In vitro cytotoxicity assessment of biosynthesized Apis mellifera bee venom nanoparticles (BVNPs) against MCF-7 breast cancer cell lines by Vikram Jadhav, Arun Bhagare, Ashwini Palake, Kisan Kodam, Akshay Dhaygude, Anant Kardel, Dnyaneshwar Lokhande, Jayraj Aher

“…These functional groups, as confirmed by their specific stretching and bending vibrational modes, contribute to the diverse biological activities of BVNPs, including cytotoxicity against MCF-7 breast cancer cells. …”
Get full text

A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…A prognostic model was built with Cox and Least Absolute Shrinkage and Selection Operator (LASSO) methods and validated by Kaplan-Meier analysis, Receiver Operating Characteristic (ROC) curves, and Principal Component Analysis (PCA). Functional analysis revealed immune infiltration and drug sensitivity differences. …”
Get full text

Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…In this study, new piperidine-based ligands, analogs of the potent and selective D4R compounds 77-LH-28-1 (<b>7</b>) and its 4-benzyl analog <b>8</b>, were synthesized and studied to investigate the effects produced by variations in the distances between the pharmacophoric features on the D4R affinity and selectivity. …”
Get full text

Internal transformation of fertilizer-derived organic nitrogen fractions in an arable soil and the regulation of maize residue mulching by Shuhan Dong, Fangbo Deng, Feng Zhou, Sicong Ma, Zhenying Wang, Wanqi Wang, Wei Zhang, Hongbo He, Xudong Zhang

“…Therefore, the HN served as a reservoir with residual effects of fertilizer N and both the HN and NHN fractions contributed to long-term N retention in the soil. …”
Get full text

Numerical thermodynamic-economic study and machine learning-based optimization of an innovative biogas-driven integrated power plant combined with sustainable liquid CO2 and liquid... by Ruijia Yuan, Fan Shi, Azher M. Abed, Mohamed Shaban, Sarminah Samad, Ahmad Almadhor, Barno Abdullaeva, Mouloud Aoudia, Salem Alkhalaf, Samah G. Babiker

“…The optimal outcomes reveal the mentioned objective functions' values at 47.22 %, 58.73 M$, and 33.53 $/GJ, respectively. …”
Get full text

Straw Incorporation and Nitrogen Fertilization Enhance Soil Organic Carbon Sequestration by Promoting Aggregate Stability and Iron Oxide Transformation by Zhichang Jing, Shirong Zhang, Zeqiang Sun, Zhaohui Liu, Shenglin Liu, Xiaodong Ding

“…Soil barrenness and a poor stability of organic carbon are important factors restricting sustainable agricultural development. The effects of straw incorporation and nitrogen (N) fertilization on soil aggregates, soil organic carbon (SOC) functional groups, iron (Fe) oxides, and SOC sequestration were evaluated in saline–alkali soil. …”
Get full text

COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression by Yajun Wang, Bo Zhang, Fengjuan Fan, Fei Zhao, Jian Xu, Yuhuan Zheng, Chunyan Sun, Yu Hu

“…Methods: Comprehensive bioinformatics analyses were conducted on bone marrow and extramedullary samples to determine the expression of COMMD3, which was validated through in vitro and in vivo functional assays. The MM cell lines RPMI8226 and MM1S underwent lentiviral transfection for COMMD3 overexpression and knockdown. …”
Get full text

Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies by Yuhan Wang, Tingting Zhou, Jiajing Zhao, Hongjun Zhu, Xiaodong Tan, Jiahao Chen, Zhuojun Zhang, Lijuan Shen, Shu Lu

“…This review aims to systematically analyze how structural and functional remodeling of Ca2+-handling proteins drives DCM progression and to evaluate therapeutic strategies targeting these pathways. …”
Get full text

Investigating the shared genetic structure between rheumatoid arthritis and stroke by Qian Qin, Yong’An Jiang, Hengyi Fan, Raorao Yuan, Bo Zhong, Yichen Zhang, Zile Zhang, Xin Lei, Jianhui Cai, Shiqi Cheng

“…Single nucleotide polymorphisms (SNPs) at risk were identified using genome-wide association study multiple trait analysis and PLINK software (P snp <5e-08), followed by functional localization and annotation using Functional Mapping and Annotation of Genome-Wide Association Studies to identify specific genes and genetic variants that may contribute to the disease. …”
Get full text

Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8 by Zhong-He Zhang, Zhong-He Zhang, Zhong-He Zhang, Hector Barajas-Martinez, Hector Barajas-Martinez, Hector Barajas-Martinez, Hong-Yi Duan, Hong-Yi Duan, Hong-Yi Duan, Guo-Hua Fan, Hong Jiang, Hong Jiang, Hong Jiang, Charles Antzelevitch, Charles Antzelevitch, Hao Xia, Hao Xia, Hao Xia, Dan Hu, Dan Hu, Dan Hu

“…The present study aims to explore the functional significance of Nav1.8 expression among different cell types present in the ventricular myocardium.MethodsThe effect of the specific Nav1.8 blocker, A-803467, on action potential was recorded from epicardial, mid-myocardial (M cells) and Purkinje tissue slices isolated from the canine left ventricle using standard microelectrode techniques and on late sodium current from Purkinje cells using patch-clamp techniques.ResultsA-803467 treatment did not significantly affect maximum diastolic potential, action potential amplitude or maximum rate of rise of the action potential upstroke in epicardial cells, M cells or Purkinje fibers. …”
Get full text

Trophic Change and Community Decline in Acrobat Ants After Rainforest Conversion to Cash Crops by Jessica Ehlers, Tamara R. Hartke, Noah Janotta, Amanda Mawan, Rizky Nazarreta, Rizky Desriana, Purnama Hidayat, Damayanti Buchori, Stefan Scheu, Melanie M. Pollierer, Jochen Drescher

“…This likely affects Crematogaster‐driven ecosystem functions in agricultural systems in Southeast Asia.…”
Get full text

CO-CREATION-HF protocol: clinical trial to evaluate the impact of a comprehensive and hybrid cardiac rehabilitation model on patients with heart failure by Pamela Seron, Daniela Gómez-Pérez, Edgardo Opazo-Díaz, Maria Jose Oliveros, Maria Francisca Contreras, Alejandra Salinas, Omar Andrade-Mayorga, Gabriel Nasri Marzuca-Nassr, Kathleen Saavedra, Cinthya Espejo, Sergio Muñoz, Fernando Lanas, Sherry L. Grace, Sherry L. Grace

“…The main outcomes are cardiorespiratory fitness (VO2 max), functional capacity (m from 6 MWT), and quality of life (Minnesota Living with Heart Failure Questionnaire). …”
Get full text

Incremental Prognostic Value of Hippocampal Metabolic Activity for Sudden Cardiac Death in Patients With Heart Failure With Reduced Ejection Fraction by Zhiyong Shi, Mingkai Yun, Binbin Nie, Yujie Bai, Yaqi Zheng, Enjun Zhu, Yuetao Wang, Marcus Hacker, Yongqiang Lai, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li

“…Results Overall, 34 (12.6%; median follow‐up, 4.3 years) patients experienced SCD‐related events. Functional myocardial scarring and HMA were strongly associated with SCD‐related events (all P<0.01). …”
Get full text

Magnitude and durability of ProC6C-AlOH/Matrix-Mtm vaccine-induced malaria transmission-blocking antibodies in Burkinabe adults from a Phase 1 randomized trial by Mohammad Naghizadeh, Kazutoyo Miura, Ebenezer Addo Ofori, Carole Long, Issaka Sagara, Alfred B. Tiono, Jordan Plieskatt, Michael Theisen

“…The Phase 1 clinical trial (PACTR202201848463189) conducted in Burkina Faso, showed ProC6C-AlOH/Matrix-M was safe, well tolerated, immunogenic and generated a functional antibody response to all three constituent antigens at the primary output (D70). …”
Get full text

The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers an... by A. N. Uvarova, L. V. Putlyaeva, E. A. Zheremyan, E. M. Stasevich, M. M. Murashko, E. A. Bogomolova, K. V. Korneev, D. E. Demin, A. M. Schwartz, D. V. Kuprash

“…This disorder is a chronic autoimmune inflammatory disease characterized by dysregulation of B lymphocytes, production of a large number of autoantibodies, and various abnormalities in immune regulation, such as changes in the number and functions of T helper cells and T regulatory (Treg) lymphocytes. …”
Get full text

Efficacy and Safety of Intravenous Thrombolysis Beyond 4.5 Hours in Ischemic Stroke: A Systematic Review and Meta-Analysis by Muhammad Ahmad, Chavin Akalanka Ranasinghe, Mais Omar Abu-Sa’da, Durga Prasad Bhimineni, Muhammed Ameen Noushad, Talal Warsi, Ahmad Mesmar, Munikaverappa Anjanappa Mukesh, Sagar K. Patel, Gabriel Imbianozor, Ali Mustansir Bhatty, Ahmad Alareed, Quratul Ain, Eeshal Zulfiqar, Mushood Ahmed, Raheel Ahmed

“…Compared to controls, IVT significantly improved excellent functional outcomes [OR: 1.40; 95% CI: 1.21–1.62] and good functional outcomes [OR: 1.26; 95% CI: 1.06–1.50] at 90 days. …”
Get full text

Ayahuasca partially preserves striatal integrity in juvenile non-human primates exposed to chronic stress: evidence from stereological evaluation by Wigínio Gabriel Lira-Bandeira, Lílian Andrade Carlos Mendonça Batista, Andréa Silva Medeiros-Bandeira, Paulo Leonardo Araújo Góis Morais, Luiz Roberto Fernandes Pereira, Maria Lara Porpino Meiroz-Grilo, Jeferson Souza Cavalcante, Melquisedec Abiaré Dantas Santana, Ruthnaldo Rodrigues Melo Lima, Nicole Leite Galvão-Coelho, Fernando Vagner Lobo Ladd, Expedito Silva Nascimento

“…IntroductionThe striatum (St) integrates cognitive, motor, and limbic functions and plays a critical role in processing emotions, motivation, and rewards. …”
Get full text

Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…Preliminary results from a single institution pilot trial are promising: pain relief is substantial and side effects minimal. The goals of this study are to validate these findings in an international multisetting, and investigate the impact on quality of life and functional status among patients with terminal cancer.Methods and analysis A single-arm prospective phase II clinical trial. …”
Get full text

Parental perceptions of a wearable vital signs monitor for observation of newborns: in-depth interviews in three tertiary hospitals, Southwest Nigeria by Yetunde Olufisayo John-Akinola, Adejumoke Idowu Ayede, Ayomide Adeyemi, Assumpta Nantume, Adesewa Oluwatomisin Olaleye, Olugbenga Akinrinoye, Olukemi Oluwatoyin Tongo, Michael Abe Alao, Adenike Oluleye, Oluseye Sobande, Olatayo Sunday Olayemi, Bertha Akinyi Oketch, Rosena Olubanke Oluwafemi, Rosena Olubanke Oluwafemi, Patricia Ireti Eniowo, Samuel Ojo, Omolayo Adebukola Olubosede, Emmanuel Olaseinde Bello, Ismaila Sani, Teresa Cauvel, Sona Shah

“…Participants appreciated the device's functionality, ease of use, and potential to detect health issues in newborns. …”
Get full text

Unidirectional electric field enables reversible ferroelectric domain engineering by Xingan Jiang, Muzhi Li, Yuanyuan Cui, Xiao Wu, Zunyi Deng, Xiangping Zhang, Jianming Deng, Xiaolei Wang, Dongdong Zhang, Xiangdong Yang, Zhuoyin Peng, Zhao Liang, Xueyun Wang, Weiyou Yang

Get full text