COMPARATIVE EFFICACY OF RITUXIMAB AND METHOTREXATE MONOTHERAPY IN STANDARD DOSES IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (PRELIMINARY RESULTS) by E. I. Alexeeva, S. I. Valieva, R. V. Denisova, T. M. Bzarova, K. B. Isaeva, E. V. Mitenko, T. V. Sleptsova, E. G. Chistyakova

“…Within 24 weeks there was a significant decrease of the disease activity, improvement of joint functional activity and decrease in disability degree. 25% of patients were diagnosed with inactive stage of the disease. …”
Get full text

Gender differences in spousal caregiver strain and paid service use among dementia caregivers in rural Appalachia by Jyoti Savla, Jyoti Savla, Karen A. Roberto, Karen A. Roberto, Leslie A. Fontaine

“…Logistic regression analyses revealed that greater emotional strain (overload and loneliness) and higher functional impairment of the PLwD were independently associated with increased likelihood of paid service use. …”
Get full text

Improved TODIM Method for Probabilistic Linguistic MAGDM Based on New Distance Measure by Ke Li, Lei Xu, Yi Liu, Hongjuan Wang, Yuan Rong

“…Meanwhile, we present an innovative distance measure, deeply anchored in linguistic scale functions, designed to overcome the shortcomings of current distance metrics. …”
Get full text

GEODES: Geometric Descriptors for the Assessment of Global and Local Flexibility of Proteins During Molecular Dynamics Simulation by Karina Pats, Igor Glukhov, Stepan Petrosian, Maria Mamaeva, Alexey Sergushichev, Marie-Dominique Devignes, Ferdinand Molnar

“…Molecular dynamics simulations offer insights into macromolecular structures and functions through extensive time-series atomic data. …”
Get full text

Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa by Desalegn W. Kifle, Aravindan Kalyanasundaram, Adebayo J. Molehin, Mumtaz Y. Balkhi, Aryandra Arya, Weidong Zhang, Gul Ahmad, Workineh Torben, David Carey, James F. Papin, Lisa A. Jackson, Sean A. Gray, Darrick Carter, Afzal A. Siddiqui

“…Sm-p80-specific antibodies produced by immunized non-human primates and humans induced statistically significant larval schistosomula killing ex vivo. This reproducible functional assay has the potential to serve as one of the biomarkers for the effectiveness of the SchistoShield vaccine in human trials in Africa.…”
Get full text

Molecularly Imprinted Polymer-Silica Hybrid Particles for Biomimetic Recognition of Target Drugs by Sumaira Roshan, Adnan Mujahid, Adeel Afzal, Izzut Nisar, Mirza Nadeem Ahmad, Tajamal Hussain, Sadia Zafar Bajwa

“…., nonimprinted polymer- (NIP-) silica hybrid particles, exhibits much lower response during the drug rebinding assay suggesting the lack of functionality due to the absence of imprinting effects. …”
Get full text

Dealloying of Quasi-High Entropy Alloys: Fabrication of Porous Noble Metals/Metal Oxides by Ziying Meng, Jun Zhou, Chunling Qin, Zhifeng Wang

“…These products present great potential for application as functional materials in hot fields such as catalysis and energy storage.…”
Get full text

Potential regulation of linoleic acid and volatile organic compound contents in meat of chickens by PLCD1 by Xiao-jing LIU, Yong-li WANG, Li LIU, Lu LIU, Gui-ping ZHAO, Jie WEN, Ya-xiong JIA, Huan-xian CUI

“…Omega-3 (linolenic acid (ALA), docosapentaenoic acid, eicosapentaenoic acid) and omega-6 (linoleic acid (LA), arachidonic acid) polyunsaturated fatty acids are essential for health and normal physiological functioning in humans. Here we report a genome-wide association study (GWAS) on LA content in chicken meat. …”
Get full text

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins by Sandra Zakrzewska, Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, J. Du Bois, Daniel L. Minor

“…These findings expand understanding of toxin sponge action and provide a foundation for strategies to monitor and mitigate the harmful effects of STX congeners.…”
Get full text

Anabolic steroid-induced myositis and osteitis. Case report through a radiologic approach by Andrés Felipe Donado-Moré, Enrique Calvo-Páramo

“…Case presentation: A 37-year-old male, bodybuilder, presented pain and edema in the left gluteal region, associated with functional limitation, 5 days after receiving an intramuscular anabolic steroid injection (stanozolol). …”
Get full text

Neurophysiological Basis of Electroacupuncture Stimulation in the Treatment of Cardiovascular‐Related Diseases: Vagal Interoceptive Loops by Yun Liu, Tiancheng Xu, Zhi Yu, Bin Xu

“…Additionally, we clarified the multidimensional coding pattern in the VSNs, revealing that the targeted control of multimodal interoceptive is the functional basis of the synchronization of cardiovascular system. …”
Get full text

Hemispherical Retina Emulated by Plasmonic Optoelectronic Memristors with All‐Optical Modulation for Neuromorphic Stereo Vision by Xuanyu Shan, Zhongqiang Wang, Jun Xie, Jiaqi Han, Ye Tao, Ya Lin, Xiaoning Zhao, Daniele Ielmini, Yichun Liu, Haiyang Xu

“…Therefore, retinomorphic electronics with structural and functional similarities to biological eyes are always highly desired to develop stereo vision perception system. …”
Get full text

Engineering a drug-inducible pyroptosis platform enables precise tumor suppression in colorectal cancer by Xiang Yao, Yu Wei, Yuan Gao, Lei Li, Junchi Liu, Wenmin Zhou, Tao Yan, Letian Gong, Yang Zhou, Ganglong Gao

“…Here, we report the design and functional validation of a chemically inducible gene circuit that harnesses Gasdermin E (GSDME) to trigger pyroptotic cell death on demand. …”
Get full text

Estimation of Non-Stationary Frequency and Fundamental Components for Power Electronics-Dominated Energy Systems by Peng Li, Hin Sang Lam, Boli Chen, Raymond Wai M. Ng, Thomas Parisini, S. Y. Hui

“…The method is based on a kernel-based estimation scheme and characterized by high accuracy, fast response, and noise immunity because of the inclusion of non-asymptotic kernel functions. The effectiveness of the proposed estimation scheme for non-stationary frequency tracking and fundamental signal reconstruction is verified by simulation and experimental results, which explore the use of the proposed scheme for frequency extraction of power signals appear in real world low-inertia systems.…”
Get full text

Extracellular Vesicles: Evolving Factors in Stem Cell Biology by Muhammad Nawaz, Farah Fatima, Krishna C. Vallabhaneni, Patrice Penfornis, Hadi Valadi, Karin Ekström, Sharad Kholia, Jason D. Whitt, Joseph D. Fernandes, Radhika Pochampally, Jeremy A. Squire, Giovanni Camussi

“…Collectively, these functions ensure an enormous potential for future therapies.…”
Get full text

Multi-Timescale Nested Hydropower Station Optimization Scheduling Based on the Migrating Particle Whale Optimization Algorithm by Mi Zhang, Guosheng Zhou, Bei Liu, Dajun Huang, Hao Yu, Li Mo

“…Validation on classical test functions and the Jiangpinghe River of the multi-timescale nested optimal scheduling model demonstrates that MPWOA exhibits faster convergence and stronger optimization capabilities and significantly improves power generation. …”
Get full text

Reversible Switching of Light‐Gated Organic Transistors Employing Dihydroazulene/Vinylheptafulvene Photo‐/Thermochromic Molecules by Sten Gebel, Oumaima Aiboudi, Vladimir Grigorescu, Zhitian Ling, Tomasz Marszalek, Paul W. M. Blom, Charusheela Ramanan, Franziska Lissel, Ulrike Kraft

“…Abstract An innovative possibility to introduce additional functionality to organic field‐effect transistors (OFETs) is to employ photochromic molecules, which undergo reversible isomerization under applied stimuli such as irradiation with specific wavelengths. …”
Get full text

Experience of Parenteral Administration of Methotrexate in a Female Patient Suffering from Early Juvenile Idiopathic Arthritis and Uveitis by Т. V. Sleptsova, Е. I. Alexeeva, Т. М. Bzarova, S. I. Valieva, R. V. Denisova, K. B. Isaeva, Е. G. Chistyakova, А. М. Chomakhidze, N. I. Taybulatov

“…The remission has persisted for 6 years. No side effects have been observed throughout methotrexate treatment.…”
Get full text

Thio-ProTide strategy: A novel H2S donor–drug conjugate (DDC) alleviates hepatic injury via innate lysosomal targeting by Haowen Jin, Jie Ma, Bixin Xu, Sitao Xu, Tianyu Hu, Xin Jin, Jiankun Wang, Guangji Wang, Le Zhen

“…These findings provided a novel pattern for the design of optimally therapeutic H2S DDC and organelle-targeting functional molecules.…”
Get full text

Tackling Microbial Contamination: Safesink Solution with Silver-Coated Microspheres by Eulalia Zumaquero, David Terrado, Rosa de Llanos, Marina Puerta, Rocío Cejudo, María Pilar Gómez-Tena

“…Ceramic and vitreous materials can be functionalized to exhibit biocidal activity. This research evaluates the biocidal properties of silver-modified vitreous microspheres designed to be included in water endpoints and siphons to prevent nosocomial diseases produced in hospital environments. …”
Get full text