Dual action of pyrimidine derivatives: Targeting tamoxifen resistance in breast cancer by Jie Yuan, Geng Wang, Narasimha M. Beeraka, Hua Zhang, Qun Wang, Danfeng Zhang, Minghua Wang, Akshay Ravish, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Vladimir N. Nikolenko, Basappa Basappa, Li Yang

“…The differences in the functions of the two pyrimidine structures are attributed to their additional structures bearing both TRX-01 and TTP-05. …”
Get full text

New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice by Xiangpei Yue, Yufei Mei, Yun Zhang, Zheng Tong, Dehua Cui, Jun Yang, Aibo Wang, Rui Wang, Xuechao Fei, Li Ai, Yalan Di, Hongjun Luo, Hui Li, Wenhong Luo, Yu Lu, Rui Li, Chunli Duan, Ge Gao, Hui Yang, Binggui Sun, Rongqiao He, Weihong Song, Hongbin Han, Zhiqian Tong

“…Methods We compared the heating effects on the brains of rats illuminated with laser light at 630, 680, and 810 nm for 40 minutes, respectively. …”
Get full text

Simulation and analysis of a high-k electron-scale turbulence diagnostic for MAST-U by D.C. Speirs, J. Ruiz Ruiz, M. Giacomin, V.H. Hall-Chen, A.D.R. Phelps, R. Vann, P.G. Huggard, H. Wang, A. Field, K. Ronald

“…Plasma turbulence on disparate spatial and temporal scales plays a key role in defining the level of confinement achievable in tokamaks, with the development of reduced numerical models for cross-scale turbulence effects informed by experimental measurements an essential step. …”
Get full text

The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells by Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren

“…SCFAs exert various metabolic functions, which in part can be explained by activation of G protein-coupled receptors (Gpr) 41 and 43. …”
Get full text

Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Rikkunshito, a Japanese traditional herbal medicine, has been shown to improve cisplatin-induced anorexia and functional dyspepsia, and our exploratory study found that rikkunshito has an additive beneficial effect on CINV in patients with uterine corpus and cervical cancer receiving cisplatin containing chemotherapy (JORTC KMP-02). …”
Get full text

SLNP-based CDK4- targeted nanotherapy against glioblastoma by Uzma Ghani, Fareeha Khalid Ghori, Muhammad Usman Qamar, Muhammad Usman Qamar, Hina Khan, Basit Azad, Sabahat Habib, Saira Justin, Ishaq N. Khan, Ishaq N. Khan, Tawaf Ali Shah, Gamal A. Shazly, Mohammed Bourhia, Fouzia Perveen, Aneela Javed

“…Their nuclear structure and drug-like properties were predicted through Lipinski rule and density functional theory analysis. Physio-chemical characterizations of naked and drug-encapsulated SLNPs assessed size, stability, entrapment efficiency, and drug release rate. …”
Get full text

CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process by Mikel Tainta, Mikel Tainta, Mikel Tainta, Mikel Tainta, Mirian Ecay-Torres, Myriam Barandiaran, Myriam Barandiaran, Myriam Barandiaran, Ainara Estanga, Carolina López, Miren Altuna, Miren Altuna, Ane Iriondo, Jon Saldias, Maite Garcia-Sebastian, Marta Cañada, Maria de Arriba, Imanol Reparaz-Escudero, Mikel L. Sáez de Asteasu, Mikel L. Sáez de Asteasu, Mikel Izquierdo, Mikel Izquierdo, Nekane Balluerka, Arantxa Gorostiaga, Naia Ros, Goretti Soroa, Jara Domper, Jara Domper, Lucia Gayoso, Lucia Gayoso, Maria Arrizabalaga-Lopez, Usune Etxeberria, Usune Etxeberria, Maria Ines Torres, Elena Alberdi, Elena Alberdi, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Maider Mateo-Abad, Itziar Vergara, Javier Mar, Pablo Martinez-Lage

“…The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. …”
Get full text

Transcriptomic profiling reveals RetS-mediated regulation of type VI secretion system and host cell responses in Pseudomonas aeruginosa infections by Yinglin Wu, Yinglin Wu, Yinglin Wu, Shan Huang, Shan Huang, Shan Huang, Kai Zhang, Yangcheng Shen, Yangcheng Shen, Yangcheng Shen, Shebin Zhang, Shebin Zhang, Shebin Zhang, Haining Xia, Haining Xia, Haining Xia, Jieying Pu, Jieying Pu, Jieying Pu, Cong Shen, Cong Shen, Cong Shen, Cha Chen, Cha Chen, Cha Chen, Jianming Zeng, Jianming Zeng, Jianming Zeng

“…The objective of this study was to elucidate the regulatory mechanisms and pathogenic effects of the T6SS during P. aeruginosa infection, utilizing transcriptome sequencing and functional assays. …”
Get full text

Replacement of fish oil with Schizochytrium-derived monoglycerides enriched in docosahexaenoic acid on the growth performance, lipid composition, and intestinal microbiota of Pacif... by Wei Huang, Wei Huang, Yongkang Song, Xiaonan Wang, Daiyan Lin, Tuyan Luo, Kaimin Cheng, Qiaolian Li, Baoyu Tian, Yongbiao Zheng, Yongjin He

“…Docosahexaenoic acid (DHA) positively influences growth development, feed efficiency, physiological functions, and DHA accumulation in aquatic organisms. …”
Get full text

Determination of the optimal frequency and duration of micro-spray patterns for high-temperature environment tomatoes based on the Fuzzy Borda model by Run Xue, Chuan Zhang, Haofang Yan, Kinde Negessa Disasa, Imran Ali Lakhiar, Muhammad Akhlaq, Muhammad Usman Hameed, Jun Li, Jiangtao Ren, Shuaishuai Deng, Biyu Wang, Rongxuan Bao

“…The results showed that micro-spray effectively improved tomato growth indicators and fruit quality. …”
Get full text

Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…During neurodevelopment, CB1 receptors exhibit unique expression patterns, including transient localization in brainstem regions critical for neurovegetative functions. These developmental dynamics likely explain children’s heightened sensitivity to THC’s neurological and neurovegetative effects, often resulting in more severe outcomes compared to adults. …”
Get full text

Oxidative, Inflammatory, and Constipation Stress Modulation by a Heteropolysaccharide from <i>Lacticaseibacillus rhamnosus</i> CRL75 by René Emanuel Lobo, Ana Magdalena Ávila, Jonathan Laiño, Verónica Molina, Diego Navarro, María Inés Gómez, María Inés Torino, María Pía Taranto

“…Due to its viscosifying and health-promoting attributes, CRL75 offers promising applications for functional dairy products.…”
Get full text

Assessing the Impact of the Prostate Cancer Patient Empowerment Program (PC-PEP) on Relationship Satisfaction, Quality of Life, and Support Group Participation: A Randomized Clinic... by Cory Burgher, Gabriela Ilie, Ross Mason, Ricardo Rendon, Andrea Kokorovic, Greg Bailly, Nikhilesh Patil, David Bowes, Derek Wilke, Cody MacDonald, Markos Tsirigotis, Calvin Butler, David Bell, Jesse Spooner, Robert David Harold Rutledge

“…<b>Conclusions:</b> The PC-PEP program effectively maintains relationship satisfaction and enhances emotional well-being, particularly in patients with fewer physical side effects. …”
Get full text

Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Alistair Perry, Laura E. Hughes, Natalie E. Adams, Michelle Naessens, Niels A. Kloosterman, Matthew A. Rouse, Alexander G. Murley, Duncan Street, P. Simon Jones, James B. Rowe

“…Whilst these two syndromes are partially convergent in cognitive effects, they differ in disease mechanisms such as molecular pathologies and prefrontal atrophy. …”
Get full text

Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis by Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno

“…This blood supply is structured into three main arterial groups, each serving different regions of the pancreas to effectively support its endocrine and exocrine functions. …”
Get full text

Graphene-Based Absorber: Tunable, Highly Sensitive, Six-Frequency by Xinmei Wang, Xianding He, Hua Yang, Xu Bao, Yongjian Tang, Pinghui Wu, Yougen Yi

Get full text

Pore-scale numerical simulation of in situ microemulsion formation and enhanced oil recovery in porous media by Yingxue Hu, Kai Dong, Dan Zhang, Tianjiang Wu, Tianjiang Wu, Wei Xu, Zhaolin Gu

Get full text

Chemical incorporation of SiO2 into TiO2 layer by green plasma enhancer and quencher agents for synchronized improvements in the protective and bioactive properties by Mosab Kaseem, Ananda Repycha Safira, Mohammad Aadil, Han-Choel Choe

Get full text

Comprehensive Approaches to Pain Management in Postoperative Spinal Surgery Patients: Advanced Strategies and Future Directions by Dhruba Podder, Olivia Stala, Rahim Hirani, Adam M. Karp, Mill Etienne

“…Effective postoperative pain management remains a major clinical challenge in spinal surgery, with poorly controlled pain affecting up to 50% of patients and contributing to delayed mobilization, prolonged hospitalization, and risk of chronic postsurgical pain. …”
Get full text

HAPS-ISAC: Enhancing Sensing and Communication in 6G Networks With Advanced MIMO Beamforming by Parisa Kanani, Mohammad Javad Omidi, Mahmoud Modarres-Hashemi, Halim Yanikomeroglu

“…This paper introduces a novel high altitude platform station (HAPS)-based integrated sensing and communication (ISAC) system, referred to as HAPS-ISAC, designed to enhance the capabilities of future 6G networks by simultaneously optimizing communication and sensing functions. HAPS operates as a super-macro base station in the stratosphere, utilizing advanced beamforming techniques within a multiple-input multiple-output (MIMO) architecture, supplemented by multiple-input single-output (MISO) configurations, effectively enabling the system to serve ground communication users (CUs) while conducting high-resolution sensing of potential targets. …”
Get full text