M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…This study systematically investigates the functional interplay within the RBP-circRNA-autophagy network in LUAD pathogenesis. …”
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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

“…Consensus cluster analysis was followed by Gene Set Enrichment Analysis, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses of DEGs to determine the biological functions and pathways regulated by PMTRGs. CIBERSORT, TIMER, MCPCOUNTER, and XCELL algorithms were used to analyze immune cell infiltration patterns. …”
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A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis by Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, David R. Kaplan, Freda D. Miller, Brian A. MacVicar, Haakon B. Nygaard

“…This novel, well characterized, functional in vitro platform offers unique opportunities to study the roles and responses of microglia to Aβ modelling key aspects of human AD. …”
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Microbial diurnal rhythmicity in the rumen fluid impacted by feeding regimes and exogenous microbiome providing novel mechanisms regulating dynamics of the rumen microbiome by Yangyi Hao, Wei Wang, Mengmeng Li, Youyoung Choi, Mi Zhou, Yixin Wang, Zhijun Cao, Ya Jing Wang, Hongjian Yang, Linshu Jiang, Le Luo Guan, Shengli Li

“…Similar circadian patterns were found among feed intake, ruminal volatile fatty acid concentrations, bacterial functions such as glycolysis/gluconeogenesis, and deterministic assembly processes of bacterial communities. …”
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Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity by Hamada Hashem, Shadwa Abdelfattah, Hesham M. Hassan, Ahmed Al-Emam, Mohammed Alqarni, Ghallab Alotaibi, Ibrahim Taha Radwan, Kirandeep Kaur, Devendra Pratap Rao, Stefan Bräse, Abdullah Alkhammash

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Tuning Surface Phonon Polaritons in One‐Dimensional Complementary Nanostructures via Curvature and Dielectric by Li Zhang, Feiyue Lu, Zhiwen Liang, Guanghui Wang, Junjie Shi, Qi Wang

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Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review by Andreea Smeu, Iasmina Marcovici, Cristina Adriana Dehelean, Stefania-Irina Dumitrel, Claudia Borza, Rodica Lighezan

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Correlating structure, magnetism, and electrical transport in sol-gel processed Nd0.55Ca0.45MnO3 manganite by Gaurav Joshi, Hira Ilyas, Sudha Tomar, Shivam Kumar Miglani, Yogesh Kumar, Upendra Kumar, D.S. Raghav

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Roles of fermented plant-, dairy- and meat-based foods in the modulation of allergic responses by Muhamad Hafiz Abd Rahim, Nur Hazlin Hazrin-Chong, Hanis Hazeera Harith, Wan Abd Al Qadr Imad Wan-Mohtar, Rashidah Sukor

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The agricultural plastic paradox: Feeding more, harming more? by Kai Wang, Xuejun Liu, David R. Chadwick, Changrong Yan, Michaela Reay, Tida Ge, Fan Ding, Jingkuan Wang, Ruimin Qi, Mouliang Xiao, Rui Jiang, Yanling Chen, Ji Ma, Charlotte Lloyd, Richard P. Evershed, Yongming Luo, Yongguan Zhu, Fusuo Zhang, Davey L. Jones

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Mitigation of mycotoxin residues and activation of endogenous stem cells in broiler chickens using a toxin binder: Implications for meat safety and performance enhancement by Erma Safitri, Hery Purnobasuki, Tita Damayanti Lestari, Suzanita Utama, Rimayanti Rimayanti, Mirni Lamid, Mutmainah Wardatul Jannah, Siti Darodjah, Goo Jang, Mitsuhiro Takagi

“…Conclusion: Administering a toxin binder at 1.6 g/kg effectively reduced AFB1 and OTA residues and significantly activated endogenous stem cells, suggesting a protective and regenerative effect. …”
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MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment by Diego Salagre, Juan Sanjuán‐Hidalgo, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy, Pedro P. Medina, Ahmad Agil

“…Small interfering RNAs (siRNAs) are powerful tools for inhibiting gene expression, enabling the analysis of gene functions and roles in molecular pathway activation. …”
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Cosmetic Potential of <i>Haberlea rhodopensis</i> Extracts and Extracellular Vesicles in Human Fibroblast Cells by Milena Georgieva, Bela Vasileva, Penyo Ivanov, Kamelia Hristova-Panusheva, Tsvetelina Paunova-Krasteva, Ivan Lesov, Zlatina Gospodinova, Natalia Krasteva, George Miloshev, Vasil Georgiev

“…<i>Haberlea rhodopensis</i> in vitro culture extracts and EVs were found to preserve fibroblast morphology, enhance mitochondrial mass, and upregulate collagen-related gene expression. These effects were concentration-dependent. The extracts exhibited biocompatibility with minimal genotoxic effects, indicating their potential as safe bioactive agents for skin rejuvenation. …”
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Development of a Digital Health Intervention for the Secondary Prevention of Cardiovascular Disease (INTERCEPT): Co-Design and Usability Testing Study by Irene Gibson, Lis Neubeck, Marissa Corcoran, Chris Morland, Steve Donovan, Jennifer Jones, Caroline Costello, Lisa Hynes, Aisling Harris, Mary Harrahill, Mary Lillis, Alison Atrey, Chantal F Ski, Vilius Savickas, Molly Byrne, Andrew W Murphy, John William McEvoy, David Wood, Catriona Jennings

“…ObjectiveThis study aimed to optimize the acceptance and effectiveness of a DHI for the secondary prevention of CVD through co-design, integrating end users’ perspectives throughout. …”
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Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tissues by Minseo Kim, Dianjun Cao, Vincent Cavaleri, Kyudong Han, Kyudong Han, Kyudong Han, Seyoung Mun, Seyoung Mun, Seyoung Mun, Soo Jin Jeon

“…In this study, we investigated the effects of ESD on four major tissues of the lobster (testis, intestine, hepatopancreas, and green gland) using transcriptomic analysis. …”
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A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy by Yingying Wu, Shaojie Cheng, Ting Zhang, Leilei Wang, Ting Li, Yongbo Zheng, Guo Yang, Xiaohou Wu, Chunli Luo, Tingmei Chen, Liping Ou

“…The clinical significance of FLJ was evaluated in a collected cancer cohort. Functional loss assays were performed to assess the effects of FLJ on CRPC cells both in vitro and in vivo. …”
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Translocation of probiotics via gut–lung axis enhanced pulmonary immunity of weaned piglets exposed to low concentrations of ammonia by Jiajun Yang, Jing Wang, Peng Shang, Zongliang Liu, Bo Zhang, Dongsheng Yang, Hao Zhang

“…L. salivarius was supplemented to explore its effects on pulmonary immunity and its potential for bacterial translocation. …”
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Regular aerobic exercise ameliorates radiation-induced pulmonary fibrosis: An animal study by Da Bin Ko, Seungwoo Cha, Jae Yong Jeon, Su Ssan Kim, Won Kim, Sei Won Lee, Joongkee Min, Si Yeol Song, Seung Hak Lee

“…Background and purpose: A definitive treatment for radiation-induced pulmonary fibrosis (RIPF), a common side effect of radiation therapy for thoracic cancer, remains to be established. …”
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Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis by Zhonghua Xiong, Lei Zhao, Geyu Liu, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Zhi Guo, Peng Zhang, Mantian Zhang, Tianshuang Gao, Jinju Sun, Xin Liu, Yonggang Wang

“…Abstract Background The hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous system functions. However, the involvement of hypothalamic subregions in migraine remains unclear. …”
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Influence of altitudes and development stages on the chemical composition and antioxidant capacity of Andean blackberries (Rubus glaucus Benth) by Mabel Guevara-Terán, Mabel Guevara-Terán, Eduardo Tejera, Wilson Vásquez-Castillo, Celestino Santos-Buelga, Ana M. González-Paramás, José M. Alvarez-Suarez, José M. Alvarez-Suarez

“…Overall, our findings highlight the high functional value of this fruit, supporting its health-protective effects when consumed regularly, either as fresh fruit or in nutraceutical form.…”
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