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66261
RET enhancer haplotype-dependent remodeling of the human fetal gut development program.
Published 2023-11-01“…Here, we demonstrate that these RET enhancer variants specifically alter the human fetal gut development program through significant decreases in gene expression of RET, members of the RET-EDNRB gene regulatory network (GRN), other HSCR genes, with an altered transcriptome of 2,382 differentially expressed genes across diverse neuronal and mesenchymal functions. A parsimonious hypothesis for these results is that beyond RET's direct effect on its GRN, it also has a major role in enteric neural crest-derived cell (ENCDC) precursor proliferation, its deficiency reducing ENCDCs with relative expansion of non-ENCDC cells. …”
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66262
ANALYSIS OF FOREIGN EXPERIENCE OF INTRODUCTION OF THE SCHOOL DRESS CODE
Published 2016-12-01“…The correlation between the wording of the requirements of the dress code and the effectiveness of its implementation from the point of view of minimization of internal stresses in the school team is defined.Practical significance. …”
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66263
Synthesis and Characterization of TiO2 Nanoparticle as Adsorbent on The Treatment of Methylene Blue Dye Pollutant
Published 2019-06-01“…Infrared spectroscopy of Ti-O functional group was at 467 cm-1 and there were hydroxyl groups of the surface TiO2. …”
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66264
Expert-Trajectory-Based Features for Apprenticeship Learning via Inverse Reinforcement Learning for Robotic Manipulation
Published 2024-11-01“…This paper explores the application of Inverse Reinforcement Learning (IRL) in robotics, focusing on inferring reward functions from expert demonstrations of robot arm manipulation tasks. …”
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66265
Photodynamic therapy for oral cancer: Mechanisms, efficacy, and clinical applications
Published 2024-09-01“…PDT's non-invasive nature and potential for preserving critical anatomical functions make it particularly suitable for cases where surgical intervention may pose higher risks or affect quality of life adversely. …”
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66266
Physically secure and fog-enabled lightweight authentication scheme for WBAN
Published 2025-08-01“…The above-said shortcomings are addressed by proposing a lightweight, physically secure, fog-enabled authentication scheme that guarantees data privacy and system resilience by integrating Physically Unclonable Functions ( $$\:PUFs$$ ) and Fog Computing. This approach involves two phases: WBAN node registration and secure anonymous authentication. …”
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66267
EDUCATION AND EDUCATIONAL SYSTEM MANAGEMENT: STATUS, TRENDS, PROBLEMS AND PROSPECTS
Published 2017-03-01“…Detailed analysis of paradigmatic foundations of management is carried out; its systemacity and balance are presented from the positions of management members and a specific variety of the functions realized by them. System-genetic foundations of management, its recurrence, compliance with the principles of system inheritance are analysed; effectiveness, equifinality, management efficiency in its social, economic, pedagogical and organizational measurements are studied.Scientific novelty concludes in the reasons identification of a gap between the proper and existing management of an educational system. …”
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66268
Development of RNA interference-based therapy for rare genetic diseases
Published 2024-08-01“…Nonetheless, challenges remain, such as side effects, difficulties in targeting specific cells, and high development cost. …”
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66269
Design and Processing of Metamaterials
Published 2025-04-01“…According to recent developments, novel devices and tools based on metamaterials are attracting great interest as they offer improved performance, functionality, sensitivity, biocompatibility, complex structures, and design freedom. …”
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66270
The bridge to business evolvability: strategic agility’s mediating role for innovation and collaboration
Published 2025-03-01“…To foster SA and enhance BE, hotel executives should prioritize investments in adaptive technologies, promote cross-functional collaboration, and cultivate an organizational culture that embraces continuous innovation and strategic responsiveness. …”
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66271
Smart and Sustainable Doha? From Urban Brand Identity to Factual Veracity
Published 2024-12-01“…With most of Qatar’s population residing in the metropolitan area, Doha effectively functions as a city-state. While the rapid growth of this Gulf metropolis is often celebrated as an emerging center of economic and cultural activity, the subtle yet crucial socio-cultural influences shaping its development as a rentier city-state are frequently overlooked in the existing literature. …”
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66272
Novel Multimodal Fusion Algorithm for Non-Intrusive Anxiety Detection
Published 2025-03-01“…Early detection of anxiety disorders in a non-intrusive manner is crucial, as these conditions can profoundly impact an individual’s health and daily functioning. Traditional approaches relying solely on unimodal data often fall short, potentially introducing bias and inaccuracies. …”
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66273
The Use of Vascular Endothelial Growth Factor Inhibitors in Patients with Proliferative Diabetic Retinopathy
Published 2022-07-01“…Diabetic retinopathy (DR) have been taking a leading position among retinal disorders, causing a persistent and significant decrease in visual functions. The base of the disease is a retinal vascular microangiopathy, which induces a tissue ischemia and excessive production of vascular endothelial growth factors. …”
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66274
Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction
Published 2025-07-01“…The effects of CELF2 overexpression on cell proliferation and angiogenesis were assessed via CCK-8 and angiogenesis assays. …”
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66275
Experimental Evaluation of Mechanical Properties in Transmission Mechanisms of Electromechanical Actuators
Published 2025-03-01“…However, the use of EMAs is currently limited to non-safety-critical functions due to the still limited understanding of their behavior. …”
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66276
Impact of adjuvant intrabladder therapy on quality of life in patients, suffering musculo-noninvasive cancer of the bladder
Published 2020-09-01“…The lower quality of life in patients of Group I, who obtained immunotherapy with BCG vaccine, was connected with multiple side effects and enhanced toxicity of this therapy, accordingly.…”
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66277
Analisis Komparasi Kebijakan Fiskal Masa Umawiyah, Abbasiyah, Umawiyah Di Spanyol dan Kerajaan Kecil
Published 2025-03-01“…Fiscal policy during these times not only functions to collect revenue but also to support development, social welfare, and maintain political stability. …”
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66278
An asymmetric NARDL approach to the J-curve phenomenon and export competitiveness in India-US trade
Published 2025-12-01“…Using the Non-linear Autoregressive Distributed Lag (NARDL) model, impulse response functions, and other econometric techniques, the study investigates both short- and long-run dynamics. …”
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66279
Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds
Published 2023-01-01“…Therefore, additional research is required to comprehend the usefulness of these chemicals in many functional areas and to improve the present understanding of macrofungi.…”
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66280
KNOT OPTIMIZATION FOR BI-RESPONSE SPLINE NONPARAMETRIC REGRESSION WITH GENERALIZED CROSS-VALIDATION (GCV)
Published 2025-01-01“…Nonparametric regression is a statistical method used to model relationships between variables without making strong assumptions about the functional form of the relationship. Nonparametric regression models are flexible and can capture complex relationships that may not be adequately represented by simple parametric forms. …”
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