Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an examp... by Jinchao Zhu, Qingyuan Lin, Honglin Zhu, Siqi Xie, Shengdong Nie

“…GO and KEGG analyses were employed to elucidate related functions and molecular mechanisms. STRING and Cytoscape software were utilized to identify key hub genes, while molecular docking validation was performed using the CB-Dock2 database. …”
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Thematic Issue on “Red Beetroot as a Source of Nutrients, Bioactive Compounds and Pigments” by Wiesław Wiczkowski

“…This Thematic Issue of Polish Journal of Food and Nutrition Sciences deals with the trans-disciplinary aspects of red beetroot as well as the red beetroot-derived products in the following topics: processing and storage – effect on the quality and functionality; bioactive constituents and nutritional value; profile, absorption, metabolism, and bioavailability of phytochemicals; potential health-promoting and microbiological activities; and new analytical methods for compounds study. …”
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The Mediating Roles of Self-Compassion and Emotion Regulation in the Relationship Between Psychological Resilience and Mental Health Among College Teachers by Rehman S, Addas A, Rehman E, Khan MN

“…Cognitive reappraisal was found to have a positive mediating effect on this relationship (β=0.16, p< 0.01), highlighting its functional significance in regulating emotions. …”
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Impact of Metabolic Dysfunction-Associated Fatty Liver Disease of Varying Severity on Antiviral Treatment Outcomes and Clinical Prognosis in Patients with Chronic Hepatitis B: A Sy... by Qianqian Zhu, Chengde Su, Mingdan Li, Yali Xu, Qian Liu, Ying Zhang, Xinyi Zhang, Qiuxiang Li, Huajun Wang, Yawen Luo, Ping Yang

“…CHB combined with moderate-to-severe MAFLD is associated with HBsAg/HBeAg seroclearance rate and the likelihood of achieving functional cure, suggesting that MAFLD may exert a potentially beneficial effect on antiviral therapy. …”
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Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation by Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi

“…Methods Cross‐validation and Density Functional Theory analysis were conducted utilizing the SwissDock server and the Gaussian 09 W software suite for the top‐ranked compounds. …”
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Iodine Content of Salt Use after Years of Universal Iodization Policy and Knowledge on Iodized Salt among Households in the Sissala East Municipality in Upper West Region of Ghana by Prince Kubi Appiah, Clement Tiimim Yanbom, Martin Amogre Ayanore, Alex Bapula

“…Iodine deficiency is a global public health concern as it leads to inadequate production of thyroid hormone in the body, causing too many destructive consequences on the roles and functions of different human organs and muscles including brain growth and can manifest into many damaging effects such as intestinal cerebral impedance, cancer of intestine, breast disorders, and physical deformities like goitre and cretinism to one’s body. …”
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Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing by Tomoki Yanagi, Shean Fu Phen, Jonah Ayala, Deniz Ece Aydin, Susanna Jaramillo, David M. Truong

“…To solve this issue, we tested different spacer sequences between A2UCOE and the inducible promoter and found that the SV40 poly-A terminator fully eliminated FOXN1 leakage, and we show this effect is not due to AT- or GC-content. Unexpectedly, this architecture further enhanced anti-silencing effects > 60% providing prolonged stability for at least 30 days. …”
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THE USE OF CRYOCONSERVATED PLACENTA FOR PREVENTION OF PATHOLOGIC SCAR FORMATION OF THE HEAD AND NECK AT THE INTRA- AND POSTOPERATIVE STAGE IN PLANNED SURGERY by O.A. Toropov, D.S. Avetikov, K.P. Lokes, D.V. Steblovskyi, V.M. Skrypnyk, R.A. Prykhidko

“…With the development of technology, it became possible to detect the phenotypic and functional heterogeneity of cell types. Discovering the role of each of these cell types and their interaction with each other is important for understanding the mechanisms of wound regeneration. …”
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Prognostic value of albumin-based malnutritional indices on short-term outcome in acute ischemic stroke patients undergoing reperfusion therapy by Junle Zhao, Mingjie Chen, Junning Mo, Yutong Zhong, Jiamin Qiu, Yanjiao Qiu, Youjia Li, Xiaoyan Han, Xiaoyan Han

“…Malnutrition was associated with the risk of 3-month poor functional outcome for CONUT (per 1-point increased, adjusted OR 1.59, 95%CI 1.40–1.82), for PNI (per 1-point increased, adjusted OR 0.86, 95%CI 0.82–0.90), and the NPAR (per 1-SD increased, adjusted OR 23.97, 95%CI 7.15–85.72). …”
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A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma by Yuan Zhang, Xiaochen Du, Yujuan Yang, Yaqiong Ren, Lijun Zhou, Jun Hua, Hongying Wang

“…Despite extensive genome-wide analyses pinpointing multiple susceptibility loci, the precise functional contributors to asthma pathogenesis remain elusive. …”
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IMMUNOINFLAMMATORY MECHANISMS OF THE FORMATION OF CHRONIC DUST BRONCHITIS IN MINERS by Николай Иванович Панев, Софья Олеговна Кунгурова, Анастасия Сергеевна Казицкая, Сергей Николаевич Филимонов, Наталья Александровна Евсеева, Галина Анатольевна Герасимова, Надежда Викторовна Ягнюкова

“…A particularly pronounced immunosuppressive effect of hypoxia on humoral immunity is manifested in patients with grade 2 DN, which leads to the addition of an infection of the bronchopulmonary system and an increase in the level of inflammation activity. …”
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THE STRUCTURE OF HAPPINESS REPRESENTATION FOR RUSSIAN AND AMERICAN REPRESENTATIVES by S. Yu. Zhdanova, A. V. Pecherkina, A. A. Strokanov

“…Emotional state of students exerts direct impact on their ability and readiness to cope with challenges when studying, gives rise to the success of educational process and its effectiveness. In this regard, the search of methods and determination of the tasks of psychological diagnostics is brought into focus. …”
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SBFI-26 enhances apoptosis in docetaxel-treated triple-negative breast cancer cells by increasing ROS levels by Gang He, Mei Liu, Tang cong Chen, Li fen Huang, You qiang Ke

“…This study delves into the functional mechanism and impact of combining SBFI-26 with docetaxel in treating MDA-MB-231 cells of triple-negative breast cancer. …”
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Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Research suggests that psoriasis-induced inflammation can trigger insulin resistance and high blood sugar (hyperglycemia), which in turn triggers abnormal functioning of the blood vessel’s inner lining, ultimately leading to atherosclerosis and cardiovascular disease. …”
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Higiene postural: factores que influyen en una correcta postura en niños y adolescentes. Una revisión sistemática (Postural hygiene: factors that influence correct posture in child... by Jorge Eduardo Olivares Arancibia, Rodrigo Nanjarí-Miranda, Felipe Aranda-Bustamante, Valerie Saavedra-León, Janis Zuñiga-Vivanco, Antonio Castillo-Paredes, Rodrigo Yáñez-Sepúlveda

“…Key words: Body posture, children, school, physical education, backpack effect. …”
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Fatigue impact of mixed reality in mass casualty incidents training by Ana María Cintora-Sanz, Raúl Muñoz-Romo, Alberto Blanco-Lara, Paula Sanchíz-Torres, Tatiana Vazquéz-Rodríguez, Helmut Schrom-Feiertag, Carmen Cardós-Alonso

“…Research on the psychological effects of fatigue from the use of MR in emergency professional training is crucial, but the understanding of its effects is still evolving. …”
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FOLR1-Targeted Oxygen-Delivering Nanosomes Enhance Chemo-Induced Apoptosis in Hypoxic Cancer by Lee G, Kim J, Yang J, Jang Y, Jang J, Tanaka M, Niepa THR, Lee HY, Choi J

“…This dual-delivery system effectively alleviated hypoxia within the tumor microenvironment and reduced the expression of the hypoxia-related gene HIF-1α by 50%. …”
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USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression by Beh Ning, Shao-An Wang, Ming-Jer Young, Yung-Ching Chen, Yun Hung, Tran Thu Huong, Wen-Chang Chang, Yi-Ching Wang, Ming-Lung Yu, Kai-Cheng Hsu, Jan-Jong Hung

“…Methods This study utilized CRISPR/Cas9 to create functional knockout mice (USP24C1695A) and treated HFD-fed mice with USP24 inhibitor (USP24-i-101). …”
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Balloon Guide Catheter Versus Non–Balloon Guide Catheter: A MR CLEAN Registry Analysis by Robrecht R.M.M. Knapen, Robert‐Jan B. Goldhoorn, Jeannette Hofmeijer, Geert J. Lycklamaà Nijeholt, René van den Berg, Ido R. van den Wijngaard, Robert J. van Oostenbrugge, Wim H. van Zwam, Christiaan van der Leij

“…A significant treatment effect was found between BGC use and thrombectomy technique. …”
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Autonomous International Classification of Diseases Coding Using Pretrained Language Models and Advanced Prompt Learning Techniques: Evaluation of an Automated Analysis System Usin... by Yan Zhuang, Junyan Zhang, Xiuxing Li, Chao Liu, Yue Yu, Wei Dong, Kunlun He

“…MethodsWe integrated 4 components into our framework: a medical pretrained BERT, a keyword filtration BERT in a functional order, a fine-tuning phase, and task-specific prompt learning utilizing mixed templates and soft verbalizers. …”
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