Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…Using a xenograft mouse model, the effects of MPM-1 in tumor treatment were also identified. …”
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Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes by Sungmoo Hong, Kyungsook Jung, Meejung Ahn, Jeongtae Kim, Changjong Moon, Taekyun Shin

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A Pain in the Butt: The Association Between Endo-Parasite Diversity and Horn Growth in Rocky Mountain Bighorn Sheep by Tanisha C. Henry, Samridhi Rijal, Joana Alves, Peter Neuhaus, Susan Kutz, Kathreen E. Ruckstuhl

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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…Furthermore, we demonstrated that the phenotype of M2 macrophages and CAFs can be directly modulated by TGFβ-specific T cells induced by the TGFβ vaccine, as well as indirectly modulated as a result of the immune-modulatory effects of the vaccine within the TME. TAMs tend to have tumor-promoting functions, harbor an immunosuppressive phenotype and are linked to decreased overall survival in pancreatic cancer when they harbor an M2-like phenotype. …”
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Pirfenidone Attenuates the EMT Process and the Secretion of VEGF in TGF-β2-Induced ARPE-19 Cells via Inhibiting the Activation of the NF-κB/Snail Signaling Pathway by Hongsong Li, Lijun Wang, Meilin Shao, Meimei Ren, Wenyi Zhang, Jian Zhou, Jianming Wang

“…Pirfenidone (PFD), an antifibrotic drug, has various beneficial functions such as antioxidant, antifibrotic, and anti-inflammatory effects. …”
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EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN ACHIEVEMENT OF TARGET BLOOD PRESSURE IN DIABETIC PATIENTS by O. A. Koshel'skaya, O. A. Zhuravleva, R. S. Karpov

“…Three drugs were needed to achieve target BP in baseline systolic BP >150 mm Hg (office) or >134 mmHg (ABPM). Marked beneficial effect on the morphological and functional characteristics of the vascular wall and its elastic properties, improvement of glycemic control, tissue insulin sensitivity and lipids profile were found. …”
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Parameters of lipid and oxidative-antioxidant status in persons aged 18-23 from radiation-contaminated areas under conditions of moderate physical activity by Vadym L. Sokolenko, Svitlana V. Sokolenko

“…There is a significant amount of data on the stressful effects of exercise, which contain conflicting results. …”
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mHealth Intervention for Dementia Prevention through lifestyle Optimisation (MIND-PRO) in a primary care setting: protocol for a randomised controlled trial in people with low SES... by Esther Van den Berg, Ron Handels, Henrike Galenkamp, Eric P Moll van Charante, Marieke P Hoevenaar-blom, Anne Roos van der Endt, Martien J H Kas

“…The study aims to evaluate the effectiveness and implementation of an mHealth intervention designed for self-managing lifestyle modifications with remote coaching to reduce dementia risk factors.Methods and analysis This prospective randomised open-label blinded end point (PROBE) trial follows a type 2 hybrid effectiveness-implementation design with a 12-month intervention period. …”
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Top-down generated micro- and nanoplastics reduce macrophage viability without eliciting a pro-inflammatory response by Annemijne E. T. van den Berg, Kas J. Adriaans, Luke A. Parker, Elena M. Höppener, Hanna M. Dusza, Juliette Legler, Raymond H.H. Pieters

“…This study aims to investigate whether fragmented MNPs have cytotoxic and pro-inflammatory effects on human macrophages. We examined the immunotoxic effects of mechanically degraded secondary polyvinylchloride, polypropylene and polyamide particles (PVC, PP; < 1 μm and 1–5 μm, PA6.6; 1–5 µm), in addition to primary polystyrene beads (PS; 0.05, 0.2 and 1 μm) and titanium dioxide particles (TiO2; < 0.1 μm) on human THP-1 macrophages. …”
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Meta-Analysis of Tai Chi Chuan in Treating Lumbar Spondylosis and Back Pain by Fushun Zhang, Junfang Zhao, Nan Jiang, Qiao Zhai, Juanjuan Hu, Jing Zhang

“…Background. The effectiveness of Tai Chi Chuan in treating various ailments has been well reported; however, its effect on back pain and lumbar spondylosis remains unclear. …”
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Onion Peel Powder’s Impact on the Leptin Receptors in the Hippocampus of Obese Rats by Małgorzata Komar, Monika Michalak-Majewska, Radosław Szalak, Agata Wawrzyniak, Waldemar Gustaw, Wojciech Radzki, Marcin B. Arciszewski

“…It can be speculated that the observed changes have a protective effect on the CNS structures during obesity, but this undoubtedly requires further research.…”
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Climate factors dominate the spatial variation of forest soil nutrients: a meta analysis by Xiaoxuan Du, Xinyi Li, Jiangfeng Wang, Jiali Xu, Jie Gao

“…Climate factors directly or indirectly affect the soil nutrients of planted and natural forests by influencing stand factors and key leaf functional traits, and their direct effects are greater than their indirect effects. …”
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Synthesis and swelling studies of modified chitosan smart hydrogels containing alkyl sulfonate anionic pendant groups as microparticles for insulin release by Sabikeh G. Azimi, F. Mehdi Moosavi, Zahra Khoshbin, Neda Shakour, Sohrab Kazemi

“…Abstract The hydrogel system effectively delivered insulin, demonstrating its potential to overcome challenges associated with conventional injectable insulin therapies. …”
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A reproducible ddRAD-seq protocol reveals novel genomic association signatures for fruit-related traits in peach by Najla Ksouri, Gerardo Sánchez, Carolina Font i Forcada, Bruno Contreras-Moreira, Yolanda Gogorcena

“…By assessing the allelic effect of significant markers on phenotypic attributes, nine SNP alleles were deemed favorable. …”
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Environmental and genetic risk factors for Parkinson’s disease by M. A. Nikitina, V. M. Alifirova, E. Yu. Bragina, N. P. Babushkina, D. E. Gomboeva, S. M. Nazarenko

“…The severity of the disease was studied according to the MDS-UPDRS scale; the stage of PD was determined according to the Hoehn and Yahr scale. Cognitive functions were assessed by the MoCA test and MMSE. …”
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Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System by Xiaoping Li, Yuwei Zhang, Wen Zhao, Tian Ren, Xiaolong Wang, Xinzhong Hu

“…In the present study, the effect of polyphenol extracts from tartary buckwheat sprouts (TBSE) on the redox system of HepG2-cell-induced oxidative injury by hydrogen peroxide were investigated for evaluating the protective effect and mechanism of tartary buckwheat sprouts (TBS). …”
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Association of multiple dietary metal intake with cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES 2003–2018 by Sihan Hu, Baojian Wei, Aihua Zhang

“…WQS regression and qgcomp models did not reveal significant effect of the mixture. Subgroup analysis found that the effect of Cu was robust in various subgroups.ConclusionIn conclusion, higher dietary intake Cu was linked to a reduced prevalence of advanced CKM stages in the U. …”
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User Experiences of the Cue2walk Smart Cueing Device for Freezing of Gait in People with Parkinson’s Disease by Matthijs van der Laan, Marc B. Rietberg, Martijn van der Ent, Floor Waardenburg, Vincent de Groot, Jorik Nonnekes, Erwin E. H. van Wegen

“…Freezing of gait (FoG) impairs mobility and daily functioning and increases the risk of falls, leading to a reduced quality of life (QoL) in people with Parkinson’s disease (PD). …”
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CRISPRi screening reveals E. coli’s anaerobic-like respiratory adaptations to gentamicin: membrane depolarization by CpxR by Donghui Choe, Eunju Lee, Yoseb Song, Sun Chang Kim, Ki Jun Jeong, Bernhard Palsson, Byung-Kwan Cho, Suhyung Cho

“…ABSTRACT Bacterial genes serve diverse cellular functions and many affect fitness in response to environmental challenges. …”
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Longitudinal Relations Between Father Hunger and Adolescent Hyper-Competitiveness: Basic Psychological Needs Satisfaction as a Mediator and Mother-Child Attachment as a Moderator by Peng C, Zhang Z, Wang Y, Liu Y, Li X, Yao Y, Zheng X, Fan H

“…Basic psychological needs satisfaction (BPNS) functions as a significant mediator, with higher levels of satisfaction correlating with lower hyper-competitiveness. …”
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