Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment by Li-Li Shen, Li-Xia Zhang, Li-Mei Wang, Rong-Jing Zhou, Cheng-Zhe Yang, Jin Zhang, Pi-Shan Yang

“…In conclusion, EphB4 plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 can be effectively compensated, most possibly by other ephrins with similar chemical structures.…”
Get full text

Lung cancer vaccine strategies: exploring the spectrum from traditional to RNA-based platforms by Alireza Pazoki, Alireza Pazoki, Sepehr Dadfar, Sepehr Dadfar, Atefe Alirezaee, Atefe Alirezaee, Valentyn Oksenych, Dariush Haghmorad

“…This approach not only promotes tumor regression but also does so with minimal adverse effects. The death of tumor cells induced by these vaccines triggers a cascade of immune responses, activating functional T cells and sustaining the cancer-immunity cycle. …”
Get full text

The impact of non-ionizing electromagnetic radiation emitting devices on the male reproductive system by Michał Sienkiewicz, Bartosz Pawłowski, Magdalena Kłusek, Dorota Zatłoka-Mazur, Filip Klimas, Kacper Rusiński, Bartłomiej Sienkiewicz

“…The aim of the study was to analyse the current state of knowledge on the impact of NIR emitted by modern devices on the functioning of the male reproductive system and to identify possible mechanisms behind it. …”
Get full text

The Role of Physical Activity in Male Reproductive Health – A Systematic Review by Joanna Prus, Klaudia Łuczak, Hanna Sitarek, Adrianna Tabeau, Patryk Dudek, Wiktoria Ulicka, Marcel Chudzikowski, Justyna Pięta, Agnieszka Pawlik, Agata Prokopiuk

“…The negative effect is caused by many mechanisms, such as impairing the functioning of hormonal axes, worsening semen parameters or injuries causing urogenital disorders. …”
Get full text

Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals by Alejandra Álvarez-Mínguez, Natalia del Río, Ana Belén-Blázquez, Elena Casanova, José-María Orduña, Patricia Camarero, Carolina Hurtado-Marcos, Carmen del Águila, María–Jesús Pérez-Pérez, Miguel A. Martín-Acebes, Rubén Agudo

“…We have validated this method as a sensitive and suitable assay for the identification of WNV MTase inhibitors assessing the inhibitory effect of the broad MTase inhibitor sinefungin, a natural nucleoside analog of the universal methyl donor S-adenosyl methionine (SAM). …”
Get full text

The gender-sensitive spectrum of neurodevelopmental disorders: a case report on a ZMYM3 variant in a 19-year-old female by Alberto Cordella, Silvia Beatrice Maitz, Daniela Distefano, Marianna Lissi, Lucia Morellini, Leonardo Sacco, Leonardo Sacco, Leonardo Sacco

“…BackgroundNeurodevelopmental disorders (NDDs) such as Intellectual Disability, Autism Spectrum Disorder (ASD), and Attention-Deficit/Hyperactivity Disorder (ADHD) impact cognitive, behavioral, and social functions. The Zinc finger MYM-type protein 3, located on the X-chromosome, has been implicated in neurodevelopment, but its effects in females remain poorly understood due to limited research.Case presentationWe report a 19-year-old female with a de novo heterozygous variant in ZMYM3 (NM_201599.3:c.1927C>G, p.…”
Get full text

Resveratrol from grape pomace: Mitigation of lead-induced oxidative stress-related renal toxicity: In silico and In vivo studies by Mohamed Seif, Hanan Y. Aati, Bin Wei, Mohamed A. Tantawy, Mohamed Sayed, Ziyu Guo, Sherien M. Bakry, Mahmoud Emam

“…However, co-treatment with RES together with PbAc relieved the oxidative stress and inflammation at the protein and mRNA levels, as well as improved renal functions in PbAc-exposed rats. The integrated biomarker response (IBR) illustrated that RES significantly mitigated the toxic effects of PbAc exposure, which considers RES a potential nephroprotective natural drug obtained from grape pomace.…”
Get full text

The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer by Juan Guzman, Martin Hart, Katrin Weigelt, Angela Neumann, Achim Aigner, Chiara Andolfi, Florian Handle, Stefanie Rheinheimer, Ulrike Fischer, Uta D. Immel, Verena Lieb, Eckart Meese, Zoran Culig, Bernd Wullich, Helge Taubert, Sven Wach

“…To study their molecular and functional features, the enzalutamide-resistant PCa cell lines LNCaP Abl EnzR and DuCaP EnzR constitute valuable in vitro models. …”
Get full text

Microstructural design opportunities and phase stability in the spray-formed AlCoCr0.75Cu0.5FeNi high entropy alloy by Vikas Shivam, Shubhada Kar, Gopi K. Mandal, N.K. Mukhopadhyay, V.C. Srivastava

“…High entropy alloys (HEAs) have gained significant attention due to their enhanced mechanical and functional properties compared to conventional alloys, particularly based on opportunities for microstructural design. …”
Get full text

Potentiality of Antibacterial Gels for the Prophylactic Coating of Hernia Repair Prosthetic Materials by Bárbara Pérez-Köhler, Selma Benito-Martínez, Celia Rivas-Santos, Verónica Gómez-Gil, Francisca García-Moreno, Gemma Pascual

“…This study assessed the in vitro response of two antibacterial gels made of 1% carboxymethylcellulose (CMC) functionalized with an antiseptic (chlorhexidine, CHX) or an antibiotic (rifampicin, RIF), developed for the coating of polypropylene (PP) meshes for hernia repair. …”
Get full text

Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells by Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, Saveria Aquila

“…In summary, this article indicates a novel functional interplay between estrogen receptor beta and sirtuin-3 counteracting reactive oxygen species production in TCam-2 cells. …”
Get full text

Invasive common milkweed strongly simplifies insect flower-visiting networks by Edina Török, Riho Marja, Ágota Réka Szabó, Róbert Gallé, Péter Batáry

“…More diverse networks were observed in the control areas. Functional complementarity and the cluster coefficient of networks were significantly higher in milkweed-invaded areas compared to control areas during milkweed flowering. …”
Get full text

N-Trimethylation of nanochitin for high dispersibility and pH-independent antibacterial activity by Masaki Kawamoto, Toshifumi Mizuta, Hironori Kaminaka, Masaaki Akamatsu, Shinsuke Ifuku

“…Their surface charge plays a crucial role in their antibacterial functions, which occur through electrostatic interactions. …”
Get full text

Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy by Man Fang, Lei Cao, Zhao Zhang, Zhen Yu, Yue Shen, Jieqi Chen, Juan Chen, Yue-Qin Li, Zhaoqian Liu, Yingcai Meng, Haihua Xiao, Qiang Qu, Ji-Ye Yin, Xiang-Ping Li

“…While numerous studies concentrate on their functional modifications and targeted delivery, tumor-induced platinum resistance is frequently overlooked. …”
Get full text

Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies by Andressa V. B. Nogueira, Marjan Nokhbehsaim, Sema Tekin, Rafael S. de Molon, Luis C. Spolidorio, Svenja Memmert, Anna Damanaki, Andreas Jäger, Sigrun Eick, James Deschner, Joni A. Cirelli

“…The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium. In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease. …”
Get full text

A Neuropsychological Rehabilitation Program for Cognitive Impairment in Psychiatric and Neurological Conditions: A Review That Supports Its Efficacy by Ainara Gómez-Gastiasoro, Javier Peña, Naroa Ibarretxe-Bilbao, Olaia Lucas-Jiménez, María Díez-Cirarda, Oiane Rilo, Genoveva Montoya-Murillo, Leire Zubiaurre-Elorza, Natalia Ojeda

“…These changes were not restricted to specific neurocognitive domains since participants attending the REHACOP program also showed changes in social cognition and daily functioning variables by means of both direct and transfer effects. …”
Get full text

MSPO: A machine learning hyperparameter optimization method for enhanced breast cancer image classification by Haonan Li, Vijay Govindarajan, Tan Fong Ang, Zaffar Ahmed Shaikh, Amel Ksibi, Yen-Lin Chen, Chin Soon Ku, Ming Chern Leong, Fatiha Hana Shabaruddin, Wan Zamaniah Wan Ishak, Lip Yee Por

“…Tests using the CEC 2022 benchmark functions reveal that MSPO surpasses leading algorithms regarding optimization precision and convergence rate. …”
Get full text

Zinc in Dermatology: Exploring Its Emerging Role in Enhancing Botulinum Toxin Formulations and Clinical Efficacy by Lacey Foster, Jose A. Foppiani, Helen Xun, Daniela Lee, Begum Utz, Angelica Hernandez Alvarez, Maria J. Domingo-Escobar, Iulianna C. Taritsa, Dominika Gavlasova, Theodore C. Lee, Gavin J. Lin, Umar Choudry, Samuel J. Lin

“…Zinc is widely recognized for its critical functions in skin health, including morphogenesis, regeneration, and protection, and its use in aesthetic medicine offers a unique opportunity for innovation. …”
Get full text

Metabolomics analysis of extracellular vesicles derived from bovine colostrum and mature milk by Sitong Zhang, Xipeng Sun, Yameng Zhang, Rong Huang, Wenyou Situ, Huaxi Yi, Lingjun Tong

“…This study aims to explore the metabolomic profiles of C-mEVs and M-mEVs to uncover their molecular characteristics and potential biological functions. The mEVs were purified from both bovine colostrum and mature milk using ultracentrifugation combined with size exclusion chromatography. …”
Get full text

Microbial community shifts drive biodegradable microplastic inhibition of seed germination in plateau wetlands by Hong Xiang, Jia-Xian Luo, Hao-Ran Bao, Xiao-Long Sun, Hao-Qin Xiong

“…This study elucidates the mechanistic role of microplastic (MPs)-induced microbial shifts in suppressing soil seed bank functionality within plateau wetlands. A greenhouse soil pot experiment was designed to examine the impact of varying MPs particle sizes and concentrations. …”
Get full text