Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction by Qian Qin, Linlin Fan, Xin Zeng, Danyang Zheng, Han Wang, Mengyue Li, Yutong Jiang, Hui Wang, Hao Liu, Shengjun Liang, Lijie Wu, Shuang Liang

“…Futhermore, PD-L1 deficient weakened the effect of MSC-EVs on neuroinflammation, glycolysis and autism-like behaviors in MIA offspring mice. …”
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The Impact of Urodynamic Findings on Fatigue and Depression in People with Multiple Sclerosis by Anke K. Jaekel, Julius Watzek, Jörn Nielsen, Anna-Lena Butscher, John Bitter, Marthe von Danwitz, Pirmin I. Zöhrer, Franziska Knappe, Ruth Kirschner-Hermanns, Stephanie C. Knüpfer

“…The effects of abnormal UDS on the FSMC and ADS scores were examined. …”
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Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants by Claire Burny, Mia Potočnjak, Mia Potočnjak, Annika Hestermann, Sophie Gartemann, Michael Hollmann, Frank Schifferdecker-Hoch, Nina Markanovic, Simone Di Sanzo, Simone Di Sanzo, Michael Günsel, Victor Solis-Mezarino, Moritz Voelker-Albert, Moritz Voelker-Albert

“…Monitored exercise therapy is a commonly prescribed treatment to relieve pain and functional limitations. However, the benefits of exercise are often gradual, subtle, and evaluated by subjective self-reported scores. …”
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Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity by Jiahao Li, Yufeng Tang, Guangping Lu, Qingbo Liu, Yuanfang Guo, Jie Wang, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Junlian Gu

“…Methods: We engineered Fgf21 KO mice and used long-term (4 months) and short-term (0.5 months) HFD feeding, and ADR-injected mice, as well as STZ-induced type 1 diabetic mice and type 2 (db/db) diabetic mice to produce an in vivo model of nephrotoxicity. The specific effects of p53/FGF21 on the regulation of lipid metabolism disorders and its downstream mediators in kidney were subsequently elucidated using a combination of functional and pathological analysis, RNA-sequencing, molecular biology, and in vitro approaches. …”
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Association of long-term exposure to PM2.5 with hypertension prevalence and blood pressure in China: a cross-sectional study by Jing Li, Shuang Hu, Yan Gao, Di Zhang, Jiali Song, Matteo Renzi, Emanuela Medda, Guigang Tang, Wenbo Zhang, Maria Antonietta Stazi

“…Objective Evidence of the effects of long-term fine particulate matter (PM2.5) exposure on hypertension and blood pressure is limited for populations exposed to high levels of PM2.5. …”
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A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome by Moritz Güttes, Marianna Lucio, Adam Skornia, Eva Rühl, Fritz Steußloff, Julia Zott, Christian Mardin, Wolfgang Mehringer, Marion Ganslmayer, Georg Michelson, Bettina Hohberger

“…RT and CR detecting 3D-stimuli in a virtual 3D- environment might offer novel functional diagnostic approaches in PCS.…”
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Modulatory role of Spirulina platensis in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity by Amina Zedan, Amira M. El-Moslemany, Rasha M. Bahnasy, Hanan Salah Eldeen Eldamaty, Suzan S. Ibraheim, Badriyah S. Alotaibi, Mohamed Abdelmegeid, Mohamed Abdelmegeid, Mustafa Shukry, Ahmed A. Elolimy

“…The rising prevalence of hyperlipidemia and hepatic disorders has intensified interest in the therapeutic use of functional foods and botanical drugs. Spirulina platensis, a blue-green microalga, is known for its antioxidant, anti-inflammatory, and lipid-lowering properties. …”
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Oil, Metal, and Agricultural Raw Material Prices in Global Markets and the Iranian Economy by simin akbari, Seyed aziz Arman, Abdolmajid Ahangari

“…This is reflected in the form of the positive impacts of global prices on internal inflation in the impulse response functions. However, these effects can be investigated from the demand perspective. …”
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Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population by Andrea Méndez-García, Adriana Aguilar-Galarza, Willebaldo García-Muñoz, Juan Brandon Araujo-Mendoza, Teresa García-Gasca, Miriam Aracely Anaya-Loyola, Aarón Kuri-García, Nerina Veyna-Salazar, Lorenza Haddad-Talancón, Ma. de Lourdes Anzures-Cortés, Ulisses Moreno-Celis, Víctor Manuel Rodríguez-García

“…Future research should focus on functional validation of these SNPs and their integration into precision medicine strategies for metabolic disease prevention.…”
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The Consumption of Beeswax Alcohol (BWA, Raydel^®) Improved Zebrafish Motion and Swimming Endurance by Protecting the Brain and Liver from Oxidative Stress Induced by 24... by Kyung-Hyun Cho, Yunki Lee, Ashutosh Bahuguna, Sang Hyuk Lee, Chae-Eun Yang, Ji-Eun Kim, Hyo-Shin Kwon

“…In contrast, no protective effect of CoQ₁₀ consumption (1.0%) was observed on the survivability of zebrafish. …”
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Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma by Yuqing Xie, Fengna Yan, Xinhui Wang, Lihua Yu, Huiwen Yan, Qing Pu, Weihong Li, Zhiyun Yang

“…Abstract Objective To identify the key drugs of Yangyin Fuzheng Jiedu prescription (YFJP) and investigate their therapeutic effects against hepatocellular carcinoma (HCC) and the potential mechanism using network pharmacology. …”
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CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism by Mian Liu, Yi Gong, Hong Cai, Rui Hua, Hong Li, Zhe Wang, Yao Zhou, Yanlin Ma, Song Quan

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Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched a... by Federico De Santis, Raffaele Ornello, Eleonora De Matteis, Lucio D’Anna, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Maria Grazia Piscaglia, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Giuli Papiri, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Sabrina Anticoli, Cinzia Roberti, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Leonardo Barbarini, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Manuela De Michele, Stefano Ricci, Simona Sacco, Matteo Foschi

“…However, patients with PCI may experience worse short-term functional outcome. Trial registration: URL: www.clinicaltrials.gov ; Unique identifier: NCT05476081.…”
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Illumination-adaptative granularity progressive multimodal image fusion method by Chuanyun WANG, Dongdong SUN, Mingqi ZHOU, Tian WANG, Qian GAO, Zhaokui LI

“…Homogeneous and heterogeneous loss functions are constructed based on different environmental conditions, enabling adaptive learning. …”
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Parental BPA exposure disrupts offspring transcriptomic profiles and impairs embryonic lineage specification during zygotic genome activation by Yuequn Chen, Kusheng Wu, Wenlong Huang

“…Transcriptomic data underwent differential gene expression functional enrichment and gene set enrichment analyses. …”
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A Novel Enhanced-Majority-Voter Universal Gate in Quantum Dot Cellular Automata with Energy Dissipation Analysis by S. Umira, R. Qadri, Z.A. Bangi, M. Tariq Banday, G. Mohiuddin Bhat

“…The Quantum effects instigate to dominate device recital when transistor geometries are abridged. …”
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A Robust Multi-Objective Evolutionary Framework for Artificial Island Construction Scheduling Under Dynamic Constraints by Tianju Zheng, Liping Sun, Mingwei Li, Guangyao Yuan, Shuqi Li

“…MACEMGA combines cooperative coevolution, adaptive dynamic weighting, dynamic penalty functions, and advanced genetic operators to navigate the solution space efficiently and identify Pareto optimal schedules. …”
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Nanotechnology-based paper microfluidics for rapid point-of-care detection and differentiation of snake venom types by Lakshmi Narashimhan Ramana, Nitin Salvi, M.V. Khadilkar, Tarun Kumar Sharma

“…To address this, the current study focuses on detecting functional enzyme components of venomous snake species, such as phospholipase A2, hyaluronidase, and proteases. …”
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Application and exploration of garbage enzymes in soil remediation of multiple heavy metal pollution by Guangxu Zhu, Xingfeng Wang, Rongkun Chen, Yunyan Wang, Qiang Tu

“…[Conclusions] Garbage enzymes demonstrate dual functionality in metal immobilization and soil revitalization, offering an eco-sustainable solution for restoring agricultural productivity in contaminated ecosystems.…”
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Experimental study on the buffering mechanism of EPS bead-sand cushions under single and multiple impacts by Feifan Ren, Jiahao Liu, Qiangqiang Huang, Huan Ding, Zhipeng Hu, Guan Wang

“…Abstract As a main functional component of rock sheds in rockfall protection projects, traditional sand cushions have shortcomings such as heavy weight and weak buffering capacity. …”
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