A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells by Rui Guo, Xiaoyang Chen, Lu Ying, Wenjing Zhang, Zufa Sabeel, Lianhui Zhao, Jian Dong, Yiyang Dong, Zhao Yang

“…Notably, HLB-apt enhanced the killing effect of Jurkat cells on A549 and HepG2 cancer cells, with a killing rate of up to 29.00% for A549 and 7.46% for HepG2. …”
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Immediate parent-infant skin-to-skin study (IPISTOSS): study protocol of a randomised controlled trial on very preterm infants cared for in skin-to-skin contact immediately after b... by Agnes Linnér, Björn Westrup, Karoline Lode-Kolz, Stina Klemming, Siri Lillieskold, Hanne Markhus Pike, Barak Morgan, Nils Johannes Bergman, Siren Rettedal, Wibke Jonas

“…Instead of continuing in the in-utero environment, maturation needs to occur in a neonatal unit with support of vital functions, separated from the mother’s warmth, nutrition and other benefits. …”
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Synthesis and battery thermal management of coal gasification slag based Fe2O3 nanofluid: An experimental research by Chunlei GAO, Junsheng HOU, Zihan DING, Lei HUANG, Hao ZHANG, Baiqi TIAN, Junjie WU, Nanjing HAO

“…Enhanced thermal conductivity and the disturbance effect of nanoparticles are related to the heat transfer enhancement. …”
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Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice by Xiaoxiao Li, Kai Wang, Yunhong Sun, Yirong Wang, Jiaxuan Wu, Yanqi Dang, Meng Li, Wenjun Zhou

“…DHCR7 expression in macrophages from MASH patients and model mice was evaluated. Functional studies involving in vitro knockdown and overexpression experiments, were complemented using myeloid-specific DHCR7 knockout mice. …”
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Network pharmacology-based insights into the role of gut microbiota metabolites in insulin resistance by Bing Xiao, Xin Chen, Ruiyu Zong, Yiming Guan, Zhu Zhu, Siling Bi

“…However, the pharmacological mechanisms and functional roles of gut microbiota metabolites remain insufficiently understood. …”
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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. by George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes

“…Genes NAT8 and PYROXD2, both with relatively uncharacterized functional roles, are good candidates for mediating the corresponding mQTL associations. …”
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Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning by Changjin Wei, Yongfeng Zhu, Caiming Chen, Feipeng Li, Li Zheng

“…Cinnamaldehyde, a potential traditional Chinese medicine monomer component, was identified to potentially exert anti-inflammatory effects by targeting the CXCL8 protein.ConclusionThis study reveals significantly enriched biological processes and pathways in COPD patients, identifies multiple inflammatory-related COPD feature genes, and finds that cinnamaldehyde may have potential therapeutic effects on inflammatory subtypes of COPD.…”
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Assessment of the TGF-β gene and its target miR-1908-5p gene expression and its role in the treatment of beta-thalassemia in Iraqi patients by Manal Lafta Abdulhassn, Hiba Muneer Abdel Hassan Al-Khafaji, Maryam Qasim Mohammed

“…Transforming growth factor-beta (TGF-β) is a cytokine that has multicellular functions. The miRNAs have been confirmed to play important roles in gene expression regulation during the development of a variety of human diseases. …”
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Bidirectional Transcriptome Analysis of Rat Bone Marrow-Derived Mesenchymal Stem Cells and Activated Microglia in an In Vitro Coculture System by Da Yeon Lee, Moon Suk Jin, Balachandran Manavalan, Hak Kyun Kim, Jun Hyeok Song, Tae Hwan Shin, Gwang Lee

“…Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been shown to have therapeutic effects, resulting from the regulation of inflammatory conditions in the brain. …”
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MANAGEMENT OF IN-PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION by I. V. Logacheva, V. V. Safronova, N. I. Maximov, S. P. Baranova

“…To investigate the antihypertensive effectiveness of a fixed perindopril/ amlodipine combination (Prestans) and its effects on the visit-to-visit variability of blood pressure levels and quality of life (QoL) among in-patients with uncontrolled arterial hypertension (AH).Material and methods. …”
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Mendelian Randomization Analysis of the Possible Causal Relationships Between Neurodevelopment‐Related Proteins and Bipolar Disorder by Yanyan Li, Qianqian Gui, Shurong Ren, Zhifen Liu, Aixia Zhang, Penghong Liu, Xueping Zhou, Ning Sun, Chunxia Yang

“…Mendelian randomization (MR) allows evaluation of the causal effects of biomarkers by minimizing the risks of reverse causation and confounding factors. …”
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Surgical treatment of corneal perforation by auto tissue: a clinical case by E. A. Ivachev

“…Purpose: to analyze the effectiveness of therapeutically covering cornea perforation in a cancer patient with auto conjunctiva. …”
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Electronic nose and machine learning for modern meat inspection by Ivan Shtepliuk, Guillem Domènech-Gil, Viktor Almqvist, Arja Helena Kautto, Ivar Vågsholm, Sofia Boqvist, Jens Eriksson, Donatella Puglisi

“…We explored its potential as a complementary tool to traditional sensory evaluation and analytical methods, aiming to enhance the efficiency and effectiveness of current inspections. We employed a metal-oxide based gas sensor array of commercially available chemoresistive sensors, functioning as an electronic nose, to differentiate between various categories of 100 pig meat samples collected at a slaughterhouse based on their odor characteristics, including a urine-like smell and post-mortem aging. …”
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DNA-Containing Extracellular Structures of Tumor Cells Inhibit the Formation of Neutrophil Extracellular Traps <i>in vitro</i> by A. N. Kazimirskii, J. M. Salmasi, G. V. Poryadin, M. I. Panina, A. E. Kim, A. G. Chakhalian, O. O. Turishcheva

“…K562 cells suppress neutrophil defense responses by reducing the number and size of neutrophil networks. The effect of inhibition of neutrophil networks by K562 cells is probably due to the action of a soluble factor that suppresses neutrophil functions described earlier.Conclusion. …”
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Barleria extracts containing barlerin and verbascoside boost immunity and regulate CYP450 gene in prostate cancer by Sanit Kaewdaungdee, Zi Wei Sham, Hao Xuan Ho, Shiou Yih Lee, Tawatchai Tanee, Yannick D. Benoit, Thomas Liehr, Sakda Daduang, Runglawan Sudmoon, Arunrat Chaveerach

“…This study provides a comprehensive analysis of six Barleria leaf extracts, namely B. cristata, B. lupulina, B. prionitis, B. repens, B. siamensis, and B. strigosa, to elucidate their metabolite composition, toxicity, immunomodulatory functions, and roles in cytochrome P450 (CYP) gene expression. …”
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Monitoring of administrative accounts regulating tourist activity in Russia (on the Example of social network “Vkontakte”) by А. A. Chugunova, A. N. Pisareva

“…This article presents the sociological monitoring results of the official public authorities’ accounts effectiveness. The COVID-19 coronavirus pandemic in 2020 forced most businesses and organizations to move their activities online. …”
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A temporal fusion method for modeling the rate of penetration during deep geological drilling by Yang ZHOU, Chengda LU, Min WU, Xin CHEN, Ningping YAO, Haitao SONG, Youzhen ZHANG

“…Results and Conclusions The results indicate that the MDBO algorithm yielded satisfactory results in the tests of 11 benchmark functions, suggesting that the MDBO algorithm can effectively solve the problem encountered in model parameter design. …”
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Acute creatine supplementation enhances technical performance in adolescent basketball players under cognitive-motor dual-task condition by Junyu Wu, Peng Qiu, Youqiang Li

“…Creatine supplementation has been shown to enhance both physical and cognitive functions, but its acute effects on basketball skill performance under CMDT conditions remain unclear. …”
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Practice and Development Strategy of Culture and Tourism Integration Services for Children in Public Libraries by Fengwei JIANG, Qing WANG, Zhuqi LI

“…This case was found to have a promoting effect on children's growth, the expansion of library services, and the development of the rural cultural tourism economy. …”
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Investigating endometrial metabolic characteristics in patients with adenomyosis using gas chromatography/mass spectrometry by Ju Ren, Jiashuo Liu, Jingcong Dai, Li Wang, Fan He, Lina Hu

“…In vitro, functional assays revealed that hydroxyproline promoted hESCs proliferation and migration in a dose-dependent manner. …”
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