The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network by Yi Wang, Yi Wang, Moran Xu, Xiaoli Zuo, Sheng Wang, Yong Yu, Zhaobing Gao, Zhaobing Gao, Jingbo Qie, Ye Jiang, Fang Huang, Bingqing Xia, Bingqing Xia

“…However, the mechanisms by which MLKL functions in the process of intracerebral hemorrhage (ICH)-induced damage remain unclear.MethodsHere, we explored the correlation between MLKL and pathological damage in ICH patients through histopathological staining and RT-qPCR. …”
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Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…This study determined how senescent ECs communicate with monocytes, whether extracellular vesicles (EVs) released from senescent ECs affect monocyte functions, and investigated the potential for epigallocatechin-3-gallate (EGCG), a flavonoid in green tea, to reverse these effects. …”
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Efgartigimod following plasma exchange in the treatment of subjects with generalised myasthenia gravis: study protocol for a multicentre, three-arm, open-label study by Lu Zhang, Kan Wang, Yong Hao, Yangtai Guan, Jing Peng, Li Gao, Song Gao, Qiuju Li, Chong Xie, Yuhui Wang, Yanan Wu, Mengze Zhang, Xiaokun Wang, Chunran Xue, Yiwei Yang

“…This study aims to evaluate the effectiveness and safety of efgartigimod working as a bridge treatment after PLEX but before NSIST taking effect, while concurrently conducting a comparative analysis of clinical outcomes between PLEX and efgartigimod in gMG.Methods and analysis This multicentre, open-label, three-arm trial (n=45 gMG patients) assigns cohorts to PLEX+efgartigimod, PLEX alone or efgartigimod alone. …”
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Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis by Yueyi Yang, Xuchen Hu, Meiling Jing, Xiaohan Zhu, Xiaoyu Liu, Wenduo Tan, Zhanyi Chen, Chenguang Niu, Zhengwei Huang

“…OMD may optimize the immunomodulatory functions of hDPSCs and can be used for regenerative endodontics.…”
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Brain-behavior correlates of rhythmic timing and auditory-motor synchronization in children with developmental coordination disorder: an EEG study by Marija Pranjić, Marija Pranjić, Jason Leung, Ka Lun Tam, Helene Polatajko, Timothy Welsh, Tom Chau, Tom Chau, Michael Thaut, Michael Thaut

“…Although the positive effects of rhythmic entrainment on motor performance have been demonstrated in adults with movement disorders, interactions between auditory and motor systems have not been well characterized in children with DCD. …”
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Preclinical validation of electrospun fibers to achieve vaginal colonization by Lactobacillus crispatus by Christy N. Armstrong, Christy N. Armstrong, Sudeshna Saha, Sudeshna Saha, Marnie A. Aagard, Marnie A. Aagard, Mohamed Y. Mahmoud, Mohamed Y. Mahmoud, Nissi M. Varki, Nissi M. Varki, Nissi M. Varki, Nicole M. Gilbert, Nicole M. Gilbert, Hermann B. Frieboes, Hermann B. Frieboes, Hermann B. Frieboes, Hermann B. Frieboes, Warren G. Lewis, Warren G. Lewis, Amanda L. Lewis, Amanda L. Lewis

“…There is a pressing need for therapeutic platforms that apply biologically active agents such as probiotic bacteria, to the vagina with little user effort but lasting effect.MethodsHere, we use a mouse model to investigate the functional utility and potential harms of soft, slow-dissolving fibers made by electrospinning polyethylene oxide (PEO) and poly(lactic-co-glycolic acid) (PLGA). …”
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Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

“…To determine whether the ags and crh gene families have redundant functions, both gene families were deleted using iterative CRISPR/Cas9 mediated genome editing. …”
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The temporal onset of associations of cortical proteins with cognitive resilience vary during late life by Andrea R. Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aron S. Buchman

“…We then used functional mixed-effects models to examine non-linear associations between proteins and cognitive resilience to identify their temporal onset. …”
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Plain radiograph evaluation of concurrent filling of tibial peg holes with bone in cementless total knee arthroplasty by Kazue Hayakawa, Hideki Date, Sho Nojiri, Yosuke Kaneko, Kohei Shibata, Nobuyuki Fujita

“…Purpose: This study aimed to evaluate the effectiveness of a novel technique for securing the tibial component in cementless total knee arthroplasty (TKA) by utilizing resected cancellous bone to fill the peg holes. …”
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Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α by Chang Liu, Huayong Zhang, Xiaojun Tang, Ruihai Feng, Genhong Yao, Weiwei Chen, Wenchao Li, Jun Liang, Xuebing Feng, Lingyun Sun

“…Impaired osteogenic differentiation functions were indicated by decreased ALP activity (P<0.001) and reduced mRNA and protein levels of osteogenic marker genes (P<0.05) in CIA mice compared with DBA/1 mice. …”
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Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles by Crescenzo Massaro, Giulia Sgueglia, Annamaria Muro, Damiana Pieragostino, Paola Lanuti, Maria Concetta Cufaro, Cristina Giorgio, Erika D’Agostino, Laura Della Torre, Serena Rubina Baglio, Marinella Pirozzi, Mariacarla De Simone, Lucia Altucci, Carmela Dell’Aversana

“…The epigenetic modulation of leukemia-secreted EVs content on interesting key target molecules was validated, and their differential functional impact on cellular viability, cell cycle progression, apoptosis, and tumorigenicity was assessed. …”
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Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress by Lauren A. Hennessy, Bhedita J. Seewoo, Liz A. Jaeschke, Leah A. Mackie, Abbey Figliomeni, Yasmin Arena-Foster, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin, Jennifer Rodger

“…CRS induced an agitated depression-like phenotype but therapeutic effects from the accelerated protocol were not detected. …”
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Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons by Nolan M. Dvorak, Paul A. Wadsworth, Guillermo Aquino-Miranda, Pingyuan Wang, Douglas S. Engelke, Jingheng Zhou, Nghi Nguyen, Aditya K. Singh, Giuseppe Aceto, Zahra Haghighijoo, Isabella I. Smith, Nana Goode, Mingxiang Zhou, Yosef Avchalumov, Evan P. Troendle, Cynthia M. Tapia, Haiying Chen, Reid T. Powell, Timothy J. Baumgartner, Jully Singh, Leandra Koff, Jessica Di Re, Ann E. Wadsworth, Mate Marosi, Marc R. Azar, Kristina Elias, Paul Lehmann, Yorkiris M. Mármol Contreras, Poonam Shah, Hector Gutierrez, Thomas A. Green, Martin B. Ulmschneider, Marcello D’Ascenzo, Clifford Stephan, Guohong Cui, Fabricio H. Do Monte, Jia Zhou, Fernanda Laezza

“…Abstract Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential as drug targets for brain disorders remains underexplored. …”
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Dyeing of silk with isolated bixin based orange yellow natural dye: Kinetic, thermodynamic and colorimetric aspects by Muhammad Ibrahim, Bisma, Shahid Adeel, Al Mojnun Shamim, Mohammad Khajeh Mehrizi, Muhammad Imran, Muhammad Asif Tahir, Rony Mia

“…Dyeing parameters were optimized, and the effects of eco-friendly mordants (Al, Fe salts, pomegranate, and myrobalan) were evaluated. …”
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Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma by Corentin Bouvier, Maria Gonzalez-Santamarta, Núria Profitós-Pelejà, Marc Armengol, Grégoire Quinet, Quentin Alasseur, Laurie Ceccato, Wendy Xolalpa, Raimundo Freire, Julie Guillermet-Guibert, Karine Reybier, Anne-Marie Caminade, Hans C. Beck, Ana Sofia Carvalho, Rune Matthiesen, Jean Christophe Rain, James D. Sutherland, Rosa Barrio, Gaël Roué, Manuel S. Rodriguez

“…Interestingly, the combined apoptogenic activity of dTRIM24 and BTZ was preserved in a second BTZ-resistant clone (JBR) that lacks functional p53, indicating that this tumor suppressor is not required for the observed effect. …”
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Bisphenol F exposure induced vascular toxicity through intestinal microbiota imbalance by Jianlong Yan, Yanbin Pan, Huadong Liu, Jie Yuan, Jie Chen, Yannan Gao, Chaolan Lin, Feng Lin, Rongning Wang, Yaqiong He, Caiping Wang, Cong Xu, Tangzhiming Li, Peng Zhang, Yu Lan, Wenming Shao, Xinli Pang, Da Yin, Xin Sun, Weixiang Luo

“…We then explored the effects of BPF exposure on normal and vitamin D3 + nicotine (VDN)-treated rats. …”
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Theaflavins enhances laying hen production performance and egg antioxidant capacity via improving antioxidant status and regulating lipid metabolism by Ling Zhou, Pinyao Zhao, Jinwei Zhang, Jie Zhong, Yulin Rao, Jia Tang, Longsheng Jiang, Fen Chen, Lijuan Chen, Keying Zhang, Weimin Ouyang, Jialong Peng

“…IntroductionTheaflavins (TF), natural compounds extracted from black tea, demonstrate various beneficial functions including antioxidant properties and lipid metabolism regulation. …”
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Screening for endocrine-disrupting chemicals in the serum and cerebrospinal fluid of patients with autoimmune encephalitis by Songyi Huang, Li Xiao, Minqi Luo, Jiehao Li, Xiaojie Li, Chenyan Zeng, Lixin Zhou, Baohua Cao, Yajie Gong, Pan Yang, Yaqing Shu

“…Our findings support an evidence base for the effects of specific chemicals may impair neural functions.…”
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CO2 utilization and sequestration potential in deep coal seams: A case study on Carboniferous coals from the Karaganda Basin, Kazakhstan by Majid Safaei-Farouji, David Misch, Reinhard F. Sachsenhofer, Nikolaos Kostoglou, Garri Gaus, Thorsten Bauersachs, Medet Junussov, Milovan Fustic

“…This is probably due to interactions between CO2 and functional groups leading to enhanced physisorption at LP and chemisorption and matrix swelling at HP conditions. …”
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Recipient 3-Hepatic Vein Technique with Graft Venoplasty to Maximize Venous Outflow in Left Lobe Living Donor Liver Transplantation by Yuki Miyazaki, MD, PhD, Masato Fujiki, MD, PhD, Munkhbold Tuul, MD, PhD, Mazhar Khalil, MD, Alejandro Pita, MD, Jaekeun Kim, MD, Andrea Schlegel, MD, Choon H.D. Kwon, MD, PhD, Federico Aucejo, MD, Antonio D. Pinna, MD, Charles Miller, MD, Koji Hashimoto, MD, PhD

“…Augmentation of hepatic venous outflow is crucial in living donor liver transplantation (LDLT) to maximize functional graft size and prevent venous complications. …”
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