COMORBIDITIES IN PATIENTS WITH ULCERATIVE COLITIS by T. E. Chernyshova, E. Yu. Varenik, A. A. Valinurov, S. N. Styazhkina

“…Objective: to assess comorbidities in patients with ulcerative colitis (UC) and their effect on the disease course. We examined 61 patients (39 women and 22 men aged between 18 and 60 years) with a confirmed diagnosis of UC. …”
Get full text

The nonstructural protein 13 of porcine deltacoronavirus coordinates ATP-driven duplex unwinding and ATP-independent strand annealing for nucleic acid remodeling by Lihan Tao, Quanyong Zhou, Chengcheng Wu, Hongping Jiang, Jianzhen Huang

“…And a series of experiments with protein mutants revealed the effect of deletion of different domains on the unwinding and annealing activities of PDCoV NSP13. …”
Get full text

DIFFERENCE IN THE DISTRIBUTION OF SELECTED BLOOD VARIABLES AMONG ATHLETES DURING A COMPETITION PERIOD by Sam Mugandani, Trayana Djarova-Daniels

“…Exercise is known to cause considerable changes in leucocyte counts and functions. The aim of the present study was to investigate the effect of exercise on leukocyte counts in athletes of different sporting codes during the competition time of the season. …”
Get full text

Isolation, synthesis, mechanism of action, and pharmacological activities of bisabolangelone and related bisabolenoids by Christian Bailly

“…BBG was shown to competitively inhibit cAMP binding to the regulatory subunit of protein kinase A, to alter the functioning of transcription factors CREB and SOX9 implicated in melanogenesis. …”
Get full text

Superior linear and comparable rotational protection of an air-filled helmet versus foam helmets by R. Tan, C. E. Baker, X. Yu, M. Ghajari

“…Abstract Air-filled chambers offer a promising approach for designing lightweight and portable bicycle helmets, yet their effectiveness in real-world cycling accidents, particularly under oblique impacts, remains unexplored. …”
Get full text

Identification of two point mutations associated with inherited antithrombin deficiency by Shiue-Wei Lai, Chia-Yau Chang, Hwei-Jen Lee, Yeu-Chin Chen

“…Abstract Background Antithrombin (AT) is a serine protease inhibitor which exerts its anticoagulant effect through binding to serine residues in the active centers of procoagulant serine proteases. …”
Get full text

INNOVATION IN PHARMACEUTICAL TREATMENT OF PULMONARY ARTERIAL HYPERTENSION: STIMULATOR OF SOLUBLE GYANYLATE CYCLASE - RIOCIGUAT by I. N. Taran, T. V. Martynyuk, S. N. Nakonechnikov, I. Ye. Chazova

“…Pulmonary arterial hypertension (PAH) is a rare disease, diagnosed at a late stage with low functional class III or IV (WHO). PAH leads to severe right heart failure and ultimately, death. …”
Get full text

Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels by Kangjun Li, Vaishali Satpute Janve, Jerod Denton

“…Interestingly, VU0543336 and VU0212387 exhibit paradoxical stimulatory effects on Kir6.2/SUR1 at higher doses. This study broadens our understanding of KATP channel pharmacology, generally, and reveals novel chemical matter for the development of Kir6.1/SUR2-selective drugs, specifically.…”
Get full text

Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression. by Peter Marx, Peter Antal, Bence Bolgar, Gyorgy Bagdy, Bill Deakin, Gabriella Juhasz

“…Using the subnetwork of depression and metabolic disorders for functional analysis, the interactome-based system-level score showed the best agreement with the sparse disease network. …”
Get full text

THE ROLE OF FINANCIAL AND CREDIT TOOLS IN OPTIMIZATION OF AGRARIAN POLICY by Z. B. Alyeva

“…The paper economically substantiates the effectiveness of supporting small-scale processing enterprises in the region, as they are the most adapted to the changes in the market situation.…”
Get full text

Utilization of whey proteins in beverages using Baobab (Adansonia digitata L.), Roselle (Adansonia digitata L.) and Doum (Hyphaene thebaica) fruits by Malaz N. A. M. Saied, Ibtisam E. M. El Zubeir

“…Hence, the present study concluded that it is possible to use some indigenous Sudanese fruits to utilize the whey proteins as functional food instead of its negative effect on the environment.…”
Get full text

Impact of heart myxoma localization upon its clinical course and outcome by Rafajlovski Sašo, Ilić Radoje, Gligić Branko, Kanjuh Vladimir, Tatić Vujadin, Ristić Anđelka, Obradović Slobodan, Dinčić Dragan, Ratković Nenad, Romanović Radoslav, Karić Jasna, Đenić Nemanja, Vukotić Snježana

“…Their growth is usually slow and they can be for a long time silent, particularly if they do not compromise vital functional parts of the heart. Myxomas grow in the atria, mostly in the left one and very rarely in the ventricles. …”
Get full text

Experiences of rehabilitation one year after breast cancer diagnosis-A focus group study from the ReScreen randomized controlled trial. by Ing-Marie Olsson, Charlotta Dykes, Lisa Rydén, Ulrika Olsson-Möller, Marlene Malmström

“…<h4>Background</h4>Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. …”
Get full text

Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. by Vino T Cheriyan, Ying Wang, Magesh Muthu, Shazia Jamal, Di Chen, Huanjie Yang, Lisa A Polin, Adi L Tarca, Harvey I Pass, Q Ping Dou, Sunita Sharma, Anil Wali, Arun K Rishi

“…Dithiocarbamate compound Disulfiram (DSF) that binds with copper and functions as an inhibitor of aldehyde dehydrogenase is a Food and Drug Administration approved agent for treatment of alcoholism. …”
Get full text

Predictors of Long-Term Outcomes after Surgical Myocardial Revascularization by V. S. Kaveshnikov, M. A. Kuzmichkina, V. N. Serebryakova

“…Data of Russian and foreign literature show that the long-term prognosis after CABG is largely determined by preoperative factors, in particular – age, set of cardiovascular risk factors (RF) and comorbidity, specifically – severity of coronary and systemic atherosclerosis, incident cardiovascular complications, structural and functional state of the heart. In the aggregate these factors reflect the cumulative effect and further potential of actual cardiovascular RFs, affect longterm risk of adverse events, and determine the therapeutic targets of secondary prevention. …”
Get full text

Analysis of China’s High-Speed Railway Network Using Complex Network Theory and Graph Convolutional Networks by Zhenguo Xu, Jun Li, Irene Moulitsas, Fangqu Niu

“…This study investigated the characteristics and functionalities of China’s High-Speed Railway (HSR) network based on Complex Network Theory (CNT) and Graph Convolutional Networks (GCN). …”
Get full text

Unveiling non-monochromatic modes and nonlinearity in Piet Hein quantum semiconductor waveguides by Shahid Idrees, M. Jamil, Jiangtao Su, A. Rasheed, Abdul Waheed, Jie Chen, Yuanyong Deng

“…The $$B_{\xi }$$ B ξ component exhibits a non-uniform distribution with distinct pits and bumps, with a resurgence towards the waveguide edges potentially due to higher-order mode contributions and local field enhancement effects. Our findings pave the way for the development of novel photonic devices with enhanced functionalities based on Piet Hein semiconductor quantum plasma waveguides.…”
Get full text

Global Governance of Biogenic Threats by M. M. Lebedeva, D. A. Kuznetsov

“…The authors of the article consider the experience of individual global and regional associations, which are considered to be the elements of global governance, whose functions, among the other, include responding to challenges of a biogenic nature, identifying several important trends, among which are the intensification of previously emerging trends, the strengthening of isolationism, the growing political fragmentation of the world, destructive influence of “coronacrisis” on globalization, but with parallel sectoral polarization in global economy, a new balancing between cooperation and competition in international relations. …”
Get full text

Assessing the impact of polyphenol-rich plant extracts on ice cream meltdown behavior and structural elements using multivariate analysis by Hesti Ayuningtyas Pangastuti, Songsak Wattanachaisaereekul, Praphan Pinsirodom

“…Plant extracts are a rich source of polyphenols and become popular as a functional ingredient in ice cream products. However, addition of polyphenols in an ice cream mix can influent its structure and meltdown parameters. …”
Get full text

Circadian disruption impairs Leydig cell maturation and reproductive development in male rats by Dijana Z. Travicic, Dejan Miljkovic, Silvana A. Andric, Tatjana S. Kostic

“…Gene expression profiles associated with Leydig cell maturation, including steroidogenic, mitochondrial, and clock-related genes, as well as markers of germ cell differentiation, were analyzed alongside functional mitochondrial parameters in Leydig cells. …”
Get full text