Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1 by Zonglai Liu, Dan Du, Shizhong Zhang

“…Rescue assays suggested that the effect of miR-1247-3p inhibition on the viability, migration, and angiogenesis of HUVECs was partly abrogated by the knockdown of FOXO1. …”
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Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans. by Susan K Glendinning, Steven D Buckingham, David B Sattelle, Susan Wonnacott, Adrian J Wolstenholme

“…Anthelmintic resistance is a major problem in livestock farming, especially of small ruminants, but our understanding of it has been limited by the difficulty in carrying out functional genetic studies on parasitic nematodes. An important nematode infecting sheep and goats is Haemonchus contortus; in many parts of the world this species is resistant to almost all the currently available drugs, including ivermectin. …”
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Targeting prostate cancer by new bispecific monocyte engager directed to prostate-specific membrane antigen. by Gargi Das, Jakub Ptacek, Jana Campbell, Xintang Li, Barbora Havlinova, Satish Kumar Noonepalle, Alejandro Villagra, Cyril Barinka, Zora Novakova

“…Our findings illustrate that 5D3-CP33 effectively and specifically activates monocytes upon PSMA-positive target engagement, resulting in the elimination of tumor cells. …”
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The visuomotor synchronization immersive virtual reality of a depression avatar in a stigma context experience mobilizes the fronto-parietal cortex and anterior insula by Kelssy Hitomi dos Santos Kawata, Kelssy Hitomi dos Santos Kawata, Wey Guan Lem, Koki Ono, Hiroshi Oyama

“…IntroductionThe gradual synchronization of the movement of one’s real hand with a virtual one can effectively induce a sense of embodiment (SoE) with an avatar with depression. …”
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DEPDC1 facilitated malignant phenotypes and disease progression of liposarcoma by modulating KIF20A by Mingwei Yu, Huishan Zhao, Yujie Sun

“…In vitro assays showed that DEPDC1 overexpression enhanced cell proliferation, migration, and invasion in 93T449 cells, whilst an opposite effect was observed in SW872 cells with DEPDC1 knockdown. …”
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The Diverse Activities and Mechanisms of the Acylphloroglucinol Antibiotic Rhodomyrtone: Antibacterial Activity and Beyond by Rupa Rani, Gabriela Marinho Righetto, Ann-Britt Schäfer, Michaela Wenzel

“…Furthermore, rhodomyrtone has shown antioxidant activity and displays cognitive effects, such as decreasing depressive symptoms in mice. …”
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Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders by Lu Bai, Mei Jin, Qi Zhang, Suzhen Sun

“…Nutritional factors influence the dopaminergic system's functionality by affecting neurotransmitter synthesis and metabolism, modulating gut microbiota and contributing to neuroinflammation. …”
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Machine learning projection of climate and technology impacts on crops key to food security by Dan Li, Vassili Kitsios, David Newth, Terence John O’Kane

“…Our key finding is that technological effects are prone to have a diminishing impact on wheat and rice production over time and may not adequately offset the negative effects of climate change under certain future emission scenarios. …”
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The impact of different adverse childhood experiences on the dimensions of emotional dysregulation in adults with major depression by Paula Dagnino, Cecilia Cordeu, Eduardo Franco-Chalco, Sergio Gloger, Martín Duisallant, Joaquín Mizon, Loreto Romero

“…Six follow-up linear regressions predicted each DERS subscale and the total DERS score from the CTQ-SF dimensions.ResultsPhysical abuse was the only CTQ dimension with a significant multivariate effect. In univariate models, emotional abuse predicted higher overall dysregulation and increased emotional dyscontrol, everyday interference, and emotional inattention, whereas greater physical abuse was associated with reduced everyday interference.DiscussionEmotional abuse appears to be the principal driver of both global and facet-specific emotion-regulation difficulties in adults with MDD, suggesting that interventions emphasizing impulse control, emotion awareness, and reduction of functional interference may be particularly beneficial for this subgroup.LimitationsThe cross-sectional, selfreport design precludes causal inferences and may be subject to recall bias; future work should employ longitudinal, multimethod approaches to elucidate mechanisms and resilience factors.…”
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Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. by Ignacio E Schor, David Llères, Guillermo J Risso, Andrea Pawellek, Jernej Ule, Angus I Lamond, Alberto R Kornblihtt

“…Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing. …”
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The lived experiences of childhood trauma in war: has post-traumatic growth occurred? by Marzie Hashemi, Maryam Mahmoudzadeh

“…Background: This study seeks to explore the Post-Traumatic Growth (PTG) condition, a transformative psychological process that promotes improved cognitive functioning and resilience in individuals who suffered childhood trauma, including those affected by the Iran-Iraq war. …”
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Methodological approach to the quantitative assessment of risk caused by a collision between birds and aircraft by A. G. Guziy, A. P. Kostina

“…The proposed methodological approach ensures the functioning of the risk management loop in the flight safety management system of any aircraft operator when performing a monthly risk analysis associated with seasonal and regional BASH in Russia.…”
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DEVELOPMENT OF THE LINGUOCULTURAL COMPETENCE OF FUTURE TEACHERS OF PRESCHOOL EDUCATION INSTITUTIONS AS A PEDAGOGICAL PROBLEM by Inna D. Davydchenko

“…On the basis of the analysis of theoretical sources, the notion of formation of linguistic and cultural competence as a pedagogical phenomenon and linguistic and cultural education as a pedagogical process is most effectively considered in the implementation of several procedures, which include: a) analysis of the concept of „linguistic and cultural competence” in the scientific and pedagogical theory; the emphasis of the main stages and social and historical preconditions of the formation of the researched issue; c) analysis of the evolution of theoretical concepts of linguistic and cultural competence, its relationship with the culture of society, language and the laws of functioning in the historical context on the basis of the highlighted social and historical background. …”
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The quality of fixed prosthetic work provided by undergraduate dental students and its correlation with patient satisfaction: a prospective study by Noor H. Ismail, Sanaa Aljamani, Alaa AL-Haddad, Othman Sa’deh, Faisal Alkiswani, Islam Abd Alraheam

“…Abstract Objectives To assess the quality of fixed prosthetic work provided by the undergraduate dental students at The University of Jordan Hospital after 3 years follow up, and its’ effect on patients’ satisfaction with the dental treatment provided. …”
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Modulation Instability and Dynamical Analysis of New Abundant Closed-Form Solutions of the Modified Korteweg–de Vries–Zakharov–Kuznetsov Model With Truncated M-Fractional Derivativ... by Md. Shafiqul Islam, Md. Mamunur Roshid, Mahtab Uddin, Ashek Ahmed

“…Under the condition of parameters, the obtained solutions exhibit hyperbolic, trigonometric, and rational functions with free parameters. Using the Maple software, we present three-dimensional (3D) plots with density plots and two-dimensional (2D) graphical representations for appropriate values of the free parameters. …”
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Living Away From Specialized Pollinators: The Pollination System of Ceiba pentandra in the Yucatan Peninsula by Henry Dzul‐Cauich, Kathryn E. Stoner, Carlos N. Ibarra‐Cerdeña, Miguel A. Munguía‐Rosas

“…As predicted, we found five functional groups of nocturnal and diurnal pollinators. …”
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The Role of microRNA-31 in the Initiation and Progression of Colorectal Cancer by Mohammad Kordkatouli, Mehr Ali Mahmood Janlou, Audrius Dulskas, Aryan Sateei

“… miR-31 is critically involved in the initiation and progression of CRC by regulating multiple pathways essential for tumorigenesis and influencing various cellular functions, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. miR-31 also impacts EMT-related transcription factors such as ZEB1, SNAIL, and TWIST, which further facilitate the shift to a mesenchymal state, leading to increased invasiveness and metastatic spread of CRC cells, commonly to organs like the liver, which worsens patient prognosis in the context of apoptosis, miR-31 inhibits pro-apoptotic factors such as BAX and Caspase-3, reducing programmed cell death and allowing cancer cells to survive longer this anti-apoptotic influence is essential for miR-31’s role in chemoresistance, as it enables cancer cells to evade the cytotoxic effects of chemotherapy. …”
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Assessment the impact of palygorskite modified by chlorides on speciation and environmental risk of heavy metals in soil contaminated by Elnour Mohamed, Jun Ren, Ling Tao, Azizza Mala

“…Characterization methods involving Scanning Electron Microscopy (SEM), X-ray deflection (XRD and Fourier Transform Infrared Spectroscopy (FT-IR) were used to characterize the effects of palygorskite on the chemical functional groups of chloride stick and the construction of stabilizers. …”
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The clinical efficacy and influencing factors of uterine artery embolization in the treatment of different types of uterine adenomyosis by Wen-Jiang Wei, Zuo-Fu Tian, Hao Liu, Cheng-Jiang Xiao

“…Compared with traditional surgery and drug therapy, uterine artery embolization (UAE), as a new treatment with less trauma, faster recovery and uterine preservation, can relieve pain while preserving normal physiological and reproductive functions of the uterus, which is favored by the majority of patients. …”
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Antibacterial Efficacy of Eucalyptus Essential Oil against Respiratory Infection Pathogens and Characterization of its Bioactive Compounds by Ajijolakewu Kamoldeen Abiodun, Ahmed Risikat Nike, Kazeem Muinat Olanike, Otuyelu Frank Olakunle, Abdulraheem Zulaikhat Mojisola

“…A total of 12 compounds were found to have bioactive functions with p-Cymene having 34.07%, gamma-Terpinene (7.01%), Cyclohexasiloxane (5.30%), 2-Aminobenzoic acid (4.59%). …”
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