CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury by Deng R, Yang H, Zhong W, Zhou J, Huang G, Zeng K

“…CITED2 silencing and overexpression were employed to elucidate its regulatory role, focusing on the AKT signaling pathway.Results: S-AKI causes structural and functional kidney damage, aggravated inflammatory responses, and dysregulated glucose metabolism, accompanied by increased expression of CITED2. …”
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MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas by Oleksii Nikolaienko, Garnet L. Anderson, Rowan T. Chlebowski, Su Yon Jung, Holly R. Harris, Stian Knappskog, Per E. Lønning

“…Sensitivity analyses limited to subregions of the MGMT promoter and to individuals with different genotypes of a functional SNP in the MGMT promoter (rs16906252), revealed no significant effect on HR for any of the cancer forms. …”
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Patient Experience of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Qualitative Exploration of Signs, Symptoms, and Health-Related Quality of Life Impacts by Anna Roberts, Natasha Griffiths, Kieran Thiara, Sophie Wallace, Alyson L. Young, Nicola Williamson, Adam Gater, Omar Saeed, Charles Minor, Natalia Hawken

“…Patients reported that current CIDP treatments lacked effectiveness in treating specific symptoms, caused unwanted side effects, and impacted their independence. …”
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Necrotic and Inflammatory Changes on Acute Studies of Siam Leaf (Chromolaena Odorata) Alcoholic Extract on Lead Induced Toxicity of Cardio-Pulmonary Morphology of Adult Albino Wist... by Ilegbedion, I.G.1*, Beredugo, S.,2 Aturaka, O.S.3, Tabowei, W.T.4.

“…Long-term exposure of adults can result in decreased performance in some tests of cognitive performance that measure functions of the nervous Cardio-pulmonary system.  …”
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Foreign experience of the social consequences of scientific and technological development: a place of education by N. E. Khristolyubova, E. A. Hudorenko

“…In order to ensure the comprehensiveness and reliability of research results publications on research topic in the press and the Internet were used in the work.When conducting research and presenting the material philosophical and scientific methods and approaches, specific institutional methods of analysis: system-structural, functional, comparative, evolutionary, interdisciplinary, comparative analysis method were applied.Results: The study data were obtained, indicating the complex nature of the impact and far ambiguous and contradictory infl uence of NTP on the life of human, taking place «lag» awareness of the consequences of scientific and technical progress.Conclusion: Formation of the scientific and technical policy of the state must be carried in the conditions of state control systems for development of the of NTP in a risk society.Key importance in this system belongs to education as one of the major factors directly affecting the understanding of the effect of NTP on all aspects of human life, the formation of advanced consciousness, and, as a consequence, enhance the security of human society life.…”
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Family Resilience and Its Influencing Factors Among Patients With Lung Cancer Based on Double ABC‐X Theoretical Framework by Ziyi Shen, Yan Fang, Chengcheng Li, Xin Luo, Junling Cui, Yanchang Liu, Jingfang Hong

“…Individual resilience has a significant positive effect on self‐efficacy, with a path coefficient of β = 0.377. …”
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Single-Cell Analysis Reveals Aspirin Restores Intervertebral Disc Integrity via Ferroptosis Regulation by Niu H, Qi H, Zhang P, Meng H, Liu N, Zhang D

“…Subtype identification, differential expression analysis, enrichment analysis, and cell proportion analysis were conducted to explore functional alterations in various nucleus pulposus cell (NPC) subpopulations. …”
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Morphologic Pattern Differences in Reconstructive Tissue Repair of Bone Defects Mediated by Bioactive Ceramics and Hydrogels: A Microscopic Follow-Up Evaluation of Re-Ossification by Róbert Boda, Viktória Hegedűs, Sándor Manó, Andrea Keczánné-Üveges, Balázs Dezső, Csaba Hegedűs

“…Although publications have documented the osteo-inductive effects of various bioactive materials on tissue sections, the associated morphologic patterns of tissue remodeling pathways at the cellular level have not been detailed. …”
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Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology by Yihao Pei, Ziqi Yang, Ben Li, Xiping Chen, Yiming Mao, Yun Ding

“…Paclitaxel (PTX), a standard chemotherapeutic agent for HGSOC, exerts cytotoxic effects on cancer cells and modulates the tumor microenvironment. …”
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Toward precision oncology in LUAD: a prognostic model using single-cell sequencing and WGCNA based on a disulfidptosis relative gene signature by Panpan Li, Han Zhang, Limin Sun, Xiaojuan Wu

“…Univariate Cox regression analysis revealed genes with significant effects on LUAD prognosis. A prognostic model was developed using LASSO and Cox regression, utilizing median model scores for stratifying patient risk. …”
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Association of Activin A Levels and Body Mass Index with Human CGB (Chorionic Gonadotrophin Beta) in Ectopic Pregnancies and Missed Abortion Patients by Hussein Al-Rkaby, Manal Kamal Rasheed, Farah Abdul Hussein Salih Al-Asadi

“…Activin A is a protein that participates principally in reproductive functions. In the adult brain, Neuroprotective effects of activin. …”
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Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing by Qiong Deng, Fangzhou Du, Shenzhen Pan, Yuchen Xia, Yuxin Zhu, Jingzhong Zhang, Chenglong Li, Shuang Yu

“…The pro-vascular stabilizing effects of MSCANG1 were assessed in primary endothelial cell cultures. …”
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Artificial intelligence in psychiatry: A systematic review and meta-analysis of diagnostic and therapeutic efficacy by Moustaq Karim Khan Rony, Dipak Chandra Das, Most. Tahmina Khatun, Silvia Ferdousi, Mosammat Ruma Akter, Mst. Amena Khatun, Most. Hasina Begum, Md Ibrahim Khalil, Mst. Rina Parvin, Daifallah M Alrazeeni, Fazila Akter

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Empagliflozin-Pretreated MSC-Derived Exosomes Enhance Angiogenesis and Wound Healing via PTEN/AKT/VEGF Pathway by Wang H, Bai Z, Qiu Y, Kou J, Zhu Y, Tan Q, Chen C, Mo R

“…In vivo, diabetic mouse wound models were used to evaluate the healing efficacy of EMPA-Exos.Results: EMPA pretreatment enhanced the functional properties of MSC-derived exosomes, significantly improving HUVECs’ proliferation, migration, invasion, and angiogenesis compared to non-pretreated exosomes (P < 0.05). …”
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Up-regulation of miR-338-3p alleviatesIL-13-induced injury of human bronchial cell line BEAS-2B by FU Haiwei, GUO Weiwei, SHENG Fen, LIU Donghong

“…Objective To investigate the effects of miR-338-3p on interleukin (IL) -13-induced human bronchial epithelial cell line (BEAS-2B) injury and airway inflammation in mice with ovalbumin (OVA) -induced asthma. …”
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Carbohydrate metabolism parameters in angina patients treated with metoprolol and its combination with trimetazidine by E. V. Bochkareva, O. V. Aleksandrovich, P. Yu. Bardybakhin, E. K. Butina, N. G. Kucheryavaya, I. N. Ozerova, V. A. Metelskaya

“…In total, 28 men aged 46-68 years, with Functional Class (FC) II-III stable angina, positive exercise stress test (EST), and no prior β-AB therapy were examined. …”
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Workload and salary as determinants of pedagogical graduates’ employment by occupation by L. M. Nurieva, S. G. Kiselev

“…The problem of the effectiveness of the pedagogical education system remains one of the most discussed topics in modern professional discourse. …”
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Tyrosine kinase inhibitor, masitinib, limits neuronal damage, as measured by serum neurofilament light chain concentration in a model of neuroimmune-driven neurodegenerative diseas... by Olivier Hermine, Laurent Gros, Truong-An Tran, Lamya Loussaief, Kathleen Flosseau, Alain Moussy, Colin D Mansfield, Patrick Vermersch

“…Furthermore, EAE mice treated with masitinib showed significantly lower concentrations of several well-established pro-inflammatory cytokines relative to control at day-15. A beneficial effect of masitinib on functional performance was also observed, with both M50 and M100 groups showing significantly less relative deterioration in grip strength at day-15 as compared with control (p < 0.001).…”
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Natural epigallocatechin-3-gallocarboxylate nanoformulation loaded doxorubicin to construct a novel and low cardiotoxicity chemotherapeutic drug for high-efficiency breast cancer t... by Ke Wang, Siqi Geng, Fang Wang, Baoru Fang, Huifeng Qian, Ying Li, Yiqing Zhou, Yanping Chen, Zhangsen Yu

“…Meanwhile, the anti-oxidant properties of EGCG can effectively eliminate a large amount of free radicals produced by DOX and significantly alleviate DIC by improving mitochondrial functional pathways. …”
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Exploring the mechanism of platycodin D in inhibiting nasopharyngeal carcinoma based on network pharmacology combined with experimental validation by LEI Benlan, YANG Jiangping, CHEN Yanfang, HUANG Jinglun, ZHANG Xiping, MA Canfang, LIANG Gang, JIAO Aijun

“…Conclusion Platycodin D may exert its anti-NPC effects by inhibiting the activation of the MAPK/ERK signaling pathway through down-regulating the expression of p-ERK protein.…”
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