Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem -dimethylation modification: discovery of potent anti-cancer agents with improved druggability by Chao Zhang, Yugang Song, Xiuyun Sun, Qianlong Liu, Zhen Li, Shenyi Yin, Jianzhong Jeff Xi, Xin Zhai, Yu Rao

“…The gem -dimethyl group is an organic chemistry functional group that consists of two methyl groups bonded to the same carbon atom. …”
Get full text

Identification of the Oncogenic Role of MSH2 in the Stemness and Progression of Glioma Through Regulating Wnt Signaling Pathway by Jun Liu, Jiayu Chen, Lianglei Jiang

“…Methods We analyzed public datasets and clinical samples to assess MSH2 expression and its clinical relevance. Functional assays in vitro and in vivo were performed to investigate the effects of MSH2 knockdown on glioma cell behavior. …”
Get full text

Control of the gut microbiome by fecal microRNA by Shirong Liu, Howard L. Weiner

“…We investigated potential mechanisms for this effect and found that miRNAs were able to regulate the gut microbiome. …”
Get full text

Increased resting heart rate indicates high-workload hearts with augmented aortic hydraulic power in hypertensive pigs. by Pao-Yen Lin, Bo-Wen Lin, Tong-Sian Lai, Yan-Hsiang Yang, Meei Jyh Jiang

“…Through coarctation of the infrarenal abdominal aorta (AA), we induced hypertension in minipigs and evaluated physiological reactions and morpho-functional changes of the heart. Moderate aortic coarctation was achieved with approximately 30 mmHg systolic pressure gradient in minipigs. …”
Get full text

The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. by Elizabeth B Draganova, Hui Wang, Melanie Wu, Shiqing Liao, Amber Vu, Gonzalo L Gonzalez-Del Pino, Z Hong Zhou, Richard J Roller, Ekaterina E Heldwein

“…This stabilization strategy is powerful enough to override the otherwise deleterious effects of mutations that destabilize the NEC lattice by different mechanisms, resulting in a functional NEC hexagonal lattice and restoration of membrane budding.…”
Get full text

Floral Closure in Lesser Celandine (<i>Ficaria verna</i>) Protects Anthers from Pollen Flushing and Preserves Pollen Viability by Pavol Prokop, Zuzana Provazník, Kristián Tučník

“…This demonstrates that flower closure effectively protects pollen from rain-induced flushing, thus enhancing reproductive success. …”
Get full text

On the role of nutrition in physical, psychomotor, and mental development in infants and young children by V. M. Studenikin

“…To date, it is generally recognized that the amino acid composition of protein, oligosaccharides, omega-3 and omega-6 fatty acids and a number of other nutrients have a positive effect on the development of the central nervous system and its functions.Objective. …”
Get full text

The Law of Instant Equality of the Purchasing Power of Money by V. N. Yusim

“…The article proves effectiveness of the law of instant equality of money unit buying capacity. …”
Get full text

Aqueous−humor biomarkers and real−world efficacy of conbercept for diabetic macular edema: a prospective study in elderly patients by Min Xie, Min Xie

“…Treatment was well−tolerated, with no unexpected ocular or systemic adverse events.ConclusionConbercept produced meaningful anatomical and functional benefits in an elderly DME cohort. Baseline aqueous VEGF and IL−6, while not definitive stand−alone tests, may help identify eyes likely to achieve pronounced anatomical improvement and warrant further investigation as components of a multi−marker predictive panel.…”
Get full text

Artificial intelligence-based intelligent computing using circular q-rung orthopair fuzzy information aggregation by Jian Qi

“…Finally, utilizing a comparison technique, we identified the supremacy and effectiveness of proposed theories.…”
Get full text

Rethinking composite quantification by capturing biological and ecological diversity across multiple dimensions by Ioan Sîrbu, Ana-Maria Benedek, Monica Sîrbu

“…We defined and measured overall biodiversity by integrating taxonomic, functional, genetic-, and niche-based diversity, lambda diversity, which expresses the cumulative sequential differences in communities along a gradient, and xi ecological integrative diversity combining community, spatial, and environmental heterogeneity. …”
Get full text

ASSESSMENT OF UTILISATION OF SOIL MANAGEMENT PRACTICES AMONG ARABLE CROP FARMERS IN OGUN STATE: IMPLICATION FOR SUSTAINABLE AGRICULTURE IN NIGERIA by Rukayat Abiodun ADEYEMO, Afolabi Mohammed OLADOJA, Michael FAMAKINWA, Dorcas Lola ALABI

“…A multi-stage sampling procedure was used to select 110 farmers from selected six functional fadama sites in Ogun State. Results showed that majority (92.7% and 79.1 %) of the respondents were male and married respectively with mean age of 37.5 years. …”
Get full text

Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells. by Stefanie Bernaudo, Shahin Khazai, Eilyad Honarparvar, Alina Kopteva, Chun Peng

“…Cyclin G2 (CCNG2) is an atypical cyclin that functions to inhibit cell cycle progression and is often dysregulated in human cancers. …”
Get full text

THE ROLE OF SOME INFLAMMATORY CYTOKINES IN THE DEVELOPMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON THE BACKGROUND OF OBESITY by L. V. Savchenko, I.P. Kaidashev

“…Cytokines induce acute inflammatory response, may have immunopathological effects on cells and tissues, providing consistency, harmony and completeness of the immune response. …”
Get full text

The Contributions of Party System to Democratic Development in Africa: A Historical Perspective by Ameen Abdulkadir

“…The paper therefore recommends that; assumptions about the trajectory and outcomes of democratic development in Africa need to be more effectively investigated on the basis of empirically informed analysis of operationalized politics in these systems. …”
Get full text

Reliability Modeling of Wind Turbine Gearbox System Considering Failure Correlation Under Shock–Degradation by Xiaojun Liu, Ziwen Wu, Yiping Yuan, Wenlei Sun, Jianxiong Gao

“…Relative to natural degradation-only models, failure rates rise by >60%, validating the model’s effectiveness and alignment with real-world operational conditions.…”
Get full text

IoT-Based Nerve Stimulator for Women’s Safety by K Revathi, W Gracy Theresa

“…Rechargeable batteries provide continuous functioning, which in turn guarantees the dependability and efficacy of the system in protecting women's safety.…”
Get full text

Review of Recent Advances in Thiazolidin-4-One Derivatives as Promising Antitubercular Agents (2021–Present) by Wiktoria Drzał, Nazar Trotsko

“…Several compounds demonstrate potent inhibitory effects with MIC values lower than or comparable to first-line TB drugs, alongside favorable cytotoxicity profiles. …”
Get full text

SDG integration into the management of region’s sustainable development by Татьяна Алферова

“…Based on the analysis and synthesis of scientific information, the author applied the methods of conceptual and functional modeling to design and describe the SDG integration into regional development programs, as well as research integration into preparing political decisions in the field of sustainable development. …”
Get full text

Reliability Methods in Maintenance and Failure Analysis of Marine Systems by Damir BUDIMIR, Ivan GRGUREVIĆ, Jasna LEDER HORINA

“…HMM revealed how changes in pump performance directly impact engine functionality, whereas failure data alone often fail to provide a clear understanding of system conditions. …”
Get full text