Comorbidity Between Hikikomori and Autistic Traits May Be Identified as a Phenotypical Presentation Characterized by Greater Severity by Liliana Dell’Osso, Benedetta Nardi, Dario Muti, Chiara De Felice, Valeria Tognini, Francesca Parri, Federico Giovannoni, Filippo Del Grande, Chiara Bonelli, Gabriele Massimetti, Stefano Pini, Andrea Fiorillo, Barbara Carpita

“…<b>Objectives</b>: Hikikomori is a condition characterized by extreme social withdrawal, functional impairment, and mental distress, which has gained increasing recognition worldwide. …”
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Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling by Zongjuan Li, Yang Zhang, Weifeng Hong, Biao Wang, Yixing Chen, Ping Yang, Jian Zhou, Jia Fan, Zhaochong Zeng, Shisuo Du

“…Studies of the gut–liver axis have enhanced our understanding of the pathophysiology of various liver diseases and the mechanisms underlying the regulation of the effectiveness of therapies. Radiotherapy (RT) is an important therapeutic option for patients with unresectable hepatocellular carcinoma (HCC). …”
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A comparative investigation of ultrasonication and magnetic stirring methods for green synthesis of zinc oxide nanoparticles using Punica granatum peels by Komal Bhandari, Niki Nautiyal, Geeta Bhandari, Archna Dhasmana, Sanjay Gupta, Saurabh Gangola, Sunil Kumar, Azmat Ali Khan, Sabiha Fatima, Pradeep Kumar

“…The research explores the potential of both methods for nanoparticles synthesis. The effects of both methods on nanoparticles size, crystallite size, functional group composition, and optical properties were investigated by different characterization techniques. …”
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Microwave-assisted optimization extraction for green chili paste and investigation of its alpha-glucosidase inhibitory activity with molecular docking and molecular dynamics simula... by Woorawee Inthachat, Natnicha Promyos, Uthaiwan Suttisansanee, Rungrat Chamchan, Sirinapa Thangsiri, Boonrat Chantong, Pornsiri Pitchakarn, Piya Temviriyanukul

“…The findings warrant further clinical validation for future applications as a functional ingredient, contributing to sustainable and health-conscious dietary interventions.…”
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The influence of correlated features on neural network attribution methods in geoscience by Evan Krell, Antonios Mamalakis, Scott A. King, Philippe Tissot, Imme Ebert-Uphoff

“…Our study is the first to quantify the effects of strong correlation on XAI, to investigate the reasons that underlie these effects, and to offer a promising way to address them.…”
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Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain by Ningjing Song, Ningjing Song, Ningjing Song, Ningjing Song, Ling Long, Ling Long, Ling Long, Ling Long, Nianquan Liu, Nianquan Liu, Nianquan Liu, Nianquan Liu, Yujun Luo, Yujun Luo, Yujun Luo, Yujun Luo, Meng Wei, Meng Wei, Meng Wei, Meng Wei, Hai Huang, Hai Huang, Hai Huang, Hai Huang, Wan Liu, Wan Liu, Wan Liu, Wan Liu

“…Neural oscillations play a critical role in the regulation of brain functions, with theta waves (4–8 Hz) in the sensorimotor cortex significantly influencing pain perception and modulation. …”
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USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination by Sha Hu, Zhouxiang Wang, Kun Zhu, Hongjie Shi, Fang Qin, Tuo Zhang, Song tian, Yanxiao Ji, Jianqing Zhang, Juanjuan Qin, Zhigang She, Xiaojing Zhang, Peng Zhang, Hongliang Li

“…Conclusions USP29 functions as a novel negative regulator of MASLD by stabilizing ACSL5 to promote FAO. …”
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Site suitability analysis of urban green parks in Ranchi city using GIS–AHP based multi-criteria decision analysis by Md Saharik Joy, Priyanka Jha, Pawan Kumar Yadav, Taruna Bansal, Pankaj Rawat, Shehnaz Begam

“…Urban green parks (UGPs) help create sustainable cities while providing fundamental ecological functions. However, rapid urbanization has destroyed crucial green areas in Ranchi City, endangering inhabitants’ health. …”
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Technological and microbiological characterization of an industrial soft-sliced bread enriched with chitosan and its prebiotic activity by Margherita D'Alessandro, Maria Alessia Schouten, Davide Gottardi, Sara Cortesi, Santina Romani, Francesca Patrignani

“…Several studies have described the effects of chitosan as an ingredient in bread, particularly from a technological and functional point of view. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC by Maliazurina B. Saad, Qasem Al-Tashi, Lingzhi Hong, Vivek Verma, Wentao Li, Daniel Boiarsky, Shenduo Li, Milena Petranovic, Carol C. Wu, Brett W. Carter, Girish S. Shroff, Tina Cascone, Xiuning Le, Yasir Y. Elamin, Mehmet Altan, Simon Heeke, Ajay Sheshadri, Joe Y. Chang, Percy P. Lee, Zhongxing Liao, Don L. Gibbons, Ara A. Vaporciyan, J. Jack Lee, Ignacio I. Wistuba, Cara Haymaker, Seyedali Mirjalili, David Jaffray, Justin F. Gainor, Yanyan Lou, Alessandro Di Federico, Federica Pecci, Mark Awad, Biagio Ricciuti, John V. Heymach, Natalie I. Vokes, Jianjun Zhang, Jia Wu

“…Benefit scores are calculated using five distinct functions derived from 28 genomic and 6 clinical features. …”
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Unveiling kaempferol glycosides as the key antiglycative components in butterfly pea (Clitoria ternatea) flower by Jun Wu, Jun Gong, Qiaochun Chen, Wen Hao, Jiayi He, Mingfu Wang, Qian Zhou

“…Collectively, our findings highlight the beneficial effects of BFPF with clearly identified active components, which might further promote its application in functional food and medical industry.…”
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Experimental case study for optimizing heat sink performance using ZnO nanocarriers integrated with phase change materials for environmental sustainability by Muhammad Farooq, Imran Zahid, M. Yasar Javaid, Noreen Sher Akbar, Enio Pedone Bandarra Filho, M. Farrukh Shahzad, M. Imran Khan, Mohammad Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Electronic equipment generates heat during prolonged operation, making efficient heat dissipation essential to ensure continuous functionality and prevent premature device failure. Accordingly, phase change materials (PCMs) were employed for thermal management; however, their low thermal conductivity limits their effectiveness in temperature-sensitive electronic systems. …”
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Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits by Dongbo Li, Chao Li, Ning Liu, Hanzhong Liu, Zhiju Yu, Quanjin Liu, Gang Shu, Juchun Lin, Wei Zhang, Guangneng Peng, Ling Zhao, Huaqiao Tang, Haohuan Li, Funeng Xu, Hualin Fu

“…Traditional Chinese medicine (TCM) has been widely used in animal due to its advantages of natural origin, diverse functions, safety, reliability, economy and environmental protection. …”
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Tannic acid-iron stabilized probiotic silver nano hybrids: Multi-target gut microbiota modulation and intestinal barrier restoration by Saisai Gong, Zhibo Zeng, Mingjue Liu, Xianfu Wang, Chuxian Quan, Muhammed Farhan Rahim, Yaping Wang, Aoyun Li, Md. F. Kulyar, Zhexue Lu, Jiakui Li

“…The limited efficacy and adverse effect profile of current pharmacological treatments for intestinal inflammation underscore the need for modalities that preserve gut microbiota balance while attenuating inflammation. …”
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Experimental investigation on the resistivity and mechanical properties of high-resistance cement-based grouting materials for mining by Bin Xu, Bin Xu, Bin Xu, Rongrong Qi, Shuning Dong, Zhenxue Dai, Shangxian Yin, Hewen Ma, Cen Zhong

“…These findings provide critical insights for developing high resistivity grouting materials with dual functionality as geophysical contrast agents and structural reinforcements.…”
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Anti‐Inflammatory and Antioxidant Activities of Polyphenols From Loquat (Eriobotrya japonica Lindl.) Leaf Hair in Lipopolysaccharide‐Induced In Vitro and In Vivo Models by Can Hu, Jiazheng Hu, Hongyu Ye, Mengxin Wang, Manxi Wu, Han Yang, Kang Chen, Jinping Cao, Yanshuai Wang, Yue Wang, Chongde Sun

“…Collectively, these findings demonstrate LLH polyphenols' potent antioxidant and anti‐inflammatory effects and suggest their potential as natural functional agents for managing inflammation‐related oxidative stress.…”
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Study on Prosthetic Hand Proprioception Feedback Based on Hybrid Vibro-Electrotactile Stimulation by Guangfei Wu, Wenqing Gu, Yi Luo, Xin Zhang, Lei Li, Jingming Hou, Haoyue Deng, Wensheng Hou, Lin Chen, Xing Wang

“…It enables accurate perception of prosthetic motion without the need for continuous visual monitoring, showing significant potential for enhancing everyday prosthetic functionality.…”
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Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials pa... by Keith W Muir, Gary Ford, Philip M Bath, Adnan I Qureshi, Thompson G Robinson, Rustam Al-Shahi Salman, Hisatomi Arima, Lisa J Woodhouse, Eivind Berge, Nikola Sprigg, Xia Wang, Tom J Moullaali, Zhe Kang Law, Candice Delcourt, Kailash Krishnan, Else C Sandset, Craig S Anderson, Yuko Palesch, John Potter, Jeff Saver, Nerses Sanossian, Ken Butcher, Kennedy R Lees, Janneke Horn

“…The primary outcome will be functional outcome according to the modified Rankin Scale. …”
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Surgical Robots Improve Tunnel Angle and Graft Bending Angle in Anatomic ACL Reconstruction: A Multicenter Study by Ling Zhang, Hansheng Hu, Wennuo Huang, Mengling Hu, Zhuman Li, Jinzhong Zhao, Wenyong Fei, Shaobai Wang

“…The results suggest that surgical robot-assisted ACL reconstruction enhances safety in the inclination of the tunnel and graft, helping to avoid potential biomechanical issues such as the wiper effect and the bungee effect, which may lead to tunnel widening and surgical failure.…”
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