Software development for a personalized approach in the treatment of subretinal hemorrhages by R.R. Fayzrakhmanov, E.D. Bosov, V.A. Bogdanova, G.O. Karpov

“…Application of the proposed software in clinical practice has proven its effectiveness in relation to morphological and functional perspectives in the treatment of submacular hemorrhages.…”
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Seismic Reliability-Based Design Versus Safety-Factor Based Design of Shallow Foundations Near a slope by Ali Shojaeian, Faradjollah Askari, Saeideh Farahani

“…This study investigates the effects of the foundation and slope properties on the Reliability-based Design (RBD) and Safety-Factor Based Design (SBD). …”
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The CLIP - GPT Image Captioning Model Integrated with Global Semantics by TAO Rui, REN Honge, CAO Haiyan

“…It combines the two loss functions of masked language modeling and image-text matching, selects highly difficult negative samples to train the cross-modal hop network to extract consistent global semantics, improving the accuracy of distinguishing highly similar image and text feature points within the neighborhood of the subspace. …”
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Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice by Vanessa Kristina Wazny, Aparna Mahadevan, Nhi Nguyen, Hannah Wee, Ashwati Vipin, Tammy Lam, Kai Yi Tay, Jia-Xiang See, Gurveen Sandhu, Yi Jin Leow, Giuseppe D’Agostino, Martin Graf, Aravind Sivakumar, Sichen Lin, Nguyen Cao Thien Phuc, James Xiao Yuan Chen, Sarah R. Langley, Lay Teng Ang, Kyle M. Loh, Nagaendran Kandiah, George J. Augustine, Christine Cheung

“…Here, we create bilateral common carotid artery stenosis in mice, which effectively impairs blood flow to the brain, a major cause of the disease. …”
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The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma by Zhiyong Pan, Yuyi Liu, Hui Li, Huisi Qiu, Pingmei Zhang, Zhiying Li, Xinyu Wang, Yuxiao Tian, Zhengfu Feng, Song Zhu, Xin Wang

“…Key enzymes such as hexokinase 2, lactate dehydrogenase A, phosphofructokinase 1, and pyruvate kinase M2 are discussed for their regulatory functions in NPC glycolysis through signaling pathways like PI3K/Akt and mTOR. …”
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Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis by Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi, Yuan Liu

“…However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. …”
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A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling by Anders Dalby, Mathias Kaas, Lars Meinertz Byg, Signe Bundgaard Christiansen, Christian M. Longworth, Simon Bøggild Hansen, Per Qvist, Jens R. Nyengaard, Peder Madsen, Simon Mølgaard, Simon Glerup

“…Here we report that the SorCS2 intracellular domain (ICD) contains a triple serine motif that potentially functions as a signaling switch to induce intracellular signaling in hippocampal neurons. …”
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DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy by Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu

“…Abstract Adoptive T‐cell therapy (ACT) holds significant promise for treating solid tumors but is often constrained by insufficient T‐cell infiltration, survival, and functional persistence. To overcome these obstacles, we developed DON‐loaded nanodrug‐T cell conjugates with PD‐L1 blockade, forging a dynamic mutualistic relationship between T cells and therapeutic agents. …”
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Synthesis, Growth, and Characterization of Methyl Orange Dye-Doped Potassium Sulphate Single Crystal and Its Multifaceted Activities by D. Jini, M. Aravind, S. Ajitha, C. Parvathiraja, M. Muniyappan, P. A. Vivekanand, P. Kamaraj, Natarajan Arumugam, Abdulrahman I. Almansour, R. Arulnangai, Raju Suresh Kumar, Karthikeyan Perumal, Girma Gonfa

“…The reaction involved in the functional group of the grown crystal has been confirmed from the FTIR analysis. …”
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Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice by Masaya Yamamoto, Takahide Itokazu, Hiroki Uno, Takakuni Maki, Nao Shibuya, Toshihide Yamashita

“…Recent studies have unveiled its diverse functions under pathological conditions within the central nervous system, such as spinal cord injury, multiple sclerosis, and Parkinson's disease. …”
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The biosynthesis of trillin 6′-O-glucoside: A low-abundance yet pharmacologically active polyphyllin from Paris polyphylla by Yaran Suo, Shuyu Li, Haining Lyu, Xin Zhao, Jiale Xing, Xin Chai, Qian Zhang, Chunjin Fu, Chengchao Xu, Jingjing Liao

“…Additionally, their complex stereochemistry and functional groups make chemical synthesis and purification difficult. …”
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The antioxidant role of aromatic plant extracts in managing neurodegenerative diseases: A comprehensive review by Youyang Zhu, Miao Tian, Shiyu Lu, Yuliang Qin, Ting Zhao, Hongling Shi, Zhaofu Li, Dongdong Qin

“…They are caused by lesions in cells and tissues of the central nervous system, resulting in corresponding dysfunctions and consequent decline in cognitive and motor functions. Neural tissues are extremely vulnerable to oxidative stress, which plays critical biological roles in NDDs. …”
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Microelectromechanical System Resonant Devices: A Guide for Design, Modeling and Testing by Carolina Viola, Davide Pavesi, Lichen Weng, Giorgio Gobat, Federico Maspero, Valentina Zega

“…We validate it through the fabrication and testing of a cantilever beam resonator functioning in the nonlinear regime and we employ it to design a ring resonator working in the linear regime. …”
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Unlocking the Potential of <i>Lacticaseibacillus rhamnosus</i> 73 as a Ripening Agent in Semi-Hard Cheese After Freeze-Drying and a Six-Month Storage Period by Mara E. Batistela, Carina V. Bergamini, Elisa C. Ale, Guillermo H. Peralta

“…Dehydration and storage conditions used to preserve dairy cultures in the industry may negatively impact their viability and functionality. This study investigated the effects of freeze-drying and storage on the metabolic activity of <i>Lacticaseibacillus rhamnosus</i> 73 (L73). …”
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Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment by Mahmoud F. Abo-Ashour, Hadia Almahli, Alessandro Bonardi, Amira Khalil, Tarfah Al-Warhi, Sara T. Al-Rashood, Hatem A. Abdel-Aziz, Alessio Nocentini, Claudiu T. Supuran, Wagdy M. Eldehna

“…In searching for new molecular drug targets, Carbonic Anhydrases (CAs) have emerged as valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 homeostasis, metabolic pathways, and much more. …”
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Examination of the Ovarian Reserve after Generation of Unilateral Rudimentary Uterine Horns in Rats by Hasan Toyganözü, Hakan Nazik, Raziye Narin, Deniz Satar, Mehmet Ali Narin, Sinem Büyüknacar, Murat Api, Hakan Aytan

“…The results of this experimental rat model study suggest that the excision of rudimentary horn could have negative effects on ipsilateral ovarian functions.…”
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Heterogeneous tissue-specific macrophages orchestrate metastatic organotropism of breast cancer: implications for promising therapeutics by Cenzhu Wang, Pinchao Fan, Yu Zhou, Meican Ma, Haowei Zhong, Lei Liu, Qin Chen, Kun Xu

“…Herein, we decipher multiple diversities of TSMs, including evolvement, profiles, functions and metabolic characteristics under different polarization states. …”
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Thermal-mechanical characteristics of groundnut shell/ ATH/ Si/ SiC ceramic particulates reinforced glass fiber-epoxy hybrid composites by H. Mohit, V.V. Vamsi Krishna, M.R. Sanjay, Suchart Siengchin, Ibrahim M. Alarifi, Adel Alblawi, Mohammed A. Alamir, Femiana Gapsari

“…The investigation illustrates the capability of natural and inorganic filler blends to improve the effectiveness of epoxy laminates for cutting-edge applications.…”
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Recurrent ischemic strokes caused by hereditary protein S deficiency from a novel PROS1 mutation: a case report by Mei-Ying Huang, Ning Su, Ya-Ping Liu, Yi-Cheng Zhu

“…Abstract Background Protein S deficiency (PSD) is an inherited thrombophilia caused by functional defects in protein S encoded by the PROS1 gene. …”
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Secoisolariciresinol Diglucoside with Antioxidant Capacity from Flaxseed: A Study on Microwave-Assisted Germination Optimization by Jinling Hu, Qingyi Zhang, Yaning Li, Qiqi Zhang, Caihua Jia, Fenghong Huang, Qianchun Deng, Cuie Tang

“…This study investigated the effect of microwave-assisted germination on the lignan concentration and antioxidant activity of several flaxseed tissue components. …”
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