Design and Prototype of a Local Relay Fault Detection System for Three Phase Power Lines. by Lutaama, Samuel

“…Results show that the system functions effectively, with accurate sensor readings and a responsive user interface, though certain design limitations exist. …”
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Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy by Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

“…These findings deepen the understanding of cccDNA modulation and strengthen the scientific basis for the potential of combination therapy.IMPORTANCESince there are currently no approved drugs targeting and silencing covalently closed circular DNA (cccDNA), achieving a “functional cure” remains difficult. This study aims to comprehensively compare the effects of IFNα, small-interfering RNA targeting hepatitis B virus (HBV), and their combination on the activity, accessibility, and epigenetic modifications of cccDNA minichromosomes in cell models. …”
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses by Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

“…Abstract Background Recent studies have revealed that CD8+ T cells can be activated via genetic upregulation of HIF-1α, thereby augmenting antitumor effector functions. HIF-1α upregulation can be attained by inhibiting HIF-prolyl hydroxylase (HIF-PH) under normoxic conditions, termed pseudohypoxia. …”
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CELF6 as an Oncogene in Colorectal Cancer: Targeting Stem-Cell-Like Properties Through Modulation of HOXA5 mRNA Stability by Zhiming Fu, Xiang Wang, Zhiju Chen, Baochun Wang, Weiwei Huang, Xin Liu

“…Furthermore, the knockdown of HOXA5 reversed the inhibitory effects of CELF6 on CRC cell proliferation and stemness, demonstrating that silencing HOXA5 counteracted the suppressive effects of CELF6. …”
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Ultrasound-assisted optimization extraction and biological activities analysis of flavonoids from Sanghuangporus sanghuang by Yanhua Wang, Chen Zhang, Yilin Zhao, Fuhua Wu, Yaoli Yue, Yingjun Zhang, Dandan Li

“…In the current investigation, the study successfully demonstrated the inhibitory effects of S. sanghuang flavonoids on cell proliferation and migration in glioma cells. …”
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MiR-122-5p inhibits the epithelial mesenchymal transition of liver cancer cells by inducing hiPSCs to differentiate into hepatocyte-like cells by Qianzhe Xing, Yanjie Xu, Ying Luo, Chenglong Li, Peng Wang, Bin Kang, Chengjun Lu

“…One promising treatment for liver cancer is cell therapy, where stem cells are stimulated to develop into functional liver cells. This study aimed to investigate the effect of miR-122-5p on the differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells and its impact on the EMT process in liver cancer cells. …”
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Insights into the optoelectronic, quantum chemical, NBO and dynamic nonlinear optical properties of meso-BODIPY dyes by Oluwatoba Emmanuel Oyeneyin, Nathanael Damilare Ojo, Adesoji Alani Olanrewaju, Blessing Lully Isaiah, Nnenna Winifred Odozi, Edmore Farayi Kangara, Matshawandile Tukulula

“…Herein, understanding the effect of substituents on the electronic absorption, optoelectronic, static and dynamic nonlinear optical (NLO) properties, and molecular stability of (CF3-, CH3-, CCl3-, NH2-, NO2-) meso-substituted BODIPY dyes was specifically aimed at using density functional (B3LYP and CAM-B3LYP) approach with 6–311++G(d,p). …”
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Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis by Ipek Pervaz, Lilly Thurn, Cecilia Vezzani, Luisa Kaluza, Anne Kühnel, Nils B. Kroemer

“…Background: Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation has been recognized as a promising biomarker for tVNS-induced monoaminergic release. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Objectives The main objective of this review is to assess evidence about the effects of detention on the mental and physical health and social functioning of asylum seekers. …”
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Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…The hCOs, characterized by expression of key cardiac markers (cTnT) and functional ion channels (Cav1.2, Nav1.5, hERG), exhibited structural and electrophysiological properties reflective of human cardiac physiology. …”
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Inoculum of Endophytic <i>Bacillus</i> spp. Stimulates Growth of Ex Vitro Acclimatised Apple Plantlets by Jurgita Vinskienė, Inga Tamošiūnė, Elena Andriūnaitė, Dalia Gelvonauskienė, Rytis Rugienius, Muhammad Fahad Hakim, Vidmantas Stanys, Odeta Buzaitė, Danas Baniulis

“…Root zone microbiota functional diversity analysis implied that growth stimulation was not related to improved nutrient uptake but could involve a pathogen-suppressing effect. …”
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Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis by Hao Xu, Xueni Sun, Miaoru Peng, Yuanshu Zhao, Shuxian Li, Ping Li, Fan Zhang, Xiaodong Fu, Xiaoyang Xu

“…In addition to its lipid-modifying functions, whether the direct effect of niacin on lysosomal cholesterol efflux contributes to its anti-atherosclerotic actions remains unknown. …”
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Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction by Anurak Muangsanguan, Warintorn Ruksiriwanich, Pipat Tangjaidee, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Sarana Rose Sommano, Korawit Chaisu, Apinya Satsook, Juan Manuel Castagnini

“…These in vitro results support its further investigation for potential application in functional food or nutraceutical development targeting scalp and hair health.…”
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Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcinoma Cell Line, Influencing Cell Proliferation, Quiescence, and Chemoresistance in a Cell-of-Origin-Sp... by Isabel Lemos, Catarina Freitas-Dias, Ana Hipólito, José Ramalho, Fabrizio Carteni, Luís G. Gonçalves, Stefano Mazzoleni, Jacinta Serpa

“…<b>Results:</b> This study demonstrated that despite inducing similar effects, different variants of cfDNA promote different effects on cells derived from the ES-2 cell line. …”
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Biomimetic design and integrated biofabrication of an in-vitro three-dimensional multi-scale multilayer cortical model by Ling Wang, Luge Bai, Sen Wang, Jiajia Zhou, Yingjie Liu, Chenrui Zhang, Siqi Yao, Jiankang He, Chaozong Liu, Dichen Li

“…Micrometer-scale (10 μm) cross-layer fibers effectively guided and controlled the extension length and direction of the neurites of surrounding neural cells but had no significant effect on the migration of neurons. …”
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Deciphering organic substrate impacts in Anammox systems: A machine learning driven framework for predictive classification and process mechanism analysis by Zemin Li, Yulun Wu, Tao Chen, Bo Yan, Chaohai Wei

“…Mechanistic interpretation through molecular-level inhibition analysis further validates the scientific rationale for employing Biochemical Oxygen Demand/Chemical oxygen demand (BOD/COD) ratio as a comprehensive indicator of carbon source effects on Anammox systems. In summary, machine learning framework effectively integrates and optimizes the regulation of material stoichiometry, environmental parameters, and microbial functionality, thereby advancing the development of energy-efficient nitrogen removal technologies and enhancing the evaluation system for wastewater treatment processes.…”
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Utilization of Ultrasonic-Assisted Extraction for Bioactive Compounds from Floral Sources by Sepidar Seyyedi-Mansour, Pauline Donn, Maria Carpena, Franklin Chamorro, Paula Barciela, Ana Perez-Vazquez, Ana Olivia S. Jorge, Miguel A. Prieto

“…Its effectiveness is influenced by a multitude of factors, including operational variables and the matrix effect, both of which have the potential to impact the molecular structures of the specific compounds being targeted. …”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Divergence of approaches and findings between preclinical studies and clinical trials highlights the need for evaluating the design of future clinical studies with particular emphasis on radiation dose and fractionation, immune biomarkers and selecting appropriate end points for combination radiation/immune modulator trials, recognizing that direct effect on the tumor and potential abscopal effect may well be different. …”
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Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease by Maria Olaru, Amelia Hahn, Maria Shcherbakova, Simon Little, Wolf-Julian Neumann, Reza Abbasi-Asl, Philip A. Starr

“…However, the incidence of entrainment during chronic therapeutic stimulation, its relationship to the basal ganglia stimulation site, and its effect on dyskinesia remain unknown. Objective: Determine whether the behavioral effects and statistical properties of levodopa-induced gamma oscillations are altered when entrained with deep brain stimulation. …”
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Long-Term Cognitive Outcomes of Esketamine Nasal Spray in Treatment-Resistant Depression: A Preliminary Report by Matildes de Freitas Menezes Sobreiro, Paulo Sergio Panse Silveira, Vitor Breseghello Cavenaghi, Leandro Paulino da Costa, Bruno Pinatti Ferreira de Souza, Rachel Emy Straus Takahashi, Renato Vianna Marotta Starek, José Oliveira Siqueira, Renerio Fraguas

“…<b>Background/Objectives</b>: Ketamine/esketamine has a rapid/robust antidepressant effect on treatment-resistant depression (TRD). However, its long-term cognitive effects remain unclear. …”
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