Metabarcoding-based characterization of soil nematode communities to assess soil health in viticulture by Rubén Blanco-Pérez, María de Toro, Sergio Álvarez-Ortega, Alícia Pou, Sara Sánchez-Moreno, Raquel Campos-Herrera

“…In contrast, tillage and cover cropping had limited effects on nematode community structure and soil health indices, suggesting a weaker influence on nematode-mediated soil functions under the studied conditions. …”
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Molybdenum Can Regulate the Expression of Molybdase Genes, Affect Molybdase Activity and Metabolites, and Promote the Cell Wall Bio-Synthesis of Tobacco Leaves by Yuan Zhao, Yu Zhang, Kai Zhang, Jiashu Tian, Huanyu Teng, Zicheng Xu, Jiayang Xu, Huifang Shao, Wei Jia

“…This study thoroughly investigated the regulatory effects of different concentrations of Mo on tobacco cell wall biosynthesis from physiological and metabolomic aspects. …”
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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate by Ruirui Li, Shufang Shan, Yujie Xu, Jingyuan Xiong, Guo Cheng

“…Fermentation-released bioactive peptides have the potential to contribute to the neuroprotective effects of fermented dairy products. However, known neuroprotective peptides are mostly prepared by enzymatic hydrolysis, and physicochemical screening of food-derived functional peptides typically overlooks the interference of biotransport after ingestion. …”
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Trauma resuscitation with Low-Titer Group O Whole Blood Or Products: study protocol for a randomized clinical trial (the TROOP trial) by Jan O. Jansen, Claudia Pedroza, Luis Leon Novelo, Tianyao Hao, Gina R. DeWildt, Charles F. Coton, Kiran Mansoor, Shannon W. Stephens, Marisa B. Marques, James R. Stubbs, Jillian R. Richter, Henry E. Wang, John B. Holcomb, Stacia M. DeSantis

“…The aim of the “Trauma Resuscitation with Low-Titer Group O Whole Blood Or Products” (TROOP) trial is to compare the effectiveness and safety of LTOWB and CT in critically injured patients predicted to require a large volume transfusion. …”
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Zero-field chiral edge transport in an intrinsic magnetic topological insulator MnBi2Te4 by Chusheng Zhang, Xiufang Lu, Naizhou Wang, Tianye Huang, Hanxiang Zhang, Ning Cao, Aifeng Wang, Xiaoyuan Zhou, Kenji Watanabe, Takashi Taniguchi, Su-Yang Xu, Weibo Gao

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Antioxidant and <i>In Vitro</i> Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of <i>Citrus lumia</i> Risso (Rutaceae) by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia, Vincenzo Mollace

“…In particular, the polyphenolic fraction of <i>Citrus lumia</i> peel showed promising effects on lipid metabolism and cellular energy balance and may prove valuable in the treatment of metabolic disorders such as MASLD, where lipid accumulation disrupts normal cellular functions.…”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…Post-HDACs inhibition, Treg proportions increased with enhanced immunomodulatory effects. Importantly, HDACs exhibited a positive promoting role on Th17 cells. …”
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Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

“…Hypernatraemia adversely affects various physiological functions and is associated with delirium, prolonged length of stay and increased ICU and post-discharge mortality. …”
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Novel artificial tricalcium phosphate and magnesium composite graft facilitates angiogenesis in bone healing by Yuan-Hsin Tsai, Chun-Chieh Tseng, Yun-Chan Lin, Howida M. Nail, Kuan-Yu Chiu, Yen-Hao Chang, Ming-Wei Chang, Feng-Huei Lin, Hui-Min David Wang

“…Conclusion: In summary, we introduced a novel CPC sponge, which had a similar property to human bone promoted the biological functions of bone cells, and could serve as a promising material used in bone regeneration for critical bone defects.…”
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A Novel Cystatin Gene from Sea Cucumber (<i>Apostichopus japonicus</i>): Characterization and Comparative Expression with Cathepsin L During Early Stage of Hypoxic Exposure-Induced... by Siyu Yao, Rui Zhang, Siyuan Ma, Ting Zhao, Qinhao Liu, Lin Zhu, Chang Liu, Liming Sun, Ming Du

“…Additionally, recombinant SjCyt was prepared and demonstrated an evident autolysis-inhibiting effect. The results of this study indicated that the anti-autolytic regulation of SjCyt functions at the very early stage of hypoxic exposure, exerting effects at both the transcriptional and translational levels. …”
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A mindfulness-based, cognitive, social, digital relapse-prevention intervention for youth with depression in Australia: study protocol for a randomised controlled trial of Rebound by Mario Alvarez-Jimenez, Sarah Bendall, Peter Koval, Simon Rice, Daniela Cagliarini, Lee Valentine, Penni Russon, Jess Phillips, Reeva Lederman, Cathrine Mihalopoulos, Helen Herrman, Cesar Gonzalez-Blanch, Alexandra Parker, Shaminka N Mangelsdorf, Richard M Ryan, Sarah Hetrick, Yong Yi Lee, Greg Murray, Christopher Davey, Virginia Liu, Simon D'Alfonso, Brendan Pawsey, John Gleeson

“…Introduction Major depressive disorder (MDD) causes significant disease burden and functional impairment during adolescence and young adulthood. …”
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Deep learning of the particulate and mineral-associated organic carbon fractions using a compositional transform and mid-infrared spectroscopy by Mingxi Zhang, Zefang Shen, Lewis Walden, Farid Sepanta, Zhongkui Luo, Lei Gao, Oscar Serrano, Raphael A. Viscarra Rossel

“…The SHAP values reflected the compositional modelling and identified important organic and inorganic functional groups that differed by fraction and land use. …”
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Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma by Wenyu Shi, Zijun Y. Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai, Anamarija M. Perry, Shi Wang, Xiaoxiao Wang, April Chiu, Mina L. Xu, Carlo Visco, Karen Dybkaer, Henry Withers, Mark Long, Alyssa F. Yuan, Yi Miao, Everardo Macias, Dehong Wu, Wen Shuai, Bangchen Wang, Jianyong Li, Govind Bhagat, Youli Zu, Zenggang Pan, William Choi, Santiago Montes-Moreno, Weina Chen, J. Han van Krieken, Michael B. Møller, Xinfang Yu, Benjamin M. Parsons, Shanxiang Zhang, Eric D. Hsi, Aliyah R. Sohani, Jeremy S. Abramson, Andrés J. M. Ferreri, Bing Xu, Yong Li, Ken H. Young

“…Genetic alteration analysis found that multiple chromosomal copy number variations (CNVs), TP53 transcript mutations with high variant allele frequency, and MCD subtype had significantly adverse prognostic effects, whereas elevated microsatellite instability had a significantly favorable prognostic effect in PT-DLBCL. …”
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Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer by Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu

“…Methods High‐throughput sequencing‐based approach was employed to identify HBV integrations in tumour and para‐tumour tissues of PDAC. The biological functions of KMT2B were evaluated in PDAC cell lines as well as in subcutaneous and orthotopic mouse models of PDAC. …”
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Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…Publicly available data from the Gene Expression Omnibus (GEO) database were analyzed to assess the association between PDPN expression and patient survival. Functional assays using direct and indirect co-culture systems investigated the influence of macrophage infiltration on stromal PDPN expression and its effect on colon adenocarcinoma cell growth. …”
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Reproductive resilience and trade-offs: Egg component allocation under nutritional constraints in Japanese Quail by Gebrehaweria K. Reda, Sawadi F. Ndunguru, Renáta Knop, James K. Lugata, Brigitta Csernus, Gabriella Gulyás, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi

“…While these dietary shifts are known to influence overall reproductive output, their specific effects on the proportional composition of egg components remain unexplored. …”
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Planar chlorination engineering induced symmetry-broken single-atom site catalyst for enhanced CO2 electroreduction by Shengjie Wei, Jiexin Zhu, Xingbao Chen, Rongyan Yang, Kailong Gu, Lei Li, Ching-Yu Chiang, Liqiang Mai, Shenghua Chen

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Land-sea integrated suitability evaluation of underground space based on Pythagorean fuzzy Bayesian network by Xinyu Liu, Hongjun Liu, Jie Dong, Peng Yu, Honghua Liu, Guanghua Cheng

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Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational... by Christopher E Brightling, Kamlesh Khunti, Naveed Sattar, Colin Berry, John P Greenwood, Gerry P McCann, Kelly S Parke, Joanne V Wormleighton, Stefan Neubauer, Betty Raman, Charalambos Antoniades, Elizabeth M Tunnicliffe, Alastair Moss, Jayanth Ranjit Arnold, Mark Toshner, Sue Francis, Sandeep S Hothi, Stephen M Smith, Mohamed Elshibly, Simran Shergill, Rachel J England, George J Hudson, James Wild

“…Results will be disseminated via peer-reviewed journals and scientific meetings.Trial registration number COSMIC is registered as an extension of C-MORE (Capturing Multi-ORgan Effects of COVID-19) on ClinicalTrials.gov (NCT04510025).…”
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Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…In addition, through GO and KEGG pathway annotations, we analyzed gene functions and their related pathways. We also adopted ELISA and TUNEL to investigate the effect of si-NEAT1 on endothelial inflammation and apoptosis. …”
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