Toxicity analysis of amoxicillin, polyphosphate ester and its complex with amoxicillin on mice by Mariia Kozak, Iryna Petruh, Iryna Kovalchuk, Vasyl Vlizlo

“…It is known to be the first reason of adverse effects caused by medications in human and animals. …”
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Melatonin Treatment Delays the Senescence of Cut Flowers of “Diguan” Tree Peony by Affecting Water Balance and Physiological Properties by Mengdi Wu, Peidong Zhang, Yuke Sun, Wenqian Shang, Liyun Shi, Shuiyan Yu, Songlin He, Yinglong Song, Zheng Wang

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COMPARATIVE ANALYSIS OF CYTOKINE PRODUCTION BY BLOOD IMMUNOCOMPETENT CELLS AND TUMOR IN DIFFERENT AGE GROUPS OF PATIENTS WITH INVASIVE DUCTAL CARCINOMA by T. A. Kunts, E. S. Mikhaylova, I. O. Marinkin, N. A. Varaksin, A. I. Autenshlyus

“…Increase of SIPA for all cytokines in blood cells supernates, in comparison to SIPA of tumor supernates, could be explained by initially high levels of spontaneous cytokine production by the tumor and its microenvironment that are able to promote tumor growth. Therefore, effect of PA upon tumor tissue was not so expressed as its effect upon immunocompetent blood cells. …”
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Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands by Cheryl Hunter, Tejas B. Kadakia, Dianne Cooper, Mauro Perretti, Richard C. Schwartz, Simon B. Brown

“…We demonstrate here that dofetilide (DOF), a selective inhibitor of the Kv11.1 current, had a profound inhibitory effect on neutrophil recruitment in mice following TLR/IL-1R–elicited peritonitis or intrascrotal injection of IL-1β, but had no effect on responses seen with TNFα. …”
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Extracellular vesicles from melatonin-preconditioned mesenchymal stromal cells protect human umbilical vein endothelial cells against hypoxia/reoxygenation detected by UHPLC-QE-MS/... by Liwei Cai, Qian Ma, Danli Zhuo, Qingcheng Chen, Yiming Zhuang, Shengkun Yuan, Xin Lu, Changyi Zhang, Yu Zhou

“…Melatonin (MT), however, not only exerts a significant protective effect in the treatment of cardiovascular diseases but also enhances biological functions of MSCs through pretreatment. …”
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Oxidative Processes and Xenobiotic Metabolism in Plants: Mechanisms of Defense and Potential Therapeutic Implications by Caterina Vicidomini, Rosanna Palumbo, Maria Moccia, Giovanni N. Roviello

“…These compounds effectively neutralize ROS and help regenerate other antioxidants, offering extensive protection against oxidative stress. …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…Numerous studies have shown that low levels of TTR are associated with increased mortality overall and in relation to cardiovascular disease and several malignancies.Purpose There is a growing portfolio of approved and investigational transthyretin amyloidosis (ATTR) treatments that differ in their mechanisms and effects on circulating TTR. When selecting an ATTR therapy, clinicians must decide whether to stabilize and preserve TTR and its functions or knockdown and drastically reduce TTR. …”
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Physiological and transcriptome analyses provide new insights into the mechanism mediating the enhanced tolerance of melatonin-treated rhododendron plants to heat stress by Yan-xia XU, Jing ZHANG, Zi-yun WAN, Shan-xia HUANG, Hao-chen DI, Ying HE, Song-heng JIN

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LncRNA FLG-AS1 inhibits esophageal squamous cell carcinoma by regulating the miR-23a-3p/HOXD10 axis by Zhigao Zhang, Fucheng Zhang, Chuan Xue, Xiaoling Song, Yaojun Wang

“…Long non-coding RNAs (lncRNAs) have been proven to be severely dysregulated in EC, but the functions of more lncRNAs still need to be explored. …”
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Dynamic risk factors for complex regional pain syndrome after distal radius fracture surgery: multivariate analysis and prediction by Weipan Xu, Yue Liu, Bin Zhang, Junhua Ma

“…Early physical and occupational therapy can effectively prevent CRPS, but further research is needed to evaluate their long-term effects.…”
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Application of Magnetic Aquatic Plant Biochar for Efficient Removal of Antimony from Water: Adsorption Properties and Mechanism by Luyi Nan, Yuting Zhang, Min Liu, Liangyuan Zhao, Yuxuan Zhu, Xun Zhang

“…This dual functionality presents promising application prospects for the efficient adsorption and removal of Sb from water.…”
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Mindfulness-based cognitive program as a potential intervention for managing smartphone addiction and resilience in adolescents: a pilot evaluation by Anson Chui Yan Tang, Regina Lai-Tong Lee, Alex Chi-Keung Chan, Rick Yiu Cho Kwan, Paul Hong Lee

“…Smartphone behavior was evaluated by daily time spent on smartphone and frequency of using smartphone functions. Resilience was evaluated by Connor-Davidson Resilience Scale. …”
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Cardiac-targeted FGF4 encapsulated nanoliposomes improve acute myocardial injury induced by ischemia-reperfusion and adriamycin in in vitro and in vivo models by Kaihao Wang, Yipeng Du, Peixin Li, Chang Guan, Min Zhou, Lanlan Wu, Zengfu Liu, Zheng Huang

“…The current study lays an important research foundation for exploring the potential therapeutic effects of FGF4 targeting the heart.…”
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A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice by Bining Zhao, Haowen Wu, Qiyang Yao, Wenpei Bai, Jihong Kang

“…Ovarian functions were improved in some letrozole + KD mice. …”
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Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies by Anna Wawruszak, Jarogniew Luszczki, Damian Bartuzi, Joanna Kalafut, Estera Okon, Arkadiusz Czerwonka, Andrzej Stepulak

“…Accumulative evidence suggests that each sirtuin possesses individual character, implicating its role in the regulation of multifaceted biological functions leading to BC initiation, progression and metastasis. …”
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Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway by Xiaomei Fu, Jianfang Zhang, Xuanjie Huang, Zhifeng Mo, Ziyang Sang, Wenfei Duan, Wenfeng Huang

“…Curcumin (Cur) is a principal curcuminoid of turmeric and possesses specific protective properties in kidney functions. Cur also participates in the regulation of aerobic glycolysis switch. …”
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<i>Angelicae Pubescentis</i> Radix Remitted Intestine Damage in Mice Induced by <i>Escherichia coli</i> via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut... by Kehong Deng, Chang Xu, Qing He, Muhammad Safdar, Mudassar Nazar, Xiaocong Li, Kun Li

“…Additionally, these findings confirm APR’s role in addressing immediate effects rather than chronic adaptations. Future studies should investigate the prolonged effects of APR treatment beyond the acute phase.…”
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Physiological Response to Speed Endurance Soccer Training in Amateur Players by I Dewa Made Aryananda Wijaya Kusuma, Nining Widyah Kusnanik, Bayu Agung Pramono, Adi Pranoto, Yanyong Phanpheng, Resti Nurpratiwi, Mokhamad Nur Bawono, Faridha Nurhayati

“…The findings of this study indicate that SEST has a notable effect on the body’s physiological functions, namely on the cardiovascular system, anaerobic metabolism, and blood pressure. …”
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Landscape analysis of matrix metalloproteinases reveals key prognostic markers for prostate cancer by Wei Li, Xi Wei, Ying Yu, Yuan Tian, Qi Yu, Jun Qiao, Yuewei Tao, Yanfeng Li, Tao Li

“…COX-regression analysis was utilized to identify MMPs that affected (Disease-free survival) DFS. Various cellular functional experiments and conditional medium cultivation system were utilized to verify the effect of MMP11 on PCa cells. …”
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Integrated omics reveal the mechanisms underlying softening and aroma changes in pear during postharvest storage and the role of melatonin by Jiayu Xu, Ying Zhang, Hongliang Huo, Dan Qi, Xingguang Dong, Luming Tian, Chao Liu, Yufen Cao

“…Mdm-miR10988-p3 was functionally diverse and as major regulatory components in ceRNA network. …”
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