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68061
Characteristics of ecosystem multifunctionality and influencing factors of different grassland types in temperate desert of Longzhong Loess Plateau
Published 2025-07-01“…Soil factors primarily exerted direct effects and indirectly promoted EMF by enhancing plant factors, with a total effect of 0.921. …”
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68062
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model
Published 2025-01-01“…In neuropathic pain (NP), a dysregulation of glial functions in the central and peripheral nervous systems has been described, and the balance between pro-inflammatory and anti-inflammatory mediators is lost in the transition from acute to chronic pain. …”
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68063
Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation
Published 2025-07-01“…Despite HSD and LT4 effectively alleviating the THs profile, only HSD offered substantial protection from hypothyroidism-associated cardiac inflammation and injury through its potent impact on the transcriptional miRNAs level and Nrf2/NF-κB protein expression (key regulators of the redox biomarkers and the inflammatory mediators).ConclusionHSD provides dual thyroprotective and cardioprotective effects that enhance THs bioavailability and functionality in the cardiovascular system.…”
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68064
Molecular characterization of heavy metal-tolerant bacteria and their potential for bioremediation and plant growth promotion
Published 2025-08-01“…IntroductionHeavy metal pollution adversely affects soil health by disrupting the microbial community structure and functions. The current study aimed to isolate and characterize heavy metal-tolerant bacterial strains and evaluate their potential for soil bioremediation and promoting agricultural sustainability.MethodsA total of 68 bacterial strains were isolated from industrial discharge-contaminated sites and screened for their maximum tolerance limits (MTL) against Cr, Cu, Pb, As, and Cd. …”
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68065
Anti-cariogenic potential and pharmacokinetics of Licorice and Xylitol infused chewing gum
Published 2025-05-01“…Conclusion: This novel chewing gum demonstrates significant potential as an anti-cariogenic product with a balanced formulation of functional, structural, and sensory properties. Future research, including clinical trials and consumer testing, will be essential to optimize its effectiveness and marketability, addressing the demand for user-friendly oral health solutions.…”
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68066
Injection of human umbilical cord mesenchymal stem cells exosomes for the treatment of knee osteoarthritis: from preclinical to clinical research
Published 2025-06-01“…Abstract Background Background: Exosomes (Exos) derived from mesenchymal stem cells (MSCs) share similar biological functions with MSCs but are more stable under various pathophysiological conditions, with a lower risk of immune rejection. …”
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68067
Multi-Objective Optimization of Pressure-Reducing Valves Operation in Extreme Water Consumption Scenarios (Case Study: Najaf Abad Urban Water Distribution Network)
Published 2024-10-01“…Additionally, three objective functions were optimized using the NSGA-II multi-objective optimization algorithm. …”
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68068
Horizontal Control System for Maglev Ruler Based on Improved Active Disturbance Rejection Controller
Published 2025-04-01“…SYSTD is constructed using specific elementary functions. Through rigorous theoretical derivation, its favorable stability is verified. …”
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68069
Is there a Common Genetic Basis for Autoimmune Diseases?
Published 2006-01-01“…Their identification and functional characterization will allow us to predict their effect as well as to indicate potential new therapeutic interventions. …”
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68070
Novel Approach to Diagnose Safe Electrical Power Distribution
Published 2024-11-01“…Safety-relevant consumers are critical loads, for example, electric power steering, braking systems with functionalities like Anti-Lock Braking or Electronic Stability Control, and autonomous drive systems. …”
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68071
Minimising inhaled corticosteroids for COPD
Published 2024-12-01“…Long-term ICS use may lead to serious side effects, including pneumonia and fractures. Initial COPD therapy should focus on short-acting bronchodilators, not ICS. …”
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68072
EDECO: An Enhanced Educational Competition Optimizer for Numerical Optimization Problems
Published 2025-03-01“…Finally, this paper conducts experiments on the proposed EDECO algorithm with 29 CEC 2017 benchmark functions and compares EDECO with four basic algorithms as well as four advanced improved algorithms. …”
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68073
Determining the Strength of Structural Materials by Solving Inverse Problems of Thermoelasticity
Published 2025-04-01“…The Tikhonov method uses a stabilizing functional with a regularization parameter. The search of the regularizator is carried out using an algorithm for calculating the root of a nonlinear equation, which allows increasing the accuracy of results. …”
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68074
Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy
Published 2025-07-01“…Functional enrichment revealed hypoxia response, apoptosis, and programmed cell death. …”
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68075
Approaches to Regulating Relations in the Sphere of Developing and Using the Artificial Intelligence Technologies: Features and Practical Applicability
Published 2023-06-01“…Objective: to review the modern scientific approaches to regulating relations in the sphere of using the artificial intelligence technologies; to reveal the main features and limitations of using the risk-oriented and technological approaches in order to determine the directions of their further development.Methods: the methodological basis of the research is a set of scientific cognition methods, including the general scientific dialectic method and the universal scientific methods (analysis and synthesis, comparison, summarization, structural-functional, and formal-logical methods).Results: it was determined that the use of the risk-oriented approach implies building constructive models of risk management. …”
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68076
Algorithmic Generation of Realistic 3D Graphics for Liquid Surfaces Within Arbitrary-Form Vessels in a Virtual Laboratory and Application in Flow Simulation
Published 2025-03-01“…Hellenic Open University has developed Onlabs, a virtual biology laboratory designed to safely and effectively prepare its students for hands-on work in the university’s on-site labs. …”
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68077
Some Characteristics of Breakfast Spreadable Cornelian Cherry (Cornus mas L.) Nectar Produced Using Potentially Probiotic Starter Culture
Published 2023-02-01“…It was investigated whether this strain has an effect on various sensory properties of nectar. In the study, sensory and various chemical properties of nectar produced without probiotic microorganism were determined. …”
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68078
Harnessing mRNA vaccines for viral diseases: bottleneck and breakthrough
Published 2025-08-01“…Recent studies have demonstrated the effectiveness of mRNA vaccines in combating various viral infections and cancer, particularly in cases where traditional vaccine platforms may not produce protective immune responses. …”
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68079
Large-Deflection Mechanical Modeling and Surrogate Model Optimization Method for Deformation Control of Flexible Pneumatic Structures
Published 2025-03-01“…These structures have attracted significant research interest due to their variable aerodynamic performance, functional diversity, and dynamic response characteristics that distinguish them from rigid structures. …”
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68080
Seeking help for menstrual pain during adolescence: A mixed-methods retrospective survey of treatment experiences and preferences
Published 2025-02-01“…Background: Menstrual pain can significantly impact adolescents’ well-being and functioning. Despite the prevalence of adolescent menstrual pain, information about adolescents’ experiences seeking treatment is limited. …”
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