Advancing Enzyme-Based Detoxification Prediction with ToxZyme: An Ensemble Machine Learning Approach by Kashif Iqbal Sahibzada, Shumaila Shahid, Mohsina Akhter, Muhammad Faisal, Reham A. Abd El Rahman, Muhammad Imran, Yangyong Lv, Dongqing Wei, Yuansen Hu

“…The aaccurate prediction of enzymes with environment detoxification functions is crucial, not only to achieve a better understanding of bioremediation strategies, but also to alleviate environmental pollution. …”
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Bio inspired nanocontainers: intracellular delivery and controlled cargo release by Kanika Arora, Sherilraj PM, Shyam Lal Mudavath

“…Also, advanced surface functionalization allows organelle-specific targeting, leading to improved therapeutic outcomes in genetic disorders, cancer, and metabolic diseases. …”
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USP10 stabilizes BAZ1A to drive tumor stemness via an epigenetic mechanism in head and neck squamous cell carcinoma by Yanni Shi, Jiawei Ding, Xiao Ling, Danfeng Xu, Yan Shen, Xingjun Qin

“…In this study, we identified that ubiquitin-specific peptidase 10 (USP10) is up-regulated in HNSCC tissues, and high USP10 is associated with poor prognosis of patients. Functionally, USP10 serving as an oncogene potentiates the proliferation and metastasis of HNSCC cells in vitro and in vivo. …”
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New analytical solution of the nonlinear Gribov-Levin-Ryskin-Mueller-Qiu equation by Yanbing Cai, Xiaopeng Wang, Xurong Chen

“…The GLR-MQ equation is a nonlinear evolution equation that takes into account the shadowing effect, which tames the growth of the gluon at small-x. …”
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USE OF THE SF-36 QUESTIONNAIRE IN ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION by N. A. Shostak, A. N. Klimenko, V. S. Shemenkova, A. V. Svet

“…Statistically significant correlations between the clinical symptoms of the disease, the severity of pulmonary hypertension, and the assessment of the possible physical activity of patients with CTEPH with various scales of mental and physical functioning of SF-36 questionnaire have been obtained.Conclusion. …”
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A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials by Wenchuan Ma, Lakshmanji Verma, Huan-Jui Lee, Weichun Pan, Michael B. Sherman, David J. Sullivan, Jeffrey D. Rimer, Jeremy C. Palmer, Peter G. Vekilov

“…Abstract Organic biocrystals support essential functions or drive pathologies in numerous living organisms. …”
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Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3 by Yi Miao, Haoqing Wang, Kevin M. Jude, Jie Wang, Jinzhao Wang, Marius Wernig, Thomas C. Südhof

“…This unique binding mechanism not only enhances our understanding of the C1ql-BAI3-mediated synaptic organization but also sheds light on the functional dynamics of BAI3 in the brain.…”
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Metabolic reprogramming of tumor-associated neutrophils in tumor treatment and therapeutic resistance by Jun Lin, Jun Lin, Xian-Lu He, Wei-Wei Zhang, Chun-Fen Mo, Chun-Fen Mo

“…The metabolic reprogramming of TANs not only modulates their functional phenotypes but also reshapes tumor biological behaviors and therapeutic responses by regulating metabolic intermediates and cellular interactions within the TME. …”
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An MCDM Approach to Lean Tool Implementation for Minimizing Non-Value-Added Activities in the Precast Industry by Haritha Malika Dara, Musa Adamu, Prachi Vinod Ingle, Ashwin Raut, Yasser E. Ibrahim

“…The construction industry is growing with the shortfall issues of productivity, functionality, and cost. Precast construction has significant potential to address these issues by incorporating lean principles. …”
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Digital Twin Control Method of Machine Tool Feed Rate Based on Fuzzy Neural Network by YIN Jia, BAI Lele, TIAN Hui, WU Shijie, Hou Guijin, TANG Yuyang, LIU Hongguang, ZHANG Jun

“…The fuzzy neural network is trained based on the machining data, and the corresponding fuzzy control rules and membership functions are obtained. The control rules are modified according to the actual machining conditions. …”
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Pangenome analysis of transposable element insertion polymorphisms reveals features underlying cold tolerance in rice by Yongqing Qian, Zuwen Zhou, Tianmin Ouyang, Dongao Li, Ru Li, Ping Gan, Renfei Qiao, Yingying Tan, Mingchao Qian, Liezhao Liu, Jiana Li, Kun Lu, Jijing Luo, Ling-Ling Chen, Jia-Ming Song

“…Our TIP-GWAS analysis reveal two cold tolerance genes OsCACT and OsPTR. The biological functions of these genes are confirmed using knockout and overexpression lines. …”
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Numerical Simulations of Impact River Morphology Evolution Mechanism Under the Influence of Floodplain Vegetation by Heng Xiang, Zhimeng Zhang, Chunning Ji, Dong Xu, Xincong Chen, Lian Tang, Yuelei Wang

“…Shallow floodplains play a crucial role in river basins by providing essential ecological, hydrological, and geomorphic functions. During floods, intricate hydrodynamic conditions arise as flow exits and re-enters the river channel, interacting with the shallow vegetation. …”
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Pipe Resistance Loss Calculation in Industry 4.0: An Innovative Framework Based on TransKAN and Generative AI by Qinyu Zhang, Huiying Liu, Zhike Liu, Yongkang Liu, Yuhan Gong, Chonghao Wang

“…Thus, reducing energy loss while ensuring the filling effect becomes crucial for improving process efficiency. …”
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A FAN1 point mutation associated with accelerated Huntington’s disease progression alters its PCNA-mediated assembly on DNA by Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F. Vogt, Julien Boudet, Brinda C. Prasad

“…Biophysical interaction studies demonstrated that FAN1 enhances the binding affinity of PCNA for DNA, a synergistic effect disrupted in mutants carrying the R507H mutation. …”
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Redefining Urban Traffic Dynamics With TCN-FL Driven Traffic Prediction and Control Strategies by K. M. Karthick Raghunath, C. Rohith Bhat, Venkatesan Vinoth Kumar, Velmurugan Athiyoor Kannan, T. R. Mahesh, K. Manikandan, N. Krishnamoorthy

“…In this study, we have introduced a traffic prediction and handling system that utilizes Temporal Convolutional Networks (TCNs) combined with Federated Learning (FL) to deal with urban traffic effectively. This approach leverages the sophisticated functionalities of TCNs to evaluate and estimate traffic trends, such as congested phases, traffic flow, and ideal mobility routes. …”
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Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries by Yang Qingyi, Li Fan, Ye Yangyang, Zhang Xu

“…The primary objective in caries management is to maintain biofilm homeostasis while facilitating the repair and regeneration of dental hard tissues, thus restoring both structural integrity and functionality of affected teeth. Though antimicrobial and remineralization approaches haven shown promise, their standalone utilization without concurrent bacterial control or rebalancing lacks an integrated strategy to effectively arrest caries progression. …”
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Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats by Zhang Yida, Mustapha Umar Imam, Maznah Ismail, Der-Jiun Ooi, Nadarajan Sarega, Nur Hanisah Azmi, Norsharina Ismail, Kim Wei Chan, Zhiping Hou, Norhayati Binti Yusuf

“…The results suggest that EBN may be used as functional food to prevent insulin resistance.…”
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GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma by Jiaru Hu, Fang Meng, Lei Lv, Fu Hong, Qing He, Qi Zhu, Tian Tian, Na Chang, Shiqiang Zhang, Qiyi Yi, Liting Qian

“…Further investigation revealed that GPR37 level is inversely regulated by promoter methylation but positively regulated by ZNF750. Functionally, GPR37 could not only overcome radioresistance of ESCC, but also inhibit proliferation, migration, and invasion. …”
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Hybrid Additives of 1,3-Diketone Fluid and Nanocopper Particles Applied in Marine Engine Oil by Yuwen Xu, Yan Yang, Li Zhong, Xingyuan Jing, Xiaoyu Yin, Tao Xia, Jingsi Wang, Tobias Amann, Ke Li

“…Besides that, octadecylamine-functionalized nanocopper particles (ODA-Cu) were also added to the marine oil to improve its anti-wear behavior. …”
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Sustainable Packaging Solutions: Food Engineering and Biodegradable Materials by Kai-Chao Yao, Hsi-Huang Hsieh, Kuo-Yi Li, Jing-Ran Xu, Wei-Sho Ho, Wei-Lun Huang, Shu-Hua Huang, Yu-Hsiang Liao, Ying-Ju Tseng

“…Through a systematic innovation design process, this research proposes a biodegradable food container capable of decomposing entirely into particles and water within one month, blending naturally with the soil without compromising functionality. Moreover, the container incorporates a quick-alignment mechanism and an intuitive sealing design that ensures airtightness and spill prevention. …”
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