Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma by Marina Goryunova, Yiran He, Carson Karakis, Elizaveta K. Titerina, Ana I. Salazar-Puerta, Sayumi Tahara, Nipin Sp, Neil N. Thakkar, Orlando Cómbita-Heredia, Kavya Dathathreya, Alessandro La Ferlita, Yanping Xu, Zhentao Zhang, Raphael Pollock, Daniel Gallego-Perez, Hua Zhu, Christopher M. Hadad, Joal D. Beane

“…Both were predicted to mimic Spt6 phenylalanine (F217) and disrupt the complex, which was confirmed by co-immunoprecipitation. Functional assays showed that treatment with either compound reduced migration, invasion, and spheroid formation in DDLPS cell lines. …”
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Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease by Yuechang Wang, Yonggang Zhang, Wei Wang, Yanmin Zhang, Xueqian Dong, Yang Liu

“…Numerous studies are actively investigating the relationship between tryptophan metabolism and physiological functions. These studies are highlighting the interactions among metabolites that may exert synergistic or antagonistic effects, such as neuroprotective or neurotoxic, and pro-oxidative or antioxidant activities. …”
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Interpretability in deep learning for finance: A case study for the Heston model by Damiano Brigo, Xiaoshan Huang, Andrea Pallavicini, Haitz Sáez de Ocáriz Borde

“…Being able to interpret the inner functioning and the input–output relationship of these networks has become key for the acceptance of such tools and for reducing the risks inherent in their use. …”
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New Strategies in the Code of Uncertainty and Sensitivity Analysis (CUSA) and Its Application in the Nuclear Reactor Calculation by Jiayu Du, Chen Hao, Ji Ma, Peijun Li, Xiaoyu Zhou, Lixun Liu

“…The numerical results indicate that the implicit sensitivity analysis model and the uncertainty quantification functions developed in CUSA are correct and can be used for sensitivity and uncertainty analysis in nuclear reactor calculations. …”
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Adaptive Robust Dynamic Surface Integral Sliding Mode Control for Quadrotor UAVs under Parametric Uncertainties and External Disturbances by Ye Zhang, Ning Xu, Guoqiang Zhu, Lingfang Sun, Shengxian Cao, Xiuyu Zhang

“…The simulation results show the effectiveness of the proposed control method.…”
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Innovative Solutions to the Fractional Diffusion Equation Using the Elzaki Transform by Saima Noor, Albandari W. Alrowaily, Mohammad Alqudah, Rasool Shah, Samir A. El-Tantawy

“…Our findings demonstrate the robustness and effectiveness of combining the VIM and the Elzaki transform in handling fractional differential equations, offering explicit functional expressions that are beneficial for theoretical analysis and practical applications. …”
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Census and Analysis of Higher-Order Interactions in Real-World Hypergraphs by Xihang Meng, Xuemeng Zhai, Gaolei Fei, Sheng Wen, Guangmin Hu

“…This framework features the encoding, census, and evaluation of higher-order patterns, effectively overcoming their inherent complexity and diversity. …”
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Enhanced antibacterial potential of exopolysaccharide-stabilized spice oil emulsions against foodborne pathogens by Jahnavi Kumari Singh, Steve Djiazet, Palanisamy Bruntha Devi, Horliane Nzali Ghomdim, G. Bhanuprakash Reddy, Digambar Kavitake, Digambar Kavitake, Prathapkumar Halady Shetty

“…Exopolysaccharides (EPSs) from lactic acid bacteria (LAB) are known to have diverse applications in food and pharmaceuticals due to their functional properties. Emulsification is one of the important potentials of microbial polysaccharides, revealing its role as a natural emulsifier. …”
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Reconstructing Total Water Storage Anomalies Over the Lake Victoria Basin (1971–2022) Using an Enhanced RecNet Model by Jielong Wang, Yunzhong Shen, Joseph Awange, Yongze Song, Ling Yang, Qiujie Chen, Allan Kasedde

“…ERecNet integrates a multi‐layer perceptron and a combination of gridded and basin‐averaged loss functions for improving reconstruction performance. …”
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Research Progress in Microbe-Gut-Liver Axis and Alcoholic Liver Disease and Nutritional Interventions for It by ZHENG Hongxing, JI Le, QI Shanshan

“…It is our hope that this review will provide basic data for the discovery of anti-ALD substances targeting the gut-liver axis and for the development of new nutritional interventions and functional foods.…”
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Influence of environmental factors on college alcohol drinking patterns by Ridouan Bani, Rasheed Hameed, Steve Szymanowski, Priscilla Greenwood, Christopher M. Kribs-Zaleta, Anuj Mubayi

“…Sensitivity and uncertainty analyses are carried out on the relevant functions (for example, on the drinking reproduction number and the extinction time of moderate and heavy drinking because of interventions) to understand the impact of environmental interventions on the distributions of drinkers.The reproduction number helps determine whether or not the high-risk alcohol drinking behavior will spread and become persistent in the population, whereas extinction time of high-risk drinking measures the effectiveness of control programs. …”
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Expedient access to bora-butenolide bioisosteres by counteranion-mediated trans-hydroboration of alkynes by Yuan-Wen Liu, Yu Liu, Yanting Zheng, Mengfan Zhang, Meng-En Ren, Peiyu Hua, Jie Han, Alois Fürstner, Hongming Jin

“…The practical method is distinguished by excellent regioselectivity, a broad substrate scope, and high compatibility with a variety of functional groups. The exploration of trans-selective patterns affords not only a stereo-complementary approach to traditional organic synthesis, but also mandates a new perspective on the noncanonical trans-hydroboration mechanism. …”
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Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS by Iwona Stelniec‐Klotz, Stefan Legewie, Oleg Tchernitsa, Franziska Witzel, Bertram Klinger, Christine Sers, Hanspeter Herzel, Nils Blüthgen, Reinhold Schäfer

“…As predicted by the model, we found two functional groups among the selected transcription factors. …”
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A Novel Shearer Cutting State Recognition Method Based on Improved Variational Mode Decomposition and LSSVM with Acoustic Signals by Zhongbin Wang, Bin Liang, Lei Si, Kuangwei Tong, Chao Tan

“…VMD can decompose a signal into various modes by using calculus of variation and effectively avoid the false component and mode mixing problems. …”
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Vanillin as eco-friendly corrosion inhibitor for aluminum immersed in 0.5 M H2SO4 by América María Ramírez-Arteaga, Martha Patricia Hernández-Valencia, Rene Guardián-Tapia, Ana Karen Gálvez-Larios, José Gonzalo González-Rodríguez, Roy López-Sesenes

“…Results indicate that Vanillin is a mixed corrosion inhibitor. Its inhibitory effect can be attributed to aldehyde functional groups forming a protective layer by reacting with Al3+ ions, which are chemisorbed onto the metal’s surface, as was demonstrated via SEM analysis of the metal surface. …”
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Gate‐Tunable Dual‐Mode Optoelectronic Device for Self‐Powered Photodetector and Optoelectronic Synapse by Yi Ouyang, Chaoyi Zhang, Jun Wang, Zheng Guo, Zegao Wang, Mingdong Dong

“…The device leverages the photovoltaic effect in the MoTe2/MoS2 PN junction for self‐powered photodetection and utilizes trapping states at the SiO2/MoS2 interface to emulate synaptic behavior. …”
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Geographical origin identification of dendrobium officinale based on NNRW-stacking ensembles by Yinsheng Zhang, Chen Chen, Fangjie Guo, Haiyan Wang

“…Dendrobium officinale is a well-recognized functional food material. Considering its therapeutic effect and price vary among different geographical origins, this paper proposed an origin identification method based on Raman spectroscopy and NNRW (neural network with random weights)-stacking ensemble model. …”
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Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus by Loredana Cumpana, Olivia Zanoletti, Dinesh Kankanamge, Bryan Copits, Carmen Sandi, Simone Astori

“…The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, remained unexplored. …”
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Role of Adiponectin in Central Nervous System Disorders by Jenna Bloemer, Priyanka D. Pinky, Manoj Govindarajulu, Hao Hong, Robert Judd, Rajesh H. Amin, Timothy Moore, Muralikrishnan Dhanasekaran, Miranda N. Reed, Vishnu Suppiramaniam

“…In the brain, adiponectin signaling through its receptors, AdipoR1 and AdipoR2, directly influences important brain functions such as energy homeostasis, hippocampal neurogenesis, and synaptic plasticity. …”
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Exploring the Impact of Bi Content in Nanostructured Pd-Bi Catalysts Used for Selective Oxidation of Glucose: Synthesis, Characterization and Catalytic Properties by Mariya P. Shcherbakova-Sandu, Semyon A. Gulevich, Eugene P. Meshcheryakov, Kseniya I. Kazantseva, Aleksandr V. Chernyavskii, Alexey N. Pestryakov, Ajay K. Kushwaha, Ritunesh Kumar, Akshay K. Sonwane, Sonali Samal, Irina A. Kurzina

“…This work is devoted to the study of the effect of small Bi additives on the functional properties of Pdx:Bi/Al₂O₃ catalysts in the selective oxidation of glucose to gluconic acid. …”
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