The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex by Emmanuelle Gruz-Gibelli, Natacha Chessel, Clélia Allioux, Pascale Marin, Françoise Piotton, Geneviève Leuba, François R. Herrmann, Armand Savioz

“…This phenomenon would remain functional up to a point when Aβ increase and RA decrease probably lead to a pathological state.…”
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Spatial navigation skills in older adults with and without cognitive impairment by Dorota Kossowska-Kuhn, Michael J. Prevratil, Neil Charness, Walter R. Boot, Sara J. Czaja, Wendy A. Rogers

“…IntroductionNavigation is a fundamental cognitive ability essential for daily functioning. However, navigation skills decline with age and are further impaired in individuals with cognitive impairment (CI). …”
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Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol by Grace Lu-Yao, Jennifer M Johnson, Amy L Shaver, Nikita Nikita, Swapnil Sharma, Daniel S Lefler, Atrayee Basu-Mallick, Meghan L Butryn

“…Sex plays an important role in both the development of cancer as well as the functioning of the immune system. Though a difference in response to immune therapy is emerging between men and women it is unclear how this difference affects cancer outcomes and what the potential underlying mechanisms are for those effects. …”
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Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients by Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli

“…Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions and regulate neuroinflammation. They are reduced in neurodegenerative diseases, while in the Wobbler mouse model, allopregnanolone and its precursor progesterone showed protective effects on motor neuron degeneration. …”
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The aging behavior and mechanism of polyphenylene oxide foams in gamma radiation-compression environments by DOU Ruiyang, ZHANG Yiqian, JIN Bihui, HUANG Wei, LI Guangxian, GONG Pengjian, LEI Yajie, LIU Qiang, CHEN Hongbing

“…No significant changes were observed in the internal radicals or surface functional group structures of the samples before and after aging. …”
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Enhancing Fault Detection in Stochastic Environments Using Interval-Valued KPCA: A Cement Rotary Kiln Case Study by Abdelhalim Louifi, Abdelmalek Kouadri, Mohamed-Faouzi Harkat, Abderazak Bensmail, Majdi Mansouri

“…Existing approaches, such as kernel principal component analysis (KPCA), struggle with these challenges because they rely on single-valued data representations and are unable to effectively handle interval-based variability. To address these limitations, this paper introduces the interval-valued model KPCA (IV-KPCA), which extends KPCA by redefining similarity measures and kernel functions to accommodate interval-valued uncertainty. …”
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Development of polymer systems capable of counteracting surface-induced fibrillogenesis by A. Hansen, A. Sloutski, R. Wong, Y. Fang, L. Stotchel, C. Sadasivan, M. Rafailovich

“…To improve the mechanical properties and increase the hydrophilicity of PVA, a chemical approach was used with the addition of the clay functionalized with resorcinol diphenyl phosphate (RDP). …”
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Extracellular vesicles in cancer drug resistance: Mechanistic insights and therapeutic implications by Jing Zuo, Han Yan, Siyuan Qin, Yonghao Yan, Shiqi Wang, Li Yang, Jinlin Yang, Jun Yang

“…We also discuss how this knowledge can contribute to improvements in clinical practice, that is, the opportunities and challenges of EVs in functioning as potential biomarkers in predicting therapeutic resistance and, by extension, EV‐based therapy in achieving deeper and longer‐lasting clinical responses.…”
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Electrochromism via reversible electrodeposition of solid iodine by Shanlin Li, Yingyu Chen, Zhen Wang, Mengmeng Wang, Xianglin Guo, Xueqing Tang, Xiaoyu Wang, Wende Lai, Meiyun Tong, Changhong Wang, Shan Cong, Fengxia Geng, Yong Chen, Zhigang Zhao

“…A practical 400 cm2 complementary dynamic window is fabricated to demonstrate good electrochromic performance, including high optical contrast, a near colour-neutral opaque state, fast response time, uniform modulation, and polarity-switchable functionality.…”
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The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma by Mujahid Azfar, Weiman Gao, Chris Van den Haute, Lin Xiao, Mawar Karsa, Ruby Pandher, Ayu Karsa, Dayna Spurling, Emma Ronca, Angelika Bongers, Xinyi Guo, Chelsea Mayoh, Youri Fayt, Arthur Schoofs, Mark R. Burns, Steven H. L. Verhelst, Murray D. Norris, Michelle Haber, Peter Vangheluwe, Klaartje Somers

“…High‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning. We have previously shown that neuroblastoma cells increase polyamine uptake when exposed to the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), and this mechanism is thought to limit the efficacy of the drug in clinical trials. …”
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A standardized fold change method for microarray differential expression analysis used to reveal genes involved in acute rejection in murine allograft models by Weichen Zhou, Yi Wang, Masayuki Fujino, Leming Shi, Li Jin, Xiao‐Kang Li, Jiucun Wang

“…The group included genes for important reactions of transplantation rejection and revealed functional changes of the immune system in both heart and liver of the mouse model. …”
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LncRNA938/ TAF9/TTK axis promotes EMT and serves as a therapeutic target in hepatoblastoma by Chen Jin, Bingzi Dong, Yuwei Xie, Xin Chen, Shengze Wu, Fangqian Du, Qian Dong, Chengzhan Zhu

“…Methods Bioinformatic analysis was performed using sequencing datas to evaluate clinical diagnostic and prognostic values of molecules. Biological functions were assessed using in vitro and in vivo experiments. …”
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RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10 by Jingtian Yu, Liang Chen, Gang Wang, Kaiyu Qian, Hong Weng, Zhonghua Yang, Hang Zheng, Mengxin Lu

“…RBPMS depletion in BLCA cells resulted in AS of ANKRD10 and increased ANKRD10-2 expression. ANKRD10-2 functioned as a transcriptional co-activator of MYC proteins, thereby augmenting their transcriptional activity. …”
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Novel photodynamic therapy using two-dimensional NiPS3 nanosheets that target hypoxic microenvironments for precise cancer treatment by Wu Zongze, Liu Quan, Wageh Swelm, Sun Zhe, Al-Hartomy Omar A., Al-Sehemi Abdullah G., Yan Lesen, Chen Jiaojuan, Zhang Wenjian, Yang Jilin, Zhang Han, Liu Liping

“…Modified with triphenylphosphine (TPP) and based on density functional theory (DFT) calculations and experimental data, the NiPS3@TPP nano-system underwent targeted action toward mitochondria. …”
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Enhanced spin polarization in GQDs/TiO2 fibers via magnetic field and oxygen vacancies for photocatalysis by Yu-Ze Sun, Jin-Hua Liu, Zhi Li, Li-Peng Qiu, Jia-Bin Song, Shuai-Jie Wang, Zhen Zhang, Ru Li, Hong-Di Zhang, Wen-Peng Han, Jun Zhang, Yun-Ze Long

“…Oxygen vacancies, as key active sites, enabled spin polarization during the photocatalytic reaction, and the material’s spin polarization was verified by X-ray Absorption Spectroscopy (XAS) and Density Functional Theory (DFT). For the first time, the effects of high magnetic fields (1000–5000 mT) on photocatalytic performance were systematically explored. …”
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Extraction of Bioactive Component from Herbal Anoectochilus formosanus Hayata by Microwave, Ultrasound and Lactic Fermentation by Le Thi Kim Ngan, Nguyen Thi Ly, Nguyen Thi Tham, Dang Thi Kim Thuy, Do Dang Giap, Lieu My Dong

“…This study would suggest a novel use of lactic fermenting A. formosanus in the production of functional foods.…”
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Multifractal Analysis of Geological Data Using a Moving Window Dynamical Approach by Gil Silva, Fernando Pellon de Miranda, Mateus Michelon, Ana Ovídio, Felipe Venturelli, Letícia Moraes, João Ferreira, João Parêdes, Alexandre Cury, Flávio Barbosa

“…The results demonstrate that the proposed methodology effectively captures a wide range of fractal dimensions, from high to low, in artificially generated data. …”
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Does rehabilitation improve work participation in patients with chronic spinal pain after spinal surgery: a systematic review by Jonas Callens, Olivia Lavreysen, Lisa Goudman, Ann De Smedt, Koen Putman, Dominique Van de Velde, Lode Godderis, Dries Ceulemans, Maarten Moens

“…The included interventions comprised multiple treatment components, consisting of back school, self-care, functional restoration, multidisciplinary rehabilitation, physiotherapy, and digital care programmes to improve work participation. …”
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Design, Synthesis, and Biological Evaluation of New Analogs of Aurein 1.2 Containing Non-Proteinogenic Amino Acids by Nora Angelova, Ivan Iliev, Veronica Nemska, Tatyana Dzimbova, Nelly Georgieva, Dancho Danalev, Emilia Naydenova

“…Cytotoxicity and antiproliferative effects were studied using 3T3 NRU and MTT tests, respectively. …”
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Spatial transcriptomic analysis of 4NQO-induced tongue cancer revealed cellular lineage diversity and evolutionary trajectory by Feng Liu, Feng Liu, Xiaojun Wu, Shaoqing Yu, Deqiang Cheng, Jun Pan, Xiaodong Wang, Guanzhen Yu, Guanzhen Yu, Chaofu Li

“…Evolutionary tree analysis revealed the dynamic appearance and disappearance of functionally and genetically diverse cell subgroups during the progression from epithelial dysplasia to in situ carcinoma and invasive cancer. …”
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