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64821
Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption
Published 2024-09-01“…., defect-type interfacial polarization. Such “Janus effect” (Janus effect means versatility, as in the Greek two-headed Janus) of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first time. …”
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64822
Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis
Published 2025-06-01“…Additionally, it discusses the necessary precautions for the clinical application of these inhibitors due to potential off-target effects and the need for dose optimization. Key scientific concepts of review:: CDKs regulate key neutrophilic functions, including chemotactic responses, degranulation, NET formation, and apoptosis. …”
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64823
Impaired mucosal IgA response in patients with severe COVID-19
Published 2024-12-01“…We found that the early systemic IgA response strongly induced in patients with severe disease did not block IgG neutralization functions and activated FcRs more effectively than IgG. …”
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64824
The role of influencer content value and credibility in purchase intention
Published 2025-07-01“…This study aimed to explore the effects of different dimensions of influencer value of content and influencer credibility on purchase intention among young Egyptian adult consumers. …”
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64825
Harnessing the regenerative potential of interleukin11 to enhance heart repair
Published 2024-11-01“…While deciphering the regenerative and fibrotic effects of il11a, we found that il11-dependent fibrosis, but not regeneration, is mediated through ERK activity, suggesting to potentially uncouple il11a dual effects on regeneration and fibrosis. …”
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64826
Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor
Published 2025-03-01“…Overall, our research validates that D-PROTAC can successfully target and eliminate the “undruggable” STAT3, showcasing specificity and potent antitumor effects. This strategy will suggest a promising avenue for the development of targeted therapies against the critical functions of STAT3 in human cancers and potentially other diseases.…”
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64827
Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. L...
Published 2020-12-01“…With the introduction of molecular and cell biology into medical practice, today, stem cell therapy can become an alternative method of nonsurgical restoration of myocardial functions. The most studied and attractive is the use of mesenchymal stem cells (MSCs). …”
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64828
Enhanced and selective photocatalytic reduction of CO2 to CH4 using a Pt-loaded CuPc/g-C3N4 Z-scheme heterojunction catalyst
Published 2025-06-01“…X-ray photoelectron spectroscopy (XPS), density functional theory (DFT) calculations, and in-situ infrared (IR) analysis revealed that the Pt0 species effectively lower the activation energy for CH4 formation, while CuPc extends the light absorption range and enhances charge separation. …”
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64829
Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to...
Published 2025-07-01“…In this study, we investigated the effect of STARD1 and STARD3 on P450scc efficiency in E. coli expression models. …”
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64830
Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet
Published 2022-05-01“…Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora, and thus preventing hypertension induced by high-salt diet.…”
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64831
Gut-lung axis, probiotics, and prebiotics: insights on dysbiosis, mechanism, and prevention of lung cancer
Published 2025-07-01“…The human gastrointestinal tract is inhabited by microbiota responsible for various bodily functions and reactions. This review provides an overview of lung-related diseases and the role of the gut-lung axis (GLA) related to lung cancer. …”
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64832
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
Published 2025-01-01“…Overall, maternal exposure to PS-NPs induced profound and enduring effects on the reproductive functions of female offspring, raising critical alarms regarding the multigenerational reproductive toxicity risks associated with nanoplastic exposure in mammals.…”
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64833
Bioactive Glycyrrhizic Acid Ionic Liquid Self‐Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti‐Photoaging Signal Peptides
Published 2025-02-01“…The components ratios and inherent forming mechanisms of GA‐OMT (GAO) are optimized by molecular dynamics simulations and density functional theory calculations. Remarkably, GAO can significantly improve the sparingly soluble properties of palmitoyl pentapeptide‐4 (PAL‐4), a model peptide drug. …”
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64834
Microbially Mediated Carbon Regulation by Straw Mulching in Rainfed Maize Rhizosphere
Published 2025-06-01“…However, the specific effects of mulching on soil microbial community and carbon dynamics in semi-arid rainfed regions remain insufficiently understood. …”
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64835
Feasibility of Xenogeneic Mitochondrial Transplantation in Neuronal Systems: An Exploratory Study
Published 2025-06-01“…These findings support the feasibility of xeno-MTx and its dose-responsive biological effects in neuronal systems while underscoring the need for further research to determine long-term functional outcomes and clinical applicability.…”
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64836
ISOA‐DBN: A New Data‐Driven Method for Studying the Operating Characteristics of Air Conditioners
Published 2025-01-01“…The results show that ISOA performs better than SOA in the test of 14 standard functions. Finally, the ISOA is used to adjust the DBN parameters finely. …”
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64837
Nitrogen addition substantially affects plant phenology in terrestrial ecosystems: a meta-analysis
Published 2025-08-01“…A positive correlation exists between temperature elevation and the advancement of key phenological stages (e.g., flowering) in forest ecosystems, while temperature, precipitation, and nitrogen addition had little effect on the phenology of grassland and farmland plants.DiscussionThis is because different ecosystems have different functions, resource allocation, and climate adaptation strategies, resulting in different responses to different environmental factors. …”
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64838
Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis
Published 2025-07-01“…Design The immunosuppressive and anti-inflammatory effects of BX-BC08 were evaluated in a MC903-induced AD mouse model. …”
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64839
ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
Published 2014-08-01“…Taking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variantscould determine thrombosis risks both in arterial and venous circulation. …”
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64840
Immunosuppression of Tumor-Derived Factors Modulated Neutrophils in Upper Tract Urothelial Carcinoma Through Upregulation of Arginase-1 via ApoA1-STAT3 Axis
Published 2025-04-01“…Additionally, neutrophils from UTUC patients showed increased expression of arginase-1 and exhibited inhibitory effects of T cell functions. These findings suggest that UTUC orchestrates an immune-suppressive microenvironment through Apo-A1-mediated upregulation of arginase-1 in neutrophils, ultimately leading to the inhibition of T cell proliferation.…”
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