When and Why Adults Abandon Lifestyle Behavior and Mental Health Mobile Apps: Scoping Review by Patrick G Kidman, Rachel G Curtis, Amanda Watson, Carol A Maher

“…In total, 22 unique reasons for abandonment were organized into six categories: (1) technical and functional issues, (2) privacy concerns, (3) poor user experience, (4) content and features, (5) time and financial costs, and (6) evolving user needs and goals. …”
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Patient–Health Care Professional Communication via a Secure Web-Based Portal in Severe Mental Health Conditions: Qualitative Analysis of Secure Messages by Eva Meier-Diedrich, Carolyn Turvey, Jonas Maximilian Wördemann, Justin Speck, Mareike Weibezahl, Julian Schwarz

“…Regarding the purposes of SM, 4 core functions of SM were identified: reporting and feedback, interpersonal uses, intrapersonal uses, and organizational uses. …”
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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…Using up to five independent iPSC donors, we performed several assays for macrophage functions and polarization, such as marker protein staining by flow cytometry, lipoprotein uptake, phagocytosis, cytokine release, inflammasome activation, and the effects of M1-like and M2-like polarization. …”
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Study protocol for a 1-year, randomized, single-blind, parallel group trial of stand-alone indoor air filtration in the homes of US military Veterans with moderate to severe COPD i... by Brent Stephens, Insung Kang, Kaveeta Jagota, Zane Elfessi, Nancy Karpen, Saeed Farhoodi, Mohammad Heidarinejad, Israel Rubinstein

“…Participants are randomized to receive a placebo/sham unit or a normally functioning filtration unit containing high efficiency particulate air (HEPA), activated carbon, and zeolite media. …”
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Dose-Dependent Amelioration of Protein-Energy Malnutrition in Rats by Trigonella foenum-graecum Seed Supplementation by Lambe, M. O., Abdullahi, S., Sulyman, R. A., Akanmu, Z. I., Muhammad, K. T., Abdullahi, S., Chidolu, C. K.

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Electroencephalographic changes after one nigth of sleep deprivation Respostas eletrencefalográficas após uma noite de privação de sono by Camila Ferreira, Andréa Deslandes, Helena Moraes, Maurício Cagy, Fernando Pompeu, Luis Fernando Basile, Roberto Piedade, Pedro Ribeiro

“…Total or partial sleep deprivation (SD) causes degrading effects on different cognitive and psychomotor functions that might be related to electrophysiological changes frequently observed. …”
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Serum CD5L Responds Positively to Selenium and Coenzyme Q₁₀ Supplementation with Relation to Thyroid Hormones, Mortality, and Health-Related Quality-of-Life—A Sub-Analys... by Urban Alehagen, Jan O. Aaseth, Trine B. Opstad, Anders Larsson, Sabrina Asaad, Lutz Schomburg, Jan Alexander

“…It is an innate immune mediator protein with a multitude of functions, such as binding of invading microorganisms and oxidised LDL, and it is associated with clinical conditions, i.e., atherosclerosis and inflammation. …”
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The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism by Wilhelm Gottschall, Florent Ailloud, Christine Josenhans, Sebastian Suerbaum

“…Methylation has been associated with multiple functions in H. pylori, including the defense against foreign DNA and transcriptional regulation. …”
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Upregulation of 15-Hydroxyprostaglandin Dehydrogenase by Celecoxib to Reduce Pain After Laparoendoscopic Single-Site Surgery (POPCORN Trial): A Randomized Controlled Trial by Kyung Hee Han, Sunwoo Park, Seungmee Lee, Jiyeon Ham, Whasun Lim, Gwonhwa Song, Hee Seung Kim

“…Moreover, celecoxib effectively reduced NRS pain scores compared to placebo. …”
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Stimuli-Responsive Nodal Dual-Drug Polymer Nanoparticles for Cancer Therapy by Kuang G, Ding J, Xie W, Ye Z, Zhang Q

“…Developing functionally integrated and simplified multiple stimuli-responsive DDSs is crucial to addressing tumor diversity and enhancing treatment efficacy.Methods and Results: Here, we develop a dual-sensitive nodal dual-drug polymer nanoparticle (DDPoly NP) system for cancer therapy. …”
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Determination of malachite green in sediment by ultra performance liquid chromatography-mass spectrometry by Mei Guangming, Guo Yuanming, Zhang Xiaojun, Yan Zhongyong, Li Peipei, You Juju, Ding Yueping

“…However, owing to low cost and marked effect, MG may still be used illegally. Additionally, the environment has been polluted because of MG's wide use before. …”
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Changes in Hemostasis during Liver Transplantation in Children by D. I. Novikov, A. Yu. Zaitsev, K. V. Dubrovin, E. K. Bespalov, A. V. Filin

“…Within 1 hour after the start of arterial blood flow, the effects of systemic heparinoid effects persist, which is confirmed by the dynamics of CT 360.0 (219.5; 2,116.5) s with up to 960.0 (560.5; 1,440.5) s with p < 0.05 in the EXTEM test.Conclusion. …”
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Neuroprotective properties of n-phenylacetyl-l-prolylglycine ethyl ester nasal gel in an experimental model of multiple sclerosis equivalent by B.S. Burlaka, I.F. Belenichev, O.O. Nefedov, O.G. Aliyeva, N.V. Bukhtiyarova

“…., Spain) D003U1 series, 500 mg/kg, intragastrically. The in­tegrative functions of rats’ brain with EAE were studied using the “Open Field” method with an arena of own production with dimensions 80x80x35 cm. …”
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Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies. by Reecha Sofat, Jackie A Cooper, Meena Kumari, Juan P Casas, Jacqueline P Mitchell, Jayshree Acharya, Simon Thom, Alun D Hughes, Steve E Humphries, Aroon D Hingorani

“…Analyses were carried out within study, and, where appropriate, pooled effect estimates were derived using meta-analysis. …”
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Multi-Source Rainfall Data Assimilation based on Broad Learning System over Yunnan Province by Yuanyuan ZHOU, Xiaohui YANG, Tiangui XIAO

“…The accurate estimation of rainfall is always a topic of concern， given its pivotal role in accurately predicting rainfall-related disasters.This study proposed a multi-source rainfall assimilation technology based on a broad learning system （BLS） to improve the accuracy of rainfall estimation.Yunnan Province， located in China's low-latitude plateau， was chosen as the geographical area of interest to establish a multi-source rainfall assimilation model within this region.In particular， the model utilizes five satellite-derived rainfall datasets （3B42V7， IMERG， GSMaP， CMORPH， PERSIANN） and the latitude and longitude information as the source data， and the ground-based rainfall gauge data serves as the reference data.The time span of all the datasets is from April 2014 to December 2017.A leave-one-year-out cross-validation （LOYOCV） method was applied to verify the performance of the established assimilation model， where statistical indicators including Pearson’s correlation coefficient （CC）， root-mean square error （RMSE）， mean absolute error （MAE）， Nash efficiency coefficient （NSE） and Kling-Gupta efficiency （KGE） were used to quantify the accuracy of assimilation rainfall at different spatiotemporal scales.Concurrently， assimilation models based on support vector machine （SVM） and deep neural network （DNN） were established to highlight the accuracy and efficiency of the BLS， respectively.Additionally， the effectiveness of the latitude and longitude information within the proposed assimilation model was examined.The results show that the daily average statistical index of assimilation rainfall based on BLS is better than that of the other five satellite-based products in LOYOCV.At the temporal scale， the proposed assimilation technique effectively reflects the temporal variations observed in gauge-recorded rainfall.Moreover， it can accurately estimate the rainfall amounts during rainstorms in Yunnan Province throughout 2017.It is worth noting that the rainfall data generated through the BLS method outperforms the CMORPH product （the most accurate one among the five satellite-derived rainfall products） in both rainy and dry seasons （May to October and November to April of next year， respectively）.At the spatial scale， BLS-based rainfall results in most areas of Yunnan Province showed higher CC and NSE as well as smaller RMSE and MAE than the satellite-based products.The evaluation of the assimilation models based on BLS， SVM， and DNN highlights that the BLS exhibits superior functional mapping capabilities compared to SVM and demands fewer computational resources than DNN.It is reasonable to conclude that the multi-source rainfall assimilation approach utilizing the BLS while incorporating latitude and longitude information can enhance the precision of rainfall estimates in Yunnan Province.The proposed method presents practical significance in multi-source rainfall data assimilation.…”
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<i>C11orf58</i> (Hero20) Gene Polymorphism: Contribution to Ischemic Stroke Risk and Interactions with Other Heat-Resistant Obscure Chaperones by Irina Shilenok, Ksenia Kobzeva, Vladislav Soldatov, Alexey Deykin, Olga Bushueva

“…<b>Background</b>: Recently identified Hero proteins, which possess chaperone-like functions, are promising candidates for research into atherosclerosis-related diseases, including ischemic stroke (IS). …”
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Intermolecular FRET Pairs as An Approach to Visualize Specific Enzyme Activity in Model Biomembranes and Living Cells by Igor D. Zlotnikov, Alexander A. Ezhov, Elena V. Kudryashova

“…Therefore, we have shown that the method suggested has good potential in the visualization of enzyme functioning inside living cells, which is often a challenging task. …”
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Identification of potential druggable targets for endometriosis through Mendelian randomization analysis by Peng Chen, Xin Wei, Xiao-Ke Li, Yi-Hang Zhou, Yi-Hang Zhou, Qi-Fang Liu, Ling Ou-Yang

“…Additionally, we conducted a protein-protein interaction (PPI) network as well as functional enrichment analyses to unveil potential associations among target proteins.ResultsMR analysis revealed that a decrease of one standard deviation (SD) in plasma R-Spondin 3 (RSPO3) level had a protective effect on EM (OR = 1.0029; 95% confidence interval (95% CI): 1.0015–1.0043; P = 3.2567e-05; Bonferroni P &lt; 5.63 × 10−5). …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…The nanocomplex accumulated efficiently and uniformly across all CRC cell lines, regardless of their aggressiveness or drug sensitivity. The effect of nanocomplex-assisted PDT was the same among CRC cell lines, contrasting with the variable sensitivity to 5-fluorouracil. …”
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Exploring the Causal Association Between 91 Circulating Inflammatory Proteins and Neurodegenerative Diseases: A Bidirectional Two‐Sample Mendelian Randomization and Bioinformatics... by Ziwei Gong, Rong Cao, Hong Zhu

“…Four Mendelian randomization (MR) methods were employed to analyze causal effects, accompanied by sensitivity and pleiotropy analyses. …”
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