcare: A Collaborative Representation and Adaptive Fusion Approach for Generative Artificial-Intelligence-Driven Diagnosis by Jianhui Lv, Adam Slowik, Shalli Rani, Byung-Gyu Kim, Chien-Ming Chen, Saru Kumari, Keqin Li, Xiaohong Lyu, Huamao Jiang

“…MMLMH’s successful functioning in such complicated circumstances suggests that it can combine and process information streams from several sources. …”
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Mutual Validation of Data Sets for Analyzing Tilt Angles in Solar Active Regions by Lang Qin, Jie Jiang, Ruihui Wang

“…The σ _α values demonstrate a strong correlation with AR flux and sunspot area, with the dependency functions reevaluated using mutually validated data sets. …”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…A series of experiments including cross-validation, independent testing, ablation studies, and visualizations demonstrate the effectiveness of the DGIL-6 method.…”
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Safety Assessment of Cassava Pulp-Derived Dietary Fiber: Acute and Sub-Acute Toxicity Evaluation by Naiyana Nontamart, Kakanang Posridee, Parin Suwannaprapha, Rungrudee Srisawat, Ratchadaporn Oonsivilai

“…This study rigorously evaluated the safety profile of dietary fiber extracted from cassava pulp, a promising functional food ingredient, through acute and 28-day sub-acute oral toxicity assessments in Wistar rats. …”
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Synthesis and characterization of magnetic chitosan microspheres as coking wastewater adsorbents by Yunlong Zhao, Hao Peng, Lei Zhang, Wanwan Fu, Man Zhang, Zhishan Chen, Longfei Li, Yutao Chen

“…As a new type of polymer functional material, magnetic chitosan has been widely used in wastewater treatment. …”
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Cerebral perfusion is correlated with cerebral metabolism and amyloid deposition in Alzheimer’s disease by Ping Che, Li Cai, Fang Liu, Yidi Wang, Yanxin Zhang, Ying Wang, Qingzheng Lu, Zhiyan Piao, Xiaoyi Zhang, Wen Qin, Nan Zhang

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Enhanced Control of Single Crystalline Ag Dendritic Growth on Al Foil via Galvanic Displacement and Simultaneous Oxidation of D‐Glucose by Lidija D. Rafailović, Stefan M. Noisternig, Jana Bischoff, Christian Rentenberger, Daniel Bautista – Anguis, Huaping Sheng, Christoph Gammer, Jia Min Chin, Adam Elbataioui, Huanqing Zhang, Jürgen Eckert, Tomislav Lj. Trišović

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Nanoconfinement Engineering of Covalent Organic Frameworks in Polyamide Membranes for High‐Perselectivity Li+/Mg2+ Separation by Shuzhen Zhao, Liheng Dai, Zhaohuan Mai, Bowen Li, Pengfei Zhang, Mengxiao Zhang, Atsushi Matsuoka, Kecheng Guan, Ryosuke Takagi, Hideto Matsuyama

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Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators by Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing

“…The robustness of our findings was established through stringent criteria, comprehensive sensitivity analyses, and Bayesian colocalization, followed by functional validation with TCGA data and a transcriptome-wide association study (TWAS). …”
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Nutrient, Organic Matter and Shading Alter Planktonic Structure and Density of a Tropical Lake by Marina Isabela Bessa da Silva, Luciana Pena Mello Brandão, Ludmila Silva Brighenti, Peter A. U. Staehr, Cristiane Freitas de Azevedo Barros, Francisco Antônio Rodrigues Barbosa, José Fernandes Bezerra-Neto

“…Understanding tropical plankton dynamics in response to environmental changes, such as those simulated in this work, is important for understanding the effects of climate and anthropogenic changes on tropical lake functioning. …”
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Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

“…In the FER, the YOLOv10 (You Only Look Once, version 10)-based classifier functions as an automatic object detection (OD) framework, enabling infant facial capture and expression recognition. …”
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