Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies by Wei Q, Lin N, Wang L

“…Additionally, we evaluated the effects of TOP2A modulation in subcutaneous and liver metastasis mouse xenograft models.Results: TOP2A was significantly overexpressed in RB tissues (p < 0.0001). …”
Get full text

Demystifying the New Dilemma of Brain Rot in the Digital Era: A Review by Ahmed Mohamed Fahmy Yousef, Alsaeed Alshamy, Ahmed Tlili, Ahmed Hosny Saleh Metwally

“…These factors impair executive functioning skills, including memory, planning, and decision-making. …”
Get full text

Optimization of the Fc-fusion protein refolding method produced from the bacterial expression system by P. S. Astrelina, S. A. Ishchuk, A. V. Kabanova, R. V. Drai

“…The production of Fc-fused proteins in prokaryotic systems often results in the formation of insoluble aggregates due to improper folding of polypeptide chains. To obtain functional proteins, a refolding step is required. However, developing refolding parameters can be time-consuming. …”
Get full text

Characterization, Microbial Community Structure, and Pathogen Occurrence in Two Typical Eel Farms by Jing-Ying Lai, Hui-Rong Lin, Xiao-Hui Sun, Gong-Ren Hu, Rui-Lian Yu, Jia-Qi Li

“…The treatment processes could not effectively remove nitrogen pollution, and the abundance of nitrogen functional bacteria was low. …”
Get full text

Enhancement of Antioxidative and Anti-Inflammatory Activities of Corn Silk Polysaccharides After Selenium Modification by Zheng YY, Tong XY, Zhang DY, Ouyang JM

“…Yu-Yun Zheng, Xin-Yi Tong, Da-Ying Zhang, Jian-Ming Ouyang Institute of Biomineralization and Lithiasis Research, College of Chemistry and Materials Science; Jinan University, Guangzhou, 510632, People’s Republic of ChinaCorrespondence: Jian-Ming Ouyang, Email toyjm@jnu.edu.cnObjective: This study aimed to study the effect of selenium modification on the bioactivity of corn silk polysaccharides, particularly its antioxidant and anti-inflammatory functions.Methods: HNO3-NaSeO3 was used to selenize degraded corn silk polysaccharides (DCSP). …”
Get full text

In vitro evaluation of the biocompatibility and bioactivity of a SLM-fabricated NiTi alloy with superior tensile property by Yu Sun, Zhihui Zhang, Qingping Liu, Luquan Ren, Jincheng Wang

“…Abstract Because nickel-titanium (NiTi) alloys have unique functions, such as superelasticity, shape memory, and hysteresis similar to bone in the loading-unloading cycles of their recoverable deformations. …”
Get full text

Indigenous Wild Edible Mushrooms: Unveiling the Chemical Compositions and Health Impacts by Nattaya Konsue, Sunantha Ketnawa, Si Qin

“…This study not only underscores the nutritional and health benefits of WEMs but also establishes a vital scientific foundation for future research on their health effects and in vivo applications. In turn, these findings could serve as a crucial resource for optimizing the use of WEMs in ethnic cuisines and strengthening claims regarding their functional food properties.…”
Get full text

Sensory Processing Measure and Sensory Integration Theory: A Scientometric and Narrative Synthesis by Hind M. Alotaibi, Ahmed Alduais, Fawaz Qasem, Muhammad Alasmari

“…A narrative analysis, guided by these clusters, explored sensory processing differences in children with developmental disorders like autism spectrum disorder (ASD) compared to typically developing children, the relationship between sensory processing and other functional areas, the impact of classroom contexts on sensory processing, the use of EEG in sensory processing disorder (SPD) diagnosis, and the effectiveness of interventions like sound-based therapy and sensory integration therapy. …”
Get full text

The Impact of Physiological and Psychological Fatigue on Work Efficiency: A Case Study of Parcel Sorting Work by Miaomiao Li, Zuqin Ma, Rui Yan, Jielin Yin

“…It often results in reduced energy levels and diminished functionality, significantly impacting an individual’s performance at work and their overall well-being. …”
Get full text

Differentiation of European yellow rust subraces within the 'Warrior(-)' genetic group. by Claudia Breitkreuz, Philipp Schulz, Anne-Kristin Schmitt, Kerstin Flath, Tiphaine Vidal, Amelia Hubbard, Kostya Kanyuka, Andreas Stahl, Jens Keilwagen, Dragan Perovic

“…From these, we established four functional genetic markers capable of distinguishing between the 'Amboise' and 'Benchmark' subraces, though differentiation of 'Kalmar' was not successful. …”
Get full text

Radiative transitions of χ cJ → ψγ and χ bj → Υγ by Su-Yan Pei, Wei Li, Tianhong Wang, Guo-Li Wang

“…Abstract In the framework of instantaneous Bethe-Salpeter equation, according to the J PC of quarkonia, we find that their wave functions all contain multiple partial waves, rather than pure waves. …”
Get full text

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice by Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang

“…APPL1 is a signaling protein with multiple functional structural domains and plays an important role in the APN signaling pathway. …”
Get full text

Enhancing chemical reaction search through contrastive representation learning and human-in-the-loop by Youngchun Kwon, Hyunjeong Jeon, Joonhyuk Choi, Youn-Suk Choi, Seokho Kang

“…Scientific contribution This study seeks to enhance the search functionality of chemical reaction databases by drawing inspiration from recommender systems. …”
Get full text

Rifampin mediated decapsulation and enhanced bacterial clearance: a new mechanism of rifamycinsResearch in context by Gi Young Lee, Jeongmin Song

“…Computational and functional studies on other encapsulated bacteria were also carried out. …”
Get full text

Probiotic Potential of Lactic Acid Bacteria Strains Isolated from Artisanal Cheeses: Impact on <i>Listeria monocytogenes</i> Infection by Carla Burgos, Constanza Melian, Lucía M. Mendoza, Susana Salva, Patricia Castellano

“…Exposure to LAB supernatants resulted in a significant reduction in the adhesion and intracellular count of <i>L. monocytogenes</i> in Caco-2 cells, with <i>Lat. curvatus</i> SC076 showing the most significant effect. Based on its probiotic characteristics, <i>Lat. curvatus</i> SC076 is a promising candidate for functional foods, pending further in vivo studies to assess its potential in the food industry.…”
Get full text

Phytochemical Screening and In Vitro Antioxidant and Anticancer Evaluation of Stem and Leaf Extracts of Cissampelos pareira L. by Arthid Thim-uam, Chutamas Thepmalee, Wittaya Chaiwangyen, Napapan Kangwan, Ratchanaporn Chokchaisiri, Piyawan Nuntaboon, Angkana Songkrao, Amnart Onsa-ard

“…Therefore, both leaf and stem extracts of C. pareira L. hold promise for development as functional foods or dietary supplements due to their diverse and significant biological activities.…”
Get full text

MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN by Di Zhao, Youbin Chen, Shunliang Chen, Chuangyi Zheng, Jun Hu, Shaowei Luo

“…Recent evidence has indicated that miR-19a participates in the cancer tumorigenic progression. However, the functional roles of miR-19a in cancer stem cells are still unclear. …”
Get full text

Anticorrosion Protection of Low-Carbon Steel by the Eco-Friendly Composition Based on Gum Arabic by Mariia-Olena Danyliak, Serhii Lavrys, Yuliia Rizun, Sergiy Korniy

“…It was established that the inhibitory efficiency of the composition is enhanced with increasing concentration (0; 0.25; 0.50; 0.75; 1; 1.50; 2.0 g/L) and reaches a maximum at 2.0 g/L of each component. The protective effect of the composition is determined by the combination of two compounds of different natures, which have hydroxyl and carboxyl functional groups. …”
Get full text

Endocrine disruptors as promoters of biosphere carcinogenic background by G. A. Belitsky, K. I. Kirsanov, E. A. Lesovaya, E. M. Zhidkova, I. A. Khitrovo, M. G. Yakubovskaya

“…For the review preparation, we analyzed articles on molecular mechanisms of the effects of endocrine disruptors, available at biomedical literature databases sciVerse scopus, pubmed, Web of science, Rsci. …”
Get full text

The has-miR-526b binding-site rs8506G>a polymorphism in the lincRNA-NR_024015 exon identified by GWASs predispose to non-cardia gastric cancer risk. by Qiu-Hong Fan, Rong Yu, Wei-Xian Huang, Xi-Xi Cui, Bing-Hui Luo, Li-Yuan Zhang

“…Further stratification analysis showed that the risk effect was more pronounced in subgroups of smokers (P = 0.001). …”
Get full text