Reclassification of Two MLH1 Variants of Uncertain Significance Utilizing Clinical and Functional Data by Jane Hübertz Frederiksen, Ulf Birkedal, Sarah Bachmann, Elisabeth Victoria Eliesen, Lene Juel Rasmussen, Katja Venborg Pedersen, Lana Al‐Zehhawi, Susanne E. Boonen, Lotte Krogh, Karina Rønlund, Lise Graversen, Jannie Assenholt, Kjeld Schmiegelow, Karin Wadt, Anne‐Marie Gerdes, Thomas v. O. Hansen

“…Conclusion By applying all collected data and functional results we propose to reclassify the c.696_698del, p.…”
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A novel loss-of-function SYCP2 variant causes asthenoteratozoospermia in infertile males by Cong Liu, Cong Liu, Cong Liu, Yinfeng Zhang, Yinfeng Zhang, Yinfeng Zhang, Youming Zhao, Youming Zhao, Youming Zhao, Haining Luo, Haining Luo, Haining Luo

“…Mini-gene splicing assays were performed to validate the effect on the alternative splicing of the variation.Results:A novel heterozygous splice variant was identified in SYCP2 (c.2600+ 5G>C) in the patient ,which inherited from his phenotypically normal mother. …”
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Integrated Perspective on Functional Organic Electrochemical Transistors and Biosensors in Implantable Drug Delivery Systems by Xiao-Le Han, Tao Zhou, Jian-Ming Xu, Shu-Feng Zhang, Ye-Zhou Hu, Yi Liu

“…This review systematically summarizes recent advances in IDDSs and functional OECT-based biosensors across various application domains. …”
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The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function by Gulshara Zh Abildinova, Gulshara Zh Abildinova, Valeriy V. Benberin, Valeriy V. Benberin, Tamara A. Vochshenkova, Tamara A. Vochshenkova, Alireza Afshar, Alireza Afshar, Nadiar M. Mussin, Asset A. Kaliyev, Zhanna Zhussupova, Amin Tamadon, Amin Tamadon, Amin Tamadon

“…These approaches have shown promising results in improving insulin sensitivity and cognitive function in both animal models and human studies. The article also emphasizes the need for further research to elucidate the specific microbial species and metabolites involved in modulating the gut-brain axis, as well as the long-term effects and safety of these therapeutic interventions. …”
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Functional properties of hard kombucha brewed with deep ocean water using Lachancea thermotolerans by Hayeong Kim, Kibeom Jin, Ji Yeon Lee, Tae-hui Yang, Sejin Oh, Soochul Park, Gia-Buu Tran, Huong Thuy Le, Kunal Pal, Ghahyun Jeffrey Kim, Doman Kim

“…However, DOWHK suppressed α-glucosidase activity 1.63 times more effectively than TWHK. This study supports the use of deep ocean water in the development of functional fermented beverages for industrial applications.…”
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LINC00673 binds with leptin to regulate osteogenic function in periodontal ligament stem cells by Yang Yang, Peng Yang, Yuxing Zhang, Zhaoyan Wu, Xuxia Wang, Jun Zhang

“…However, overexpression of LINC00673 reversed this effect, suggesting that LINC00673 functions as a competing endogenous RNA for miR-188-3p. …”
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Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function by Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier

“…We also reveal a critical role for this epigenetic regulator in supporting the suppressive functions of Treg cells in vivo.…”
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Functionalized-AgNPs for Long-Term Stability and Its Applicability in the Detection of Manganese Ions by Van-Tuan Hoang, Mai Mai, Le Thi Tam, Ngoc Phan Vu, Nguyen Tien Khi, Phuong Dinh Tam, Tran Quang Huy, Anh-Tuan Le, Ngo Xuan Dinh, Vinh-Hoang Tran

“…PHMB-functionalized silver nanoparticles (AgNPs/PHMB) exhibited better stability than others and could be stored at ambient temperature for at least 180 days. …”
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Disruptive behaviors in early childhood: the influence of family practices and functionality in a Turkish sample by Merve Çıkılı Uytun, Esra Yürümez, Gökçe Yağmur Efendi, Hande Konşuk Ünlü, Serpil Aktaş Altunay, Didem Behice Öztop

“…The aim of the current study was to highlight the effect of disruptive behaviors on functionality in preschool children and their families and identify factors that may be related to functionality. …”
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Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang by Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong

“…This study focuses on the molecular characterization and functional analysis of thioredoxin glutathione reductase (TGR) from O. turkestanicum, a key enzyme involved in the parasite’s antioxidant defense system. …”
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The Relatıonship Between Functional Movement And Body Stability With Service Speed On Veteran Tennis Players by İpek Eroğlu Kolayiş, Hüseyin Günay

“…The purpose of this study is to investigate the effect of functional mobility analyse and body stability on service performance among veteran tennis players. 25 veteran (senior) players (X̄age: 40.79±4.2) who are active licenced, have participated in the study voluntarily. …”
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Risk factors of functional dyspepsia, gastrointestinal reflux disease and non-erosive reflux disease by Malik Ayesha, Din Rafi Ud, Asif Mahrosh, Naeem Iqra, Habib Aamir, Khan Asma Arshad

“…Background/Aim: Functional dyspepsia, erosive and non-erosive gastroesophageal reflux disease (GERD) present a major health burden, adversely effecting quality of life. …”
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KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients by Cairui Xu, Kangli Cao, Along Ma, Meijuan Zheng, Yuanhong Xu, Ling Tang

“…However, it remains unclear whether there are any alterations in the quantity and functional status of NK cells in colorectal cancer (CRC). …”
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Re-evaluating riboflavin requirements for laying quails: Implications for productivity and yolk antioxidant function by Osman Olgun, Esra Tuğçe Gül, Gözde Kılınç, Alpönder Yıldız, Ainhoa Sarmiento-García

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Chronotype and Cognition: Comparison of Executive Functions, Sleepiness, and Fatigue According to Circadian Rhythm Preference by Hasan Demirci, Yıldız Bilge, Merve Şirin, Ahmet Fatih Sarıkaya, Sümeyye İlhan

“…Therefore, it can be said that circadian typology has a limited effect on executive functions. Conclusion: Chronotypes have been found to perform similarly in executive functions such as attention, working memory, verbal fluency, mental flexibility, resistance to interference, planning, and problem-solving.…”
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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release by Xiaowei Mao, Kexin Chen, Yanlong Zhao, Chunrong Xiong, Jing Luo, Yuguang Wang, Bo Wang, Hongyu Zhang

“…Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). …”
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Differential Change in Retina Structure and Function in Children and Adolescents with Drusens of the Optic Nerve Disk by A. G. Shchuko, D. Yu. Samsonov, S. I. Zhukova, T. N. Iureva, I. M. Mikhalevich, A. V. Grigorieva, Yu. S. Samsonova

“…Central vision in patients with drusens of the optic nerve disc is reduced rarely, and their diagnosis is reduced to ascertaining of the fact of having drusen without taking into account the structural and functional changes in the visual system.Purpose of the work: to identify the pattern of changes in visual functions in children and adolescents with druses of the optic nerve disk, the development and addition of classification criteria.Patients and methods. 45 children with drusens were examined, a comprehensive analysis of the visual system included a standard ophthalmological examination, a comprehensive study of visual system with ultrasound scanning, OCT and OCTA, standard automated and pulsarperimetry.Based on the results of the cluster analysis, a graph of the distribution of patients into three groups (control group and two clinical groups) was constructed, and the structural and functional state of the visual system was analyzed. …”
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Evaluation of nutritional and functional characteristics of noodles formulated with chickpea flour and moringa leaf powder by Tanjum Kabir Khuku, Sanaullah Mazumdar, Borhan Uddin, Md. Syduzzaman

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The relationship of systemic inflammatory response with structural and functional changes in the myocardium in patients with pulmonary tuberculosis by D. V. Kolchin, V. I. Ruzov, L. N. Savonenkova, V. A. Razin

“…Taking into account the conflicting data on the effect of the systemic inflammatory response on the structural and functional changes in the myocardium in clinical forms of tuberculosis, we conducted an echocardiographic study and an assessment of pro- and anti-inflammatory cytokines in the blood serum.The purpose: to study the relationship of structural and functional changes in the myocardium with markers of systemic inflammation IL-6, IL-10, VEGF-A in patients with various forms of pulmonary tuberculosis.Materials and methods. …”
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Teaching Internal Medicine Residents to Critically Appraise the Role of Race in Pulmonary Function Testing by Ananya Bhatia-Lin, Nirav Bhakta, Neha Deshpande, Laura Granados, Rosemary Adamson

“…Mean score differences were evaluated for level 2 questions using Cohen's d effect size. Results Thirty-eight respondents completed the pretest survey, and 24 completed the posttest survey. …”
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