IGF2BP3 curbed by miR-15c-3p restores disrupted lipid storage and progesterone secretion in chicken granulosa cells under oxidative stress through AKT-Raf1-ERK1/2 signaling pathway by Zhongzhen Lin, Yanrong Gong, Chunlin Yu, Chaowu Yang, Lingqian Yin, Donghao Zhang, Yuan Tang, Feng Xu, Ye Wang, Yiping Liu

“…These regulatory effects were mediated through the sequential downstream signaling cascade of AKT-Raf1-ERK1/2. …”
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Landscape of the Peripheral Immune Response Induced by Intraoperative Radiotherapy Combined with Surgery in Early Breast Cancer Patients by Danian Dai, Xuerui Li, Hongkai Zhuang, Yun Ling, Lezi Chen, Cheng Long, Jinhui Zhang, Yunjie Wang, Yuehua Li, Hailin Tang, Bo Chen

“…IORT+Surgery demonstrated the ability to partially suppress the anti‐tumor effects of neutrophils. Flow cytometry analysis and co‐culture experiments are utilized to delve deeper into the functional alterations in T cells. …”
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Novel Mutation at Cys225 in GNAO1‐Associated Developmental and Epileptic Encephalopathies: Clinical, Molecular, and Pharmacological Profiling of Case Studies by Yonika A. Larasati, Gonzalo P. Solis, Alexey Koval, Marie‐Céline François‐Heude, Julie Piarroux, Agathe Roubertie, Ruihan Yang, Ying Zhang, Dezhi Cao, Christian M. Korff, Vladimir L. Katanaev

“…Being the immediate transducer of a number of neuronal G protein‐coupled receptors, Gαo plays crucial functions in brain development and physiology. Here, we discover a novel mutation site in GNAO1, Cys225 mutated to Tyr or Arg in pediatric individuals from France and China (p.…”
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Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential by Pengfei Bao, Taiwei Wang, Xiaofan Liu, Shaozhen Xing, Hanjin Ruan, Hongli Ma, Yuhuan Tao, Qing Zhan, Efres Belmonte-Reche, Lizheng Qin, Zhengxue Han, Minghui Mao, Mengtao Li, Zhi John Lu

“…Accurate identification of the fragmented cfRNA signals, especially those originating from pathological cells, is crucial for understanding their biological functions and clinical value. However, many challenges still need to be addressed for their application, including developing specific analysis methods and translating cfRNA fragments with biological support into clinical applications. …”
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ClimeApp: data processing tool for monthly, global climate data from the ModE-RA palaeo-reanalysis, 1422 to 2008 CE by R. Warren, R. Warren, N. E. Bartlome, N. E. Bartlome, N. Wellinger, N. Wellinger, J. Franke, J. Franke, R. Hand, R. Hand, S. Brönnimann, S. Brönnimann, H. Huhtamaa, H. Huhtamaa

“…Together, these allow researchers to separate the effects of model simulations and observations on the reanalysis. …”
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Intelligent bacteria‐targeting ZIF‐8 composite for fluorescence imaging‐guided photodynamic therapy of drug‐resistant superbug infections and burn wound healing by Xiaoxue Li, Wei Wang, Qiuxia Gao, Shanshan Lai, Yan Liu, Sitong Zhou, Yan Yan, Jie Zhang, Huanhuan Wang, Jiamei Wang, Yi Feng, Ronghua Yang, Jianyu Su, Bin Li, Yuhui Liao

“…The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response‐guided photodynamic therapy (PDT), and anti‐inflammatory. …”
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Defect‐Engineered Multi‐Intermetallic Heterostructures as Multisite Electrocatalysts for Efficient Water Splitting by Xiang‐Feng Wu, Zi‐Yan Li, Hui Wang, Jun‐Chuan Wang, Guo‐Qiang Xi, Xiao‐Jin Zhao, Chen‐Xu Zhang, Wu‐Gang Liao, Johnny C. Ho

“…Advanced characterization techniques and density functional theory (DFT) reveal that the formation of defect sites and heterojunctions not only induces electronic modulation but also enhances intermetallic interactions and charge transfer from Ni and Mo to Cu and Co, facilitating intermediate formation and transformation, thereby boosting intrinsic activity. …”
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Newly Designed PCL-Wrapped Cryogel-Based Conduit Activated with IKVAV Peptide Derivative for Peripheral Nerve Repair by Abdulla Yergeshov, Mohamed Zoughaib, Kenana Dayob, Marat Kamalov, Duong Luong, Albina Zakirova, Ruslan Mullin, Diana Salakhieva, Timur I. Abdullin

“…<b>Methods:</b> In this study, IKVAV peptide was functionalized with terminal lysine residues to allow its in situ cross-linking with gelatin macromer, resulting in the formation of IKVAV-containing proteinaceous cryogels. …”
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EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming by Bo Guan, Cong Huang, Cong Huang, Cong Huang, Jun He, Jun He, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…Subsequently, EPHX2 was stably overexpressed in the 786-O and ACHN cell lines via lentiviral transfection technology, and its functional effects were validated through in vitro experiments. …”
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HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer by Xiaoyu Qi, Jing Zhou, Xinyue Wang, Yan Shen, Yuxun Cao, Liangzi Jiang, Miaomiao Shen, Haoran Zhang, Tianjiao Wang, Pengjun Wei, Ruoqi Xu, Yue Yang, Xiangya Ding, Cong Wang, Xuemei Jia, Qin Yan, Wan Li, Chun Lu

“…Abstract Although a fraction of functional peptides concealed within long non‐coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA‐encoded peptides are involved in the malignancy of cervical cancer (CC). …”
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Physics-Informed Deep Learning for Musculoskeletal Modeling: Predicting Muscle Forces and Joint Kinematics From Surface EMG by Jie Zhang, Yihui Zhao, Fergus Shone, Zhenhong Li, Alejandro F. Frangi, Sheng Quan Xie, Zhi-Qiang Zhang

“…Musculoskeletal models have been widely used for detailed biomechanical analysis to characterise various functional impairments given their ability to estimate movement variables (i.e., muscle forces and joint moments) which cannot be readily measured in vivo. …”
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3D-printed resins used in occlusal splints modified with graphene nanoplatelets by Celso Ricardo Adami, Isandra Caroline Rodrigues, Letícia Cauzzi Rodrigues, Rafaele Frassini, Mariana Roesch Ely, Lilian Vanessa Rossa Beltrami, Diego Piazza, Lídia Kunz Lazzari, Heitor Luiz Ornaghi Júnior, Ademir José Zattera, Thiago Oliveira Gamba

“…It was evaluated the mechanical characteristics and cytotoxic effects of polymethylmethacrylate (PMMA) resin enhanced with graphene nanoplatelets (GNP at 0.125%, 0.250%, and 0.500% w/w) utilizing the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. …”
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Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced o... by Kangqing Zuo, Aonan Li, Taoning Si, Weiyi Lei, Yusheng Liu, Linbo Zhang, Taixing Zhang, Guiyong Xiao, Yupeng Lu, Ningbo Li

“…Abstract Phosphate conversion coatings on metallic implants can synergistically integrate functional components and structural regulation, offering excellent biocompatibility and osteogenic activity. …”
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The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic by Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le

“…Abstract Introduction The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. …”
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A simple polydopamine‐based platform for engineering extracellular vesicles with brain‐targeting peptide and imaging probes to improve stroke outcome by Xiaojing Shi, Lu Zhang, Shengju Wu, Chunfu Zhang, Muyassar Mamtilahun, Yongfang Li, Zhijun Zhang, Changjing Zuo, Fengzhen Cui, Wanlu Li, Guo‐Yuan Yang, Yaohui Tang

“…Here we developed a dopamine surface functionalization platform that facilitates easy and simultaneous conjugation of targeting peptide and multi‐mode imaging probes to the surface of EVs. …”
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HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2 by Ying Wang, Juan Chen, Zhan Wang, Xia Luo, Nayiyuan Wu, Jing Wang

“…HKDC1 knockdown reversed these effects, which were restored by adding FFA. Mechanistically, HKDC1 interacted with and stabilized glucose-6-phosphatase catalytic subunits (G6PC/G6PC2), supporting its tumor-promoting functions. …”
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Genomic insights into monensin resistance development in Eimeria tenella by Xiaolong Gu, Xiaolong Gu, Sufang Fang, Hongbin Liu, Yubo Shi, Yubo Shi, Yuanyuan Zhang, Peng Wang, Ping Cui, Xinming Tang

“…IntroductionMonensin resistance in Eimeria tenella poses a significant challenge in poultry farming, compromising the effectiveness of this widely used anticoccidial drug. …”
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Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice by Yunting Xie, Linlin Cai, Zhiji Huang, Kai Shan, Xinglian Xu, Guanghong Zhou, Chunbao Li

“…These findings provide a new insight into understanding the differences in nutritional functions of meat and plant-based meat analogues.…”
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Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target by Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Manuel Galán-Cañete, Francisco Porcel-Pastrana, Jesús M. Pérez-Gómez, María Ortega-Bellido, Julia Carrasco-Valiente, Laura Chamorro-Castillo, Juan P. Campos-Hernández, Oriol A. Rangel-Zuñiga, Teresa González-Serrano, Rafael Sánchez-Sánchez, André Sarmento-Cabral, Manuel D. Gahete, Juan M. Jiménez-Vacas, Raúl M. Luque

“…High plasma SRRM1 levels were associated with a shorter castration-resistant PCa-free survival and correlated with androgen-receptor (AR)/AR-splicing variant 7 (AR-V7) expression levels and activity in PCa tissues. Therefore, the functional and molecular effects of in vivo SRRM1 silencing were then tested in 22Rv1-derived xenograft tumors. …”
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Recent advancements and sustainable solutions in adsorption-based cooling systems integrated with renewable energy sources and industrial waste heat: A review by Sumit Kumar Singh, Dibakar Rakshit, K Ravi Kumar, Anurag Agarwal

“…A system having numerous beds offers a continual cooling effect and having minimal dead mass operates more efficiently. …”
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