The impact of active components from on the growth, intestinal barrier function, and immunity of broiler chickens by Luli Zhou, Guanyu Hou, Hanlin Zhou, Khaled Abouelezz, Yuxiu Ye, Dingfa Wang

“…Conclusion The present study provides preliminary evidence that VR and PT are two of the main active compounds in PSE, which can cooperatively improve growth performance, intestinal barrier integrity, and immune function in chickens.…”
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Deep Brain Stimulation and Brain–Spine Interface for Functional Restoration in Spinal Cord Injury by Barnabas T. Shiferaw, Max Y. Jin, Milan Patel, Lukas J. Henjum, Alaa Abd-Elsayed

“…<b>Background/Objectives</b>: Spinal cord injury (SCI) presents significant challenges in restoring motor function, with limited therapeutic options available. …”
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Neurocognitive functioning over the course of STAIR Narrative Therapy for ICD-11 complex PTSD by Madoka Niwa, Tomoko Kato, Yosuke Suga, Rieko Otomo, Mayumi Sugawara, Mie Matsui, Toshiko Kamo, Hiroaki Hori, Yoshiharu Kim

“…No significant improvements over time were observed in scores for other cognitive domains, including visuospatial construction, attention, language, and delayed memory.Conclusions: These preliminary results suggest that SNT can improve immediate memory and global cognitive functioning as well as CPTSD symptoms. Further research is needed to verify these findings and understand neurobiological mechanisms underlying the effect of SNT on neurocognitive functioning.Trial registration number: UMIN000030889.…”
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Omaveloxolone, But Not Dimethyl Fumarate, Improves Cardiac Function in Friedreich's Ataxia Mice With Severe Cardiomyopathy by Lili Salinas, Francisco Figueroa, Claire B. Montgomery, Phung N. Thai, Nipavan Chiamvimonvat, Gino Cortopassi, Elena N. Dedkova

“…Nrf2 (nuclear factor erythroid 2‐related factor 2) inducers, omaveloxolone and dimethyl fumarate (DMF), were independently tested in this mouse model to determine the effects on cardiac health and lifespan. Results Omaveloxolone significantly improved cardiac contractile function and markers of heart failure in FA such as Nppb, Aldh1a3, and Gdf15. …”
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Multivariate GWAS analysis reveals loci associated with liver functions in continental African populations. by Chisom Soremekun, Tafadzwa Machipisa, Opeyemi Soremekun, Fraser Pirie, Nashiru Oyekanmi, Ayesha A Motala, Tinashe Chikowore, Segun Fatumo

“…<h4>Background</h4>Liver disease is any condition that causes liver damage and inflammation and may likely affect the function of the liver. Vital biochemical screening tools that can be used to evaluate the health of the liver and help diagnose, prevent, monitor, and control the development of liver disease are known as liver function tests (LFT). …”
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Selenium Alleviates Low-Temperature Stress in Rice by Regulating Metabolic Networks and Functional Genes by Naixin Liu, Qingtao Yu, Baicui Chen, Chengxin Li, Fanshan Bu, Jingrui Li, Xianlong Peng, Yuncai Lu

“…In this study, low concentrations of selenium (ColdSe1) alleviated the adverse effects of cold stress on rice seedlings, improving fresh weight, plant height, and chlorophyll content by 36.9%, 24.3%, and 8.4%, respectively, while reducing malondialdehyde (MDA) content by 29.1%. …”
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Clinical Observation of Different Acupuncture Measures on Restoration of Ischemic Stroke Patients'Hand Function by Zheng JIANG, Liping ZHUO, Shaoqin LIAO, Sai'e HUANG

“…After the treatment, the functional connectivity of left M1 with the left precentral gyrus, left postcentral gyrus, the right cerebellum, and right supplementary motor area in TS group were increased; the functional connectivity of left M1 with the left postcentral gyrus, middle frontal gyrus, inferior parietal lobule and supplementary motor area in EA group were increased after treatment;the functional connectivity of left M1 with the left precentral gyrus and postcentral gyrus in MA group were increased, with the left cerebellum was decreased;the functional connectivity of left M1 with the left postcentral gyrus in SA group were increased, but the connection strength was smallest within four groups, and with the left middle frontal gyrus and precentral gyrus was decreased.Conclusion:TS, EA and MA at Quchi and Waiguan can improve upper limb function of IS patients with upper limb dysfunction.rsfMRI study reveals the effect may related to the increase of functional connectivity of left M1 with the precentral gyrus, postcentral gyrus, middle frontal gyrus and supplementary motor area.…”
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Highly conserved ion binding sites are not all functionally relevant in mouse KCC4 by Lisa Becker, Jens Hausmann, Rieke Wellpott, Anna-Maria Hartmann, Anna-Maria Hartmann

“…Three out of five residues (N131, Y216, and T432) are functionally relevant for potassium coordination. For chloride coordination in Cl1, all three residues (G134, V135, and I136) are important, whereas three out of four residues (G433, M435, and Y589) are relevant for chloride binding in Cl2. …”
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Functional and histological changes of the pancreas and the liver in the rats after the acute and subacute administration of diazinon by Ivanović Saša R., Borozan Nevena, Janković Radmila, Ćupić-Miladinović Dejana, Savić Mila, Ćupić Vitomir, Borozan Sunčica

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Insights into associations between Life’s essential 8 and lung function from NHANES data by Tong Lin, Zhenye Xie, Shanshan Huang, Jialu Chen, Haiyan Mao, Zhikui Chen

“…Conversely, BMI, blood lipids, blood glucose, and blood pressure exhibited variable effects. Subgroup and sensitivity analyses consistently supported findings, confirming a positive correlation between LE8 and lung function. …”
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Physical activity and executive function in Chinese preschool children: the mediating role of sleep problems by Xiaolong Chen, TianChang Li, TianChang Li, Weiling Zhou, Lancheng Huang, Sanhua Zhang, Sanhua Zhang

“…Statistical analyses including correlation and mediation analyses were conducted using SPSS 29.0 and Mplus 8.0.Results(1) Light physical activity (LPA) (r = −0.53, p &lt; 0.01), moderate-to-vigorous physical activity (MVPA) (r = −0.61, p &lt; 0.01), and total physical activity (TPA) (r = −0.64, p &lt; 0.01) showed significantly negatively correlated with executive function scores. (2) LPA (r = −0.27, p &lt; 0.01), MVPA (r = −0.29, p &lt; 0.01), and TPA (r = −0.31, p &lt; 0.01) were significantly negatively correlated with sleep problems. (3) Sleep problems were significantly positively correlated with executive function scores (r = 0.47, p &lt; 0.01). (4) Sleep problems mediated 24.65–28.20% of the effects of LPA, MVPA, and TPA on executive function.ConclusionHigher levels of LPA, MVPA, and TPA were significantly associated with better executive function and fewer sleep problems in preschool children. …”
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Long-Term Impact of Recurrent Acute Otitis Media on Balance and Vestibular Function in Children by Mirko Aldè, Pietro Bosi, Stefanie Muck, Thomas Mayr, Paola Di Mauro, Valentina Berto, Beatrice Gaia Aleandri, Francesco Folino, Stefania Barozzi, Diego Zanetti, Paola Marchisio

“…The present study aimed to evaluate the long-term effects of rAOM on balance and vestibular function in pediatric patients. …”
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Recent overview of kaffir lime (Citrus hystrix DC) dual functionality in food and nutraceuticals by Rahmat Budiarto, Nasrul Wathoni, Syariful Mubarok, Jajang Sauman Hamdani, Tri Ujilestari, Cici Darsih, Reka Mustika Sari, Rizal Maarif Rukmana, Mohammad Miftakhus Sholikin

“…Furthermore, future concepts regarding the engineering of nanoparticles from kaffir lime for drug delivery and functional food release systems will also be discussed.…”
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Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome by Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong

“…Furthermore, our investigation into the isoform-specific functions of JMJD6 intronic APA events supported the hypothesis that alterations in unstructured C-terminal protein regions lead to functional differences. …”
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Combining satellite and field data reveals Congo's forest types structure, functioning and composition by Juliette Picard, Maïalicah M. Nungi‐Pambu Dembi, Nicolas Barbier, Guillaume Cornu, Pierre Couteron, Eric Forni, Gwili Gibbon, Felix Lim, Pierre Ploton, Robin Pouteau, Paul Tresson, Tom vanLoon, Gaëlle Viennois, Maxime Réjou‐Méchain

“…We also described vegetation type structure and composition (floristic, functional and associated fauna) by linking the map with data from large inventories and derived from satellite images. …”
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Modulation of intracellular kinase signaling to improve TIL stemness and function for adoptive cell therapy by Hao Feng, Ling Qiu, Zixiao Shi, Yao Sheng, Peipei Zhao, Di Zhou, Fei Li, Hailin Yu, Yanan You, Hui Wang, Ming Li, Shurong Zhu, Yan Du, Jun Cui, Jingwei Sun, Yarong Liu, Hua Jiang, Xin Wu

“…Method We modulated the PI3K‐AKT pathway in TIL isolated from cervical and ovarian cancer by application of AKT or PI3K inhibitors or CRISPR knockout of AKT1 and/or AKT2, and characterized their effects on TIL phenotype and effector function. Mechanistic study was further performed with RNA‐seq analysis of AKT1/2 KO TIL in comparison to control TIL. …”
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Relationships between heart shape, function, and disease in 38,858 UK biobank participants by Richard Burns, Laura Dal Toso, Charlène A. Mauger, Alireza Sojoudi, Avan Suinesiaputra, Steffen E. Petersen, Julia Ramírez, Patricia B. Munroe, Alistair A. Young

“…ABSTRACT: Background: Cardiac functional metrics such as ejection fraction, strain, and valve excursion are important diagnostic and prognostic measures of cardiac disease. …”
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Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons by Zhenyuan Zhang, Lan Zhang, Yidan Zhang, Yuan Zhao, Ya Gao, Cong Zhang, Dongxiao Li, Xiangjian Zhang, Guofeng Yang, Jian Zhang

“…This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. Quantitative proteomic analysis revealed 67 significantly dysregulated proteins in the hippocampus of naturally aged male mice, including upregulated SIRT2 and impaired autophagy. …”
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A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML by Noor Rashidha Binte Meera Sahib, Jameelah Sheik Mohamed, Masturah Bte Mohd Abdul Rashid, Jayalakshmi, Yihao Clement Lin, Yen Lin Chee, Bingwen Eugene Fan, Sanjay De Mel, Melissa Gaik Ming Ooi, Wei‐Ying Jen, Edward Kai‐Hua Chow

“…However, effectively managing complex biological data, while also ensuring rapid conversion of actionable insights into clinical utility remains challenging. …”
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Respiratory Muscle Function in Children and Adolescents with Cystic Fibrosis in the Era of CFTR Modulator Therapies by Guillermo García-Pérez-de-Sevilla, Ángela Blanco Velasco, Thomas Yvert, Verónica Sanz-Santiago, Ana Morales Tirado, Alejandro López Neyra, Cristina de Manuel, Marta Ruiz Valbuena, Margarita Pérez-Ruiz

“…<b>Objective</b>: The objective of this study was to analyze respiratory muscle function in children and adolescents with cystic fibrosis (CF) treated with Elexacaftor/Tezacaftor/Ivacaftor (ETI) compared to healthy individuals, based on the hypothesis that CFTR modulators may improve respiratory muscle strength. …”
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