CLINICAL STUDY OF OPTIMIZED APPROACHES TO LOCAL PREVENTION OF DENTAL CARIES IN PATIENTS WITH TYPE 1 DIABETES MELLITUS by O.A. Udod, A.S. Kulish

“…The index of caries intensity DMF, structure functional indices of enamel acid resistance (TER) were determined in patients. …”
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Mitral valve leaflet clipping in patients with previously implanted heart failure devices by Ya. Sh. Karamova, T. M. Uskach, T. E. Imaev, S. N. Tereshchenko

“…Materials and Methods. 73 patients with mitral regurgitation of 3-4 degree, heart failure of II-IV NYHA functional class who underwent implantation of MitraClip system on mitral valve flaps were included in the study. …”
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PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1 by Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu, Zhenhai Yu

“…Additionally, we examined the effect of PYK2 on endometriosis cells in vitro and whether VS-6063 inhibits the biological functions of endometriosis cells. …”
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Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression by Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu

“…Exogenous SYNPO supplementation mimicked these effects and attenuated neutrophil replicative senescence by modulating p53 pathway-associated genes (TP53, CHEK1, and SERPINE1). …”
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The Interface of a Leaky Gut with Reduced Sarcopenia-Related Quality of Life (SarQoL) in Patients with Chronic Obstructive Pulmonary Disease by Qaisar R, Karim A, Muhammad T, Ahmad F, Marinho DA, Arkadianos I, Alkahtani S

“…Plasma zonulin demonstrated inverse correlations with SarQoL domains for locomotion, functionality, activities of daily living, and cumulative SarQoL scores in COPD patients (all p< 0.05). …”
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3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. Recently, 3D culturing models has been shown to significantly influence the intrinsic characteristics of these cells, their gene expression and the secretome’s composition, thus affecting ASC paracrine effects and clinical potential. …”
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Prehabilitation Program for Lung and Esophageal Cancers (Boosting Recovery and Activity Through Early Wellness): Protocol for a Nonrandomized Trial by Jodi E Langley, Daniel Sibley, Joy Chiekwe, Melanie R Keats, Stephanie Snow, Judith Purcell, Stephen Sollows, Leslie Hill, David Watton, Abbigael E Gaudry, Ibrahim Hashish, Alison Wallace

“…Secondary outcomes include measures of preliminary effectiveness including patient-reported outcomes, such as well-being, fatigue, and functional measures. …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…Perhaps, the mechanism in exhibiting the found synergistic effect of these drugs lies in their different effect on the pathogenesis of the disease. …”
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Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods by Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen

“…Conclusion Various exercise training methods have differing effects on muscle-reducing obesity treatment. Compared to aerobic training, resistance training, and mixed training may offer more pronounced improvements, enhancing physical functioning in sarcopenic obesity patients. …”
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Classification-based point cloud denoising and 3D reconstruction of roadways by Denghong CHEN, Ning PANG, Wen NIE, Juqiang FENG, Jiliang KAN, Jinjing ZHANG

“…However, the conventional algorithm based on single filtering fails to effectively remove the noise at varying scales from point clouds. …”
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Meta-analysis of TB & HIV co-infection mortality rate in sub-Saharan African children, youth, and adolescents by Fassikaw Kebede Bizuneh, Tsehay Kebede Bizuneh, Getaye Tizazu Biwota, Biruk Beletew Abate, Tilahun Gizaw Ayenew

“…The final weighted inverse variance random-effect regression indicated WHO stages III and IV (pooled HR = 4.34), poor/ fair ART adherence (pooled HR = 3.11), missed Isoniazid preventive therapy (IPT) (pooled HR = 3.07), hemoglobin levels ≤ 10 mg/dL (pooled HR = 2.84), bedridden functional status (pooled HR = 3.19), below threshold CD4 count (pooled HR = 1.80), and missed cotrimoxazole preventive therapy (CPT) (pooled AOR = 1.58) were predictors of premature death during co-infection. …”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…Abstract Background Ageing results in diminished adaptability, as well as declines in physiological and psychological functions and resilience. The epigenetic clock ‘Phenotypic Age’ (PhenoAge) represents ‘preclinical ageing’. …”
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Multi-omics analyses reveal fecal microbial community and metabolic alterations in finishing cattle fed probiotics-fermented distiller’s grains diets by Rong Zhang, Shihui Mei, Guangxia He, Miaozhan Wei, Lan Chen, Ze Chen, Min Zhu, Bijun Zhou, Kaigong Wang, Zhentao Cheng, Chunmei Wang, Erpeng Zhu, Chao Chen

“…These findings provide some new insights into clarifying the role and potential mechanisms of FDG diets and also offer a scientific basis for the development of FDG into functional feed resources.…”
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Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus by Pattanachat Lertpeerapan, Songphon Kanlayaprasit, Surangrat Thongkorn, Kasidit Kasitipradit, Pawinee Panjabud, Kwanjira Songsritaya, Thanawin Jantheang, Masanobu Morita, Takaaki Akaike, Valerie W. Hu, Depicha Jindatip, Thanit Saeliw, Tewarit Sarachana

“…Ingenuity Pathway Analysis (IPA) was used to predict associated biological functions, diseases, and molecular interaction networks. …”
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Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…Experimental validation of gene expression was performed via immunohistochemistry (IHC) and functional assays in gene-modified melanoma cell lines.ResultsTwenty-two genes involved in KRAS signaling were identified as critical for patient survival. …”
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Organic substitution regulated the soil microbial communities by modifying nutrient limitations in saline-alkaline soils by Yue Han, Zhanli Ma, Rui Chen, Yue Wen, Yonghui Liang, Jinzhu Zhang, Wenhao Li, Zhenhua Wang

“…Organic amendment strategies significantly influence soil microbial community structure and functional activity, particularly in salt-affected agroecosystems. …”
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Towards the mechanical stability of biocrusts in drylands: Insights from inorganic ions and organic compounds and their interactions by Xingxing Yu, Bo Xiao, Yousong Cao, Stephen R. Hoon, Giora J. Kidron

“…Biocrusts are an important component of dryland ecosystems as they perform crucial ecological functions like stabilizing soils, mediating the hydrological cycle, and improving nutrient availability. …”
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A novel Tc17 population recruited by tumor cells promotes tumor progression in gastric cancer by Yichao Wang, Yichao Wang, Hao Yuan, Yayun Tan, Li Wu, Li Wu, Xinchen Zhao, Xinchen Zhao, Zeyuan Yang, Zeyuan Yang, Shaoxing Dai, Shaoxing Dai, Naixue Yang, Naixue Yang

“…Additionally, cell-cell interaction analysis revealed the interactions between Tc17 cells and tumor cells. Finally, functional validation through CCK-8 proliferation assays, wound Healing assays, and transwell assays conclusively demonstrated the tumor-promoting effects of IL-17A and IL-26 on gastric tumor cells.ResultsOur results indicate that Tc17 cells are absent from blood and exclusively found in tissues, with greater enrichment in tumor tissues compared to normal tissues. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…This could result in functional hyposplenia and a higher burden of infections. …”
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Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors by Wang Wang, Jingjing Huang, Yanan Hao, Lin Zou, Xiaxia Han, Tong Chen, Meiying Shen, Bozhi Wang, Luo Li, Siyin Chen, Shengchun Liu, Xiaojian Han, Aishun Jin

“…Among the four TCR clones, one TCR (KT18) exhibited superior functional avidity, effectively recognizing and eliminating KRASG12V mutant tumor cells without off-target activity against endogenous RAB7B or similar peptides. …”
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