Adenosine improves postmenopausal obesity by regulating neutrophil extracellular traps by Anzhu Wang, Wei Zhang, Mengjiao Kang, Shan Wang, Jingjing Shi, Pengfei Xie, Linhua Zhao, Xiaolin Tong

“…In vivo, a bilateral ovariectomized (OVX) mouse model was employed to evaluate the effects of adenosine on obesity. RT-qPCR and Western blot were used to assess gene expression and NETs markers. …”
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Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines by Ye. O. Karpun, N. M. Polishchuk

“…The aim of this work was to develop the antimicrobial and antifungal effects of the homologous series of S-alkyl-substituted 4-R-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4Н-1,2,4-triazole-3-thiols and draw conclusions regarding the structural and functional relationship of the synthesized compounds. …”
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Optimal control for high-precision repeat ground-track orbits via convex optimization by Yanchao HE, Lei ZHANG, Yijun YANG, Qian CHEN

“…By formulating the optimization problem with multiple objective functions for RGT orbits, the proposed method allows one to compute the initial conditions, thus guaranteeing the repetition of ground tracks with high accuracy and low time consumption via nonlinear optimization techniques. …”
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Implementing and Evaluating a Mobile Phone–Supported and Family-Centered Rehabilitation Program for People With Stroke in Uganda (F@ce 2.0): Protocol for a Randomized Controlled Tr... by Gunilla Eriksson, Julius Tunga Kamwesiga, Uno Fors, Tonny Oyana, Lena von Koch, Charlotte Ytterberg, Susanne Guidetti

“…ConclusionsThis study will provide evidence of the plausible effects of F@ce 2.0 and the process of implementing the program in low-income countries. …”
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Construction of a Scientific Literature AI Data System for the Thematic Scenario: Technical Framework Research and Practice by Zhijun CHANG, Li QIAN, Yaoting WU, Yunpeng QU, Yue GONG, Zhixiong ZHANG

“…The results showed that the framework can effectively process S&T literature data and build a high-quality domain knowledge base, providing data support for the application of AI models in rice breeding research, verifying the effectiveness and practicality of the framework.…”
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Dynamic Electroneurostimulation in Rehabilitation: a Prospective Randomized Study of 60 Patients after Surgical Treatment of Colorectal Malignancies by Victor A. Drobyshev, Lubov A. Shpagina, Andrey A. Vlasov, Marina V. Umnikova, Tatyana M. Smarzh

“…Upon completion of the rehabilitation the autonomic nervous system balance index (LF/HF) was adjustedby 4.8 and the centralization index by 6.0 times against the baseline, the anxiety and depression index on the HADS scale was reducedby 1.5 times, the quality of life on the SF-36 scale improved: physical functioning by 1.5 times, pain by 1.2 times, general health by 1.5times, which differed from the similar indicators in the 2nd group.Dynamic electroneurostimulation using NEURODENS-PCM device can have pain-relieving and vegetative-regulating effects due toactivation of antinociceptive brain structures and influence on suprasegmental parts of the autonomic nervous system. …”
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Analysis of Students’ Motivation Formation to Study Physics in Modern Conditions by E. L. Kazakova, E. V. Moshkina, O. V. Sergeeva, E. V. Tikhomirova

“…The survey itself and survey data analysis were conducted using the functional features of the e-learning platform Blackboard Learn. …”
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Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-c... by Ruiling Zhao, Zhangyao Su, Junjie Gu, Hang Zhao, Lingling Bian, Yin Jiang, Yun Cai, Tao Yang, Yong Gu, Xinyu Xu

“…Mitochondrial division inhibitor 1 (Mdivi-1) enhanced the therapeutic effect of anti-CD3 mAb treatment by promoting the development of more TEX cells. …”
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Preparation of Magnetic Molecularly Imprinted Polymers Based on Group Sensing Quenching and Their Adsorption Characteristics on Signaling Molecules by Junqiang SUN, Haiyang YANG, Yao QU, Huarong YU, Fangshu QU, Yuxuan WAN

“…Subsequently, the adsorption performance of DMHF/SMIP and its effect on membrane fouling control were evaluated. …”
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Preliminary study on the time-correlation changes in brain neurotransmitters of mice exposed to mushroom toxin ibotenic acid by Ruanxian Dai, Ruanxian Dai, Zhantao Duan, Bin Han, Guobing Chen, Fuping Wang, Zhuange Shi, Xian Zhou, Haifei Song, Li Ma, Qiang Meng

“…Ibotenic acid is identified as the primary neurotoxin associated with this form of poisoning; however, the underlying mechanisms of its neurotoxicity remain poorly understood.ObjectiveThis study aims to systematically evaluate the effects of ibotenic acid exposure across three consecutive key time points, from intoxication to recovery, on neurotransmitters related to the GABA/Glutamic-Acid, dopaminergic, serotonergic, and cholinergic systems in five brain regions: the cerebral cortex, hippocampus, striatum, brain stem, and cerebellum.MethodsThrough behavioral tests, we assessed the effects of ibotenic acid exposure on voluntary activities and learning and memory functions in mice. …”
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Metabolomics and network pharmacology–guided analysis of TNF-α expression by Argemone mexicana (Linn) targeting NF-kB the signalling pathway in cancer cell lines by Sunanda Kulshrestha, Anjana Goel, Subhadip Banerjee, Rohit Sharma, Mohammad Rashid Khan, Kow-Tong Chen, Kow-Tong Chen

“…Phytoconstituents are being studied for their synergistic effects, which include disease prevention by altering molecular pathways and immunomodulation without side effects. …”
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A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes by Deepak B Thimiri Govinda Raj, Bart Ghesquière, Arun Kumar Tharkeshwar, Katrijn Coen, Rita Derua, Dieter Vanderschaeghe, Evelien Rysman, Murali Bagadi, Pieter Baatsen, Bart De Strooper, Etienne Waelkens, Gustaaf Borghs, Nico Callewaert, Johan Swinnen, Kris Gevaert, Wim Annaert

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Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation by Jiarui Zheng, Jiarui Zheng, Weiming Wang, Wenting Song, Yehao Zhang, Mingjiang Yao, Guangrui Wang, Zishan Huang, Feng Li, Junguo Ren, Li Lin, Xiaodi Fan, Jianxun Liu

“…The putative therapeutic targets of FS against AV were identified through target overlap analysis between drug and disease targets. Functional enrichment analyses of GO terms, KEGG pathways, and disease associations were performed using DAVID database, with results visualized by Cytoscape software. …”
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Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

“…Prolonged venous transit (PVT), a visual qualitative VO marker on CT perfusion (CTP) time to maximum (Tmax) maps, has been associated with unfavorable 90‐day functional outcomes despite successful reperfusion. …”
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The HL-60 clone 15 cell line as a model for leukocyte migration–possibilities and limitations by Lena Griesbaum, Christopher Weusthof, Thorben Sauer, Timo Gemoll, Gregor Weirich, Ludger Klimek, Ludger Klimek, Julie Petry, Ali Bashiri Dezfouli, Ali Bashiri Dezfouli, Maria Shoykhet, Barbara Wollenberg

“…The addition of IL-5 during differentiation increased this effect. Cell line cells responded weaker to activation than primary eosinophils but showed a similar migration and adherence pattern in multiple assays. …”
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Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context by Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang

“…This study aims to address this issue by generating a cartilage expression quantitative trait loci (eQTLs) and a functional fine-mapping resource. Methods: We performed cis-eQTL analysis using genomics and cartilage transcriptomics data from 204 patients with OA (largest sample size to date). …”
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Efficient Marker-Assisted Pyramiding of <i>Xa21</i> and <i>Xa23</i> Genes into Elite Rice Restorer Lines Confers Broad-Spectrum Resistance to Bacterial Blight by Yao Li, Yulong Fan, Yihang You, Ping Wang, Yuxuan Ling, Han Yin, Yinhua Chen, Hua Zhou, Mingrui Luo, Bing Cao, Zhihui Xia

“…To enable precise <i>Xa23</i> genotyping, we developed a novel three-primer functional marker (FM) system (IB23/CB23/IR23). This system complements the established U1/I2 markers used for <i>Xa21</i>. …”
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Macrogenomics-based analysis of rumen microbial composition and their metabolic pathways in yaks under different dietary concentrate-to-forage ratios by Fajie Gou, Fajie Gou, Yincang Han, Yincang Han, Yonggang Sun, Yonggang Sun, Weiqing Ding, Weiqing Ding, Shenwei Jin, Shenwei Jin, Yaqian Liu, Yaqian Liu, Jianyu Chen, Jianyu Chen

“…The C35 group exhibited higher activity in functional pathways related to starch and sucrose metabolism, fructose and mannose metabolism, cellulose degradation, and methanolysis. …”
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Assessing eco-physiological patterns of Ailanthus altissima (Mill.) Swingle and differences with native vegetation using Copernicus satellite data on a Mediterranean Island by Flavio Marzialetti, Vanessa Lozano, André Große-Stoltenberg, Maria Laura Carranza, Michele Innangi, Greta La Bella, Simonetta Bagella, Giovanni Rivieccio, Gianluigi Bacchetta, Lina Podda, Giuseppe Brundu

“…Biological invasions, one of the most pervasive components of global change, can cause irreversible alterations in the composition and functioning of ecosystems. This includes changes of eco-physiological traits of plant communities. …”
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Ginger extract inhibits c-MET activation and suppresses osteosarcoma in vitro and in vivo by Ruoping Yanzhang, Mingyang Yan, Zhaojie Yang, Huijun Zhang, Yin Yu, Xiangping Li, Ruifang Shen, Xiao Chu, Siyuan Han, Ziliang Zhang, Junyan Teng, Hao Li, Tao Li, Guoguo Jin, Zhiping Guo

“…Immunohistochemistry (IHC) staining corroborated the c-MET expression level among OS tissues relative to the controls. Functional studies involving c-MET knockdown among OS cell lines were produced to elucidate the functional role of c-MET in OS cellular processes. …”
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