Assessing the Impact of a Virtual Reality Cognitive Intervention on Tennis Performance in Junior Tennis Players: Pilot Study by Joaquin A Anguera, Aleem Choudhry, Michael Seaman, Dominick Fedele

“… BackgroundThere is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. …”
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Machine Learning in Cyber-Physical Systems and Manufacturing Singularity – it Does Not Mean Total Automation, Human Is Still in the Centre: Part I – Manufacturing Singularity and a... by Goran D. PUTNIK, Vaibhav SHAH, Zlata PUTNIK, Luis FERREIRA

“…Based on the exposed considerations, a generic architecture of intelligent CPS, with embedded ML functional modules in multiple learning loops, in order to evaluate way of use of ML functionality in the context of CPPS/CPS. …”
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The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer by Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad

“…The novel bipolar androgen therapy (BAT) uses supraphysiological androgen levels (SAL) that suppresses growth of PCa cells and induces cellular senescence functioning as a tumor suppressive mechanism. The role of long non-coding RNAs (lncRNAs) in the regulation of SAL-mediated senescence remains unclear. …”
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A role for DICAM+ mononuclear phagocytes in controlling neuroinflammation in multiple sclerosis by Marina Rode von Essen, Marie Mathilde Hansen, Sahla El Mahdaoui, Victoria Hyslop Hvalkof, Malene Bredahl Hansen, Sophie Buhelt, Finn Sellebjerg, Finn Sellebjerg

“…When patients were treated with natalizumab (n = 12), an antibody blocking migration of blood leukocytes to the CNS, we observed that DICAM+ monocytes were still recruited to the CSF and that the level of soluble DICAM (sDICAM) in CSF was significantly increased in natalizumab-treated patients (n = 42) compared to untreated patients (n = 43). sDICAM and the prevalence of DICAM+ mononuclear phagocytes in CSF furthermore correlated negatively with concentrations of various cytokines, including TNFα. Analysing the functional properties of DICAM showed that LPS-induced TNFα-production in mononuclear phagocytes was effectively reduced by signalling through surface-bound DICAM. …”
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Hypoxia alters the response of ovarian cancer cells to the mitomycin C drug by Aleksandra Gawrylak, Aleksandra Gawrylak, Klaudia Brodaczewska, Roksana Iwanicka-Nowicka, Roksana Iwanicka-Nowicka, Marta Koblowska, Marta Koblowska, Agnieszka Synowiec, Lubomir Bodnar, Lubomir Bodnar, Cezary Szczylik, Bogdan Lesyng, Rafał Stec, Claudine Kieda, Claudine Kieda

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Liquid biopsy in gynecological cancers: a translational framework from molecular insights to precision oncology and clinical practice by Canio Martinelli, Alfredo Ercoli, Giuseppe Vizzielli, Sharon Raffaella Burk, Maria Cuomo, Vrunda Satasiya, Housem Kacem, Simone Braccia, Giulio Mazzarotti, Irene Miriello, Manuela Nana Tchamou, Stefano Restaino, Martina Arcieri, Alice Poli, Veronica Tius, Silvana Parisi, Stefano Pergolizzi, Giuseppe Iatì, Chiara Conti Nibali, Cristina Pizzimenti, Ludovica Pepe, Antonio Ieni, Salvatore Cortellino, Antonio Giordano

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Multi-Modal Analysis of Satellite Cells Reveals Early Impairments at Pre-Contractile Stages of Myogenesis in Duchenne Muscular Dystrophy by Sophie Franzmeier, Shounak Chakraborty, Armina Mortazavi, Jan B. Stöckl, Jianfei Jiang, Nicole Pfarr, Benedikt Sabass, Thomas Fröhlich, Clara Kaufhold, Michael Stirm, Eckhard Wolf, Jürgen Schlegel, Kaspar Matiasek

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Infinite Coordination Polymer Polydopamine Nanocomposites Dual‐Pathway Multistep Induction of Long‐Term Hyperimmunity Combined With Photothermal‐Chemo Synergistic Therapy Colorecta... by Xiaojiang Zhang, Yujie Zhang, Pengqian Wang, Feiyu Shi, Siyuan Du, Zhe Zhang, Daocheng Wu, Junjun She, Ya Wang

“…Furthermore, each component within the nanocomposites serves multiple functions. Notably, the incorporation of multiple components triggers a powerful antitumor immune effect and establishes enduring immune memory through a dual‐pathway and multistep approach, which is produced with the activation of the cGAS‐STING pathway and immunogenic cell death (ICD) by a four‐component multistep process. …”
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Transcriptome analysis of Thevetia peruviana cell suspensions treated with methyl jasmonate reveals genes involved in phenolics, flavonoids and cardiac glycosides biosynthesis by Olmedo Cuaspud, Olmedo Cuaspud, Dary Mendoza, Gigliola Navarro, Gigliola Navarro, Juan Arias, Isabel Calle, Juliana Arcila-Galvis, Juliana Arcila-Galvis, Rafael Eduardo Arango Isaza

“…This de novo assembly of T. peruviana transcriptome provides a valuable resource for future research in functional genomics and metabolic engineering of bioactive SMs. …”
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Performance of Ankle Exoskeletons on Irregular Terrains: Key Design Principles and Benchmarking Tests by L. Liguori, G. Mariani, J. Taborri, I. Mileti, D. Torricelli, L. Mattioli, E. Palermo, F. Patane, S. Rossi

“…Specifically, the first prototype (S-RANK) accommodates a single DoF in the sagittal plane, whereas the second prototype (M-RANK) extends the functionality to include ankle inversion/eversion and internal/external rotation. …”
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Syk inhibitors reduce tau protein phosphorylation and oligomerization by Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto

“…Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. …”
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Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3 by Mengdi Zhang, Mengdi Zhang, Xiaoli Lv, Xiaoli Lv, Chaojie Wang, Chaojie Wang, Lei Wang, Lei Wang, Han Wang, Han Wang, Xue Wang, Xue Wang, Yulu Du, Yulu Du, Jun Li, Jun Li, Jun Li, Xiuli Han, Xiuli Han, Xiuli Han, Lei Fan, Lei Fan, Yuxia Hu, Yuxia Hu, Yuxia Hu, Tuya Bai, Tuya Bai, Weizhong Huangfu, Fuhou Chang, Fuhou Chang

“…Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21) mediated pathways. …”
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Interactions of silicon and arbuscular mycorrhizal fungi on phosphorus uptake during rice vegetative growth by Li-Xue Qiu, Dong-Xing Guan, Yi-Wen Liu, Yu Luo, H. Henry Teng, Yakov Kuzyakov, Lena Q. Ma

“…Under low P availability, Si reduces AMF functioning by decreasing colonization rates, while under high P availability, Si reinforces the P-promoting effects of AMF by stimulating PSB abundance. …”
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Clinical and cost evaluation of intensive support team (IST) models for adults with intellectual disabilities who display challenging behaviour: a comparative cohort study protocol by Angela Hassiotis, Rebecca Jones, Brynmor Lloyd-Evans, Renee Romeo, Nicola Morant, Ken Courtenay, Ian Hall, Athanasia Kouroupa, Vicky Crossey, Laurence Taggart, Peter Langdon, Victoria Ratti, Vincent Kirchner

“…Secondary outcomes include mental health status, clinical risk, quality of life, health-related quality of life, level of functioning and service use. We will undertake a cost-effectiveness analysis taking both a health and social care and wider societal perspective. …”
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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via redu... by Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang

“…By constructing a functional protein interaction network of <sc>C-P4HAs</sc> and analyzing molecules whose expressions are correlated significantly with that of C-P4HAs, we identify scribble cell polarity complex component 2 (LLGL2) as a factor that antagonizes the effects of overexpressed <sc>C-P4HAs</sc> on HNSC. …”
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Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM by Xiaofeng Zhou, Zhifang Liu, Weixiong Zhang, Lin Dai, Tao Chen, Zexiong Lin, Hong Pan, Qi Qi, Henry Wei

“…Functional assays demonstrated that these sdAbs significantly inhibited cancer cell proliferation, migration, and invasion, and induced apoptosis. …”
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PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway by Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu

“…Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ferroptosis. …”
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Remembering what did not happen: the role of hypnosis in memory recall and false memories formation by Donato Giuseppe Leo, Donato Giuseppe Leo, Davide Bruno, Riccardo Proietti, Riccardo Proietti

“…Additionally, hypnosis has been shown to have some effectiveness in enhancing memory functions, although contradictory findings reported by several studies make it difficult to draw proper conclusions. …”
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Advancements in Antimicrobial Surface Coatings Using Metal/Metaloxide Nanoparticles, Antibiotics, and Phytochemicals by Preetha Ebenezer, S. P. S. N. Buddhika Sampath Kumara, S. W. M. A. Ishantha Senevirathne, Laura J. Bray, Phurpa Wangchuk, Asha Mathew, Prasad K. D. V. Yarlagadda

“…This review evaluates three principal categories of antimicrobial agents utilized in surface functionalization: metal/metaloxide nanoparticles, antibiotics, and phytochemical compounds. …”
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Study of the Safety and Toxicokinetic Parameters of the Drug Eladis® in Preclinical Trials with Repeated Administration by A. A. Matichin, M. V. Miroshnikov, A. A. Matichina, V. M. Kosman, M. V. Karlina, E. M. Petrova, A. A. Globenko, E. A. Jain, A. V. Kapashin, A. L. Vladykin, A. S. Kolosov, M. A. Pasko

“…The results indicated no significant effects of the drug on body weight gain, animal behavior in a battery of functional tests, as well as the estimated physiological, biochemical, and hematological parameters. …”
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