Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious Diseases by Nidhi Varshney, Rajan Kumar Pandey, Amit Mishra, Sunil Kumar, Hem Chandra Jha

“…This review explores AURKA’s structural and functional roles, emphasizing its involvement in cell cycle progression. …”
Get full text

A view of magnesium alloy modification and its application in orthopedic implants by Kai Zhou, Qinghua Lu, Jianing Qin, Huanjun Shi, Peilei Zhang, Hua Yan, Haichuan Shi, Xingyao Wang

“…Magnesium plays a crucial role in the human body, where an adequate level is necessary for normal cell functions and disease prevention. Magnesium-based alloys possess an elastic modulus close to that of natural human bone, which can effectively mitigate stress shielding. …”
Get full text

Biomineralization‐Inspired Membranization Toward Structural Enhancement of Coacervate Community by Chunyu Zhao, Xiaoliang Wang, Lianning Li, Hu Huang, Bingzhao Wu, Lei Zhang, Xin Huang

“…Abstract The design and assembly of protocell models that can mimic the features and functions of life present a significant research challenge with the potential for far‐reaching impact. …”
Get full text

Multi-modal MRI for objective diagnosis and outcome prediction in depression by Jesper Pilmeyer, Rolf Lamerichs, Sjir Schielen, Faroeq Ramsaransing, Vivianne van Kranen-Mastenbroek, Jacobus F.A. Jansen, Marcel Breeuwer, Svitlana Zinger

“…Research Purpose: The low treatment effectiveness in major depressive disorder (MDD) may be caused by the subjectiveness in clinical examination and the lack of quantitative tests. …”
Get full text

TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury by Yunsheng Zhang, Yunsheng Zhang, Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Hanhan Dang, Chuanpeng Zhang, Chuanpeng Zhang, Kun He, Kun He, Xu Yang, Xu Yang, Zixi Wang, Zixi Wang, Li Zhang, Li Zhang, Li Zhang, Yanbing Yu, Yanbing Yu, Yanbing Yu

“…Pharmacological targeting of TREM-1 attenuates neuroinflammation, reduces cerebral edema, preserves blood-brain barrier integrity, and improves functional recovery. These effects are mediated through suppression of TREM-1-dependent NF-κB signaling and pyroptosis. …”
Get full text

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…Current treatment options do not distinguish between healthy and malignant B cells and are thereby often limited by severe side effects in the already immunocompromised patients. …”
Get full text

A sialic acid-binding protein in Toxoplasma gondii contains a conserved globular domain in apicomplexan parasites by Xiaoyu Sang, Yize Liu, Yiwei Zhang, Ran Chen, Ying Feng, Ning Jiang, Qijun Chen

“…Virtual screening of Food and Drug Administration (FDA)-approved compounds identified eltrombopag as a high-affinity molecule (ΔGbind = −8.3 kcal/mol) targeting the SA-binding pocket in TgSABP1. Functional validation demonstrated that eltrombopag effectively blocked the TgSABP1/6′SL-PAA interaction and significantly decreased host cell invasion of T. gondii tachyzoites. …”
Get full text

N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1 by Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador

“…Results The binding of the PD-L1N35A mutant to PD-1 was not effectively blocked by anti-PD-L1 and anti-PD-1 ICBs. …”
Get full text

Cyperotundone promotes chemosensitivity of breast cancer via SRSF1 by Chao Li, Chao Li, Lin Wang, Zhaoyun Liu, Xinzhao Wang, Luhao Sun, Xiang Song, Zhiyong Yu, Zhiyong Yu

“…Cyperotundone (CYT) is the major bioactive component of sedge and reported to exhibit multiple biological functions, including its potent cytotoxic effect on breast cancer cells. …”
Get full text

Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome by H. Keskin, K. Cadirci, K. Gungor, T. Karaaslan, T. Usta, A. Ozkeskin, A. Musayeva, F. Yesildal, F. Isman, H. Y. Zengin

“…Although the negative effects of high thyroid-stimulating hormone (TSH) values on glomerular filtration rate (GFR) levels have been known for years, the negative effects of increased TSH on GFR in euthyroid cases have been reported in recent years. …”
Get full text

Forsythoside B ameliorates neuroinflammation via inhibiting NLRP3 inflammasome of glial cells in experimental autoimmune encephalomyelitis mice by Yue Wang, Yongmin Chen, Jing Lu, Qinqin Xiao, Ge Li, Rong Wang, Rong Chen, Da-Qi Zhang

Get full text

Evaluation of Morphometric Factors on the Distribution of Debris: A Case Study on the Attica Ripples on the South of Paveh- Kermanshah Province, Iran by Mohammad Ahmadi

“…Then, in order to investigate the effect of environmental factors on variance distribution, slope parameters, amplitudes, curvature, elevation classes and solar radiation were extracted using DEM and ArcGIS spatial analysis functions. …”
Get full text

Comparison of Deep Learning Models for LAI Simulation and Interpretable Hydrothermal Coupling in the Loess Plateau by Junpo Yu, Yajun Si, Wen Zhao, Zeyu Zhou, Jiming Jin, Wenjun Yan, Xiangyu Shao, Zhixiang Xu, Junwei Gan

“…As the world’s largest loess deposit region, the Loess Plateau’s vegetation dynamics are crucial for its regional water–heat balance and ecosystem functioning. Leaf Area Index (LAI) serves as a key indicator bridging canopy architecture and plant physiological activities. …”
Get full text

Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling by Cheng Huang, Xi Huang, Xiaoyi Qiu, Xiangzhan Kong, Chunmiao Wu, Xue Jiang, Mingkang Yao, Minghui Wang, Liangping Su, Cui Lv, Ping‐Pui Wong

“…In animal studies, co‐injection of cancer cells with PCs compromises TKI effectiveness, independently of blood vessel functions, while inhibition of β5‐integrin restores tumor cell sensitivity. …”
Get full text

Biosynthesis and Characterization of Mn₃O₄ Nanoparticles Using <i>Bixa orellana</i> and <i>Nerium oleander</i> Leaf Extracts at Low Temperature and Neutral pH by Eiser Valle-Rivera, Segundo R. Jáuregui-Rosas, Sergio P. R. Avila-Concepción, Fanny V. Samanamud-Moreno, Gina G. Zavaleta-Espejo, Jovanna Huaman-Quispe, Sharol Gavidia-Sare, José A. Saldaña-Jiménez

“…The greatest effect on the bandgap was observed in nanoparticles synthesized with <i>N. oleander</i> extracts. …”
Get full text

Nitric oxide mediates nitrate induced alleviation of waterlogging stress in cucumber by Neda Hesari, Iman Mirmazloum, Katalin Jäger, Henriett Kolozs, Erzsébet Kiss-Bába, Maria Eduarda Soares Ramos, Imran Khan, Dorina Babinyec-Czifra, Anita Szegő, István Papp

“…Abstract Effects of waterlogging (WL) stress and its mitigation by nitrate (NO3 –) were investigated in a commercial cucumber hybrid line. …”
Get full text

ACUTE ATORVASTATIN RECAPTURE THERAPY IN CORONARY ARTERY BYPASS GRAFTING by A. V. Panov, M. L. Gordeev, A. A. Zhloba, T. F. Subbotina, I. V. Suhova, M. I. Buthashvili, I. T. Abesadze, M. Z. Alugishvili, N. L. Lohovinina, K. V. Korzhenevskaya, M. V. Solovyova, L. V. Mihaylova, E. S. Alekseevskaya

“…The study included 42 patients with stable effort angina II-IV functional class. A special criterion for selection was the taking atorvastatin at a dose of 20 mg/day for at least 30 days before patient was directed to surgical revascularization of the myocardium. …”
Get full text

Adsorption of Pb(II) from synthetic wastewater with alkali-activated blast furnace slag and lignin composite by M.A.H. Bhuyan, J. Carvalheiras, R.M. Novais, T. Luukkonen

“…Lead contamination in water is a serious environmental concern due to its ecotoxic effects. Adsorption is one possible method for treating lead-contaminated water. …”
Get full text

Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis by Saruul Erdenebileg, Yang-Ju Son, Myungsuk Kim, Sarangerel Oidovsambuu, Kwang Hyun Cha, Jaeyoung Kwon, Da Seul Jung, Chu Won Nho

“…Methods: To investigate the anti-inflammatory effects and alleviation of IBD, using a methanol extract of Saposhnikovia divaricata (Turcz.) …”
Get full text

MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury by Lei Yuan, Duo Wang, Yale Su, Long Yuan, Mixia Li, Dongdong Zheng, Cuilin Zhu, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu

“…In the oxidative stress model, MAFF overexpression demonstrated cardioprotective effects by maintaining cell viability, significantly reducing reactive oxygen species (ROS) accumulation in both cytoplasm and mitochondria, and attenuating pyroptosis-mediated cell death.ConclusionOur findings demonstrate that MAFF exerts protective effects against oxidative stress-induced cardiomyocyte injury, positioning it as a promising therapeutic target for myocardial protection. …”
Get full text