Patient acceptability of intravitreal complement inhibitors in geographic atrophy (GA): protocol for a UK-based cross-sectional study by David P Crabb, Deanna J Taylor, Christiana Dinah, Mandeep Sekhon, Jamie Enoch, Arevik Ghulakhszian

“…The correlation between acceptability and functional and structural biomarkers of GA will be established. …”
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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor by Anhadvir Singh, Boris S. Zhorov, Luis A. Yanez-Guerra, Alessandra Aleotti, Chloe C. Koens, C. Defne Yanartas, Yunqi Song, Federico Javier Miguez Cabello, Derek Bowie, Adriano Senatore

“…Here, we explore the evolution of iGluRs by generating a broad species-guided phylogeny of eukaryotic iGluRs and a comprehensive phylogeny of placozoan receptors, uncovering marked diversification of epsilon type receptors within Placozoa. Functional characterization of one epsilon receptor from the placozoan species Trichoplax adhaerens, named GluE1αA, reveals sensitivity to glycine, alanine, serine, and valine, but not glutamate. …”
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Evaluation of an intervention addressing a reablement programme for older, community-dwelling persons in Sweden (ASSIST 1.0): a protocol for a feasibility study by Aileen Bergström, Lena Borell, Sebastiaan Meijer, Susanne Guidetti

“…Introduction Older persons with functional limitations often need assistance from home care staff to thrive and continue to live in their home environments. …”
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Investigation of potential prognostic biomarkers for colorectal cancer by Hui Li, Jie Liu, WenHui Liu, Liang Zheng, JuHui Chen

“…Next, Venn analysis, functional enrichment analysis, protein interaction network (PPI) analysis, and survival analysis were performed. …”
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GeneRiskCalc: a web-based tool for genetic risk association analysis in case–control studies by Amrit Sudershan, Kuljeet Singh, Parvinder Kumar

“…Using an HTML/CSS/JavaScript framework, we developed online software with three core functionalities: (1) automated HWE evaluation, (2) odds ratio with 95% confidence interval computation with statistical validation, and (3) dynamic Forest Plot generation for data visualization. …”
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Development of a framework for safety and resilience in overhead power cables: Use of a fuzzy inference system for risk and reliability analysis by A.M. Sakura R.H. Attanayake, R.M. Chandima Ratnayake, T. Markeset

“…Under this methodology, the FIS models uncertainties in asset performance, using expert-defined rules and membership functions to categorize risk levels and assess failure severity. …”
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СLINICAL FEATURES, DIAGNOSIS AND TREATMENT OF PATIENTS WITH RETINAL DETACHMENT DUE TO ACUTE RETINAL NECROSIS by S. V. Sdobnikova, N. R. Marchenko, N. A. Troitskaia, Z. V. Surnina, L. S. Pateyuk

“…Early primary vitrectomy promotes the most functional results: best corrected visual acuity after removal of the silicone oil reached 0,3–0,6 in the Golovin-Sivtsev table. …”
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Tasks scheduling with different structures in cloud manufacturing according to the time and cost of transportation and the task arrival time by Zohre Kiapasha, Ali Salmasnia

“…The second comparative study examines the effect of considering logistics time/costs between enterprises when allocating subtasks to services. …”
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Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review by Eliane C. Miotto, Alana X. Batista, Sharon S. Simon, Benjamin M. Hampstead

“…The primary aim of the current review was to examine neurophysiological changes measured by functional magnetic resonance imaging (fMRI) and possible cognitive changes following COTs in those with MCI. …”
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Mediterranean diet adherence and epilepsy: the mediating role of stroke based on a cross-sectional study by Mingjing Zhou, Xuyan Zhao, Peinan Liu, Xiangwei Hou, Yiyang Cao, Maode Wang, Jia Wang

“…Recent studies have indicated that the Mediterranean diet exerts a neuroprotective effect through its anti-inflammatory and antioxidant properties in non-Mediterranean regions. …”
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Evaluation of the Physicochemical, Antioxidant, and Antibacterial Properties of Tunichrome Released from Phallusia nigra Persian Gulf Marine Tunicate by Zohreh Marhamati, Mohammad Hossein Marhamatizadeh, Gholamhossein Mohebbi

“…These results showed that tunichrome of Phallusia nigra has excellent biological effects as a bioactive compound for food fortification.…”
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RIME optimization with dynamic multi-dimensional random mechanism and Nelder–Mead simplex for photovoltaic parameter estimation by Yuanping Zheng, Fangjun Kuang, Ali Asghar Heidari, Lipei Yuan, Siyang Zhang, Huiling Chen

“…To verify its effectiveness, DNMRIME was compared with 14 well-known MAs, including some champion algorithms, and the results of the Wilcoxon signed rank test showed that DNMRIME ranked first. …”
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A unique and biocompatible corneal collagen crosslinking in vivo by Ayesha Gulzar, Humeyra N Kaleli, Gülsüm D Köseoğlu, Murat Hasanreisoğlu, Ayşe Yıldız, Afsun Şahin, Seda Kizilel

“…This study is unique that demonstrates in vivo safety, biocompatibility, and functionality of ruthenium and blue light CXL. This approach can prevent toxicity caused by UV-A light and can be an immediate alternative compared to the existing crosslinking procedures that have side effects and clinical risks for the patients.…”
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Vitamin D and lipopolysaccharide jointly induce a distinct epigenetic and transcriptional program in human monocytes by Mariusz Jankowski, Emmi Hämäläinen, Mari Taipale, Sami Heikkinen, Carsten Carlberg

“…Functional annotation revealed that these genes are primarily linked to monocyte and T cell differentiation, in contrast to classical vitamin D targets associated with inflammation. …”
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Measuring Retiming Responses of Passengers to a Prepeak Discount Fare by Tracing Smart Card Data: A Practical Experiment in the Beijing Subway by Qingru Zou, Xiangming Yao, Peng Zhao, Zijia Wang, Taoyuan Yang

“…The retiming elasticity of different passenger groups, retiming elasticity over time, and retiming elasticity functions of shifted time are measured. The results show that there are considerable differences in the retiming elasticities of different passenger groups; low-frequency passengers are more sensitive to discount fares than high-frequency passengers. …”
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An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant Escherichia coli by Manisha Aswal, Nirpendra Singh, Neelja Singhal, Manish Kumar

“…Bioinformatic analysis using GO-terms, COG and KEGG functional annotations revealed that the concordantly overexpressed genes of MDR E. coli were involved primarily in biosynthesis of secondary metabolites, aminoacyl-tRNAs and ribosomes. …”
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Radiative heat and mass transfer of second-grade nanofluid slip flow with variable thermal properties by Zia Ullah, Md. Mahbub Alam, Aamir Abbas Khan, Shalan Alkarni, Feyisa Edosa Merga

“…The governing partial differential equations are simplified and effectively analyzed by transforming them into a collection of ordinary differential equations employing stream functions and similarity transformations. …”
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Advances in Chondroitin Sulfate-Based Nanoplatforms for Biomedical Applications by Peng C, Zheng A, Wang L, Shen Y, Peng C, Yu J, Shao S

“…CS can be integrated with functional molecules to construct a variety of nanostructures, further expanding its potential applications. …”
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Role of P2X7 receptor in the progression and clinicopathological characteristics of gastric cancer by Wen-jun Zhang, Xiong-wei Pi, Yi-guan Le, Teng-zheng Li

“…Therefore, this study preliminarily investigated the relationship between P2X7R and clinicopathological features of patients with gastric cancer, and further explored the effect of P2X7R on the proliferation, migration and invasion of gastric cancer cells through functional experiments. …”
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. by Pierre Sonveaux, Tamara Copetti, Christophe J De Saedeleer, Frédérique Végran, Julien Verrax, Kelly M Kennedy, Eui Jung Moon, Suveera Dhup, Pierre Danhier, Françoise Frérart, Bernard Gallez, Anthony Ribeiro, Carine Michiels, Mark W Dewhirst, Olivier Feron

“…Furthermore, using a variety of functional assays including endothelial cell migration and tubulogenesis together with in vivo imaging of tumor angiogenesis through intravital microscopy and immunohistochemistry, we documented that MCT1 blockers could act as bona fide HIF-1 inhibitors leading to anti-angiogenic effects. …”
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