Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary by Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li

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The incorporation of Cr in enhancing the corrosion resistance, mechanical property and thermal stability of NbMoTaCrx coatings by Baorui Song, Chaozheng Zhou, Jiahong Wei, Yong Hua, Wenjie Zhou, Zhongxiao Song, Dan Qian, Weihua Li

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Biocomposite Active Whey Protein Films with Thyme Reinforced by Electrospun Polylactic Acid Fiber Mat by Andreea (Lanciu) Dorofte, Iulia Bleoanca, Florentina Ionela Bucur, Gabriel Mustatea, Daniela Borda, Felicia Stan, Catalin Fetecau

“…Composite bio-based packaging materials obtained from whey proteins, functionalized with thyme essential oil (TEO) and reinforced by electrospun polylactic acid (PLA) fibers, represent a promising solution for developing new active food packaging using environmentally friendly materials. …”
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Circadian Alterations in Brain Metabolism Linked to Cognitive Deficits During Hepatic Ischemia-Reperfusion Injury Using [¹H-¹³C]-NMR Metabolomics by Yijing Li, Yanbo Liu, Zhigang He, Zhixiao Li, Hongbing Xiang

“…<b>Background</b>: Hepatic ischemia-reperfusion injury (HIRI) is known to affect cognitive functions, with particular concern for its impact on brain metabolic dynamics. …”
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Lack of canonical activities of connexins in highly aggressive human prostate cancer cells by Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez, Alejandro S. Godoy

“…However, more recently, it has been shown that Cxs exert anti- and pro-tumorigenic effects depending on the cell and tissue context. …”
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STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis by Fuda Xie, Yang Lyu, Bonan Chen, Hoi Wing Leung, Peiyao Yu, Tiejun Feng, Canbin Fang, Alvin H.K. Cheung, Bin Zhou, Jianhui Jiang, Ge Zhang, Dazhi Xu, Liang Li, Chen Jiang, Jianwu Chen, Zhaocai Zhou, Liwei An, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Kam Tong Leung, Ching Hei To, Brigette BY Ma, Chi Chun Wong, William KK Wu, Jun Yu, Ka Fai To, Wei Kang

“…The regulation of YAP1 on STK3 was assessed through a combination of bulk and single-cell RNA-sequencing, Western blot, ChIP-qPCR, gene knockout mouse models, and functional rescue assays. The oncogenic roles of STK3 were confirmed through subcutaneous xenograft formation models and functional assays including spheroid formation and organoid growth. …”
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Clinical profile, associated events and safety of vericiguat in a real‐world cohort: The VERITA study by Mario Galván Ruiz, Miguel Fernández de Sanmamed Girón, María delVal Groba Marco, Lorena Rojo Jorge, Claudia Peña Saavedra, Elvira Martín Bou, Rubén Andrade Guerra, Eduardo Caballero Dorta, Antonio García Quintana

“…Conclusions In clinical practice, treatment with vericiguat is associated with substantial improvements in functional class and quality of life and a reduction in hospitalizations for HF, with a low risk of adverse effects.…”
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Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a brown... by Lorenzo Flori, Giulia Galgani, Giorgia Bray, Chiara Ippolito, Cristina Segnani, Carolina Pellegrini, Valentina Citi, Valentina Citi, Nunzia Bernardini, Nunzia Bernardini, Alma Martelli, Alma Martelli, Alma Martelli, Vincenzo Calderone, Vincenzo Calderone, Vincenzo Calderone

“…AT is a lipid storage organ with endocrine functions that presents two main phenotypes: white adipose tissue (WAT) and brown adipose tissue (BAT). …”
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A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary by Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan

“…In experimental data, opposing effects on regulators of squamous and columnar lineage identity were uncovered between TRPS1 and classical GATA factors (GATA4/6). …”
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Altered Pharmacokinetics of Ropivacaine in Patients Undergoing Laparoscopic Major Hepatectomy by Jun Zhang, Hongyuan Lv, Jiliang Shen, Zhichao Ai, Minjun Liu, Xiaorui Liu, Tieshuai Liu, Bo Shen, Hong Yu, Xin Yu

“…<b>Results:</b> The peak total ropivacaine concentration occurred 45 min after the block, reaching 2031.5 (876.0) ng·mL⁻¹, with a tendency to exceed the toxicity threshold in patients with a CFLV (cut functional liver volume) exceeding 199.24 mL or a CFLV/TFLV (total functional liver volume) ratio surpassing 18.61%. …”
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Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma by Yi Bai, Xiyue Deng, Dapeng Chen, Shuangqing Han, Zijie Lin, Zhongmin Li, Wen Tong, Jinming Li, Tianze Wang, Xiangyu Liu, Zirong Liu, Zilin Cui, Yamin Zhang

“…Integrating ATAC-seq and RNA-seq data allowed the identification of transcription factors and their putative target genes associated with differentially accessible regions (DARs). Finally, functional experiments were conducted to investigate the effects of the identified regulatory factors and corresponding targets on HCC cell proliferation and migration. …”
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The overview and role of heat shock proteins (HSP) especially HSP 60 and 70 in reproduction and other pathologies (a literature review) by V.O. Berestoviy, Ahmad Mahmood, I.B. Venckivska, V.G. Ginzburg, I.V. Sokol, O.O. Berestoviy, D.O. Govsieiev

“…Heat shock proteins are responsible for normal folding of other proteins and prevent its abnormal folding and cause degradation of abnormally folded proteins, mitochondrial protein transport, DNA metabolism, regulation of apoptosis are their significant functions. HSP 60 is a homologue of bacterial HSP 60 (GroEL) and needs co-chaperonin HSP 10 for its proper functioning. …”
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Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease by Yung-Che Chen, Ying-Tang Fang, Chao-Chien Wu, Tung-Ying Chao, Yi-Hsi Wang, Chia-Cheng Tseng, Sum-Yee Leung, Chiu-Ping Lee, Ting-Ya Wang, Po-Yuan Hsu, Jen-Chieh Chang, Meng-Chih Lin, Chang-Chun Hsiao

“…Abstract Background This study aims to explore the role of autophagy-associated genes (ATG) and their epigenetic markers in the progression of mycobacterium tuberculosis (M. tb) infection, and to test the effects of de-methylation agents on macrophage functions against TB. …”
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Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…EAU was associated with declining microbial tryptophan metabolism and up-regulated functions related to lipid and carbohydrate metabolism; PD-L1 knockout in EAU further increased the metabolism of glycan and biosynthesis of 3-deoxy-α-D-manno-2-octulosonate (Kdo), a key component of bacterial lipopolysaccharide (LPS).ConclusionBoth EAU and PD-L1 knockout modulate gut microbiota, affecting microbial composition - particularly Akkermansia, CAG-485, Bacteroidaceae, Lachnospiraceae and Ruminococcaceae - and microbial functions such as lipid, carbohydrate and glycan metabolism.…”
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Design language learning with artificial intelligence (AI) chatbots based on activity theory from a systematic review by Yan Li, Xinyan Zhou, Hong-biao Yin, Thomas K. F. Chiu

“…Activity Theory (AT) offers a framework of elements and functions inside an activity system to accomplish desired objectives. …”
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A multi-modal transformer for predicting global minimum adsorption energy by Junwu Chen, Xu Huang, Cheng Hua, Yulian He, Philippe Schwaller

“…The AdsMT model effectively captures the intricate relationships between adsorbates and surface atoms through the cross-attention mechanism, hence avoiding the enumeration of adsorption configurations. …”
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Non-Destructive Diagnostics in the Assessment of Splice Geometry in Steel Cord Conveyor Belts by Leszek Jurdziak, Ryszard Błażej, Aleksandra Rzeszowska

“…Recently, efforts have been made to extend the system’s functionality to include splice diagnostics. This study was conducted under laboratory conditions on an ST2500 belt featuring five splices (three bias and two straight splices). …”
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Compliance and Adherence to Pelvic Floor Exercise Therapy in People with Pelvic Floor Disorders: A Systematic Review and Meta-Analysis by Inmaculada Villa-Del-Pino, José-Jesús Jiménez-Rejano, Manuel Rebollo-Salas, Álvaro-José Rodríguez-Domínguez, Carmen-María Suárez-Serrano

“…Background: The impact of muscle-training treatment on quality of life and functional outcomes in people with pelvic floor dysfunction may be related to adherence rates. …”
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Spatial Insights for Building Resilience: The Territorial Risk Management & Analysis Across Scale Framework for Bridging Scales in Multi-Hazard Assessment by Francesca Maria Ugliotti, Muhammad Daud, Emmanuele Iacono

“…BIM data further refine this assessment by incorporating building and functional characteristics, enabling a comprehensive evaluation of resilience and risk mitigation strategies tailored to dynamic environmental conditions across scales. …”
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Exploring the impact of altitude variability and apple genotype on the epiphytic microbiome by Ana María Sánchez, Jonàs Oliva, Ahmed Abdelfattah, Rosario Torres, Laura Vilanova, Neus Teixidó

“…Studying fruit microbial communities has been instrumental in understanding how this plant-associated microbiome influences key host functionalities. However, the impact of environmental changes and host genotype on this microbiome is unclear. …”
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