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66881
Alkaline-Potassium Ferrate Pretreatment Promoting Acid Production Through Co-Fermentation of Waste Activated Sludge and Corn Straw
Published 2025-04-01“…This effect was more pronounced at higher PF dosages (≥0.20 g/g VSSWAS). …”
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66882
Use of Technology to Support Health Care Providers Delivering Care in Low- and Lower-Middle-Income Countries: Systematic Umbrella Review
Published 2025-06-01“…Data extracted were deductively coded and thematically analyzed according to the 11 health system functions outlined in the 2023 World Health Organization classification of DHIs. …”
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66883
Sigesbeckia pubescens makino alleviates ulcerative colitis in mice by modulating the Nrf2/Keap1 pathway
Published 2025-04-01“…This study compared the therapeutic effects of three Siegesbeckiae Herba (SH) species used in traditional Chinese medicine—Sigesbeckia orientalis L (SO), Sigesbeckia pubescens Makino (SP), and Sigesbeckia glabrescens Makino (SG) — in dextran sulfate sodium (DSS)-induced UC mice.MethodsUC was induced in C57BL/6 mice with 3% DSS for 7 days. …”
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66884
Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and characterization
Published 2025-01-01“…Among the six identified peptides (named as P1–P6), four demonstrated inhibitory effects on the nsP2 protease (nsP2pro). Peptide P1 exhibited the strongest inhibitory effect, with a half-maximal inhibitory concentration (IC50) of 4.6 ± 1.9 µM, and a low cytotoxicity. …”
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66885
Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition
Published 2025-03-01“…We synthesized a novel broad kinase inhibitor (BK40196) and investigated its effects on tau hyper-phosphorylation, cell loss, inflammation and behavior in transgenic rTg4510 and TgAPP (TgSwDI) mice. …”
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66886
BLF1 Affects ATP Hydrolysis Catalyzed by Native and Mutated eIF4A1 and eIF4A2 Proteins
Published 2025-05-01“…However, they exert distinct effects on cancer treatment outcomes. To understand the molecular mechanism by which BLF1 modulates eIF4A isoforms in cancer cells, we investigated its effects on eIF4A-mediated adenosine 5′-triphosphate (ATP) hydrolysis. …”
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66887
circ‐TTC17 Promotes Esophagus Squamous Cell Carcinoma Cell Growth, Metastasis, and Inhibits Autophagy‐Mediated Radiosensitivity Through miR‐145‐5p/SIRT1 Axis
Published 2025-01-01“…Methods The levels of circ‐TTC17, miR‐145‐5p and sirtuin 1 (SIRT1) were determined using qRT‐PCR. ESCC cell functions were examined by CCK8 assay, flow cytometry, transwell assay and colony formation assay. …”
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66888
Features of Paradigm for forming anti-cataclysmic instruments for preventing aggressive interstate conflicts – artificial intelligence (AI) in terms of ensuring objective personnel...
Published 2024-06-01“…It is proposed to increase the effectiveness of these measures through managerial, state innovation and management mechanisms. …”
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66889
Fuzzy logic-based IoT system for optimizing irrigation with cloud computing: Enhancing water sustainability in smart agriculture
Published 2025-08-01“…Faced with the growing challenges of water scarcity and the effects of climate change, intelligent irrigation management is essential to guarantee food security and promote sustainable agriculture. …”
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66890
System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain—an explorative study
Published 2025-08-01“…Among the significant octadecanoids, 9-HODE showed most prominent facilitating effects on Kv7.2/7.3 channel activation. Conclusion:. …”
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66891
Regulation and enhancement of the optical performance of graphene oxide through Ni/Fe/Ag nanoparticles doping
Published 2025-06-01“…Graphene oxide (GO) is a two-dimensional carbon material with a graphene-like structure and many oxygen-containing functional groups, and in recent years from research into the unique optical properties of GO, GO-based composite materials formed by combining with other materials have shown improved overall performance. …”
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66892
Hypoxic preconditioning modulates BDNF signaling to alleviate depression-like behaviors in mice and its whole transcriptome sequencing analysis
Published 2025-05-01“…Therefore, this study aimed to investigate the effects of HPC on depressive behaviors via BDNF signaling. …”
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66893
A novel integrated TDLAVOA-XGBoost model for tool wear prediction in lathe and milling operations
Published 2025-09-01“…Results demonstrated the model’s effectiveness in learning nonlinear relationships between machining variables and tool wear. …”
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66894
Total Lactic Acid Bacteria (LAB) and Antioxidant Activity of Goat's Milk Yoghurt with The Addition Of Red Bran During Refrigeration Storage
Published 2023-10-01“…Background: Goat milk yogurt is a functional food made from processed food of animal origin with the help of LAB fermentation, which is healthy for the body. …”
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66895
Task difficulty modulates motor learning benefits of balance exercises in community-dwelling older adults
Published 2025-09-01“…Balance performance was measured using a stability index, and functional task difficulty was assessed using the National Aeronautics and Space Administration Task Load Index (NASA-TLX). …”
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66896
Integrating Strategy of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Verification to Investigate the Potential Mechanism of <i>Gastrodia elata</i> Against...
Published 2025-06-01“…Among them, the main functional components might be 4-hydroxybenzyl methyl ether, 4-ethoxytolyl-4′-hydroxybenzyl ether, pseudolaric acid B, palmitic acid, and myricetin. …”
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66897
Ocular Toxicity Associated with Tamoxifen Administration in Patients with Breast Cancer: A Systematic Review
Published 2025-07-01“…The analysis revealed that TAM-induced ocular toxicity results in diverse structural and functional changes within eye tissues, including retinal degeneration, macular thinning, alterations in choroidal thickness, and vascular modifications. …”
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66898
Enhancing environmental models with a new downscaling method for global radiation in complex terrain
Published 2025-01-01“…The influences of surrounding mountains' shade on direct radiation and the “bowl” (deep valley) effect (or sky-view factor) on diffuse radiation are then considered. …”
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66899
Programmatic Approach to Outpatient Cardiac Catheterization in Children With Stable Pulmonary Arterial Hypertension
Published 2025-04-01“…Data were modeled using a mixed effects logistic regression for correlated data, and a patient random effect was included to account for multiple procedures in the same patient. …”
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66900
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis
Published 2025-05-01“…Transcriptomic profiling revealed significant enrichment of ECM remodeling pathways following BMSC-Exo intervention, with connective tissue growth factor (CCN2) identified as a pivotal mediator. Functional validation through CCN2 overexpression demonstrated the mechanistic dependence of BMSC-Exo’s anti-fibrotic effects on the CCN2-TGF-β axis. …”
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