USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation by Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang

“…This cascade reduces DNA damage and apoptosis in NPCs and enhances their functional activity. Overall, our findings reveal a previously unrecognized mechanism by which apoptotic donor MSCs exert therapeutic effects through intercellular communication, specifically by modulating recipient NPCs apoptosis and DDR pathways. …”
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LSN-GTDA: Learning Symmetrical Network via Global Thermal Diffusion Analysis for Pedestrian Trajectory Prediction in Unmanned Aerial Vehicle Scenarios by Ling Mei, Mingyu Fu, Bingjie Wang, Lvxiang Jia, Mingyu Yu, Yu Zhang, Lijun Zhang

“…This framework symmetrically distributes the semantic segmentation and trajectory prediction modules, enhancing the overall functionality of the network. Additionally, we propose a novel thermal diffusion process, based on signal and system theory, which manages uncertainty by utilizing the full response and providing interpretability to the network. …”
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Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma by Hugo Swenson, Ella Ittner, Lucas Werner, Elisabeth Werner Rönnerman, Claudia Mateoiu, Anikó Kovács, Pernilla Dahm-Kähler, Ghassan M. Saed, Szilárd Nemes, Per Karlsson, Toshima Z. Parris, Khalil Helou

“…Results EOC histotypes exhibited distinct epigenetic, transcriptional, and functional profiles, with candidate histotype-specific biomarkers such as CTSE and VCAN effectively distinguishing CCC, HGSC, and MC on the transcriptional level. …”
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Mapping the integration of climate considerations in social protection in LMICs: An assessment of ninety-eight climate-relevant social protection programs by Cecilia Costella, Abhinav Banthiya, Rachel Reilly, Sajanika Sivanu, Rachel Slater, Yola Georgiadou, Maarten van Aalst

“…At the implementation level, most programs typically focus on shock response, though our findings show they already support broader climate functions. Our results empirically substantiate assumptions about climate-relevant social protection, offer key new policy insights, and identify areas for further research. …”
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Detecting benzodiazepine use through induced eye convergence inability with a smartphone app: a proof-of-concept study by Kiki W. K. Kuijpers, Markku D. Hämäläinen, Andreas Zetterström, Maria Winkvist, Marieke Niesters, Marieke Niesters, Monique van Velzen, Fred Nyberg, Albert Dahan, Albert Dahan, Albert Dahan, Karl Andersson, Karl Andersson

“…Using the NCdiff measured in a sober condition after approximately 1 week of regular eye-scanning as the individual baseline to form NCdiffInd produced a highly functional classifier with an area under the curve (AUC) = 0.88, which was superior to a classifier based on NCdiff with an AUC = 0.79.ConclusionsThe loss of eye convergence induced by lorazepam is continuous, individual, and can be partial. …”
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Bacillus megaterium NCT-2 agent alters soil nutrients, vegetable quality, and root microecology in secondary salinized soil by Yimin You, Yimin You, Shitong Li, Liran Wang, Xiyang Zhao, Dan Zhang, Dan Zhang, Dan Zhang, Dan Zhang, Shaohua Chu, Shaohua Chu, Shaohua Chu, Shaohua Chu, Xijia Yang, Xijia Yang, Xijia Yang, Xijia Yang, Pei Zhou, Pei Zhou, Pei Zhou, Pei Zhou

“…However, there is complexity in the microorganism-soil–plant system. The effects of microbial agents on soil nutrients, plant quality, rhizosphere, and endophytic microorganisms are still unclear. …”
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Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway by Manzila Kuerbanjiang, Lei Gu, Chunjie Xu, Wen Ting Xu, Siyuan Wen, Hanbing Xue, Qing Xu

“…Further study found that MPC2 knockdown in CRC cell lines activated the mTOR signaling pathway, and the addition of rapamycin reversed the promoting effect of MPC2 knockdown on CRC proliferation and glycolysis. …”
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Influence of Homogenization Heat Treatments on the Mechanical, Structural, Biodegradation, and Cavitation Behavior of Some Alloys in the ZnMg(Fe) System by Brandușa Ghiban, Ilare Bordeasu, Aurora Antoniac, Iulian Antoniac, Cristina Maria Gheorghe, Dorin Bordeasu, Lavinia Madalina Micu, Cristian Ghera, Laura Cornelia Salcianu, Bogdan Florea, Daniel Ostoia, Anca Maria Fratila

“…The experimental results demonstrate that the new alloys from the ZnMgFe system are a good option for manufacturing biodegradable implants with functional in vitro properties.…”
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Improved optimization based on parrot’s chaotic optimizer for solving complex problems in engineering and medical image segmentation by Adil Sayyouri, Ahmed Bencherqui, Hanaa Mansouri, Hicham Karmouni, Hassane Moustabchir, Mhamed Sayyouri, Abderrahim Bourkane, Abdeljabbar Cherkaoui, S. S. Askar, Mohamed Abouhawwash

“…The improved algorithm, called Chaotic Parrot Optimizer (CPO), is characterized by a better ability to avoid local minima and reach globally optimal solutions thanks to a dynamic diversification strategy based on chaotic maps. The effectiveness of the CPO algorithm has been rigorously evaluated through in-depth statistical analysis, using 23 benchmark functions as well as IEEE CEC 2019 and CEC 2020 benchmarks, covering a wide range of optimization challenges. …”
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Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission by Magda Tušek Žnidarič, Maja Zagorščak, Živa Ramšak, Katja Stare, Marko Chersicola, Maruša Pompe Novak, Aleš Kladnik, Marina Dermastia

“…In addition, chloroplast vesiculation during abscission was associated with differential expression of photosynthesis‐related genes, particularly those involved in light reactions, underscoring the possible functional impact of the observed structural changes. …”
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Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals by Ruili Wang, Baohui Hu, Ziyu Pan, Chongxia Mo, Xin Zhao, Guojia Liu, Ping Hou, Qi Cui, Zhao Xu, Wenjia Wang, Zhaojin Yu, Lin Zhao, Miao He, Yan Wang, Chen Fu, Minjie Wei, Lifeng Yu

“…This review provides a comprehensive overview of ADCs, summarizing the structural and functional characteristics of the three core components, antibody, linker, and payload. …”
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Intratumorally specific microbial-derived lipopolysaccharide contributes to non-small cell lung cancer progression by Guomeng Sha, Zhengwen Wu, Biao Wang, Yi Ding, Zhaohua Xiao, Wenhao Zhang, Jie Zhou, Yongjia Zhou, Guanhong Ji, Zhongxian Tian, Weiquan Zhang, Xiaogang Zhao

“…Mechanistically, we found that Escherichia-Shigella- and unclassified_f__Enterobacteriaceae-derived LPS activated the TLR4-mTOR-NF-κB-IL-6 axis to facilitate NSCLC cell proliferation, whereas rapamycin effectively delayed LPS-induced tumor cell proliferation in vitro and in vivo functional experiments. …”
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Efficacy of extracorporeal shock wave lithotripsy for post-transplant kidney stones. Hope or Disappointment? by S. V. Popov, R. G. Huseynov, I. A. Miloserdov, Yu. V. Kisil, D. A. Saydulaev, S. V. Sadovnikov, K. V. Sivak, N. S. Bunenkov, V. V. Perepelitsa, T. A. Lelyavina

“…The use of ESWL, as the most frequently used method, testifies to its efficiency and low-traumatic effect.…”
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Exploring the Role of Edible Dock Powder (Rumex K-1) in Enhancing Growth Performance, Organ Health, and Cecal Microbiota in Sanhua Goslings by Xianze Wang, Junliang Wang, Yi Liu, Guangquan Li, Shaoming Gong, Huiying Wang, Daqian He

“…This study investigated the effects of dietary Edible Dock Powder (EDP) on growth performance, organ development, serum biochemistry, and cecal microbiota in Sanhua goslings. …”
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GLP-1R in diabetes mellitus: from basic discovery to therapeutics development by Shujun Li, Nanqu Huang, Nanqu Huang, Mei Wang, Wendi Huang, Yong Luo, Yong Luo, Yong Luo, Juan Huang

“…This paper reviews the structural and functional characteristics of GLP-1R. Its role in glucose homeostasis and its application in diabetes treatment. …”
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Phase-pure ferroelectric quantum wells with tunable photoluminescence for multi-state optoelectronic applications by Rui Sun, Yuping Jia, Bo Lai, Zhiming Shi, Mingrui Liu, Weili Yu, Ke Jiang, Shanli Zhang, Shunpeng Lv, Yang Chen, Xiaojuan Sun, Dabing Li

“…Abstract Quasi-two-dimensional (quasi-2D) metal halide perovskite (MHP) ferroelectrics, characterized by spontaneous polarization and semiconducting properties, hold promise for functional photoferroelectrics in applications such as optical storage and in-memory computing. …”
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In Vitro Characterization of 3D-Printed PLA/CPO Oxygen Releasing Scaffolds: Mechanical and Biological Properties for Bone Tissue Engineering by Abdullah Mohammed, Alice Tirnoveanu, William Richard Webb, Ammar A. Melaibari, Adnan Memić, Mohammad Aslam, Amr Elshaer, Hany Hassanin, Khamis Essa

“…The addition of oxygen-releasing biomaterials into 3D-printed scaffolds presents a novel approach to enhancing bone scaffolds, yet no in vitro studies have demonstrated the effect of oxygen-generating filaments on scaffold biological and mechanical properties. …”
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Enhancing adolescent health: the role of strength and endurance school-based HIIT interventions in physical fitness and cognitive development by José Antonio Pérez-Ramírez, Maria Paula Santos, Maria Paula Santos, Jorge Mota, Jorge Mota, Francisco Tomás González-Fernández, Emilio Villa-González

“…However, global trends indicate how low levels of PA and physical fitness among adolescents are increasing, with over 80% failing to meet the World Health Organization (WHO) guidelines of 60 min of moderate-to-vigorous physical activity (MVPA) daily.MethodsThis study aimed to evaluate the effects of an 8-week high-intensity interval training (HIIT) intervention based on strength and endurance trainings protocols during physical education (PE) classes on body composition, physical fitness, and cognitive functions in adolescents aged 13–17 years. …”
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Baricitinib-associated changes in global gene expression during a 24-week phase II clinical systemic lupus erythematosus trial implicates a mechanism of action through multiple imm... by Daniel J Wallace, Thomas Dörner, Stephanie de Bono, Robert J Benschop, Ernst R Dow, Damiano Fantini, Richard E Higgs, Guilherme Rocha, Brenda Crowe, Nicole L Byers, Maria E Silk, Robert W Hoffman

“…Statistical and gene network analyses demonstrated that baricitinib treatment reduced the mRNA expression of functionally interconnected genes involved in SLE including STAT1-target, STAT2-target and STAT4-target genes and multiple IFN responsive genes. …”
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Comparison of Tissue Repair with Different Types of Microdissection Tips: A Randomized Histomorphometric Evaluation in Rats by Ana Luiza Vila Verde Brunelli, Luíz Henrique Soares Torres, Arthur Henrique Alécio Viotto, Izabela Fornazari Delamura, Ana Paula Farnezi Bassi, Marisa Aparecida Cabrini Gabrielli, Valfrido Antonio Pereira-Filho

“…The thin-cut electrode enables incisions with tissue repair comparable to that of a number 15 scalpel, as it performs cutting, coagulation, and blending functions at lower temperatures.…”
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