Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2 by Jinhao Wang, Yue Zhu, Jialiang Song, Fengping Yang, Peng Wang, Ziyi Zhang, Yuxuan Li, Minghe Dai, Yinuo Wang, Waleed Yousuf, Jiayu Li, Dian Yang, Shaoxuan Cheng, Shuyan Liu, Zhaoxia Dai, Xun Qiu, Yingqiu Zhang, Zengchun Hu

“…Cellular ferroptosis was induced by the GPX4 inhibitor with or without periplocin treatment. The in vivo effects of periplocin were assessed using lung cancer xenograft mouse models. …”
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Inorganic Element Identification and In Vitro Preliminary Evaluation of Three Types of Standardized Black Chokeberry Extracts Against Human Pulmonary Artery Endothelial Cells (HPAE... by Valentina Oana Buda, Camelia Oprean, Oana Isabella Gavriliuc, Zorita Diaconeasa, Adina Căta, Daniela Haidu, Daliana Minda, Andreea Păunescu, Cristina Adriana Dehelean, Corina Danciu

“…Elliott, has been employed for various purposes throughout history, being exploited both for its nutritional properties (functional foods, beverages, food preservatives, and natural food colorants) and for its therapeutic benefits (including cardiovascular and metabolic settings). …”
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Nitrate enhances salt tolerance of wild jujube by regulating nutrient homeostasis and nitrate transporters by Ayimaiti Abudoukayoumu, Yunfei Li, Yue Sun, Yan Cao, Yaning Hu, Jian Huang

“…Our results revealed interactive effects between NaCl and NaNO3 on growth performance and physiological responses. …”
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A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations by Zhenmei Zhang, Xiaoqian Ma, Lijun Ouyang, Zongchang Li, Weiqing Liu, Ying He, Jingyan Lv, Xiaogang Chen, Liu Yuan

“…Previously, we identified a stable high-intensity functional network, termed the “Frame Network,” in healthy individuals and observed its aberrations in schizophrenia patients. …”
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Unlocking Therapeutic Potential: Enhanced shRNA Delivery with Tat Peptide in the Human Respiratory Syncytial Virus Treatment by Saeid Amiri Zadeh Fard, Haniyeh Abuei, Abbas Behzad Behbahani, Gholamreza Rafiei Dehbidi, Farahnaz Zare, Maryam Nejabat, Alireza Safarpour, Ali Farhadi

“…The study aimed to assess the therapeutic potential of these shRNAs and evaluate the effectiveness of Tat peptide-mediated delivery in enhancing their functionality. …”
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Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability by Yilin Liu, Yilin Liu, Mark H. Sundman, Mark H. Sundman, Dalen Hinderaker, Allison Yu-Chin Chen, Allison Yu-Chin Chen, Jacob M. Green, Jacob M. Green, Lisbeth G. Haaheim, Lisbeth G. Haaheim, Hannah M. Siu, Hannah M. Siu, Catherine Jezerc, Kaitlyn Lai, Carol Chen, Parker Guss, Ying-hui Chou, Ying-hui Chou, Ying-hui Chou

“…Experiment 1 (descriptive observational, repeated-measures design) (N = 85) evaluates the alternate form reliability of a modified FNAME (mFNAME) by serially administering eight distinct versions of the task, revealing good reliability for mFNAME metrics and the absence of significant practice effects. Experiment 2 (cross-sectional observational design) (N = 32) examines structural and functional network topology to investigate neural correlates of mFNAME performance in non-demented older adults.ResultsExperiment 1 demonstrated good alternate form reliability with no significant practice effect. …”
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The role of biochar in enhancing soil health & interactions with rhizosphere properties and enzyme activities in organic fertilizer substitution by Aamir Ali, Aamir Ali, Nida Jabeen, Zaid Chachar, Sadaruddin Chachar, Shoaib Ahmed, Shoaib Ahmed, Nazir Ahmed, Azhar Ali Laghari, Zulfiqar Ali Sahito, Rasulov Farruhbek, Zhenping Yang

“…However, its interactive effects with rhizosphere dynamics and soil enzymatic process, particularly when used with organic fertilizers, remain insufficiently explored. …”
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The contribution of BTK signaling in myeloid cells to neuroinflammation by Claudia Bassani, Marta Molinari, Valentina Romeo, Vittorio Martinelli, Ursula Boschert, Gianvito Martino, Luca Muzio, Cinthia Farina

“…However, conditional BTK deletion in short-lived or long-lived CX3CR1-positive cells did not reduce EAE severity. DiscussionThis functional evidence questions the real contribution of BTK expressing myeloid cells to experimental MS. …”
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Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell-Transplantation after Spinal Cord Injury In Vivo by Alexander Younsi, Guoli Zheng, Moritz Scherer, Lennart Riemann, Hao Zhang, Mohamed Tail, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger

“…Moreover, “Stride length” and “Average Speed” in the CatWalk gait analysis were significantly improved 8 weeks after SCI, representing beneficial effects on the functional recovery with NPC transplantation and the administration of the three growth factors. …”
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Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children by Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim

“…Methods: In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. …”
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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xeno... by Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Casey Pulliam, Keegan A. Christensen, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath

“…Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted using the FDA-approved anti-rheumatic drug, auranofin (AF), to selectively sensitize cancer cells to therapy. …”
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GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma by Hyung Seok Kim, Jung Hwan Yoon, Ji Yi Choi, Moon Gyeong Yoon, Geum Ok Baek, Minji Kang, Se Ha Jang, Won Park, Yunjin Go, Jestlin Tianthing Ng, Suk Woo Nam, Jee-Yeong Jeong, Ji Eun Han, Hyo Jung Cho, Su Bin Lim, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun

“…Using clinical cohorts and patient sera, GULP1 roles were examined, and functional assays in vitro and in vivo were used to evaluate its effects on cell growth, epithelial–mesenchymal transition (EMT), ADP-ribosylation factor 6 (ARF6) activation, and β-catenin signaling. …”
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Pithellobium dulce (Roxb.) Benth. Fruit Flour Intake Enhances Short-Chain Fatty Acid Production and Glucose Metabolism in BALB/c Mice by Alba R. Hernández García, Dalia S. Aguilar Ávila, Juan M. Viveros Paredes, Rocío I. López Roa, Alma H. Martínez-Preciado

“…This study investigates the effects of P. dulce fruit flour (PDF) on glucose metabolism and short-chain fatty acid (SCFAs) production in healthy BALB/c mice. …”
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Stereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients by Belinda Palermo, Marta Bottero, Mariangela Panetta, Adriana Faiella, Isabella Sperduti, Serena Masi, Giuseppe Frisullo, Maria Laura Foddai, Iole Cordone, Paola Nisticò, Giuseppe Sanguineti

“…Total B and T cells decreased and Treg-to-CD8+ ratio increased. Functionality of T lymphocytes were not affected by any of the 3-fractionation schedules. …”
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Mineral fertilization reduces the drought resistance of soil multifunctionality in a mountain grassland system through plant-soil interactions by Piton, Gabin, Foulquier, Arnaud, Bernard, Lionel, Bonin, Aurelie, Pommier, Thomas, Lavorel, Sandra, Geremia, Roberto, Clement, Jean Christophe

“…Increasing droughts threaten soil microbial communities and the multiple functions they control in agricultural soils. These soils are often fertilized with mineral nutrients, but it remains unclear how this fertilization may alter the capacity of soil multifunctionality (SMF) to be maintained under drought, and how plant-soil interactions shape these effects.  …”
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In vitro fermentation of whole matrix, digested products and β-glucan enriched extract of Pleurotus eryngii mushrooms distinctively impact the fecal microbiota of healthy older adu... by Evangelia N. Kerezoudi, Marigoula Vlassopoulou, Evdokia K. Mitsou, Georgia Saxami, Georgios Koutrotsios, Ioanna Taflampa, Konstantinos C. Mountzouris, Ignacio Rangel, Robert J. Brummer, Georgios I. Zervakis, Vasiliki Pletsa, Panagiotis Georgiadis, Adamantini Kyriacou

“…Overall, the findings highlight the beneficial effect of PE on intestinal health of older adults supporting its potential incorporation into innovative functional foods. …”
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HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy by Valeria Spadotto, Chiara Ripamonti, Andrea Ghiroldi, Elisabetta Galbiati, Pietro Pozzi, Roberta Noberini, Tiziana Bonaldi, Tiziana Bonaldi, Christian Steinkühler, Gianluca Fossati

“…In vivo, ITF3756 treatment led to reduced tumor growth in a colon cancer model.DiscussionThese findings demonstrate that selective HDAC6 inhibition by ITF3756 modulates myeloid cell functionality by diminishing inhibitory signals and promoting T cell activation. …”
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Influence of Ovophospholipids on Lymphocyte Subsets and Humoral Immune Response in Mice by Magdalena Lis, Marianna Szczypka, Agnieszka Suszko-Pawłowska, Aleksandra Pawlak, Łukasz Bobak, Bożena Obmińska-Mrukowicz

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Microbiota-derived acetate suppresses sympathetic outflow via olfactory receptor 59 in the rostral ventrolateral medulla by Jinye Zhang, Xue Zhao, Lin Zhang, Jinmeng Lu, Jinlu Bai, Shuo An, Yufang Zhu, Huaxing Zhang, Yinchao Hao, Yanming Tian

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Differentiating Between Perfluorohexyloctane Ophthalmic Solution and Water-Free Cyclosporine Ophthalmic Solution 0.1% for Dry Eye Disease: A Review of Preclinical and Clinical Char... by Laura M. Periman, Darrell E. White, Douglas Katsev

“…The structure of these SFAs determines their differing behaviors and functions. The longer chain length of PFHO results in a slower evaporation rate and facilitates formation of a stable monolayer on the ocular surface. …”
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