Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD by Yuanxin Zhong, Larry W. Baum, Justin D. Tubbs, Rui Ye, Lu Hua Chen, Tian Wu, Se-Fong Hung, Chun-Pan Tang, Ting-Pong Ho, Robert Moyzis, James Swanson, Chi-Chiu Lee, Pak C. Sham, Patrick W. L. Leung

“…At the polygenic level, we also discovered a strong genetic correlation with resting-state functional MRI connectivity of the cerebellum involved in the attention/central executive and subcortical-cerebellum networks. …”
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Could the Microbial Profiling of Normal Pancreatic Tissue from Healthy Organ Donors Contribute to Understanding the Intratumoral Microbiota Signature in Pancreatic Ductal Adenocarc... by Francesca Tavano, Alessandro Napoli, Domenica Gioffreda, Orazio Palmieri, Tiziana Latiano, Matteo Tardio, Fabio Francesco di Mola, Tommaso Grottola, Markus W. Büchler, Marco Gentile, Anna Latiano, Tommaso Mazza, Francesco Perri

“…We noted the presence of a decreased abundance of bacteria with potential beneficial effects (<i>Jeotgalicoccus</i>) and anticancer activity (<i>Acinetobacter_guillouiae</i>) in PDAC vs. …”
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The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis by Julia A. Alvarez, Elisabet Gas-Pascual, Sahil Malhi, Juan C. Sánchez-Arcila, Ferdinand Ngale Njume, Hanke van der Wel, Yanlin Zhao, Laura García-López, Gabriella Ceron, Jasmine Posada, Scott P. Souza, George S. Yap, Christopher M. West, Kirk D. C. Jensen

“…While the glycan portion is conserved, species differ in sidechains added to the triple mannose core. The functional significance of the Glcα1,4GalNAcβ1- sidechain reported in Toxoplasma gondii has remained largely unknown without understanding its biosynthesis. …”
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Neuropsychiatric changes following striatal stroke– results from the observational PostPsyDis study by Anna Kufner, Ana Sofía Ríos, Benjamin Winter, Uchralt Temuulen, Ahmed Khalil, Ulrike Grittner, Johanna Schöner, Asli Akdeniz, Ulrike Lachmann, Golo Kronenberg, Arno Villringer, Karen Gertz, Matthias Endres

“…Abstract Background Ischemic stroke can lead to neuropsychiatric sequelae such as depression and post-traumatic stress disorder (PTSD), resulting in poorer functional outcomes. The POST-stroke PSYchological DIStress PostPsyDis; NCT01187342) study aimed to investigate whether ischemic lesions in the striatum increase the risk of depression and PTSD after stroke. …”
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Centralisation of specialised healthcare services: a scoping review of definitions, types, and impact on outcomes by Angus IG Ramsay, Sonila M Tomini, Saheli Gandhi, Naomi J Fulop, Stephen Morris

“…We proposed a typology of four forms of centralisation, reflecting the number and functions of specialist units (centralisation of whole pathway, centralisation of pathway components, hierarchy of specialist units, partial centralisation). …”
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Optimization of extraction conditions for chlorogenic acid extraction from honeysuckle waste residue and antioxidant activity by YUAN Yuxue, LI Chang, DAI Jiahe, MEN Deying, ZHAO Cunchao, TAO Liang, TIAN Yang

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Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

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miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization by Yu Zhou, Yuan Yuan, Xuanqi Yao, Lin Wang, Liangfang Yao, Daolin Tang, Feng Chen, Jinbao Li

“…Lastly, the therapeutic effects of miPEP31 on experimental sepsis were examined. …”
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Dietary Black Soldier Fly Larvae Meal and Its Impact on the Growth Performance and Gut Health of Broilers Under an Intestinal Challenge by Yuri Katagiri Dalmoro, Guilherme Librelotto de Godoy, Jessica Cristina Agilar, Glauco Anderson Raddatz, Fernanda de Candido de Oliveira, Natieli Witt, Catarina Stefanello

“…Background/Objectives: The use of black soldier fly (BSF) larvae meal in poultry nutrition is gaining attention as a sustainable protein source with a high nutritional value, an efficient bioconversion of organic waste, and potential functional benefits for intestinal health. This study evaluated the dietary effects of including 5% BSF larvae meal on the growth performance, nutrient digestibility, and energy utilization as well as on the intestinal integrity, gene expression, lipid profile, and short-chain fatty acid (SCFA) production of broilers under an intestinal challenge. …”
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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology by Ki‐Kwang Oh, Sang‐Jun Yoon, Sang Youn Lee, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Tae Suk

“…Finally, molecular docking assay and density functional theory (DFT) were performed to validate its affinity. …”
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Change in mental health service utilization from pre- to post-COVID-19 period in the United States by Md Rezaul Kader, Mohammod Mahmudur Rahman, Piali Dey Bristi, Foyez Ahmmed

“…Sex, age, race, education, income group, insurance coverage, birth country, marital status, limitations of social functioning, having a place for healthcare, symptoms and history of depression/anxiety, diabetes, and hypertension had significant effects on the odds of receiving mental healthcare. …”
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SEGS-1 episomes generated during cassava mosaic disease enhance disease severity by Evangelista Chiunga, Evangelista Chiunga, Evangelista Chiunga, Catherine D. Aimone, Cyprian Rajabu, Mary M. Dallas, Joseph Ndunguru, José T. Ascencio-Ibáñez, Elijah M. Ateka, Linda Hanley-Bowdoin

“…In this report, we examined the effects of exogenously applied SEGS-1 on the incidence of CMB infection, symptom severity, and viral DNA copy number in five cassava cultivars that ranged from highly susceptible to highly resistant to CMD. …”
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The greener, the richer, the happier?——Spatial distribution and coupling analysis of urban green space and residents’ emotion based on social media data by Zexun Li, Lihui Hu, Alin Lin, Jiarui Chen, Yue Xu

“…It has also discovered that enhancing the quality and functionality of green spaces can boost urban well-being, offering valuable guidance to planners in the context of park city.…”
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DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3 by Wenjian Yao, Linlin Shang, Yinghao Wang, Lei Xu, Yu Bai, Mingyu Feng, Xiangbo Jia, Sen Wu

“…Methods Expression analysis was conducted by RT-qPCR, western blotting, immunofluorescence (IF), and immunohistochemistry (IHC) assays. The functions of RORA were assessed by detecting its regulatory effects on cell viability, motility, invasion, and tumor growth. …”
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Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration by Youfeng Guo, Xiao Liu, Chao Wang, Shuguang Wang, Yufeng Huang, Shuo Ding, Zeyu Wang, Feng Wang

“…Consequently, NF-κB-driven inflammation and senescence were suppressed. The protective effects of SF/GO-gel@Trox were demonstrated by transcriptomics and functional assays to be underpinned by Tie2/PI3K-Akt signaling, whereas degeneration was exacerbated by Tie2 knockdown. …”
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Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway by Suwan Wu, Yiyi Wei, Yingqi Qiu, Kexin Ai, Mu Chen, Hao Wang, Honghao Zhang, Qingyan Cen, Peiyun Liao, Xiangyang Ding, Xiaoling Xie, Yuhua Li

“…Abstract Background Current challenges in Chimeric Antigen Receptor (CAR) -T cell therapy for hematological cancers include T cell exhaustion and limited persistence, which contribute to cancer relapse. Methods The effects of Axitinib, a VEGFR inhibitor, on the biological functions of CAR-T cells in vitro and in vivo were investigated by comparing CAR-T cells pre-treated ex vivo with Axitinib, as well as utilizing a B-ALL mouse model. …”
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The Impact of Biodex Balance on Improving Coordination and Static Balance in Patients with Diabetic Peripheral Neuropathy by Kristo Xhardo, Elona Xhardo, Mircea Bratu, Alin Pandea, Mariana Cordun, Ana-Maria Vasiliu, Dan-Eugen Costin, George Sebastian Iacob, Marjan Mihajlov, Ilie Onu, Daniel-Andrei Iordan

“…While conventional rehabilitation is widely used, the effectiveness of technology-assisted balance training remains underexplored. …”
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EPA-lactone derivative, 5,6-diHETE lactone, improves pulmonary arterial hypertension in a monocrotaline-induced model by Karthik Dhananjayan, Karthik Dhananjayan, Offir Ertracht, Shaul Atar, Shaul Atar, Shaul Atar, Alejandro Livoff, Alejandro Livoff, Mona Shehadeh, Andrea Szuchman-Sapir, Andrea Szuchman-Sapir

“…Recently, we reported that 5,6-diHETE lactone (EPA-L, a stable metabolite of the EPA fatty acid) elicits vasodilation and blood-pressure-lowering effect in 5/6 nephrectomy hypertensive rats and vasodilation in human arterioles by an endothelial-dependent mechanism.AimWe aimed to investigate the effect of EPA-L in a monocrotaline (MCT)-induced rat model of PAH.MethodsSprague-Dawley Rats were divided into four groups; 3 received MCT (60 mg/kg, s. c.), and the control group was treated with saline. …”
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Astaxanthin Mitigates ADHD Symptoms in Spontaneously Hypertensive Rats via Dopaminergic Modulation and Brain–Gut Axis Regulation by Yueyang Leng, Ning Wu, Jing Wang, Lihua Geng, Yang Yue, Quanbin Zhang

“…Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly impacts learning, daily functioning, and personal development. Astaxanthin (ASTA), a naturally occurring antioxidant, has garnered interest as a potential therapeutic agent for various diseases, particularly in mitigating oxidative stress. …”
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Natural pigments: innovative extraction technologies and their potential application in health and food industries by Ayu Masyita, Gemala Hardinasinta, Ayun Dwi Astuti, Firdayani Firdayani, Dian Mayasari, Aki Hori, Ira Nur Ainun Nisha, Firzan Nainu, Takayuki Kuraishi

“…Natural pigments, or natural colorants, are frequently utilized in the food industry due to their diverse functional and nutritional attributes. Beyond their color properties, these pigments possess several biological activities, including antioxidant, anti-inflammatory, anticancer, antibacterial, and neuroprotective effects, as well as benefits for eye health. …”
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