Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP by Tanja Fuchsberger, Imogen Stockwell, Matty Woods, Zuzanna Brzosko, Ingo H Greger, Ole Paulsen

“…The reward and novelty-related neuromodulator dopamine plays an important role in hippocampal long-term memory, which is thought to involve protein-synthesis-dependent synaptic plasticity. However, the direct effects of dopamine on protein synthesis, and the functional implications of newly synthesised proteins for synaptic plasticity, have not yet been investigated. …”
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In vitro antitumor capacity of extracts obtained from the plants Plukenetia volubilis (Sacha inchi) and Moringa oleifera in gastric cancer [version 2; peer review: 1 approved, 2 ap... by Javier Soto, Sara Robledo, Victoria Ospina, Javier Murillo, Denny Cardenas, Natalia Arbelaez, Jose Vargas

“…Moringa oleifera and Plukenetia volubilis (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity. …”
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LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma by Yuxuan Li, Jie Zhu, Fengguang Zhai, Yidong Ge, Ziqing Zhan, Shuyan Wang, Lili Kong, Jianan Zhao, Lecheng Hu, Siyuan Wang, Jiaxin Shi, Jianing Mao, Zongdong Yu, Haoyun Wang, Jiabei Jin, Mengxiang Zhao, Hong Li, Xiaofeng Jin

“…Through integrated analysis of single-cell transcription sequence data, we identified aberrant upregulation of Lamin B2 (LMNB2) specifically in immunotherapy-sensitive HCC patients. Functional characterization revealed that LMNB2 acts as a transcriptional regulator of PD-L1, potentiating immune escape mechanisms in HCC cells during co-culture with Jurkat cells. …”
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Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment by Xinya Liu, Lanchao Sun, Yongfeng Lin, Jingyue Du, Huizi Yang, Chuanhai Li

“…In this work, we investigated CDP-induced hepatic steatosis through Liver X Receptor α (LXRα) pathway across the molecular interactions, signaling pathways, cell functions, animal effects, and population risks, and compared them to triphenyl phosphate (TPHP) and tricresyl phosphate (TCRP). …”
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A vegetation strategy to balance the hazardous level of microplastics in the land–sea interface through rhizosphere remediation by Weifeng Ruan, Yanqin Peng, Xi Ling, Bailun Yu, Yiping Tai, Nora Fung-Yee Tam, Yunv Dai, Yang Yang

“…This primarily pertains to the following aspects: direct and indirect effects of MPs on plants (including combined pollution), which included growth and development; nutrient intake; and physiological, biochemical, and genetic functions. …”
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Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation by Yi Yang, Tian-Qing Cao, Sheng-Hong He, Lu-Chen Wang, Qi-Heng He, Ling-Zhong Fan, Yong-Zhi Huang, Hao-Ran Zhang, Yong Wang, Yuan-Yuan Dang, Nan Wang, Xiao-Ke Chai, Dong Wang, Qiu-Hua Jiang, Xiao-Li Li, Chen Liu, Shou-Yan Wang

“…It is imperative to further elucidate the precise modulatory effects of DBS on thalamo-cortical and cortico-cortical functional connectivity networks. …”
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Physical Properties and in Vitro Simulated Gastrointestinal Digestion Characteristics of Polygonatum cyrtonema Hua Powder with Different Particle Sizes by Chenchen ZHAO, Jiahui LÜ, Chang LIU, Ruonan TONG, Mengjin WANG, Heng LIU, Lihua XING, Jiao YU, Luna GENG, Nianjun YU

“…To investigate the functional effects of superfine grinding treatment on Polygonatum cyrtonema Hua powder, in this study, the sample was ground and sieved by pharmacopoeia test sieves (50, 100, 200 and 325 mesh) to prepare P. cyrtonema Hua powder with different particle sizes. …”
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Extraction, structural characterization, and in vitro immunomodulatory activities of Saccharomyces cerevisiae spore wall β-glucan by Mengqing Yan, Xue Wang, Jingtao Zhang, Shuheng Yang, Cong Pan, Shiwei Liu, Jia Liu, Youqiang Yu, Fangli Ding, Shenglin Duan, Huoqing Huang, Guoyu Liu, Peng Yuan

“…Additionally, YSG can bind to the Dectin-1 receptor protein on the surface of macrophages, activating the Syk/CARD9/NF-κB pathway to promote the expression of iNOS and cytokine mRNAs, thereby facilitating the release of NO and related cytokines for increased immunostimulatory effects. Collectively, our results provide foundational insights into the potential of yeast spore wall β-glucan as a functional immunostimulatory agent.…”
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Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression by Xiaodie Liu, Heming Sun, Jing Liang, Huan Yu, Ming Xue, Yuebo Li, Wenhui Li, Ying Xu, Bin Ling, Dingqing Feng

“…Cytokine profiling and functional assays further demonstrated that lactate-stimulated M2 TAMs secrete elevated IL-6, which promotes tumor progression. …”
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Integrated proteomics and metabolomics analysis reveals the impact of zinc exposure on hepatopancreas from Litopenaeus vannamei: Insights into the response mechanisms by Xianbin Su, Panhui Cao, Shuang Zhang, Zhi Liang, Jiayuan Zhang, Jieyu Guo, Xiaowen Zhu, Hui Guo

“…The results demonstrated that Zn exposure limited ATP synthesis and metabolism, impaired energy metabolism, interfered with the normal functioning of metabolites, which in turn inhibits the synthesis of DNA, RNA, and proteins, affected the antioxidant system, and disrupted lipid metabolism, leading to disturbances of the intracellular environment. …”
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HCP5 Derived Novel Microprotein Triggers Progression of Gastric Cancer through Regulating Ferroptosis by Qiuhui Li, Guoqing Guo, Yuli Chen, Lu Lu, Hanyang Li, Zihan Zhou, Jiahao Guo, Xiongkang Gan, Yanming Hu, Qiunuo Li, Ming Sun, Xianghua Liu

“…These ORFs potentially encode novel proteins or peptides with crucial roles in various human cancers, yet the translational potential of these lncRNAs and the functions of the protein products remain largely unexplored, especially in gastric cancer (GC). …”
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Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation by Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan

“…We show that the tumor suppressive effect of Grm4-deficiency requires host immunity, in particular CD8+ T cells, NK cells, and IFNγ, but independent of the nervous system. …”
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Reliability-Based Estimation of Traffic Interruption Probability due to Road Waterlogging by Manuel Contreras-Jara, Tomás Echaveguren, José Vargas Baecheler, Alondra Chamorro Giné, Hernán de Solminihac Tampier

“…Floods affect road infrastructure physically and operationally, increase road user costs and road agencies cost, and eventually isolate communities. The research of the effect of floods on vehicular circulation is mainly focused on the stability of vehicles. …”
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Spray-Drying Microencapsulation of Grape Pomace Extracts with Alginate-Based Coatings and Bioaccessibility of Phenolic Compounds by Josipa Martinović, Rita Ambrus, Mirela Planinić, Gabriela Perković, Gordana Šelo, Ana-Marija Klarić, Ana Bucić-Kojić

“…This study contributes to the understanding of biopolymer-based encapsulation systems, but also to the valorisation of grape pomace as a high-value functional ingredient in sustainable food processing.…”
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A Transition to Discharge Program for the Reduction of Early Readmission in a Mental Health Inpatient Unit: Study Protocol by Vera Carbonell-Aranda, Yaiza García-Illanes, María Traverso-Rodríguez, Antonio Bordallo-Aragón, Berta Moreno-Kustner, José Guzmán-Parra, Jesús Herrera-Imbroda

“…Success will also be measured through pre- and post-assessments of the recovery, functionality, subjective well-being, social support, and treatment satisfaction of those participating in the psychotherapeutic group. …”
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Freshness/spoilage monitoring of protein-rich foods by betacyanin-loaded gelatin/carboxymethyl cellulose halochromic labels by Reza Abedi-Firoozjah, Shamimeh Azimi-Salim, Arvin Afrah, Reza Yekta, Elham Assadpour, Maryam Azizi-Lalabadi, Seid Mahdi Jafari

“…In the present investigation, easy-to-use colorimetric on-package labels were developed based on gelatin/carboxymethyl cellulose films loaded with betacyanin-rich Mirabilis jalapa extract (MJE) for freshness tracking of shrimp and minced meat. The effect of MJE addition (2 %, 4 %, and 6 % (w/v)) on the morphology, micro-structural, optical, and functional characteristics of the labels was assessed. …”
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Photo-responsive polypropylene/zinc oxide/polydopamine-TEMPO composite membranes with light-induced self-sterilization by Huajie Wang, Hao Peng, Wenhao Ji, Jiaxin Wang, Xiaoyan Du, Wen Song, Wen Zhang, Fazli Wahid, Ali Raza

“…The membrane, created using 3D printing, underwent functionalization with zinc oxide (ZnO) and polydopamine (PDA)-TEMPO to achieve broad-spectrum light absorption and facilitate self-sterilization through photocatalytic and photothermal effects upon light exposure. …”
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Research on early warning of roof water inrush in working faces based on a transparent hydrogeological model by Huiqing LIAN, Tao YAN, Shangxian YIN, Bin XU, Jia KANG, Wang ZHOU, Guocheng YAN

“…Fourth, an intelligent platform, integrating three layers and six core functions, is developed with a hybrid mechanism of triggers and polling for comprehensive evaluation and early warning. …”
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Evaluation of NFκB-dependent inflammatory responses induced by TNFα in 3D human microvessels by Thittaya Den-Udom, Nithi Asavapanumas, Nuntavan Bunyapraphatsara, Kenjiro Muta, Pimonrat Ketsawatsomkron

“…Recently, advances in three-dimensional (3D) in vitro models that recapitulate human microvessel functions have been increasingly described. However, the pathological mechanisms of endothelial cells (ECs) in 3D microvessels remain to be elucidated. …”
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Game-based visual feedback-guided dynamic balance training versus conventional training in patients with hemiplegia: a pilot randomized controlled trial by Yan Xu, Jiadong Ni, Yajing Yang, Jiajia Yao, Lianhui Fu, Cong Xu

“…The post-training assessment revealed significant improvements (Berg Balance Scale, Functional Reaching Test, Timed “Up-and-Go” Test scores and 10-metre fast walking speed) in outcome measures in the full sample. …”
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