Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer by Wei Wang, Wei Wang, Fengyu Ling, Fengyu Ling, Dong Huang, Guomin Luo, Guomin Luo, Bixia Duan, Bixia Duan

“…CSS-high tumors displayed diminished cytotoxic T-cell infiltration and impaired CD8+ effector functions (reduced IFN-γ/granzyme B production), while CSS-low tumors showed enhanced T-cell activity. …”
Get full text

Does Time and Experience Matter in Pediatric Arterial Ischemic Stroke (AIS) Intervention in Patients with an Initial Clinical Presentation of Mild/Moderate Severity? Long-Term Foll... by Gulten Ozturk, Erhan Biyikli, Olcay Unver, Omer Dogru, Evrim Karadag Saygi, Feyyaz Baltacioglu, Dilsad Turkdogan

“…Seventeen patients (53.3%) reported normal daily functions at the last visit. A younger presentation age (≤60 months) was related to a longer hospital admission duration (24 h vs. 9 h) and worse long-term functional outcomes (<i>p</i> = 0.023). …”
Get full text

Potential to use of viral reverse transcriptase inhibitors in oncology by O. A. Vlasova, I. A. Antonova, Kh. M. Magomedova, M. A. Usolkina, K. I. Kirsanov, G. A. Belitsky, T. T. Valiev, M. G. Yakubovskaya

“…In preparing the review, articles on the functioning of the reverse transcriptase enzyme of endogenous repeat sequences LINE1, the mechanisms of action and antitumor activity of viral reverse transcriptase inhibitors. …”
Get full text

Impacts of different types of straw returning on soil physicochemical properties, microbial community structure, and pepper quality by Xiapu Gai, Biao Chen, Shijuan Xiong, Qingqing Zhou, Yuan Yuan, Yumei Mou

“…It indicated that straw types drive microbial functional differentiation by regulating nutrient availability. …”
Get full text

N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Differentially expressed proteins were categorized into functional networks to highlight altered protein functions and signaling pathways. …”
Get full text

Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study by Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song

“…The two-stage GWAS revealed statistically significant associations among MKLN1 (rs75170436, 7q32.3, beta (log odds ratio) = − 0.90, P meta  = 5.90 × 10–13), MMP14 (rs3751489, 14q11.2, beta (log odds ratio) = − 1.91, P meta  = 2.31 × 10–12). Post-GWAS functional analysis revealed strong associations on two genes highlighting deleterious effects and increased gene expression. …”
Get full text

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1 by Yuanyin Xi, Ruoding Wang, Man Qu, Qinwen Pan, Minghao Wang, Xiang Ai, Zihan Sun, Chao Zhang, Peng Tang, Jun Jiang, Ying Hu

“…CCK8, colony formation, and Transwell assays were utilized to estimate the oncogenic functions of RBBP7. The ChIP-qPCR and dual-luciferase reporter assays were used to investigate the epigenetic mechanisms of RBBP7. …”
Get full text

Assisted natural regeneration for tropical forest and landscape restoration in the Philippines: Implementation, motivations, challenges and future directions by Tomiwa V. Oluwajuwon, Robin L. Chazdon, Nestor Gregorio, Liz Ota, Rogelio Tripoli, Arturo Pasa, John Herbohn

“…Forest degradation and deforestation in the rural uplands of the Philippines threaten biodiversity, ecological functions, and local livelihoods. To address these issues, various Forest and Landscape Restoration (FLR) initiatives have been introduced, including Assisted Natural Regeneration (ANR)—a set of low-cost interventions aimed at accelerating natural recovery and enhancing ecological functionality in degraded forest landscapes. …”
Get full text

Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…The authors used the methods of various types of analysis including SWOT analysis; logical-semantic and structural-functional modelling.Results. The authors actualised the problem of creating an innovative educational content, which expands the range of professional knowledge and skills required of competitive personnel, who are capable and ready to preadapt to the rapidly changing socio-professional conditions. …”
Get full text

Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer models by James W Hodge, Howard Kaufman, Michelle R Padget, Kellsye P Fabian, Sailaja Battula, Wiem Lassoued, Ginette Santiago-Sanchez, Clint Tanner Allen

“…For MOC1, flow cytometry and cytokine array were performed to assess the immune effector functions associated with the combinational treatment. …”
Get full text

The significance of notch signaling in the regulation of Тreg-lymphocyte differentiation in patients with infiltrative pulmonary tuberculosis by A. E. Sanina, V. A. Serebryakova, O. I. Urazova, A. A. Gadzhiev, Т. E. Kononova

“…Data on the role of regulatory T lymphocytes (Treg) in the immunopathogenesis of tuberculosis are actively accumulating in the current literature. The overwhelming effect of Treg cells on the proliferation, functional activity of Th1 lymphocytes and antigen-presenting cells allows to consider this population as a possible target of modulation of the immune response in patients with tuberculosis. …”
Get full text

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina

“…C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of intracellular C5aR1 expression for the inflammatory effector functions of various cell types. However, the mechanisms regulating C5aR1 expression and localisation remain unclear. …”
Get full text

Alkaline Extraction in Air Enhances Antioxidant and Biological Activities of Humic Acids by Anna Zavarzina, Irina Davydova, Natalia Kulikova, Anastasiya Nikolaeva, Olga Philippova

“…Humic acids (HAs) possess diverse functionalities, endowing them with multiple applications as bioactive compounds in agriculture. …”
Get full text

Bovine PMN responses to extracellular vesicles released by Besnoitia besnoiti tachyzoites and B. besnoiti-infected host cells by Gabriel Espinosa, Constanza Salinas-Varas, Lisbeth Rojas-Barón, Christian Preußer, Elke Pogge von Strandmann, Ulrich Gärtner, Iván Conejeros, Carlos Hermosilla, Anja Taubert

“…Emerging evidence indicates that extracellular vesicles (EVs) modulate PMN effector functions, such as ROS production or NET formation. …”
Get full text

Inhibition of TPI1 Sensitizes Cisplatin-Resistant Oral Cancer to Ferroptosis by Dandan Wang, Huimin Zheng, Yumin Chen, Jialin Hao, Yuan Zhou, Nan Li

“…<b>Methods:</b> We conducted in vitro and in vivo analyses to evaluate the functional consequences of TPI1 knockdown in cisplatin-resistant OSCC cell lines and tumor xenograft models. …”
Get full text

Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Functional analyses were conducted using MTT, 5-ethynyl-2ʹ-deoxyuridine, transwell, and sphere formation assays, respectively. …”
Get full text

UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma by Haofeng Yin, Yibo Xue, Chen Wang, Yanqin Wu, Yuchen Guo, Chunzhen Li, Yunyan Zhang, Shulei Yin, Tiejun Zhao

“…Differences in immune microenvironment components, immunoregulatory gene expression, and immune functional activities between subgroups stratified by UBE2N expression levels. …”
Get full text

Life cycle assessment (LCA) in crop production, case study: apple and grape by Elham Ebrahimi, Laleh Ebrahimi

“…Introduction: Life Cycle Assessment (LCA) is a comprehensive assessment method that allows the estimation of cumulative environmental impacts from all life cycle stages of an activity. The destructive effects of agricultural development on the environment are of great importance. …”
Get full text

Adsorptive capacity of activated carbon derived from rice husks for azo dye removal from solution by P. C. Nwadibia, J. C. Eze, D. I. Anyaogu, H. O. Abugu, P. M. Ejikeme

“…The raw rice husk (RRH) was treated with 85% H3PO4 and H2SO4 and calcined at 500 °C in a muffle furnace. The effects of initial methyl orange (MO) concentrations, adsorbent dosage and contact time on the dye removal process was studies. …”
Get full text

SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin by Huating Sun, Yinghui Zhang, Fang Wang, Zizhao Wang, Yuhong Zhang, Youguo Chen, Li Wang, Jinhua Zhou

“…This study aimed to identify the functional isoform of SORBS3 driving LNM suppression and elucidate its mechanisms. …”
Get full text