CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity by Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Kerry A Whalen, Kavya Rakhra, Catherine C Henry, Safak Yalcin, Neil W Gibson

“…CLN-619 may thereby have therapeutic effects in a broad range of malignancies by re-establishing the MICA/B-NKG2D axis to enable NKG2D-mediated, as well as Fc-gamma receptor-mediated, tumor cell lysis.Methods CLN-619 was characterized for binding epitope and affinity, effects on surface and soluble levels of MICA/B, and in vitro tumor cell killing. …”
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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway by Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen Zhao

“…Notably, simultaneous overexpression of NLRP3 attenuated the analgesic effects induced by PIK3CG knockdown, further confirming that NLRP3 functions downstream of PIK3CG in mediating CPSP. …”
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Retinol and Hydroxyasiaticoside Synergistically Relieve Histamine-Induced Atopic Dermatitis Activity by Repressing TRPV1, L1R1, and CD130 Targets by Qin Liu, Peng Shu, Qingle Song, Zhenhai Huang, Jiyu Weng, Lanyue Zhang, Yuan Wang, Qingqing Liu

“…<b>Background:</b> Retinol, an important bioactive substance with multiple physiological functions such as promoting collagen synthesis, inhibiting matrix metalloproteinase activity, alleviating oxidative stress, regulating gene expression, and promoting epidermal cell proliferation, has a significant effect on skin damage recovery. …”
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General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial by Anthony G. B. Walters, Greg D. Gamble, Caroline A. Crowther, Stuart R. Dalziel, Carl L. Eagleton, Christopher J. D. McKinlay, Barry J. Milne, Jane E. Harding

“…Conclusions There is no evidence that antenatal corticosteroids have clinically important effects on general health and social outcomes up to 50 years of age.…”
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Prevention of Dry Eye Syndrome Before Phacoemulsification of Cataracts in Patients with a History of Cosmetic Procedures in the Periorbital Area by А. V. Trubilin, E. G. Poluninа, V. N. Trubilin, V. S. Zakatianskii

“…Phacoemulsification of cataracts in modern ophthalmological practice has reached its peak in terms of safety, predictability of the result and patient satisfaction with the result obtained. The effect of dry eye syndrome on the effectiveness of this surgical intervention has been studied to a large extent, but new risk factors affecting the development of dry eye syndrome arise, such as cosmetic intervention in the periorbital zone (botulinum toxin injections in the periorbital zone, eyelash extensions, blepharoplasty). …”
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Suppression of pseudogene MT2P1 transcription induced by E2F7 inhibits hepatocellular carcinoma cell proliferation and facilitates apoptosis via preserving its parental gene by Yiquan Lu, Yifan Zhang, Fengjie Hao, Nan Wang, Yongjun Chen, Junqing Wang

“…Their transcripts are mostly attributed to non-coding RNAs that play various functions in human tumorigenicity and progression. …”
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HENMT1 promotes the proliferation and migration of gastric cancer by activating the PI3K-AKT-mTOR signaling pathway by YANG Na, LIU Junli, BAI Jing, YANG Siyi, HAN Jiming, ZHANG Huahua

“…Moreover, siHENMT1 combined with the PI3K activator 740 Y-P effectively reversed the proliferation and migration effects induced by 740 Y-P, while overexpressed HENMT1 combined with the PI3K inhibitor 3-MA reversed the suppressive effects of 3-MA on GC cell proliferation and migration.Conclusion·HENMT1 is highly expressed in GC and positively regulates the proliferation and migration of gastric cancer cells by activating the PI3K-AKT-mTOR signaling pathway.…”
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Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats by Derya Burcu Hazer Rosberg, Derya Burcu Hazer Rosberg, Margit Mahlapuu, Raquel Perez, Raquel Perez, Lars B. Dahlin, Lars B. Dahlin, Lars B. Dahlin

“…IntroductionAlthough advanced surgical techniques are available, satisfactory functional outcomes after peripheral nerve injuries are uncommon. …”
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Human Placenta Hydrolysate Protects Against Acetaminophen-Induced Liver Injury in Mice by Inyoung Hwang, Chi-Gu Kang, So-Jung Lim, Hyun-Jin Kim, Ryun Kang, So-Hyun Jeon, Sang-Hoon Lee, Jae-Won Kim, Ju-Seop Kang

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MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells by Youzhu Li, Yuanyuan Ye, Hengyuan Zhang, Ye Yang, Ningqing Zhang, Hong Gao, Rongfeng Wu

“…MiR-19b-3p is involved in many diseases, but its functional role in EM-associated infertility remains unexplored. …”
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Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery by Leonel Pereira, Ana Valado

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Copper silicate nanoneedle arrays on reduced graphene oxide like “shelter forest” guiding Zn gradient deposition by Na Gao, Yang Wang, Zhanming Gao, Tianming Lv, Mengyu Rong, Xueying Dong, Dongzhi Chen, Changgong Meng, Yifu Zhang

“…Both electrochemical experiments and density functional theory calculations show that the negatively charged surface of rGO@CuSi with good Zn affinity is more capable of guiding Zn2+ transport. …”
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Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease by Weizhao Lu, Tianbin Song, Zhenxiang Zang, Jiping Li, Yuqing Zhang, Jie Lu

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Encapsulation of albumin from snakehead fish (Channa striata) with porous starch from arrowroot (Maranta arundinacea) by Nastitia Dian Pratiwi, Arima Diah Setiowati, Lucia Dhiantika Witasari

“…Therefore, porous starch from arrowroot can be effectively used as an albumin encapsulant.…”
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Modified Nanocellulose Hydrogels and Applications in Sensing Fields by Lan Yang, Qian-Yu Yuan, Ching-Wen Lou, Ting-Ting Li, Jia-Horng Lin

“…Due to the intensification of global warming and the greenhouse effect, the exploration and research of sustainable sensors have become a research direction of people. …”
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Digital media consumption from childhood to pre-adolescence: the research-action "One Bit at a Time" in Italy for Digital Education among children/teachers and families by Gabriele Lugaro, Jacopo Ferro, Cosimo Di Bari

“…Both training sessions employed a problematizing approach to explore the effects and functionality of digital devices and social media on children and adolescents, aiming to raise adult awareness about the necessity of incorporating Media Education and Digital Education activities from early childhood. …”
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Microcirculation and cardiovascular risk: Diagnostic value and clinical relevance by Mariana Bacelova, Julia Nikolova, Adolf Alakidi, Valentina Petkova, Vanina Mihaylova, Ivica Dimov, Radka Tafradzhiyska-Hadjiolova, Tsvetanka Dzhiganska, Rene Mileva-Popova, Anelia Bivolarska

“…Microcirculation represents the intersection of these pathogenetic mechanisms and is subject to morphological and functional alterations determined by the prolonged effects of high arterial pressure. …”
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The dual role of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: mechanisms, clinical relevance, and therapeutic opportunities by Houhong Wang, Shang Bian

“…This review synthesizes recent advancements (2023–2025) to elucidate Nrf2’s context-dependent dual functions: tumor suppressive roles during early carcinogenesis through oxidative stress mitigation, versus oncogenic effects in advanced stages via promoting proliferation, survival, and treatment resistance. …”
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ISOLATED CONGENITAL KNEE DISLOCATION: A CASE REPORT by Mesanovic Edin, Fajic Fikret, Mesanovic Amra

“…Conclusion: Early intervention in congenital knee dislocation is crucial for achieving favorable functional outcomes, emphasizing the effectiveness of non-operative strategies in neonates.…”
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Social Perception of Zoos and Aquariums: What We Know and How We Know It by Ana Villarroya, Rafael Miranda, Andrea Pino-del-Carpio, María Casas

“…At the same time, the functions they fulfill and the way they do that have been subject to scrutiny from different fields of knowledge. …”
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