Unraveling the Causal Links Between Immune Cells, Lipids, and Cardiovascular Diseases: Insights from Mendelian Randomization by Fengwei He, Tian Yang, Wentao Zhang, Ming Liu, Hao Wu

“…Mediation analyses showed LDL and triglycerides partially mediated CX3CR1-monocyte effects on MI risk. Functional enrichment identified cytokine signaling and inflammation in CVD. …”
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External Validation of a Prognostic Model for the Presence of Acute Appendicitis in Children by Olga N. Paize, Evgeniy A. Toneev, Aliia N. Mukhutdinova, Antonina V. Smolkina, Roman F. Shagdaleev, Eric A. Keshyan, Dmitry R. Shaidullin

“…Methods and Results: A new cohort of 101 pediatric patients with a confirmed diagnosis of acute appendicitis and 100 patients with functional gastrointestinal disorders were studied to assess the effectiveness of the developed logistic regression-based nomogram for predicting acute appendicitis in children. …”
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Systematic review and meta-analysis: risk factors for psoriatic arthritis. Part 1. by N. O. Pereverzina, L. S. Kruglova, T. V. Korotaeva, A. M. Lila

“…Correction of modifiable RFs, early prescription of appropriate therapy will help to reduce the number of PsA cases, the development of functional disorders and prevent the growth of disability. …”
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Herpetic infections in humans: modern approaches to etiopathogenetic therapy by D. S. Sukhanov, E. V. Timofeev, Yu. S. Alexeeva, S. N. Tretyakov, A. L. Korshunova

“…An important role is given to the use of indirect-acting drugs, among which the leading place is occupied by type I interferon drugs, which have a combined etiotropic (suppression of virus replication) and pathogenetic (restoration of functions of various parts of the immune system impaired by the virus) effect.Conclusion. …”
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Factors Influencing Older Adults’ Perception of the Age-Friendliness of Their Environment and the Impact of Loneliness, Technology Use, and Mobility: Quantitative Analysis by Eric Balki, Niall Hayes, Carol Holland

“…ObjectiveThis study examined how life-space mobility (LSM), a concept for assessing patterns of functional mobility over time, and loneliness impacted perceived AFEs and the moderating effect of technology. …”
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Clinacanthus nutans (Burm.f.) Lindau facilitates cuproptosis and ameliorates colon cancer progression by inhibiting PDE3B-mediated Apelin pathway by Gaoyun Zhou, Xueying Lin, Zhiheng Lai, Dewen Su, Long Lin, Xuewu Chen

“…The anti-tumor efficacy of CN was validated in HT29 and HCT116 cells co-treatment of CN and drug serum by functional assays and therapeutic effects on tumorigenicity were also evaluated in vivo. …”
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T&C-CROP: representing mechanistic crop growth with a terrestrial biosphere model (T&C, v1.5) – model formulation and validation by J. Buckley Paules, S. Fatichi, B. Warring, A. Paschalis

“…However, our understanding of how climate change will impact cropland functions is still limited. This knowledge gap is partly due to the simplifications made in terrestrial biosphere models (TBMs), which often overlook essential agricultural management practices such as irrigation and fertilizer application and simplify critical physiological crop processes.…”
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Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla by Paak Rewthamrongsris, Suphalak Phothichailert, Uraiwan Chokechanachaisakul, Prim Janjarussakul, Chatvadee Kornsuthisopon, Lakshman Samaranayake, Thanaphum Osathanon

“…Abstract Background Simvastatin modulates numerous stem cell functions, including stemness maintenance and differentiation. …”
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The Role of Light-Harvesting Complex II Organization in the Efficiency of Light-Dependent Reactions in the Photosynthetic Apparatus of <i>Pisum sativum</i> L. by Georgi D. Rashkov, Martin A. Stefanov, Amarendra N. Misra, Emilia L. Apostolova

“…In this study, the functions of the photosynthetic machinery were evaluated using chlorophyll <i>a</i> fluorescence technique (PAM and JIP test) in pea plants (<i>Pisum sativum</i> L. cv Borec) and its LHC II oligomerization variants (mutants <i>Costata 2</i>/<i>133</i> and <i>Coeruleovireus 2</i>/<i>16</i>). …”
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PARAMETERS OF ARACHYDONIC ACID CYCLE METABOLISM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ON THE BACKGROUND OF COMPLEX THERAPY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS by V. P. Mikhin, A. I. Shveinov, M. A. Chernyatina, A. V. Kharchenko, G. V. Panchenko, N. I. Gromnatsky

“…Conclusion. Given the lower functional activity of thromboxane B3 and the decrease in the ratio of TxB2 / TxB3, against the background of Omega-3 triglycerides [EPA/DGA — 1.2/1-90%] therapy, one can judge the presence of an independent antiaggregant effect of omega-3-polyunsaturated fatty acids as a result of their use in patients with MI.…”
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Modulation of Rage and CD147 in Cerebral Amyloid Angiopathy <i>in vitro</i> by A. I. Mosiagina, E. B. Boytsova, E. D. Khilazheva, E. A. Teplyashina, A. V. Morgun, A. B. Salmina

“…In the study of Alzheimer’s disease (AD), the cause-and-effect relationship between neurodegenerative changes and the accompanying amyloid angiopathy is becoming increasingly important. …”
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Peculiarities of university brand formation in the context of political branding of the front-line territory (on the example of the city of Kherson) by Serhii Kostiuchkov

“…The essence of the political brand of the territory, which primarily performs ideological, cultural, patriotic, political and other functions, is revealed. The role of territory branding (geobranding) is shown as a process of brand creation, which aims to promote local, regional and national projects, in particular - political ones, focused on the progressive development of a specific territory; under favorable socio-political conditions, a promising brand will provide an opportunity to effectively invest a regional resource in the political capital of society. …”
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Supervised machine learning and genotype by trait biplot as promising approaches for selection of phytochemically enriched Rhus coriaria genotypes by Hamid Hatami Maleki, Reza Darvishzadeh, Ahmad Alijanpour, Yousef Seyfari

“…Here, the identified phytochemically superior sumac group was effectively distinguished from the inferior sumac group using ISSRs information via supervised machine learning. …”
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IFN-γ could induce ferroptosis in keloid fibroblasts by inhibiting the expression of serpine2 by Jingyan Huang, Shun Yu, Jing Luo, Xusong Luo, Jun Yang, Xiuxia Wang

“…Interferon-gamma (IFN-γ) has shown significant therapeutic effects when used alone or in combination with other agents. …”
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Conceptual model of social-ecological resilience in Mexican forests communities by Lesly Elizabeth Solís-Mendoza, Leopoldo Galicia, Sophie Véronique Ávila-Foucat, Tuyeni Heita Mwampamba

“…We utilized the grounded theory method, which combines quantitative and qualitative data from existing literature and empirical knowledge about the structure and functioning of forests and human communities. Then, we developed a dynamic system conceptual model to describe the cause-effect processes of forest disturbances and resilience capacities integrating qualitative interdisciplinary information to establish causal links and adaptive strategies. …”
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Protection of the public in a large-scale radiation accident: mitigation of negative social consequences of protective actions. Part 1. Interpretation of dose characteristics of em... by Yu. O. Konstantinov

“…At a stage of an emergency, when there is enough information to consider, that the maximal public exposure to radiation will not achieve thresholds of deterministic effects, the decisions on protective actions violating normal human beings and socioeconomic functioning of territory is justified to accept on the basis of doses for the average person, instead of those for the most exposed people.…”
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Computational design and cheminformatics profiling of omeprazole derivatives for enhanced proton pump inhibition of potassium-transporting ATPase alpha chain 1. by Mahmudul Hasan, Md Ifteker Hossain, Noimul Hasan Siddiquee, Ezaz Ahmed, Md Walid Hossain Talukder, Md Rahamatolla, Tasrin Nahar, Popy Rani Paul, Mahmudul Hassan Suhag, Monir Uzzaman

“…The geometrical attributes of the analogues were further confirmed through spectral and quantum computational analysis based on density functional theory (DFT) and a B3LYP/6-31G+ G (d, p) basis set. …”
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An Adaptive PSO Approach with Modified Position Equation for Optimizing Critical Node Detection in Large-Scale Networks: Application to Wireless Sensor Networks by Abdelmoujib Megzari, Walid Osamy, Bader Alwasel, Ahmed M. Khedr

“…We employ discrete PSO (DPSO) along with the modified position equation (MPE) to effectively solve the CNDP, making it applicable to various k-vertex variations of the problem. …”
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Nisin-preconditioned mesenchymal stem cells combatting nosocomial Pseudomonas infections by Sara Enayati, Raheleh Halabian, Parvaneh Saffarian, Hossein Aghamollaei, Pardis Saeedi

“…MSCs preconditioned with Nisin were characterized using microscopy, flow cytometry, gene expression analysis, and functional assays. The effects of preconditioning on the viability, phenotype, differentiation capacity, antimicrobial peptide expression, and antibacterial activity of MSCs against Pseudomonas aeruginosa were tested in vitro. …”
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Electroacupuncture Mitigates TRPV1 Overexpression in the Central Nervous System Associated with Fibromyalgia in Mice by Doan Thi Ngoc Anh, Yi-Wen Lin

“…Background: Fibromyalgia (FM) is characterized by chronic pain, significantly affecting the quality of life and functional capabilities of patients. In addition to pain, patients may experience insomnia, chronic fatigue, depression, anxiety, and headaches, further complicating their overall well-being. …”
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