Protease-responsive protein hydrogel enabling spatiotemporal ClO2 release for precision treatment of intracellular infections and periodontitis by Xianxian Huang, Yingjuan Zhang, Yonghui Huang, Qiurui Hu, Zhisong Mai, Yuan Qin, Cui Huang, Yanhua Wei, Fengyuan Zhou, Yicai Luo, Yinge Wei, Xinglu Jiang, Hongbing Liao

“…The synergistic integration of antibacterial and regenerative functions establishes the CD/BSA/GEL hydrogel as a breakthrough platform for precision-guided periodontal therapy.…”
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Simulated Gastrointestinal Digestion and In Vitro Fecal Fermentation of Purified <i>Pyracantha fortuneana</i> (Maxim.) Li Fruit Pectin by Qingrui Xu, Yiyi Lv, Xiaohui Yuan, Guichun Huang, Zhongxia Guo, Jiana Tan, Shuyi Qiu, Xiaodan Wang, Chaoyang Wei

“…Meanwhile, PFP promotes the reproduction of beneficial bacteria such as <i>Bacteroides</i>, <i>Dialister</i>, and <i>Dysgonomonas</i>, inhibits the growth of harmful bacteria like <i>Proteus</i>, and generates metabolites such as thiamine, leonuriside A, oxoadipic acid, S-hydroxymethylglutathione, and isonicotinic acid, which exert beneficial effects on human health. These results indicate that PFP has great potential in regulating the gut microbiota and generating beneficial metabolites to promote intestinal functional health and can be used as a prebiotic to prevent diseases by improving intestinal health.…”
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Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α by Isela Martínez-Reza, Lorenza Díaz, David Barrera, Mariana Segovia-Mendoza, Sigifredo Pedraza-Sánchez, Giovanny Soca-Chafre, Fernando Larrea, Rocío García-Becerra

“…In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1β and TNF-α through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.…”
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Rapid Mental Stress Evaluation Based on Non-Invasive, Wearable Cortisol Detection with the Self-Assembly of Nanomagnetic Beads by Junjie Li, Qian Chen, Weixia Li, Shuang Li, Cherie S. Tan, Shuai Ma, Shike Hou, Bin Fan, Zetao Chen

“…The rapid and timely evaluation of the mental health of emergency rescuers can effectively improve the quality of emergency rescues. …”
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Anti-DAMP therapies for acute inflammation by Russell Hollis, Russell Hollis, Russell Hollis, Megan Tenet, Megan Tenet, Monowar Aziz, Monowar Aziz, Monowar Aziz, Ping Wang, Ping Wang, Ping Wang

“…These molecules are confined within cells under normal conditions and perform essential physiological functions. However, upon their extracellular release during cellular injury, they act as alarmins, engaging pattern recognition receptors (PRRs) on immune cells. …”
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Ultrafast Electron Dynamics at the Water‐Modified InP(100) Surface by Jonathan Diederich, Agnieszka Paszuk, Isaac Azahel Ruiz Alvarado, Marvin Krenz, Mohammad Amin Zare Pour, Diwakar Suresh Babu, Jennifer Velazquez Rojas, Christian Höhn, Yuying Gao, Klaus Schwarzburg, David Ostheimer, Rainer Eichberger, Wolf Gero Schmidt, Thomas Hannappel, Roel van deKrol, Dennis Friedrich

“…Pulsed water exposure preserves electronic states and significantly increases lifetimes at the conduction band minimum (CBM). Density‐functional theory (DFT) calculations attribute these findings to suppression of surface vibrational modes in the top P‐layer by water exposure, reducing electronic transition probabilities of near‐band‐gap surface states. …”
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Soil Microbial Properties of Durum Grown after Camelina, Carinata, Cover Crops, and Fallow by Sadikshya R. Dangi, Brett L. Allen, Jay D. Jabro, Tatyana A. Rand, Joshua W. Campbell, Rosalie B. Calderon

“…Future work is required to elucidate the biological mechanisms and functions of the soil microbial communities in the preceding and subsequent crop relative to soil health and crop productivity.…”
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Impact of a physical activity program on the health-related quality of life in pediatric cancer patients: a study protocol by Gustavo Galárraga, Gustavo Galárraga, Rebecca Wurtz, Marcos Di Stefano, Marcos Di Stefano, Libet Bosch, Erika Villanueva, Karen Unda, Yunqi Yu, Carmen Apolo, Camila Coloma, José Francisco López-Gil, José Francisco López-Gil

“…However, those living with cancer often experience reduced physical activity levels, which negatively impact their functional capacity and health-related quality of life (HRQoL). …”
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Efficacy and safety of fractional carbon dioxide laser followed by 5-aminolevulinic acid photodynamic therapy for keloids by Hao Jiang, Xiuhua Hu, Haiyan Xiang, Huiling Kou, Junbo Zhang, Xingcun Zhang, Xinying Li, Kunqian He, Yuangang Lu

“…Background: Keloids are aggressive fibroproliferative disorders that cause aesthetic and functional damage. Photodynamic therapy (PDT) has shown promise as a novel treatment for keloids. …”
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RESILIENCE (Retrospective Linkage Study of Autoimmune Encephalitis): protocol for an Australian retrospective cohort study of outcomes in autoimmune encephalitis using data linkage... by David Brown, Wendyl D’Souza, Mark Cook, Andrew McLean-Tooke, David Gillis, Udaya Seneviratne, James Boyd, John Dunne, Nicholas Lawn, Ximena Camacho, Christine Bundell, Nerissa Jordan, Sudarshini Ramanathan, Fabienne Brilot, Kerri M Prain, Elaine Pang, Katrina Lambert, Russell Dale, Lisa Gillinder, Emma Whitham, Saxon Douglass, Amy Jean Halliday, Greg Bryson, Alan Lai, Wendyl Jude D’Souza

“…Statistical analyses, including random mixed-effects regression models, will assess treatment effects, covariates and outcomes.Ethics and dissemination This project has been approved by the leading investigators’ institutional Human Research Ethics Committee (HREC), the St Vincent’s Hospital Melbourne HREC, as well as the Australian Institute of Health and Welfare HREC and relevant jurisdictional HRECs where required. …”
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Change of soil quality based on humic acid with date palm compost incorporation by Hadda Ben Mbarek, Imen Ben Mahmoud, Rayda Chaker, Hafedh Rigane, Sameh Maktouf, Aissa Arous, Nabil Soua, Mouna Khlifi, Kamel Gargouri

“…Purpose The most important factor affecting soil quality is soil humic fraction. Effects of adding carbon in soil humic compounds in arid environments have only been slightly investigated. …”
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Chemical Profiling and In Vitro Evaluation of Bioactive Properties of <i>Evernia prunastri</i> Extract: Implications for Therapeutic Applications by Dejan Stojković, Jelena Živković, Stefani Bolevich, Sergey Bolevich, Gokhan Zengin, Uroš Gašić, Marina Soković

“…The extract demonstrated a broad spectrum of biological activities, including enzyme inhibition, antioxidant effects, and antibacterial properties. This study highlights the potential of <i>E. prunastri</i> as a functional food, providing a rich source of bioactive compounds with numerous health-promoting effects, and it suggests its relevance in therapeutic applications for chronic diseases such as diabetes, Alzheimer’s, and bacterial infections.…”
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Closed-loop versus open-loop “remind-to-move” treatment using wearables for hemiparetic upper extremity in patients after stroke: A proof-of-concept study by Kenneth N. K. Fong, Jasmine P. Y. Pak, Alissa H. L. Koo, Maggie M. K. Szeto, Natalie M. T. Wong, Keily K. Y. Yau, Sharon F. M. Toh, Vivian W. Lou, Hector W. H. Tsang, Gary K. K. Lau

“…The closed-loop group showed a more significant improvement in movement frequency, hand functions, and actual arm use than did the open-loop group. …”
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Exogenous melatonin alleviates drought stress in cotton by enhancing root cortical activity and metabolic adaptation by Haitao Zhang, Congcong Guo, Congcong Guo, Hongchun Sun, Lingxiao Zhu, Ke Zhang, Yongjiang Zhang, Zhanbiao Wang, Cundong Li, Liantao Liu

“…IntroductionThe root cortex plays a critical role in water uptake and metabolic activity, directly influencing root functionality. However, despite melatonin’s known role in plant stress tolerance, its mechanisms in modulating root cortical anatomy and metabolic adaptation under drought remain unclear. …”
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ZIF-based heterojunction filler enhancing Li-ion transport of composite solid-state electrolytes by Jianshuai Lv, Yuhang Li, Ke Yang, Xinyu Liu, Ying Dou, Zheng Zhang, Danfeng Zhang, Peiran Shi, Ming Liu, Yan-Bing He

“…This work offers valuable insights into the design of functional fillers for CSEs with highly efficient ion transport.…”
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The Role of Physical Activity in Managing ADHD Symptoms in Children and Adolescents – Review of Current Literature by Barbara Chojnacka, Aleksandra Ożga, Julia Wątor, Agnieszka Woźniacka, Jerzy Krzeszowiak, Barbara Boba, Tomasz Pulanecki, Alicja Podolska, Sylwia Bryksy, Patrycja Kolano

“…Conclusions: This review’s findings show that physical activity interventions benefit ADHD symptoms and executive functions in children and adolescents. Results of the studies showed that physical activity, especially organized closed-skill activities like running and aerobic training, enhanced the core ADHD symptoms (impulsivity, attention dysregulation, hyperactivity) the most, while open-skill activities that require real-time adaptation to environmental changes, had some effect on inhibitory control. …”
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Lactylation of Mitochondrial Adenosine Triphosphate Synthase Subunit Alpha Regulates Vascular Remodeling and Progression of Aortic Dissection by Tao Yu, Xiaolu Li, Chao Wang, Yanyan Yang, Xiuxiu Fu, Tianxiang Li, Wentao Wang, Xiangyu Liu, Xiaoxin Jiang, Ding Wei, Jian-Xun Wang

“…These effects ultimately contribute to the phenotypic transformation of human aortic vascular smooth muscle cells and enhanced synthesis and secretion of matrix metalloproteinases. …”
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Afil, a Lectin from <i>Aplysina fistularis</i>, Exhibits Antibiofilm and Synergistic Antibacterial Activity Against Resistant Bacteria by Francisco Regivanio Nascimento Andrade, João Marcelo de Sousa Silva, Jéssica de Assis Duarte, Philippe Lima Duarte, Pedro Arthur Sousa Tabosa, Manoel Ferreira da Costa Filho, Juliana Sampaio Nogueira Marques, Alexandre Lopes Andrade, Renata Pinheiro Chaves, Mayron Alves de Vasconcelos, Elielton Nascimento, Ulisses Pinheiro, Edson Holanda Teixeira, Celso Shiniti Nagano, Alexandre Holanda Sampaio, Rômulo Farias Carneiro

“…Overall, our findings highlight the potential of AfiL as a novel antibiofilm agent with species-specific modulatory effects on antibiotic activity and provide new insights into the functional versatility of sponge-derived lectins in microbial control strategies.…”
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Genetic deletion of the sodium phosphate cotransporter NaPi2a ameliorates heart failure in mice by Hiroko Yamauchi-Sawada, Tomoharu Ida, Masashi Nakamura, Minato Umehara, Natsuko Okuno-Ozeki, Itaru Nakamura, Yayoi Matoba, Atsushi Minamida, Yasuto Sunahara, Tomohiro Nakata, Kunihiro Nakai, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Noriyuki Yamashita, Yuhei Kirita, Keiichi Tamagaki, Benjamin D. Humphreys, Satoaki Matoba, Tetsuro Kusaba

“…Sodium-phosphate co-transporter 2a (NaPi2a) is predominantly expressed in the apical membrane of proximal tubular epithelia and functions to reabsorb filtered phosphate and sodium. …”
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Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial by Nagore Iriarte-Yoller, José Etxaniz-Oses, Cristobal Pavón-Navajas, Mikel Tous-Espelosin, Pedro M. Sánchez-Gómez, Sara Maldonado-Martín, Ana B. Yoller-Elburgo, Edorta Elizagarate-Zabala

“…It has been shown that exercise has a low-to-moderate effect on MDD, but there is a lack of evidence on exercise interventions in RMD patients. …”
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