Europe’s lost landscape sculptors: Today’s potential range of the extinct elephant Palaeoloxodon antiquus by Franka Gaiser, Charlotte Müller, Paula Phan, Gregor Mathes, Manuel J. Steinbauer

“…Conserving the ecosystems shaped by the top-down ecosystem functions executed by the straight-tusked elephant in Europe may be especially promising in regions where the elephant could still exist today. …”
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Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/β-catenin pathway by Yuji Ma, Xuanhao Hu, Chao Shang, Ming Zhong, Yan Guo

“…Our results showed that CCAT2 functioning as a potential oncogene was upregulated in oral squamous cell carcinoma. …”
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SSDWSN: A Scalable Software-Defined Wireless Sensor Networks by Mohammed Alsaeedi, Mohd Murtadha Mohamad, Anas Al-Roubaiey

“…These policies are designed to efficiently utilize SDWSN network resources and accurately predict the network state by continuously monitoring the synchronized network state within the controller, taking appropriate actions, and updating the learning parameters based on reward functions. The simulation results demonstrate the effectiveness of PPO-ATCP and PPO-NSFP in reducing controller-bound traffic overhead by 57% and 85%, respectively, while improving energy efficiency by 28% and 53% in SDWSNs. …”
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Predicting gene expression changes upon epigenomic drug treatment [version 3; peer review: 4 approved, 2 not approved] by Monjura Afrin Rumi, Vishaka Gopalan, Sridhar Hannenhalli, Piyush Agrawal

“…Background Tumors are characterized by global changes in epigenetic modifications such as DNA methylation and histone modifications that are functionally linked to tumor progression. Accordingly, several drugs targeting the epigenome have been proposed for cancer therapy, notably, histone deacetylase inhibitors (HDACi) such as vorinostat and DNA methyltransferase inhibitors (DNMTi) such as zebularine. …”
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Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes by Sen Li, Wendy Keung, Heping Cheng, Ronald A. Li

“…We also investigated the effect of Ca2+ on gene transcription in hPSC-VCMs, and the involvement of nuclear factor of activated T-cell (NFAT) pathway was identified. …”
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Emerging trends in synthesis, characterization, and mechanism of action of antibody-drug and antibody-nanoparticle conjugates by Tanu Dixit, Annamraju Aswini, Harshal Nikam, Anuradha Vaidya, Selvan Ravindran

“…ACNPs also facilitate multivalent binding by functionalizing multiple antibody molecules on their surface, improving target cell recognition and binding strength. …”
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A mutation in transthyretin gene in a Mexican patient leading to hereditary amyloidosis: a case report by Muhammad Reebal Malik, Tarun Dalia, Zubair Shah

“…A misfolded protein can not carry out its functions and can also build up in different organs leading to a group of diseases known as amyloidosis. …”
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Environmental Assessment of the Life Cycle of Bovine Compound Feeds from a Feed Milling Plant in a Large Commercial Farm in Wielkopolska Region, Poland by Jerzy Bieńkowski, Małgorzata Holka

“…An inventory table of inputs was prepared in relation to the functional unit of 1 ton of compound feeds and two phases of production processes, i.e. upstream and core. …”
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"I have a personal claim to myself": a visually impaired student's perspective on her participation in physical activity and physical education settings by Anne Bödicker, Sandra Elisath

“…Functioning, keeping up, and being resilient in our fast-paced society now appear to be the social norm. …”
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Numerical design of nonstationary wavelets: Enhanced filter design andapplications in image compression by A. Boussaad, Y. Fourar, K. Melkemi

“…To address this, we use a nonstationary biorthogonal fil-ter banks, which modify basis functions at different scaling levels, leading to improved frequency resolution, signal representation, and compression efficiency. …”
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THE CONCEPTION OF THE PRINCIPLES OF MUNICIPAL LAW by Oleksandr V. Batanov

“…It is proven that the formation of the modern domestic municipal legal doctrine has set scientists a number of conceptual tasks, the solution of which depends on the effectiveness of rethinking the essence, content (system) and functions of municipal law as a branch of law. …”
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Applying optimized curcumin extraction techniques in the development of novel curcumin-infused products by Sucheera Laocharoen, Parinyapan Phetcharat, Kasama Chareekhot, Sunan Nuanpeng

“…The concentration of curcumin in the product was sufficiently high enough to compare with the existing functions in the market. Studies of stability showed that the quality of the jelly and its active properties could be preserved during refrigeration. …”
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Business consulting, knowledge absorptive capacity, and innovativeness: A triangular model for micro and small enterprises in Poland by Wojciech Grabowski, Edward Stawasz

“…A higher propensity to cooperate may significantly improve the functioning of an enterprise. Business consulting has an indirect and direct effect on innovativeness. …”
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Nutritional interventions in muscle hypertrophy research: a scientometric analysis within the context of resistance training (1992–2025) by Wei Chen

“…However, research on the synergistic effects of nutritional interventions and resistance training in promoting muscle hypertrophy is characterized by thematic fragmentation, insufficient integration between mechanistic and applied research, and imbalances across different regions and population groups. …”
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Bio-Impedance Analysis of Human Upper Limbs Based on Transient Simulation Using the Finite Element Method by Enver Salkim, Tayfun Abut

“…<b>Introduction:</b> Upper-limb loss results in significant functional impairment and a reduced quality of life. …”
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Notch signaling in the tumor immune microenvironment of colorectal cancer: mechanisms and therapeutic opportunities by Jiachun Sun, Yi Chen, Ziyi Xu, Weizheng Wang, Penghui Li

“…Aberrant Notch signaling in CRC fosters immune evasion and tumor progression through its effects on the balance and functionality of immune cells, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). …”
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A New Framework to Address BIM Interoperability in the AEC Domain from Technical and Process Dimensions by Ran Ren, Jiansong Zhang

“…The proposed method can be extended and applied to other application phases and functions such as cost estimation, scheduling, and energy analysis.…”
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How Error Prevention and Organizational Silence Influences Managers’ Self-Perception – A Repertory Grid Study by Laura Kussin, Henning Bundtzen

“…It becomes evident that error management functions as a link between organizational silence and managers’ overestimation. …”
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Evading efficiency-voltage trade-off in magnesium-air batteries through solute atoms and second phases synergy by Hongxing Liang, Liang Wu, Chenchen Zhao, Chuantian Zhai, Wenbo Du

“…The quest for high-energy-density magnesium-air batteries is hindered by the efficiency-voltage trade-off, ultimately leading to an unsatisfactory energy density. Here, we effectively mitigate the inherent efficiency-voltage trade-off by introducing a novel anode material, specifically, Mg-0.5Sn-0.5In-0.5Ga. …”
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The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis. by Renee Rawson, Arjun Anilkumar, Robert O Newbury, Vineet Bafna, Melissa Aquino, Jacob Palmquist, Hal M Hoffman, James L Mueller, Ranjan Dohil, David H Broide, Seema S Aceves

“…<h4>Background</h4>Eosinophilic esophagitis (EoE) is a chronic antigen mediated disease associated with substantial esophageal remodeling and fibrosis. The functional TGFβ1 promoter SNP C-509 associates with renal fibrosis and asthma. …”
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