Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms by Lu X, Ji L, Chen D, Lian X, Yuan M

“…Future research that integrates multi-ancestry GWAS, functional validation, and multi-omics approaches may further enhance the utility of Mendelian randomization. …”
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The role of various factors in the process of biofilm formation by bacilli by G.R. Akhmetova, N.L. Rudakova, T.L. Din, M.R. Sharipova

“…We also investigated the effect of ethanol and sodium chloride on the ability of the B. subtilis strains to form biofilms in a liquid medium. …”
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Carbon Nanotubes as Excellent Adjuvants for Anticancer Therapeutics and Cancer Diagnosis: A Plethora of Laboratory Studies Versus Few Clinical Trials by Silvana Alfei, Caterina Reggio, Guendalina Zuccari

“…Moreover, serious adverse effects and/or great pain usually arise during treatments and/or in survivors, thus lowering the overall effectiveness of these cures. …”
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Horse Meat Hydrolysate Ameliorates Dexamethasone-Induced Muscle Atrophy in C57BL/6 Mice via the AKT/FoxO3a/mTOR Pathway by Hee-Jeong Lee, Dongwook Kim, Yousung Jung, Soomin Oh, Cho Hee Kim, Aera Jang

“…These findings demonstrate the potential of A4 < 3kDa as a functional food ingredient for preventing muscle atrophy.…”
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Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. by Sandor Klis, Adelita Ranchor, Richard O Phillips, Kabiru M Abass, Wilson Tuah, Susanne Loth, Kristien Velding, Tjip S van der Werf, Ymkje Stienstra

“…<h4>Results</h4>The median (Inter Quartile Range) score on the DLQI was 0 (0-4), indicating good QoL. 85% of former patients indicated no effect, or only a small effect of the disease on their current life. …”
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The Probiotic Potential, Safety, and Immunomodulatory Properties of <i>Levilactobacillus brevis</i> ZG2488: A Novel Strain Isolated from Healthy Human Feces by Zhijie Cao, Mengshan Chen, Yulu Chen, Hui Sun

“…Probiotics exert beneficial effects on health improvement, infection prevention, and disease management. …”
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Laser-Induced Periodic Nanostructure on Polyimide Film Surface Using 248 nm Excimer Laser by Songqing Zhao, Xuan Xie, Mingyang Li, Limin Yang, Tongjing Liu

“…These results demonstrate the potential of UV nanosecond laser processing for the scalable fabrication of functional nanostructures on polymer surfaces for applications in surface engineering and biointerfaces.…”
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The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy by Huili-li Ren, Shao-hui Zhang, Pei-yuan Li, Pei-yuan Li

“…Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in the regulation of a variety of cellular functions. In recent years, PDE4 has attracted great interest in cancer research, and its role in tumorigenesis and development has been gradually elucidated. …”
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Assessment quality of life as a factor for the improvement of patient-focused therapy of the preschool children with type 1 diabetes by I. L. Nikitina, A. O. Plaksina, A. V. Pavlov, I. A. Kelmanson

“…Both versions enable measuring child HRQoL in physical, emotional wellbeing, self-esteem, family, friends, everyday functioning, and the disease dimensions, as well as KINDL total on a 0-100 scale. …”
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A Hiplot‐based web service for cold atmospheric plasma high‐throughput data integration and analysis on breast cancer by Xiaofeng Dai, Mingjie Wang, Yang Liu

“…However, high‐throughput data detailing the effect of CAP on cancer cells is lacking, let alone the corresponding database and analytical tool. …”
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A Pantropical Analysis of Fire Impacts and Post‐Fire Species Recovery of Plant Life Forms by Dharma P. Sapkota, David P. Edwards, Mike R. Massam, Karl L. Evans

“…Fires can negatively and positively impact biodiversity and ecosystem functioning, depending on how frequently fire occurs in the focal ecosystem, but factors influencing biodiversity responses to fire are inadequately understood. …”
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Investigation about crack propagation paths in thin rim gears by F. Curà, A. Mura, C. Rosso

“…In literature, few works are present concerning this topic, in particular related to the effect of geometrical parameters that may affect the crack propagation. …”
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Comparison of FORCE trained spiking and rate neural networks shows spiking networks learn slowly with noisy, cross-trial firing rates. by Thomas Robert Newton, Wilten Nicola

“…Despite this, rate networks still functioned well when their weight matrices were replaced with those learned from spiking networks. …”
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GuidedBox: a segmentation-guided box teacher-student approach for weakly supervised road segmentation by Teerapong Panboonyuen, Chaiyut Charoenphon, Chalermchon Satirapod

“…Additionally, we introduce noise-aware pixel loss and noise-reduced affinity loss functions to optimize the student model with pseudo masks dynamically. …”
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Endothelial dysfunction and its correction with perindopril therapy in patients with coronary heart disease by O. A. Vartanova, N. V. Mikhailova, T. E. Morozova

“…To investigate endothelial dysfunction (ED) in patients with coronary heart disease (CHD), stable effort angina, Functional Class (FC) I-III, as well as to study perindopril potential in ED correction.Material and methods. …”
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Digitalization of the planning system at mechanical engineering enterprises: results, problems, prospects by Fomin Semyon, Ermakova Zhanna

“…As a result of testing, it was largely possible to implement the proposed recommendations and achieve the declared effects of digitalization of the end-to-end planning system in the machine-building holding. …”
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How does playfulness (re)frame the world? Evidence for selective cognitive and behavioral redirecting in times of adversity by Xiangyou Shen, Zoe Crawley

“…Sequential analyses including MANOVA, ANOVA, and ANCOVA were performed to examine overall, univariate, and adjusted group differences, respectively, validated by sensitivity analysis across three group categorization methods.ResultsThree sets of contrasting findings evidenced selective playful (re)framing effects, wherein more playful individuals (1) shared similar perceptions of current risk and protective factors while adopting a more optimistic future outlook, (2) perceived similar levels of vulnerability and isolation but engaged in significantly higher levels of resilient coping and adaptive leisure, and (3) participated in similar categories and frequencies of leisure activities but with higher experiential quality, marked by greater immersion, activeness, and positive affect.DiscussionPlayfulness functions as a “color spotlight” rather than “rose-tinted glasses,” with selective influence through “lemonading”—creatively imagining and pursuing positive possibilities to cultivate adaptive, enjoyable experiences while maintaining a clear-eyed realism about challenges. …”
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Heat stress induces specific methylation, transcriptomic and metabolic pattern in dairy cows and their female progeny by Kathrin Halli, Tong Yin, Christian Koch, Stefan Krebs, Sven König

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Integrated irrigation of water and fertilizer with superior self-correcting fuzzy PID control system. by Wanjun Zhang, Jingsheng Tong, Feng Zhang, Wanliang Zhang, Jingxuan Zhang, Jingyi Zhang, Jingyan Zhang, Honghong Sun, Derek O Northwood, Kristian E Waters, Hao Ma

“…., irrigation flow fluctuations, environmental disturbances) or nonlinear interactions (e.g., coupling effects of fertilizer concentration and pH). While conventional fuzzy PID control incorporates fuzzy reasoning, its offline-designed rule bases and membership functions lack online adaptive parameter correction, leading to degraded precision in complex operating conditions. …”
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Toward a physics-guided machine learning approach for predicting chaotic systems dynamics by Liu Feng, Yang Liu, Benyun Shi, Jiming Liu

“…Specifically, our method consists of three key elements: a data-driven component (DDC) that captures dynamic patterns and mapping functions from historical data; a physics-guided component (PGC) that leverages the governing principles of the system to inform and constrain the learning process; and a nonlinear learning component (NLC) that effectively synthesizes the outputs of both the data-driven and physics-guided components. …”
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