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69941
Application of a locally developed open-access digital monitoring system for the human milk bank network in Vietnam
Published 2025-07-01“…The successful scaling up of HMB services and the monitoring system to other regions in Vietnam demonstrates the project's effectiveness and potential for broader impact. The system's adaptability has allowed continuous improvements and integration of new functions, such as financial reporting and consumables tracking. …”
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69942
RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis
Published 2025-07-01“…Methods RAD51 expression levels were examined in tumor and adjacent normal tissues from 20 NPC patients and in the radioresistant NPC cell line CNE2. Functional assays were conducted using recombinant RAD51 protein, the RAD51 inhibitor B02, and the Caspase-8 inhibitor Z-IETD-FMK. …”
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69943
Discovering linked data collections through a new national metadata platform
Published 2025-04-01“…The final design and functionality reflected user consultations and data custodian input on feasibility. …”
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69944
A model of ensuring LLM cybersecurity
Published 2025-05-01“…The main contributions of this study are the LLM and LLMS cybersecurity models, the formalization of the results of these experiments, an assessment of the criticality level for cyber risks of the models, and the choice of countermeasures based on the coefficient of their effectiveness. In this case, ensuring an acceptable risk level for LLM is possible at a minimal cost. …”
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69945
Metabolic alterations in experimental models of depression
Published 2016-10-01“…Introduction: Major depressive disorder is one of the most prevalent psychiatric disorders and is associated with a severe impact on the personal functioning, thus with incurring significant direct and indirect costs. …”
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69946
Utilizing deep learning for intelligent monitoring and early warning of slope disasters in public space design
Published 2025-05-01“…The integration of neural network-based prediction with adaptive spatial planning enhances both the precision and timeliness of disaster warnings.DiscussionThis framework offers a transformative, safe, and functional approach to slope disaster management in dynamic public spaces. …”
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69947
Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer
Published 2017-06-01“…Fructose-1,6-bisphosphatase 1, a rate-limiting enzyme in gluconeogenesis, was recently shown to be a tumor suppressor. However, the functions of fructose-1,6-bisphosphatase 1 in the regulation of mitophagy and apoptosis remain unknown. …”
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69948
Life cycle assessment of tetrapod concrete armour units
Published 2025-06-01“…The findings emphasize the need to explore alternative materials and production methods to reduce the environmental footprint of tetrapods while maintaining their protective effectiveness in coastal construction.…”
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69949
Study of the Stress State of Solid Cylinders with Inhomogeneous Structure Under Various Boundary Conditions at the Ends
Published 2025-06-01“…The solution of the problem is based on the application of the method of spline-approximation of functions in the direction of the longitudinal coordinate and the numerical method of discrete orthogonalization along the radial coordinate. …”
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69950
Challenges and solutions in diagnosis and treatment of obesity
Published 2025-02-01“…Overweight and obesity can lead to metabolic, functional, and psychological disorders, serving as critical risk factors for mortality and disability. …”
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69951
Identification and validation of key target genes of penning formula for treating rat chronic endometritis model
Published 2025-07-01“…Further analysis, including functional pathway enrichment, chromosomal mapping, expression profiling, gene interactions, regulatory networks, and molecular docking, highlighted their involvement in stress response and prolactin signaling, with distinct chromosomal distributions and differential expression across groups. …”
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69952
A clustering-aided multi-agent deep reinforcement learning for multi-objective parallel batch processing machines scheduling in semiconductor manufacturing
Published 2025-05-01“…Specifically, to achieve diverse nondominated solutions, an offline multi-objective scheduling algorithm named Multi-Subpopulation fast elitist Non-Dominated Sorting Genetic Algorithm (MS-NSGA-II) is firstly developed to obtain the Pareto Fronts, and a clustering algorithm based on cosine distance is employed to analyze the distribution of Pareto frontier solution, which would be used to guide reward functions design in multi-agent deep reinforcement learning. …”
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69953
Network pharmacology and anticancer mechanism study of Dendrobium nobile dendrobine in the treatment of colorectal cancer
Published 2024-12-01“…Functional enrichment analysis was conducted using the Metascape database, and a protein–protein interaction (PPI) network was constructed. …”
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69954
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.
Published 2011-12-01“…The non-cleavable PfAMA1 is also functional in invasion. However - in contrast to the intramembrane cleavage site - mutations that block PfSUB2-mediated shedding could not be stably introduced into the genomic pfama1 locus, indicating that some shedding of PfAMA1 by PfSUB2 is essential. …”
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69955
The efficacy of early progressive resistance exercise in the postoperative management of pancreaticoduodenectomy for pancreatic cancer: a randomized controlled trial
Published 2025-08-01“…Additionally, the incidence of urinary retention was significantly lower in the progressive resistance exercise group (p = 0.011).ConclusionProgressive resistance exercise has been demonstrated to effectively promote functional recovery and overall rehabilitation in patients with pancreatic cancer following pancreaticoduodenectomy. …”
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69956
Research on the Dynamic Behavior of “Building-Bridge Integrated” Railway Bridge-Type Station with Setting the Structural Joints on the Mainline
Published 2025-04-01“…However, in stations where the mainline speed exceeds 160 km/h, structural joints are typically incorporated to ensure the integrity and functionality of the integrated system. The inspection and maintenance of these joints, which are critical for the long-term performance of such structures, can be particularly complex. …”
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69957
Analysis of the criteria selection problem in diversification models
Published 2023-12-01“…To formalize the problem, five models are proposed that differ in vector objective functions, both in the quantity and quality of the selected criteria. …”
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69958
Bridging prediction and decision: Advances and challenges in data-driven optimization
Published 2025-03-01“…Notably, we discuss breakthroughs such as implicit differentiation techniques, surrogate loss functions, and perturbation methods, which provide methodological guidance for achieving data-driven decision-making through prediction. …”
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69959
Dust Continuum Radiation Maps from MHD Simulations of Accretion-ejection Systems around Single and Binary Stars
Published 2025-01-01“…We, therefore, present convolved images of the dust continuum emission, employing exemplary point spread functions of the MIRI instrument (5 μ m band) and the Atacama Large Millimeter/submillimeter Array (320 μ m band). …”
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69960
Deep attention model for arrhythmia signal classification based on multi-objective crayfish optimization algorithmic variational mode decomposition
Published 2025-02-01“…The Pareto optimal front was generated by MOCOA and the intrinsic mode functions of VMD with the best combination of K and $$\alpha$$ were obtained. …”
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