Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity by Wei Qiu, Ruiming Guo, Hongwen Yu, Xiaoxin Chen, Zehao Chen, Dian Ding, Jindou Zhong, Yumeng Yang, Fuchun Fang

“…Despite the critical role of NETs in the development and progression of periodontitis, their specific functions and mechanisms remain unclear. Objectives: To demonstrate the important functions and specific mechanisms of NETs involved in periodontal immunopathology. …”
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Synergistic Interactions Among Iron and Cobalt Atoms Within Bimetallic Molybdate@Carbon Paper Composite Create Bifunctional Nanoflower Electrocatalyst, Enhancing Efficiency for Ove... by Ting Cheng, Fei Wu, Chen Chen, Xiao Zhang, Mengyi Zhang, Liwei Cui, Youzhi Dai, Baoxuan Hou, Yuan Tian, Jiarui Zhu

“…Under high alkaline concentration and temperature conditions, the Co5Fe5MoO@CP composite still maintained excellent HER and OER catalytic activity and stability, indicating its satisfactory potential for industrial applications. Density functional theory (DFT) analysis revealed that the promoted hydrogen evolution capability derived from the synergistic catalytic effect of iron and cobalt atoms within the molecule, while cobalt atoms functioned as the catalytic core for the oxygen evolution process. …”
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Integrating Conservative kidney management Options and advance care Planning Education (COPE) into routine CKD care: a protocol for a pilot randomised controlled trial by Scott D Halpern, Michael K Paasche-Orlow, Nwamaka D Eneanya, Taylor L Stallings, Tamar A Klaiman, Margarita Alegria, Ann O’Hare, Nina O’Connor, Laura M Dember

“…Eligible patients will have: age ≥70 years and/or poor functional status (as defined by Karnofsky Performance Index Score <70), advanced CKD (estimated glomerular filtration rate<20 mL/min/1.73 m2), prefer to speak English during clinical encounters and self-report as black or white race. …”
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The impact of information technology applications on the quality of life of disabled older adults in nursing homes in China: a qualitative study by Hong Zhang, Xiaoyan Liao, Shuang Liang, Lifang Tong, Jun Shen, Bin Peng, Lin Wu, Lu Gao, Qianying Jia, Liu Ren, Lanyue Luo, Yixin Wang, Xiaoli Zhang

“…These measures will help maximize the positive effects of information technology on the quality of life of disabled older adults.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Stem cell signaling small molecule library functional screen was performed employing human bone marrow skeletal (mesenchymal) stem cells (hBMSCs). …”
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The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION... by Cong Luo, Rui Li, Chunrong Tao, Ming Cai, Lang Chen, Peng Hao, Xinfeng Liu, Wei Hu

“…In patients receiving endovascular treatment, associations of BACSS and time from puncture to recanalization with outcomes were evaluated, including an interaction term (BACSS×puncture to recanalization) to assess effect modification. The primary outcome was 90‐day functional independence (modified Rankin Scale score ≤2). …”
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A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques by Ya-Li Zhang, Yi-Cheng Qiao, Yun-Chao Ji, Hong-Di Huang, Long Zhang, Jian-Xiong Ruan, Chen-Yao Li, Hui-Heng Xie, Bao-Lin Zhang, Qi Zhou, Sha-Sha Yue, Xiao-Mei Yu, Ming-Hao Qiu, Chuan-Kai Yu, Si-Chu Wu, Yu-Fang Zhou, Yan-Ling Li, Hong-Mei Zhu, Shu-Zhen Dong, Kang Huang, Yun Wang, Qiong Wang, Yi-Jiang Li, Ya Xie, Hui-Ling Chen, Long-Bao Lv, Shu Liu, Yong-Gang Yao, Chun Wang, Ning Liu, Jian-Hong Wang

“…Enhanced structural and functional connectivity was observed. Network-based statistics highlighted increased functional connectivity primarily between the frontal and parietal lobes. …”
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Recent advances (2022–2024) in eye-tracking for Parkinson’s disease: a promising tool for diagnosing and monitoring symptoms by Laura Culicetto, Davide Cardile, Giulia Marafioti, Viviana Lo Buono, Francesca Ferraioli, Simona Massimino, Giuseppe Di Lorenzo, Chiara Sorbera, Amelia Brigandì, Carmelo Mario Vicario, Angelo Quartarone, Silvia Marino

“…This systematic review evaluates the effectiveness of eye-tracking in assessing motor and cognitive alterations associated with PD.MethodsA systematic review of the literature was conducted using PubMed, Web of Science, Embase, Scopus and Cochrane Library databases to identify studies applying eye-tracking to assess oculomotor functions in PD patients. …”
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Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats by Aryadi Arsyad, Irfan Idris, Andi A. Rasyid, Rezky A. Usman, Kiki R. Faradillah, Wa Ode U. Latif, Zidni I. Lubis, Aminuddin Aminuddin, Ika Yustisia, Yulia Y. Djabir

“…This study aimed to investigate the effects of long-term consumption of ketogenic diet on blood gas, hematological profiles, organ functions, and superoxide dismutase level in a rat model. …”
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Smart Digital Solutions for EARLY Treatment of COGNitive Disability (EARLY-COGN^3): A Study Protocol by Maria Cotelli, Francesca Baglio, Elena Gobbi, Elena Campana, Ilaria Pagnoni, Giovanna Cannarella, Alessandro Del Torto, Federica Rossetto, Angela Comanducci, Gennaro Tartarisco, Rocco Salvatore Calabrò, Simona Campisi, Raffaela Maione, Claudia Saraceno, Elisa Dognini, Sonia Bellini, Marta Bortoletto, Giuliano Binetti, Roberta Ghidoni, Rosa Manenti

“…<b>Background:</b> Healthy cognitive functioning is a primary component of well-being, independence, and successful aging. …”
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Exploring the growth performance, antioxidant capacity, and metabolism of Babylonia areolata in response to yeast selenium supplementation by Yunting Wang, Waqas Ahmed, Sajid Mehmood, Mohsin Mahmood, Lu Wang, Wenjie Ou, Jiannan Li, Jie Yang, Weidong Li, Lianshun Wang

“…This study aimed to examine the effects of yeast selenium on growth, antioxidant enzymes, and metabolites activity in Babylonia areolata under different selenium concentrations. …”
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Identification of novel candidate loci for Alzheimer’s disease and related dementias by leveraging the shared genetic basis with hippocampal volume by Chenyang Jiang, Sven J. van der Lee, Niccolò Tesi, Wiesje M. van der Flier, Betty M. Tijms, Lianne M. Reus

“…We identified 11 unique lead genetic loci, of which 7 loci showed discordant directional effects (loci associated with increased risk for ADRD and smaller hippocampal volumes). …”
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Simultaneous Down-Regulation of Dominant Cinnamoyl CoA Reductase and Cinnamyl Alcohol Dehydrogenase Dramatically Altered Lignin Content in Mulberry by Shuai Huang, Xiaoru Kang, Rumeng Fu, Longyan Zheng, Peijun Li, Fengjuan Tang, Nan Chao, Li Liu

“…In this study, we conducted a comprehensive functional analysis to validate the predominant <i>CCR</i> genes involved in monolignol biosynthesis. …”
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Unlocking the potential of enzymatically hydrolyzed corn gluten meal for improving growth, intestinal health, and stress resistance in juvenile Chinese mitten crab (Eriocheir sinen... by Kaiqi Huang, Long He, Weiwei Xiao, Wei Li, Song Wang, Luxi Huang, Xiaodan Wang, Jianguang Qin, Liqiao Chen, Erchao Li

“…These findings demonstrate that ECGM functions as both a growth promoter and health enhancer in Eriocheir sinensis aquaculture.…”
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Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. by Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Claire Palles, Peter Broderick, Emma E M Jaeger, Susan Farrington, Annabelle Lewis, James G D Prendergast, Alan M Pittman, Evropi Theodoratou, Bianca Olver, Marion Walker, Steven Penegar, Ella Barclay, Nicola Whiffin, Lynn Martin, Stephane Ballereau, Amy Lloyd, Maggie Gorman, Steven Lubbe, COGENT Consortium, CORGI Collaborators, EPICOLON Consortium, Bryan Howie, Jonathan Marchini, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Antoni Castells, Angel Carracedo, Sergi Castellvi-Bel, David Duggan, David Conti, Jean-Baptiste Cazier, Harry Campbell, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Steven Gallinger, Polly Newcomb, John Hopper, Mark A Jenkins, Lauri A Aaltonen, David J Kerr, Jeremy Cheadle, Paul Pharoah, Graham Casey, Richard S Houlston, Malcolm G Dunlop

“…The strongest candidate loci for additional predisposition SNPs are arguably those already known both to have functional relevance and to be involved in disease risk. …”
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The importance of measuring the levels of ionized magnesium in the blood in critically ill patients by Stanojević Marija B., Parezanovic Miro, Biorac Marko, Spasić Svetolik, Kovačević Sanjin, Lopičić Srđan, Nešović Ostojić Jelena

“…Magnesium is a bioessential element with multiple physiological effects relevant for vital body functions. It stabilizes excitable membranes contributing to proper neuromuscular, cardiovascular and respiratory functions. …”
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GG-NER’s role in androgen receptor signaling inhibitor response for advanced prostate cancer by Chuanfan Zhong, Jiaxing Wang, Hangyang Peng, Jianming Lu, Zining Long, Zhuoyuan Lin, Guo Chen, Chao Cai, Shilong Cheng, Zhongjie Chen, Le Zhang, Weibo Zhong, Rujun Mo, Xiangming Mao

“…Additionally, we mapped tumor mutations to delineate the mutational landscapes across different risk groups and explored functional pathways through GO, KEGG, and GSEA analyses. …”
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TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer by Yatendra Mulpuri, Yatendra Mulpuri, Nguyen H. Tu, Nguyen H. Tu, Kenji Inoue, Kenji Inoue, Grace Harden, Grace Harden, Samuel J. Nicholson, Samuel J. Nicholson, Anisa Seenauth, Anisa Seenauth, Yan Huang, Yan Huang, Keylin G. Escobar, Keylin G. Escobar, Yalda Moayedi, Yalda Moayedi, Nigel W. Bunnett, Nigel W. Bunnett, Nigel W. Bunnett, Nigel W. Bunnett, Donna G. Albertson, Donna G. Albertson, Brian L. Schmidt, Brian L. Schmidt, Brian L. Schmidt

“…IntroductionPatients with oral cancer often experience intense functional pain due to mechanical stimulation at the cancer site. …”
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Neurovascular coupling of inhibitory control in late-onset depression: a simultaneous EEG-fMRI study by Elena Bondi, Alessandro Pigoni, Adele Ferro, Maria Pia Marra, Guido Nosari, Giandomenico Schiena, Fabio M. Triulzi, Anna M. Bianchi, Paolo Brambilla, Eleonora Maggioni

“…Electrophysiological (EEG) and functional magnetic resonance imaging (fMRI) studies have investigated the neuronal and hemodynamic process underlying inhibition through tasks measuring the ability to suppress a dominant response when non-target stimuli are shown and reported differences between healthy controls (HCs) and MDD subjects. …”
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Changes in the energy metabolism of the gills of Litopenaeus vannamei under carbonate alkalinity stress and recovery conditions by Meng Xiao, Meng Xiao, Yuxiu Nan, Yuxiu Nan, Jitao Li, Yun Wang, Ruijie Zhu, Yafei Duan, Yafei Duan

“…The findings indicated that CA stress exerted an adverse effect on the histomorphology and energy metabolism in the gills of shrimp, likely by disrupting the functions of glycolysis, lipid metabolism, TCA cycle, and electron transport chain, which may further affect the growth and survival of the shrimp.…”
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